Musculoskeletal pain Clinical Trials

Recruiting musculoskeletal pain studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat musculoskeletal pain. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting musculoskeletal pain studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting musculoskeletal pain trials

Within

Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care

for Chronic Pain

1 site in Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07456150·Phase 1

Empowered Relief for Caregivers

for Chronic Pain

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07636980

Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy

for Cerebral Palsy (CP)

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07585292

Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy

for Chronic Pain

Sponsor: Universidad Autonoma de Madrid

Sex: All·Age: 18+

Code: NCT07451587

Multidisciplinary Health Monitoring for Esports Players

for Musculoskeletal Pain

Sponsor: Yeditepe University

Sex: Male·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07665333

Analgesic Effect of a Biophotonic Foot Massage Cream

for Musculoskeletal Pain

Sponsor: University of Seville

Sex: All·Age: 18+

Code: NCT07501273

The BRIDGE Pain Study

for Juvenile Idiopathic Arthritis (JIA)

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 14 - 26

Code: NCT07602595

Apply to this trial

Veterans' Intervention Blending NeuRomodulation and YogA for Chronic Low BackPaiN Treatment: VIBRANT

for Chronic Low Back Pain

2 sites incl. Chicago

Sponsor: VA Office of Research and Development

Sex: All·Age: 22+

Code: NCT07158567·Phase 3

Regenerative Medicine for Joint Hypermobility and Instability

for Ehlers-Danlos Syndrome Hypermobility Type (hEDS)

Sponsor: Manhattan Pain Medicine, PLLC

Sex: All·Age: 18+

Code: NCT07688096·Phase 1, Phase 2

Symptom Severity, Posture, Pain, and Physical Activity in Gastroesophageal Reflux Disease

for Gastroesophageal Reflux Disease (GERD)

Sponsor: Karabuk University

Sex: All·Age: 18 - 65

Code: NCT07643779

Using Telehealth to Improve Musculoskeletal Care Through Expanded Physical Therapy Access

for Musculoskeletal Pain

4 sites incl. Tripler AMC

Sponsor: Brooke Army Medical Center

Sex: All·Age: 18 - 64

Code: NCT07705945

Combined Physical Activity and Education Intervention for Neck and Shoulder Pain in Children

for Neck and Shoulder Pain

Sponsor: Li Sha

Sex: All·Age: 10 - 12·Accepts healthy volunteers

Code: NCT07661875

Weighted Blanket Use for Adults With Chronic Pain

for Chronic Pain

1 site in Portland

Sponsor: National University of Natural Medicine

Sex: All·Age: 18+

Code: NCT07498491

Apply to this trial

Ischemic Compression and Home Exercise in Non-Specific Neck Pain

for Myofascial Trigger Points

Sponsor: Istanbul Rumeli University

Sex: All·Age: 17 - 65

Code: NCT07685418

Apply to this trial

Video Intervention for Older Adults With Chronic Pain

for Chronic Pain

1 site in Providence

Sponsor: Butler Hospital

Sex: All·Age: 55+

Code: NCT07404618

Apply to this trial

Central Sensitization, Work-Related Stress, and Musculoskeletal Symptoms in Desk-Based Workers With and Without Migraine

for Migraine

Sponsor: Bozok University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07554664

Apply to this trial

Low Back and Neck Pain in Nursing Students at The University of The West Indies

for Back Pain

Sponsor: The University of The West Indies

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07167888

Neck and Low Back Pain in Physical Therapy Students at The University of the West Indies, Mona, Jamaica

for Back Pain

Sponsor: The University of The West Indies

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07177001

The Prevalence of Neck and Low Back Pain in FMSTRC Staff At the UWI Mona

for Neck Pain

Sponsor: The University of The West Indies

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07194746

Active Coping: Interdisciplinary Program for Chronic Pain, Physiotherapy Unit (Spain)

for Chronic Back Pain

Sponsor: Universidad de Zaragoza

Sex: All·Age: 18+

Code: NCT07504094

Virtual Reality (VR) Self-Hypnosis Software

for Musculoskeletal Pain

1 site in New York

Sponsor: Icahn School of Medicine at Mount Sinai

Sex: All·Age: 18+

Code: NCT06398847

Apply to this trial

Multicomponent Care for Aromatase Inhibitor-Related Musculoskeletal Symptoms

for Breast Neoplasms

Sponsor: Addis Ababa University

Sex: Female·Age: 18+

Code: NCT07409948

Neural Mechanisms of Light Driven Analgesia

for Musculoskeletal Pain

1 site in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07245303

Apply to this trial

Association of High PainDETECT Scores With Pain Region and Diagnosis in Patients Attending a Musculoskeletal and Sports Medicine Clinic

for Musculoskeletal Pain

Sponsor: Uskudar University

Sex: All·Age: 18+

Code: NCT07356115

Apply to this trial

Examining the Impact of a Digital Health Program and TENS Device for Patients With Chronic Low Back Pain

for Back Pain Lower Back Chronic

1 site in Eden Prairie

Sponsor: Hinge Health, Inc

Sex: All·Age: 18+

Code: NCT07011537

Online Yoga vs Acceptance and Commitment Therapy for Treating Chronic Musculoskeletal Pain

for Chronic Pain

1 site in Palo Alto

Sponsor: Palo Alto Veterans Institute for Research

Sex: All·Age: 18+

Code: NCT06704061

Apply to this trial

Phase 1 Pilot of a Pragmatic Trial of EAET for Veterans With Chronic Pain

for Musculoskeletal Pain

1 site in Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 18+

Code: NCT07218757

Apply to this trial

The PROmoting Pain Self-Management (PROs) Trial: Holistic Pain Care in the Military Health System

for Chronic Pain

5 sites incl. Fairbanks

Sponsor: Brooke Army Medical Center

Sex: All·Age: 18+

Code: NCT06940986

Apply to this trial

Mindfulness-based Rehabilitation in a University Museum Setting to Reduce Pain and Improve Quality of Life in Women With Fibromyalgia: a Randomized Controlled Trial

for Fibromyalgia

Sponsor: G. d'Annunzio University

Sex: Female·Age: 18 - 60

Code: NCT07048366

Apply to this trial

Virtual Reality-Based Rehabilitation in Chronic Low Back Pain: Effects on Muscle Architecture, Balance, and Satisfaction (VR-LBPREHAB)

for Chronic Low Back Pain (CLBP)

Sponsor: Hacettepe University

Sex: All·Age: 18 - 65

Code: NCT07172828

Integrated Healthy Lifestyle and Pain Care for People With Musculoskeletal Conditions Living in Rural Areas.

for Musculoskeletal Pain

Sponsor: University of Sydney

Sex: All·Age: 18+

Code: NCT07173335

Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries

for Musculoskeletal Pain

1 site in Buffalo

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+

Code: NCT07393503·Phase 4

Group Medical Visits and Chiropractic Care for Older Adults With Chronic Spine Pain

for Chronic Pain

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 65+

Code: NCT06632535

Apply to this trial

Is Low-load Resistance Training With Blood Flow Restriction More Effective Than Traditional Rehabilitation of Military Personnel With Lower Limb Injuries

for Pain

Sponsor: Defence Medical Rehabilitation Centre, UK

Sex: All·Age: 18 - 55

Code: NCT06621953

Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in Albanian

for Musculoskeletal Pain

Sponsor: Universidad Católica San Antonio de Murcia

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06685094

Apply to this trial

The PROACTIVE Study for Black Elders

for Musculoskeletal Pain

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 50 - 92

Code: NCT06512727

Apply to this trial

Compex SP8.0 - Symptomatic Treatment of Musculoskeletal Pain

for Musculoskeletal Conditions

Sponsor: DJO UK Ltd

Sex: All·Age: All ages

Code: NCT06717789

Targeted Realtime Assessment of Chronic Pain in Youth

for Chronic Pain

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 14 - 24

Code: NCT06867757

Apply to this trial

Life-Style Medicine for Chronic Musculoskeletal Pain in Older People

for Musculoskeletal

Sponsor: Chinese University of Hong Kong

Sex: All·Age: 60+

Code: NCT07194239

Apply to this trial

Improvement of Quality of Life Through Supportive Treatments for Hormone Therapy - Related Symptoms in Patients With Early Breast Cancer

for ER+ Breast Cancer

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT06407401·Phase 3

Is Low-load Resistance Training With Blood Flow Restriction Feasible During Rehabilitation of Military Personnel With Lower Limb Injuries? Phase One RCT.

for Pain

Sponsor: Defence Medical Rehabilitation Centre, UK

Sex: All·Age: 18 - 55

Code: NCT06621914

Apply to this trial

Evaluation of the "Intranasal Fentanyl" Protocol in Pediatric Surgical Emergencies at Strasbourg University Hospital

for Musculoskeletal Pain

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 1 - 17

Code: NCT06832046

Apply to this trial

Evaluation and Modification of Surgeon Ergonomics in the Operation Room Using Artificial Intelligence Analytics

for Work Related Upper Limb Disorder

2 sites in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 99

Code: NCT06576570

Improving Health for Older Adults With Pain Through Engagement

for Chronic Pain

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 55+

Code: NCT06119698

Apply to this trial

Effect of Reformer Exercises on Pain Perception in Chronic Musculoskeletal Pain.

for Musculoskeletal Pain

Sponsor: Atılım University

Sex: All·Age: 30 - 50·Accepts healthy volunteers

Code: NCT06706037

Apply to this trial

Equipping Patients Using Interventions for Pain and Depression

for Chronic Pain

1 site in Indianapolis

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT06500780

Apply to this trial

Stress and Musculoskeletal Health in Employees

for Musculoskeletal Diseases or Conditions

Sponsor: University of Thessaly

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT06488547

Apply to this trial

Keeping it Simple Study (KISS)

for Musculoskeletal Pain

Sponsor: Bettina Eiger

Sex: All·Age: 18+

Code: NCT06297447

Apply to this trial

Effectiveness of Virtual Reality (VR) in Non-oncologic Chronic Musculoskeletal Pain

for Musculoskeletal Pain

Sponsor: Azienda Sanitaria-Universitaria Integrata di Udine

Sex: All·Age: 18 - 50

Code: NCT06100926

MOTIVATE to Improve Outcomes for Older Veterans With Musculoskeletal Pain and Depression

for Chronic Back Pain

2 sites incl. Dallas

Sponsor: VA Office of Research and Development

Sex: All·Age: 60 - 99

Code: NCT05220202

Apply to this trial

Supraspinal Processing of Sensory Aspects of Pain

for Migraine in Children

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 10 - 17·Accepts healthy volunteers

Code: NCT05814497

Apply to this trial

Eastern Principles Acceptance and Commitment Therapy For Injury Prevention Among Nurses and Nursing Aides

for Well-Being, Psychological

1 site in Bowling Green

Sponsor: Bowling Green State University

Sex: All·Age: 18+

Code: NCT06813495

Apply to this trial

Overlapping Pain Trajectory Study

for Migraine

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 10 - 19·Accepts healthy volunteers

Code: NCT05752396

Apply to this trial

Insomnia in Patients Participating in Interdisciplinary Pain Rehabilitation

for Musculoskeletal Pain

Sponsor: Norwegian University of Science and Technology

Sex: All·Age: 18+

Code: NCT06478628

TCM as an Adjuvant Treatment in Breast Cancer Patients

for Breast Cancer

Sponsor: Universiti Tunku Abdul Rahman

Sex: Female·Age: 18+

Code: NCT04843865

Apply to this trial

Comparing Reports Recorded by the Patients at the Time at Which They Feels Pain to What Patients Report at Monthly Visits to Assess Symptoms of Musculoskeletal Diseases.

for Musculoskeletal Pain

Sponsor: Ente Ospedaliero Cantonale, Bellinzona

Sex: All·Age: 18+

Code: NCT06283199

Apply to this trial

Neck and Low Back Pain in Medical Students at The University of the West Indies, Mona, Jamaica

for Back Pain

Sponsor: The University of The West Indies

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT03707288

Apply to this trial

Effectiveness of the Healthy Workplace Participatory Program With Peer-led Teams in Public Sector Healthcare Facilities

for Work-Related Condition

Sponsor: University of Massachusetts, Lowell

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04251429

Trends in Prevalence of 11 Site-specific Musculoskeletal Pain Among U.S. Adults, 1999-2018

for Musculoskeletal Pain

Sponsor: Fan luying

Sex: All·Age: All ages

Code: NCT06494670

Musculoskeletal pain clinical trials — common questions

Are musculoskeletal pain clinical trials free to join?

Yes. Participating in a musculoskeletal pain clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a musculoskeletal pain clinical trial?

Each musculoskeletal pain study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a musculoskeletal pain trial near me?

Use the location controls above. We'll show recruiting musculoskeletal pain trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many musculoskeletal pain trials are recruiting right now?

We're currently tracking roughly 20 recruiting musculoskeletal pain trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Musculoskeletal pain trials by city

Cincinnati, OH Palo Alto, CA Boston, MA Gainesville, FL Aurora, CO Chicago, IL Indianapolis, IN Los Angeles, CA Portland, OR

Related specialties

Pain management Musculoskeletal disorders