Oncology Clinical Trials in Tyler, TX
As of August 2026, 55 paid clinical trials are recruiting for Oncology in Tyler, Texas. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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55 clinical trials for Oncology
·Clear filters·Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
A Study to Assess Adverse Events and Change in Disease Activity of Multiple Treatment Combinations With Intravenous Mirvetuximab Soravtansine in Adult Participants With Ovarian Cancer
A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
A Study to Assess Adverse Events and How Intravenously (IV) Infused Telisotuzumab Vedotin (ABBV-399) Moves Through the Body as a Monotherapy in Adult Participants With Previously Treated Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
Consolidation of First-Line MRD+ Remission With Cema-cel in Patients With LBCL
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
A Study of INCB123667 in Participants With Platinum-Resistant Ovarian Cancer With Cyclin E1 Overexpression
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1
A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator's Choice in Participants With Relapsed/Refractory Follicular Lymphoma Who Have Received at Least 1 Prior Line of Systemic Therapy (GOLSEEK-4)
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
A Study of Tacabrutideg (BGB-16673) Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors
A Study to Assess A Change in Disease Activity and Adverse Events of Intravenous Etentamig and Daratumumab (Etentamig+D) Compared to Daratumumab, Lenalidomide, and Dexamethasone (DRd) in Adult Participants With Newly Diagnosed Multiple Myeloma Not Eligible for Transplant
A Study of YL201 in Patients With Advanced Solid Tumors
A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
Study of Nab-Paclitaxel and Gemcitabine With or Without SBP-101 in Pancreatic Cancer
Top Research Study Locations in Tyler
Researchers run research studies in Tyler, TX at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Texas Oncology - Northeast Texas | Carcinoma, Non-Small-Cell Lung, Advanced Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung (NSCLC) | 23 |
| Tyler Research Institute, LLC | Crohn's Disease, Ulcerative Colitis, Colitis, Ulcerative | 16 |
| Tyler Research Institute | Ulcerative Colitis, Obesity or Overweight, Crohn's Disease | 8 |
| CHRISTUS Trinity Mother Frances Health System | Atrial Fibrillation, Beta-blocker Therapy, Cardiomyopathy | 7 |
| Texas Oncology - Northeast | Advanced Lung Cancer, Advanced Solid Tumor, B-cell Lymphoma | 5 |
| Texas Oncology - Tyler | Breast Cancer, Bone Metastases From Solid Tumors, Cancer | 5 |
| Texas Oncology | Advanced/Metastatic Solid Tumors, Colorectal Cancer, Esophageal Cancer | 4 |
| Texas Oncology, P.A. - Tyler | Gastric Cancer, Gastroesophageal Junction Cancer, Metastatic Castration-resistant Prostate Cancer | 4 |
| The University of Texas Health Science Center at Tyler | Carcinoma, Non-Small-Cell Lung, Crohn Disease, Extensive Stage Small Cell Lung Cancer (ES-SCLC) | 4 |
| Tyler Retina Consultants | DME, Diabetic Macular Edema, Diabetic Macular Edema (DME) | 4 |
| The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center | Non-small Cell Lung Cancer, Triple-Negative Breast Cancer, Breast Neoplasms | 4 |
| Texas Oncology Tyler | Chronic Lymphocytic Leukemia, CLL, Small Lymphocytic Lymphoma | 3 |
| Texas Oncology-Northeast Texas | Breast Cancer, Breast Neoplasms, Non-Small Cell Lung Cancer Metastatic | 3 |
| University of Texas Health Center at Tyler | KRAS G12C Lung Cancer, Moderately to Severely Active Crohns Disease, Moderately to Severely Active Ulcerative Colitis | 3 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 2 |
| Clinical Study Site | Metastatic Colorectal Cancer (CRC), Non-Small Cell Lung Cancer | 2 |
| GSK Investigational Site | Multiple Myeloma, Neoplasms, Newly Diagnosed Multiple Myeloma | 2 |
| Precision Spine Care | Degenerative Disc Disease, Degenerative Disc Disease (DDD), Disc Degeneration | 2 |
| Texas Oncology- Northeast Texas | B-Cell Non-Hodgkins Lymphoma, Refractory Metastatic Microsatellite Stable Colorectal Cancer (MSS-CRC) | 2 |
| Texas Oncology-Tyler | Essential Thrombocythemia, Ovarian Cancer | 2 |
| Tyler Cardiovascular Consultants | Atrial Fibrillation (AF), Cardiovascular Disease | 2 |
| UT Health East Texas HOPE Cancer Center | Carcinoma, Non-Small Cell Lung, Colorectal Neoplasms, Cutaneous Squamous Cell Cancer | 2 |
| 016 | Advanced Solid Tumor | 1 |
| Adverum Clinical | Neovascular Age-Related Macular Degeneration (nAMD), Wet AMD | 1 |
| Anthos Investigative | Atrial Fibrillation (AF) | 1 |
Active & Upcoming Studies in Tyler (2026)
Recruiting trials in Tyler grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (76 active studies)
- Study of NX-5948 in Combination With Other Agents in Adults With B-cell Malignancies · Phase 1, Phase 2 · Nurix Therapeutics, Inc.
- Gotistobart Long Term Extension (LTE) Study · Phase 3 · OncoC4, Inc.
Cardiovascular (15 active studies)
Eye & vision (8 active studies)
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections · Phase 4 · Harrow Inc
- Efficacy and Safety Study of Ixoberogene Soroparvovec (Ixo-vec) in Participants With Neovascular Age-related Macular Degeneration (AQUARIUS) · Phase 3 · Adverum Biotechnologies, Inc.
Diabetes & metabolic (5 active studies)
- Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study · Phase 3 · Eli Lilly and Company
- Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight · Phase 3 · Eli Lilly and Company
Neurology & pain (3 active studies)
- Phase III Study to Assess the Safety and Efficacy of SL1002 for Osteoarthritis Knee Pain · Phase 3 · Saol Therapeutics Inc
- Clinical Trial Evaluating the Safety and Efficacy of Nucleus Pulposus Allograft in Participants With Degenerative Disc Disease · VIVEX Biologics, Inc.
Common conditions studied in Tyler
- Crohn's Disease (11 active studies)
- Ulcerative Colitis (8 active studies)
- Chronic Lymphocytic Leukemia (5 active studies)
- Endometrial Cancer (5 active studies)
- Non-Small Cell Lung Cancer (5 active studies)
- Advanced Solid Tumor (4 active studies)
Leading research sponsors in Tyler
- AbbVie
- Merck Sharp & Dohme LLC
- Janssen Research & Development, LLC
- AstraZeneca
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Tyler?
There are approximately 159 recruiting clinical trials in Tyler, Texas listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Tyler pay participants?
Most recruiting trials in Tyler compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Tyler?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Tyler?
The most common conditions under active study in Tyler include Crohn's Disease (11), Ulcerative Colitis (8), Chronic Lymphocytic Leukemia (5), Endometrial Cancer (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Tyler?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Tyler on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Tyler?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Tyler?
Recruiting research sites in Tyler include Texas Oncology - Northeast Texas, Tyler Research Institute, LLC, Tyler Research Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Tyler right now?
The largest active categories in Tyler are Cancer & tumors (76), Cardiovascular (15), Eye & vision (8). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.