Paid Clinical Trials in Naperville, IL
As of July 2026, 68 paid clinical trials are recruiting in Naperville, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Naperville offers studies at sites including Edward Hospital/Cancer Center for conditions such as Heart Failure, Breast Cancer, Migraine, Atrial Fibrillation. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Naperville
Trials by drug in Naperville
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60 clinical trials
↓ Download CSVRandomized Study in Children and Adolescents With Migraine: Acute Treatment
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
A Study of Vedolizumab in Adults With Ulcerative Colitis or Crohn's Disease in the Community Setting
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
A Research Study to Look at How Ziltivekimab Works Compared to Placebo in People With Heart Failure and Inflammation
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
A Study to Learn About the Study Medicine Called Rimegepant in Adolescents With Frequent Migraine
The CONFORM Pivotal Trial
A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.
Prevail Global Study
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
Zenith® Fenestrated+ Clinical Study
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare
Prospective, Open-label, Non-significant Risk, Multicenter Study Comparing the Polyp Detection of the Study Device to That of the Colonoscopy Reference
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks
Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure
Hyrax Vs. Invisalign Palatal Expander Clinical Study
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Cognitive Training for Cancer Related Cognitive Impairment in Breast Cancer Survivors
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
About research studies in Naperville
Naperville has approximately 68 recruiting research studies across a wide range of therapeutic areas. Illinois's research base includes Northwestern Medicine, Rush University Medical Center, University of Chicago Medicine, and Ann & Robert H. Lurie Children's Hospital, covering oncology, cardiology, and pediatric specialties.
Top Research Study Locations in Naperville
Researchers run research studies in Naperville, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Edward Hospital/Cancer Center | Breast Cancer, Metastatic Renal Cell Carcinoma, Ovarian Carcinoma | 19 |
| Midwest Cardiovascular Institute | Heart Failure, Atrial Fibrillation, Cardiotoxicity | 10 |
| Edward Hospital | Aortic Aneurysm, Abdominal, Extent IV Thoracoabdominal, Juxtarenal Aortic Aneurysm | 3 |
| AMR-Baber Research Inc | Acute Treatment of Migraine, Pediatric Migraine | 2 |
| Chicago Headache Center & Research Institute | Acute Migraine, Migraine | 2 |
| Suburban Gastroenterology | Colonic Polyps, Crohn's Disease, Ulcerative Colitis | 2 |
| Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center | Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms, Non Small Cell Lung Cancer | 2 |
| GSK Investigational Site | Colonic Neoplasms, Neoplasms, Colon | 1 |
| AMR- Baber Research, Inc. | Treatment Resistant Depression | 1 |
| Baber Research Group | Depressive Disorder, Major | 1 |
| Baber Research Group | Bipolar I Disorder, Depression | 1 |
| Bioluminux Clinical Research | Acute Gout Flare, Acute Gouty Arthritis, Gout Flare | 1 |
| Bioluminux Clinical Research Illinois | Body Weight, Nutrition Disorders, Nutritional and Metabolic Diseases | 1 |
| CIS Clinical Research Corporation | AV Block, Heart Failure, Heart Failure With Reduced Ejection Fraction | 1 |
| Chicago Headache Center & Research Inst | Migraine | 1 |
| Chicago Headache Center and Research Institute | Migraine | 1 |
| DuPage Medical Group | Degenerative Disc Disease, Degenerative Scoliosis, Degenerative Spondylolisthesis | 1 |
| Duly Health and Care | Cervical Disc Disease, Cervical Disc Herniation, Cervical Myelopathy | 1 |
| Dupage Medical Group Pain Management Surgical Center | Lumbar Spinal Stenosis | 1 |
| Edward Cancer Center | Metastatic Non-small Cell Lung Cancer | 1 |
| Endeavor Health | Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC), Non-Small Cell Lung Cancer | 1 |
| Endotronix | Heart Failure, Heart Failure NYHA Class III | 1 |
| Innovative Orthodontic Centers | Crowding, Malocclusions, Narrow Maxilla | 1 |
| Investigative | Solid Tumors | 1 |
| Midwest Cardiovascular Center | Heart Failure | 1 |
Active & Upcoming Studies in Naperville (2026)
Recruiting trials in Naperville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (27 active studies)
- This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1. · Phase 3 · Pfizer
- Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response · Phase 3 · Canadian Cancer Trials Group
Cardiovascular (14 active studies)
- Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure · Boston Scientific Corporation
- Novel On-body Evaluation of Cardiac Health for Oncology · Skribe Medical
Neurology & pain (7 active studies)
- A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
Mental health & behavior (4 active studies)
- A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor · Phase 4 · Neurocrine Biosciences
- Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder · Phase 3 · Intra-Cellular Therapies, Inc.
Diabetes & metabolic (1 active study)
Pediatric (1 active study)
- Randomized Study in Children and Adolescents With Migraine: Acute Treatment · Phase 3 · Pfizer
Common conditions studied in Naperville
- Heart Failure (10 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Breast Cancer (3 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Migraine (3 active studies). Migraine trials evaluate CGRP antagonists, gepants, and new acute and preventive therapies for chronic and episodic migraine.
- Atrial Fibrillation (2 active studies). Atrial fibrillation studies investigate next-generation anticoagulants, ablation technologies, and left atrial appendage closure devices.
- Bipolar Disorder (2 active studies). Bipolar disorder studies explore mood stabilizers, novel adjunctive agents, and digital monitoring tools to reduce relapse.
- Heart Failure With Reduced Ejection Fraction (2 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
Leading research sponsors in Naperville
- NRG Oncology
- National Cancer Institute (NCI)
- Pfizer
- AstraZeneca
- AbbVie
Local regulations and guidelines
Clinical trials in Illinois are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Illinois studies must also comply with the Illinois Personal Information Protection Act (PIPA) and Biometric Information Privacy Act (BIPA) where applicable.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Naperville. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Naperville
Hipa.ai aggregates every recruiting study in Naperville from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Naperville?
There are approximately 68 recruiting clinical trials in Naperville, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Naperville pay participants?
Most recruiting trials in Naperville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Naperville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Naperville?
The most common conditions under active study in Naperville include Heart Failure (10), Breast Cancer (3), Migraine (3), Atrial Fibrillation (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Naperville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Naperville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Naperville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Naperville?
Recruiting research sites in Naperville include Edward Hospital/Cancer Center, Midwest Cardiovascular Institute, Edward Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Naperville right now?
The largest active categories in Naperville are Cancer & tumors (27), Cardiovascular (14), Neurology & pain (7). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.