Metastatic breast cancer Clinical Trials

Recruiting metastatic breast cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat metastatic breast cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting metastatic breast cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting metastatic breast cancer trials

Within

A Study to Learn More About Tukysa Once it is Out in the Korean Market

for HER2-positive Locally Advanced Unresectable

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT06873191

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

for Anatomic Stage III Breast Cancer AJCC v8

2 sites incl. Boston

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT07137416·Phase 1

Apply to this trial

A Phase II Study of Zongertinib Plus Fulvestrant in Participants With HR-positive/HER2-negative Advanced Breast Cancer Harboring HER2 Mutations.

for Advanced Breast Cancer

Sponsor: MedSIR

Sex: All·Age: 18+

Code: NCT07619066·Phase 2

Testing the Safety of the Anti-cancer Drug, Sn-117m-DTPA, for Advanced Cancers That Have Spread to Bones

for Anatomic Stage IV Breast Cancer AJCC v8

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT06982222·Phase 1

CRYO-TOUCH: Cryoablation of the Primary Breast Tumor in Metastatic Breast Cancer

for Metastatic Breast Cancer

Sponsor: Hospices Civils de Lyon

Sex: Female·Age: 18+

Code: NCT07676344

SHIELD: Surveillance of HR+/HER2- : Implementing ESR1m Long-term Monitoring and Detection in 1L aBC

for Advanced Breast Cancer

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07701070

Sexual Health and Rehabilitation for Women With Metastatic Breast Cancer (SHARE-MC): An Educational Intervention

for Metastatic Breast Cancer

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18+

Code: NCT07519200

T-DXd Based Therapy Followed by Endocrine Therapy Plus Dual HER2 Blockade in First-line HER2+/ HR+ Metastatic Breast Cancer and Retreatment With T-DXd

for Advanced Breast Cancer

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT07683754·Phase 3

Trastuzumab Deruxtecan and Lovastatin in HER2-low and Ultralow Advanced or Metastatic Breast Cancer

for Breast Cancer

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07619365·Phase 2

Targeting Aurora A Kinase to Overcome Treatment Resistance in Advanced HR+/HER2+ Breast Cancer

for HR+/HER2+ Breast Cancer

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18+

Code: NCT07706179·Phase 2

Pulsed Electric Field Ablation for Metastatic Breast Cancer

for Metastatic Breast Cancer

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07487844

Generative AI Patient Education Module for Breast Oncology

for Breast Cancer

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT07512271

Evaluation of a Patient-Centered Decision-Making Support Tool for Older Adults With Advanced Breast Cancer and Their Care Partners

for Metastatic Breast Cancer

1 site in Rochester

Sponsor: University of Rochester

Sex: All·Age: 65+

Code: NCT07599618

Efficacy and Safety of Utidelone Capsule and Utidelone Injection in Patients With HER-2 Negative Advanced Breast Cancer

for Advanced Breast Cancer

Sponsor: Beijing Biostar Pharmaceuticals Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07684456·Phase 3

A Phase II Study of AK146D1 Combined With AK112 in Advanced Breast Cancer

for Advanced Breast Cancer

Sponsor: Akeso

Sex: All·Age: 18 - 75

Code: NCT07591090·Phase 2

Apply to this trial

Timing of ctDNA Testing in Advanced Breast Cancer

for Advanced Breast Cancer

Sponsor: Geneplus-Beijing Co. Ltd.

Sex: All·Age: 18+

Code: NCT07681323

Apply to this trial

Real-world Study of Pyrotinib-containing Regimens of Advanced HER2-positive Breast Cancer

for HER2 + Breast Cancer

Sponsor: Peking University People's Hospital

Sex: All·Age: 18+

Code: NCT07600164·Phase 4

Apply to this trial

177Lu-DOTATATE for the Treatment of Stage IV or Recurrent Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

1 site in Portland

Sponsor: OHSU Knight Cancer Institute

Sex: All·Age: 18 - 100

Code: NCT04529044·Phase 2

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Stereotactic Ablative Body Radiotherapy (SABR) With Maintenance of Systemic Therapy Versus Physicians' Choice of Systemic Therapy for Oligoprogressive ER-positive, Her-2 Negative Breast Cancer II

for Breast Cancer, Metastatic

Sponsor: Peter MacCallum Cancer Centre, Australia

Sex: All·Age: 18+

Code: NCT06882499

A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With HR+, HER2- Advanced Breast Cancer

for Advanced Breast Cancer

15 sites incl. Hot Springs

Sponsor: TerSera Therapeutics LLC

Sex: Female·Age: 18 - 55

Code: NCT07310420·Phase 1

Apply to this trial

Study of RGT-490 in Patients With PIK3CA-Mutated Advanced Solid Tumors

for Breast Cancer

5 sites incl. Los Angeles

Sponsor: Regor Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT07524322·Phase 1

Apply to this trial

Shared Decision Making for Patients With HER2-negative Metastatic Breast Cancer (SDM-01)

for Breast Cancer

Sponsor: Federico II University

Sex: Female·Age: 18+

Code: NCT07578415

Efficacy and Safety of Trastuzumab Rezetecan or Trastuzumab Deruxtecan in Advanced Breast Cancer

for Advanced Breast Cancer

Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Sex: Female·Age: 18 - 75

Code: NCT07630103·Phase 2

Decision Support Tool for Patients With Advanced Breast Cancer

for Breast Cancer Metastatic

3 sites incl. Brooklyn

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT07635147

Apply to this trial

Exploratory Study of SHR-A1811 Via Different Administration Routes in Patients

for HER2positive

Sponsor: Tianjin Medical University Cancer Institute and Hospital

Sex: All·Age: 18+

Code: NCT07560475·Phase 2

A Study to Investigate the Effect of Food on the Bioavailability of Oral Paclitaxel Administered With Encequidar in Participants With Advanced Solid Tumors

for Metastatic Breast Cancer

Sponsor: Health Hope Pharma

Sex: All·Age: 18+

Code: NCT07580833·Phase 1

Metronomic Oral Paclitaxel Monotherapy and Combined Immunotherapy for Advanced HER2-Negative Breast Cancer: A Two-Stage Dose Exploration and Expansion Trial

for Advanced Breast Cancer

Sponsor: Zhejiang Cancer Hospital

Sex: All·Age: 18+

Code: NCT07602907·Phase 2

First-in-human Diagnostic Imaging Profile of the Theranostic Pair [68Ga]Ga-DOTA-STR-17126 and Low Dose [177Lu] Lu-DOTA-STR-17126 in Patients With Advanced or Metastatic Cancer

for Metastatic Breast Cancer

Sponsor: Integrated Haematology and Oncology Network

Sex: All·Age: 18+

Code: NCT07608848·EARLY_Phase 1

Apply to this trial

A Clinical Study of SYS6023 Combination Therapy for Advanced Breast Cancer

for Advanced Breast Cancer

Sponsor: CSPC Megalith Biopharmaceutical Co.,Ltd.

Sex: All·Age: 18+

Code: NCT07597629·Phase 2

Apply to this trial

HER2-positive Metastatic Breast Cancer in Kazakhstan

for Metastatic Breast Cancer

Sponsor: AstraZeneca

Sex: All·Age: 18 - 99

Code: NCT07593196

Fast-Her: Fasting Effects on Breast Cancer Treatment

for Metastatic Breast Cancer

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: All·Age: 18+

Code: NCT07624617

Apply to this trial

Study to Evaluate the Safety and Tolerability of Camizestrant in Combination With Atirmociclib in Women With Advanced Breast Cancer

for Advanced Breast Cancer

3 sites incl. St Louis

Sponsor: AstraZeneca

Sex: Female·Age: 18+

Code: NCT07427394·Phase 2

Apply to this trial

A Phase I Interventional Open-label, Non-randomized Dose-escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity, and Preliminary Anti-tumor Activity of Autologous p95HER2.CAR-TECH2Me T Cells in Patients With Selected Advanced Cancers.

for Metastatic Gastric Cancer

Sponsor: Vall d'Hebron Institute of Oncology

Sex: All·Age: 18+

Code: NCT07593820·Phase 1

Apply to this trial

A Study of HLD-0117 in Patients With Metastatic Breast Cancer

for Metastatic Breast Cancer

4 sites incl. New Haven

Sponsor: Halda Therapeutics OpCo, Inc.

Sex: Female·Age: 18+

Code: NCT07524855·Phase 1

Apply to this trial

Group-based Comprehensive Lifestyle Program for Women With Metastatic Breast Cancer

for Metastatic Breast Cancer

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: Female·Age: 18+

Code: NCT07179809

A Ph II Study of the TheraBionic P1 Device in Subjects With Hormone Positive Breast Cancer

for HER2-negative Breast Cancer

Sponsor: Barbara Ann Karmanos Cancer Institute

Sex: All·Age: 22+

Code: NCT07227831

[18F]FTT Positron Emission Tomography for the Measurement of PARP Tumor Expression in Patients With Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT06502691·Phase 1, Phase 2

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Study of the Kinesin Oral Molecular Degrader BBI-940 in Subjects With Advanced or Metastatic Breast Cancer

for Breast Cancer

8 sites incl. Los Angeles

Sponsor: Boundless Bio, Inc.

Sex: All·Age: 18+

Code: NCT07408089·Phase 1

Apply to this trial

Feasibility of Serial Multisite Image-guided Biopsy to Study Breast Cancer Evolution

for Breast Cancer

Sponsor: Royal Marsden NHS Foundation Trust

Sex: All·Age: 18+

Code: NCT07084571

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Evolutionary Clinical Trial for Novel Biomarker-Driven Therapies

for Breast Cancer

2 sites incl. Rochester

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07340541·Phase 2

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Phase II, Prospective, Randomized, Proof-of-concept Study to Evaluate the Effects of a Personalized Dietary Intervention in Women With Advanced Gynecologic or Breast Tumors Treated With Antibody-Drug Conjugates (ADCs).

for Gynecologic Cancers

Sponsor: TNC Nutrición Terapéutica S.L.

Sex: Female·Age: 18+

Code: NCT07406789·Phase 2

Breast Cancer Organelle Properties and Protein Expression Atlas in the Three Immunohistochemical Subtypes of Breast Cancers

for Early Breast Cancer

Sponsor: Institut Claudius Regaud

Sex: All·Age: 18+

Code: NCT07233928

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Evaluating Dose Timing (Morning vs Evening) of Endocrine-based Therapies in Metastatic Breast and Prostate Cancers

for Metastatic Breast Cancer

Sponsor: Ottawa Hospital Research Institute

Sex: All·Age: 18+

Code: NCT07252726·Phase 4

Apply to this trial

JSKN016 in Combination With D-0502 for Locally Advanced or Metastatic HR-Positive, HER2-Negative Breast Cancer

for Metastatic Breast Cancer

Sponsor: Jiangsu Alphamab Biopharmaceuticals Co., Ltd

Sex: All·Age: 18+

Code: NCT07336771·Phase 1, Phase 2

Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06860815·Phase 2

Apply to this trial

Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS Trial

for Anatomic Stage I Breast Cancer AJCC v8

1 site in Ann Arbor

Sponsor: University of Michigan Rogel Cancer Center

Sex: Female·Age: 18+

Code: NCT07158021·Phase 2

Apply to this trial

A Study to Evaluate the Effectiveness and Safety of Inavolisib in Participants With Endocrine-resistant, PIK3CA-mutated, Hormone Receptor-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer

for Locally Advanced Breast Cancer

Sponsor: Hoffmann-La Roche

Sex: All·Age: 18+

Code: NCT07347600

Apply to this trial

A Multicohort Study of Toripalimab in Combination With Investigator-Selected Chemotherapy for Advanced HER2-Negative Breast Cancer

for Advanced Breast Cancer

Sponsor: Henan Cancer Hospital

Sex: All·Age: 18+

Code: NCT07540533·Phase 2

Apply to this trial

PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

for Estrogen-receptor-positive Breast Cancer

1 site in Boston

Sponsor: Kristina A. Fanucci

Sex: All·Age: 18+

Code: NCT07222215·Phase 2

Apply to this trial

RC48 Combined With Chemotherapy in HER2-Positive Advanced Breast Cancer Patients With Prior TOP1i-ADC Failure

for HER2-positive Breast Cancer

Sponsor: Fudan University

Sex: Female·Age: 18+

Code: NCT07366840·Phase 2, Phase 3

Sequencing SG vs. T-DXd in HER2-Low/TROP2-High Metastatic Breast Cancer

for Metastatic Breast Cancer

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT07368543·Phase 2

Living Well With Advanced Breast Cancer

for Advanced Breast Carcinoma

1 site in Columbus

Sponsor: Ohio State University Comprehensive Cancer Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07227038

Apply to this trial

A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors

for Advanced Breast Cancer

13 sites incl. Duarte

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07318805·Phase 1

Apply to this trial

Feasibility of Symptom Management for Patients With Metastatic Breast Cancer to Increase Exercise

for Breast Cancer

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07313306

Apply to this trial

Assessement of Potential Interest of [68Ga]Ga-PentixaFor PET/CT in Metastatic Triple Negative Breast Cancer Patients

for Metastatic Breast Cancer

Sponsor: Institut Cancerologie de l'Ouest

Sex: All·Age: 18+

Code: NCT06962163

Apply to this trial

PTEN and Organ-Specific microRNAs in Metastatic Breast Cancer

for Breast Cancer

Sponsor: Atlas University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07297134

Apply to this trial

Phase III Study to Evaluate the Safety, Efficacy, and Impact on Quality of Life of Capivasertib Alongside Standard-of-care Endocrine Treatment in Patients With HR+/HER2- Advanced Breast Cancer and Progression on Prior Endocrine-based Treatment

for Breast Cancer

Sponsor: West German Study Group

Sex: All·Age: 18+

Code: NCT07281833·Phase 3

Apply to this trial

ERADICATE: A Phase Ib/II Study of Elacestrant Plus Trastuzumab Deruxtecan in Patients With CDK4/6 Inhibitor and Endocrine-resistant HR+/HER2-low or HER2-ultralow Metastatic Breast Cancer

for Metastatic Breast Cancer

1 site in Boston

Sponsor: Kristina A. Fanucci

Sex: All·Age: 18+

Code: NCT07198724·Phase 1, Phase 2

Apply to this trial

Optimal Methods to Characterize ADC Resistance in Solid Tumors and Identify Clinically Useful Biomarkers

for Advanced Breast Cancer

Sponsor: UNICANCER

Sex: All·Age: 18+

Code: NCT07259226·Phase 2

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Nurturing Exercise Routine for Greater Improvement in Zest and Energy on Enhertu

for Metastatic Breast Cancer

1 site in Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT07203378·Phase 2

Apply to this trial

Metastatic breast cancer clinical trials — common questions

Are metastatic breast cancer clinical trials free to join?

Yes. Participating in a metastatic breast cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a metastatic breast cancer clinical trial?

Each metastatic breast cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a metastatic breast cancer trial near me?

Use the location controls above. We'll show recruiting metastatic breast cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many metastatic breast cancer trials are recruiting right now?

We're currently tracking roughly 106 recruiting metastatic breast cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Metastatic breast cancer trials by city

Boston, MA Duarte, CA Birmingham, AL San Francisco, CA Los Angeles, CA Jacksonville, FL Chicago, IL Madison, WI Salt Lake City, UT Tampa, FL Ann Arbor, MI Beverly Hills, CA

Related specialties

Oncology Breast oncology