Lymphedema Clinical Trials

Recruiting lymphedema studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat lymphedema. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting lymphedema studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting lymphedema trials

Within

Boosted Compression for Lower Limb Chronic Edema

for Chronic Edema

Sponsor: Universiteit Antwerpen

Sex: All·Age: 18+

Code: NCT07708662

Apply to this trial

Clinical Lymphedema Evaluation - Advancing Reconstruction of Head and Neck Lymphatics With Symani

for Lymphedema

Sponsor: MMI (Medical Microinstruments, Inc.)

Sex: All·Age: 22+

Code: NCT07311876

Apply to this trial

Detecting the Undetected: Heart Failure Screening at the Lymphoedema Point of Care

for Lymphedema, Lower Limb

Sponsor: Swansea Bay University Health Board

Sex: All·Age: 18+

Code: NCT07498868

The Effect of Resistance Exercise in Patients With Lower Limb Lymphedema (the LymphEx Study)

for Lymphedema

Sponsor: Carsten Bogh Juhl

Sex: All·Age: 18+

Code: NCT07558317

Apply to this trial

Infant Massage for Lymphedema and Comfort in Preterm Newborns

for Lymphedema

Sponsor: Erzurum Technical University

Sex: All·Age: 28 Weeks - 37 Weeks

Code: NCT07418814

Multimodal Ultrasound for Differentiating Lymphedema and Lipedema

for Lymphedema

Sponsor: Kayseri City Hospital

Sex: Female·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07489248

Apply to this trial

Lymphoedema Diagnosis and Treatment

for Lymphedema

Sponsor: Fatih Sultan Mehmet Training and Research Hospital

Sex: All·Age: 18+

Code: NCT07485465

Investigation of the Effectiveness of Progressive Resistance Exercise Training in the Management of Lymphedema.

for Lymphedema

Sponsor: Uskudar University

Sex: Female·Age: 18 - 60·Accepts healthy volunteers

Code: NCT07448467

Apply to this trial

Sahid Method for Secondary Unilateral Lower Limb Lymphedema

for Lymphedema

Sponsor: University Diego Portales

Sex: Female·Age: 30 - 65

Code: NCT07198698

CONNECT: A Multi-Cohort, Prospective Investigation of the Symani® Surgical System

for Microsurgery

Sponsor: MMI (Medical Microinstruments, Inc.)

Sex: All·Age: 18 - 100

Code: NCT06866197

Apply to this trial

Nutritional Ketosis: a Novel Metabolic Strategy to Treat Lymphedema Patients?

for Lymphedema

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18+

Code: NCT03991897

Apply to this trial

A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons

for Open Surgery

6 sites incl. Beverly Hills

Sponsor: MMI (Medical Microinstruments, Inc.)

Sex: All·Age: 22+

Code: NCT06725030

Apply to this trial

Impact of Virtual Reality (VR) Based Exercises on Lower Limb Lymphedema Outcomes (LELO)

for Lymphedema

Sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital

Sex: All·Age: 18 - 65

Code: NCT07472543

Apply to this trial

Reversing External-beam Radiotherapy-associated Fibrosis Syndrome: an Interventional Bayesian Adaptive Randomized-controlled Orphan Drug Platform Trial for Orodental Sequelae (Reverse-fibrose)

for Fibrosis Syndrome

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: All ages

Code: NCT06912763·Phase 2

Apply to this trial

Supermicrosurgical Lymphaticovenous Anastomosis for Prevention of Upper Limb Lymphedema

for Breast Cancer-Related Lymphedema

Sponsor: Tianjin Medical University Cancer Institute and Hospital

Sex: Female·Age: 18+

Code: NCT07026292

Longitudinal Body Composition Assessment in Breast Cancer Patients

for Breast Neoplasms

Sponsor: Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation

Sex: Female·Age: 18+

Code: NCT07472803

Apply to this trial

Effect of Lymphovenous Anastomosis on Lower Limb Lymphedema: Pragmatic Randomized Controlled Trial

for Lymphedema

Sponsor: Herlev and Gentofte Hospital

Sex: All·Age: 18+

Code: NCT07073586

Apply to this trial

The BEACON Trial: Diagnostic Tools for Breast Lymphedema After Treatment for Breast Cancer

for Breast Edema

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT06900023

Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema

for Lymphedema

2 sites incl. Red Bank

Sponsor: Advanced Reconstructive Surgery Alliance

Sex: All·Age: 18+

Code: NCT07012642·EARLY_Phase 1

Apply to this trial

Systemic Therapy of Open-label Prophylactic Pravastatin or Pentoxifylline/Tocopherol Prevention of Lymphedema Advancing to Eventual Fibrosis: an Interventional Registry-embedded Bayesian Randomized Trial for Radiation Sequelae (STOP4-LATE-FIBROSE)

for Lymphedema

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06494111·Phase 2

Apply to this trial

A Global, Prospective, Real-World, Investigation of the Symani® Surgical System for Microsurgical Anastomosis

for Open Surgery

Sponsor: MMI (Medical Microinstruments, Inc.)

Sex: All·Age: 18+

Code: NCT06628219

Lymphedema Prevention Through Immediate Lymphatic Reconstruction (LILY) Trial.

for Lymphedema

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06989099·Phase 2

Apply to this trial

Topical Tacrolimus for Breast Cancer-related Lymphedema

for Lymphedema

Sponsor: Odense University Hospital

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06306274·Phase 2, Phase 3

Evaluating Factors In Study Experiences of Lymphedema Patients

for Lymphedema

1 site in San Francisco

Sponsor: Power Life Sciences Inc.

Sex: All·Age: 18+

Code: NCT05948345

Investigation of Lipedema, Lymphedema and Vascular Malformations by Multispectral Optoacoustic Tomography (MSOT)

for Lipedema

Sponsor: University Hospital Goettingen

Sex: Female·Age: 18 - 80

Code: NCT06399367

Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Compression Device (NPCD) for Lymphedema/Phlebolymphedema

for Phlebolymphedema

1 site in New York

Sponsor: Koya Medical, Inc.

Sex: All·Age: 18 - 100

Code: NCT06418282

Apply to this trial

Pedal Pump and Leg Lymphedema

for Lymphedema

1 site in Stratford

Sponsor: Rowan University

Sex: All·Age: 55 - 100·Accepts healthy volunteers

Code: NCT06235463

Apply to this trial

Who and Why do Patients Report Lymphedema After Breast Cancer Treatment Without an Objective Measurable Swelling

for Breast Cancer

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18+

Code: NCT06324721

Apply to this trial

Gut Microbiota in Patients With Limb Lymphedema and Recurrent Lymphangitis

for Lymphedema

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 18 - 85

Code: NCT06228937

Apply to this trial

Study of Lymphatic Dysfunction in Primary and Secondary Lymphedema

for Lymphedema

Sponsor: University Hospital, Toulouse

Sex: All·Age: 18 - 75

Code: NCT05629026

Apply to this trial

Lymphedema, Low-grade Inflammation and the Vasculature in Turner Syndrome

for Turner Syndrome

Sponsor: University of Aarhus

Sex: Female·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06325618

Apply to this trial

Effectiveness of Self-Physiotherapy in the Management of Lymphedema

for Breast Cancer

Sponsor: Dokuz Eylul University

Sex: Female·Age: 18 - 65

Code: NCT06652295

Inelastic Compression in Edema After Revascularization

for Lymphedema

Sponsor: Centre Hospitalier Universitaire de Nice

Sex: All·Age: 18 - 99

Code: NCT05910411

Apply to this trial

Testing for Increased Lipoproteins (a) [LP(a)] in Lymphedema Patients: Li-LY

for Lymphedema

Sponsor: Centre Hospitalier Universitaire de Nice

Sex: All·Age: 18 - 99

Code: NCT05962827

Apply to this trial

A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer

for Lymphedema

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: Female·Age: 18 - 75

Code: NCT06144164·Phase 3

Apply to this trial

Surgical Evaluation for Upper Extremity Lymphedema (BioBridge)

for Lymphedema

1 site in Stanford

Sponsor: Fibralign Corporation

Sex: All·Age: 18 - 75

Code: NCT05695924

Apply to this trial

Early Intervention to Prevent Lower Limb Lymphedema of Gynecological Malignancy

for Uterine Cervical Neoplasms

Sponsor: Chongqing University Cancer Hospital

Sex: Female·Age: 18 - 60

Code: NCT05793749

Apply to this trial

Early Diagnosis of Breast Cancer-related Lymphedema

for Lymphedema

Sponsor: Kaohsiung Veterans General Hospital.

Sex: Female·Age: 20 - 80

Code: NCT06046365

Apply to this trial

Lymphedema After Gyneco-oncologic Treatment

for Lymphedema

Sponsor: University Hospital, Ghent

Sex: Female·Age: 18 - 99

Code: NCT05469945

Apply to this trial

Added Value of Reconstructive Lymphatic Surgery to Usual Care in Lymphoedema

for Lymphoedema of Leg

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18+

Code: NCT05064176

Apply to this trial

Effects of Extracorporeal Shock Wave Therapy and Pulse Electromagnetic Field Therapy on Lymphoedema

for Lymphedema

Sponsor: Zheng-Yu Hoe, MD., PhD.

Sex: All·Age: 20 - 80·Accepts healthy volunteers

Code: NCT06041958

Apply to this trial

LYMPHA Procedure for the Prevention of Lymphedema After Axillary Lymphadenectomy

for Lymphedema, Breast Cancer

1 site in San Francisco

Sponsor: Stanford University

Sex: Female·Age: 18 - 75

Code: NCT05366699

Apply to this trial

A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of the Dayspring Technology for Patients With Breast Cancer Related Lymphedema (BCRL) After Lymphatic Surgery

for Lymphedema

1 site in Palo Alto

Sponsor: Koya Medical, Inc.

Sex: All·Age: 18+

Code: NCT04888975

Apply to this trial

Primary Surgical Prevention of Breast Cancer-related Lymphedema

for Lymphedema

Sponsor: Gangnam Severance Hospital

Sex: All·Age: 19+

Code: NCT04687956

Apply to this trial

LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)

for Lymphedema

2 sites incl. Chicago

Sponsor: Fibralign Corporation

Sex: All·Age: 18 - 75

Code: NCT04606030

Apply to this trial

Sub-Hertz Analysis of Viscoelasticity of Limbs in Patients With Lymphedema

for Lymphedema

2 sites incl. Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04258319

Vascular Lab Resource (VLR) Biorepository

for Cardiovascular Diseases

1 site in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT05628948

Apply to this trial

Biorepository of Biomarkers for Optimization of Microvascular Treatment of Lymphedema

for Lymphedema

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04123457

Screening For BCRL In Targeted Therapy For Breast Cancer

for Lymphedema

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 80

Code: NCT05142800

Apply to this trial

A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical Management

for Lymphedema

3 sites incl. Harrison

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18 - 80

Code: NCT03248310

Apply to this trial

The Robot-LVA Study: Robot-assisted Microsurgical Lymphaticovenous Anastomosis in Breast Cancer-related Lymphedema

for Lymphedema

Sponsor: Maastricht University Medical Center

Sex: Female·Age: 18+

Code: NCT06532955

Apply to this trial

Lymphedema Surveillance Study

for Breast Cancer

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: Female·Age: 18+

Code: NCT02743858

Apply to this trial

An Integrated Algorithm for Surgical Intervention in Chronic Lymphedema After Breast Cancer Treatment: The Basel Lymphedema Protocol

for Lymphedema

Sponsor: University Hospital, Basel, Switzerland

Sex: All·Age: All ages

Code: NCT06374745

Apply to this trial

Prospective Screening for Breast Cancer-related Lymphedema

for Lymphedema

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18+

Code: NCT01521741

Apply to this trial

Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic Disorders

for Lymphedema

3 sites incl. Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 3 Months+·Accepts healthy volunteers

Code: NCT00833599

A Real-World Registry of Chronic Wounds and Ulcers

for Diabetic Foot

1 site in The Woodlands

Sponsor: U.S. Wound Registry

Sex: All·Age: All ages

Code: NCT02280733

Apply to this trial

Lymphedema clinical trials — common questions

Are lymphedema clinical trials free to join?

Yes. Participating in a lymphedema clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a lymphedema clinical trial?

Each lymphedema study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a lymphedema trial near me?

Use the location controls above. We'll show recruiting lymphedema trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many lymphedema trials are recruiting right now?

We're currently tracking roughly 23 recruiting lymphedema trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Lymphedema trials by city

Boston, MA Jacksonville, FL San Francisco, CA Beverly Hills, CA Chicago, IL Cleveland, OH Palo Alto, CA Stanford, CA

Related specialties

Vascular medicine