Paid Clinical Trials in Springfield, MO
As of June 2026, 148 paid clinical trials are recruiting in Springfield, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Springfield offers studies at sites including Mercy Hospital Springfield for conditions such as Obesity, Overweight, Anatomic Stage IV Breast Cancer AJCC v8, Malignant Solid Neoplasm. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Springfield
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·Clear filters·↓ Download CSVAbout research studies in Springfield
Springfield has approximately 148 recruiting research studies across a wide range of therapeutic areas. Missouri hosts Washington University School of Medicine in St. Louis and University of Kansas Medical Center's Missouri partners, known for oncology, genomics, and rare-disease research.
Top Research Study Locations in Springfield
Researchers run research studies in Springfield, MO at 39 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Mercy Hospital Springfield | Anatomic Stage IV Breast Cancer AJCC v8, Malignant Solid Neoplasm, Stage IV Lung Cancer AJCC v8 | 75 |
| CoxHealth South Hospital | Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8 | 61 |
| Oncology Hematology Associates | Neoplasm Metastasis, Carcinoma, Non-Small-Cell Lung, Breast Cancer | 12 |
| Clinvest Headlands Llc | Obesity, Overweight, Chronic Low Back Pain (CLBP) | 6 |
| Clinvest Research LLC | Chronic Low-back Pain, Diabetic Neuropathic Pain, Diabetic Peripheral Neuropathic Pain | 4 |
| GSK Investigational Site | Non-alcoholic Fatty Liver Disease, Multiple Myeloma | 3 |
| Cox Medical Center South | Atrial Fibrillation, Bronchiolitis Acute, Intracerebral Hemorrhage | 3 |
| Bio-Kinetic Clinical Applications, LLC dba QPS-MO | Healthy, Diabetes Mellitus, Type 2 | 3 |
| Clinvest Research, LLC | Acute Treatment of Migraine, Pediatric Migraine | 2 |
| Cox Health | AAA - Abdominal Aortic Aneurysm, Open Midline Laparotomy | 2 |
| Delricht Research - Command Family Medicine | Gout, Tophaceous Gout | 2 |
| Mercy Clinic Cancer and Hematology - Chub O'Reilly Cancer Center | Colorectal Cancer, Non-Small Cell Lung Cancer | 2 |
| AIDS Project of the Ozarks | ART, HIV Infections, Noncompliance, Patient | 1 |
| Clinvest Research | Obesity, Osteoarthritis, Knee, Overweight | 1 |
| Cox Health South Hospital | Breast Carcinoma, Colorectal Carcinoma, Lung Non-Small Cell Carcinoma | 1 |
| Cox Medical Center | Triple Negative Breast Cancer | 1 |
| Cox Medical Center North | Fallopian Tube Neoplasms, Neoplasm Metastasis, Ovarian Neoplasms | 1 |
| Cox Medical Center North | Non-small Cell Lung Cancer | 1 |
| Cox Medical Centers | Structural Heart Disease | 1 |
| Cox South Hospital | Cutaneous Melanoma, Stage II | 1 |
| CoxHealth | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 1 |
| DelRicht Clinical Research - Springfield | Chronic Idiopathic Constipation (CIC) | 1 |
| DelRicht Research | Influenza | 1 |
| DelRicht Research @ Command Family Medicine | Diabetes, Type 2, Obesity, Overweight | 1 |
| Headlands Research | Diabetes Mellitus, Type 2 | 1 |
| Hulston Cancer Center | Non Small Cell Lung Cancer | 1 |
| Local Institution - Unk058 | Advanced NSCLC, Metastatic Lung Cancer | 1 |
| Mercy Children's Hospital - Springfield | Normal and Diseased Tissue and Body Fluids Samples | 1 |
| Mercy Clinic Springfield Communities | Epidermal Growth Factor Receptor Gene Mutation, Non Small Cell Lung Cancer, Stage III Lung Cancer | 1 |
| Mercy Health - Springfield | Cancer | 1 |
| Mercy Hospital | Lung Cancer, Pulmonary Nodule, Solitary | 1 |
| Mercy Hospital - SPG | Advanced Solid Tumors Cancer, Bladder Cancer, Cancer | 1 |
| Mercy Medical Research Institute | Chronic Pain | 1 |
| Mercy Research | Acute Myocardial Infarction (AMI), Cardiovascular Risk | 1 |
| Mercy Research - Springfield | Hypothyroidism | 1 |
| Ohio State University Telemedicine | Advanced Pancreatic Carcinoma, Metastatic Pancreatic Carcinoma, Stage II Pancreatic Cancer AJCC v8 | 1 |
| QPS Bio-Kinetic | Healthy Participants, Pharmacokinetics | 1 |
| Site 0226 - CoxHealth | High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer | 1 |
| St Johns Health System Inc | Lumbar Spinal Stenosis | 1 |
Active & Upcoming Studies in Springfield (2026)
Recruiting trials in Springfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (95 active studies)
- A Study to Evaluate the Efficacy and Safety of Belantamab Mafodotin in Combination With Standard of Care in Participants With Relapsed-Refractory Multiple Myeloma (RRMM) · Phase 2 · GlaxoSmithKline
- A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer · Phase 3 · Incyte Corporation
Diabetes & metabolic (11 active studies)
- A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight · Phase 2 · Eli Lilly and Company
- AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain · Phase 3 · Novo Nordisk A/S
Neurology & pain (9 active studies)
- A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Diabetic Peripheral Neuropathic Pain · Phase 2 · Eli Lilly and Company
- A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain · Phase 3 · Eli Lilly and Company
Cardiovascular (4 active studies)
- Improvement of an Algorithm to Detect Structural Heart Murmurs in Adult Patients Using Electronic Stethoscopes · Eko Devices, Inc.
- Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS · Phase 3 · DalCor Pharmaceuticals
Mental health & behavior (2 active studies)
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
- Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program · Phase 3 · Alliance for Clinical Trials in Oncology
Vaccines (1 active study)
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
HIV / STI (1 active study)
- Accelerated ART Initiation for PWHIV Who Are Out of Care · Phase 4 · University of Missouri-Columbia
Pediatric (1 active study)
- Randomized Study in Children and Adolescents With Migraine: Acute Treatment · Phase 3 · Pfizer
Common conditions studied in Springfield
- Obesity (6 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
- Overweight (6 active studies). Recruiting Overweight studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Anatomic Stage IV Breast Cancer AJCC v8 (5 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Malignant Solid Neoplasm (5 active studies). Recruiting Malignant Solid Neoplasm studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Stage IV Lung Cancer AJCC v8 (5 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
- Anatomic Stage II Breast Cancer AJCC v8 (4 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
Leading research sponsors in Springfield
- National Cancer Institute (NCI)
- NRG Oncology
- Alliance for Clinical Trials in Oncology
- SWOG Cancer Research Network
- Eli Lilly and Company
Local regulations and guidelines
Clinical trials in Missouri are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Missouri research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Springfield. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Springfield
Hipa.ai aggregates every recruiting study in Springfield from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Springfield?
There are approximately 148 recruiting clinical trials in Springfield, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Springfield pay participants?
Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Springfield?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Springfield?
The most common conditions under active study in Springfield include Obesity (6), Overweight (6), Anatomic Stage IV Breast Cancer AJCC v8 (5), Malignant Solid Neoplasm (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Springfield?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Springfield?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Springfield?
Recruiting research sites in Springfield include Mercy Hospital Springfield, CoxHealth South Hospital, Oncology Hematology Associates, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Springfield right now?
The largest active categories in Springfield are Cancer & tumors (95), Diabetes & metabolic (11), Neurology & pain (9). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.