OsteoFlo HydroFiber Ambispective Evaluation
for OsteoFlo HydroFiber
Sites in Naperville +1 more location
Sponsor: SurGenTec LLC
Sex: All·Age: 18+
Code: NCT07784673·Enrolling By Invitation·Listed Aug 25, 2026
Paid Clinical Trials in Naperville, IL
As of September 2026, 63 paid clinical trials are recruiting in Naperville, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Naperville offers studies at sites including Edward Hospital/Cancer Center for conditions such as Heart Failure, Atrial Fibrillation, Bipolar Disorder, Breast Cancer. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Naperville
Trials by drug in Naperville
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Newly added in Naperville
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59 clinical trials
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A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
for Migraine
Drug: Elismetrep
Sites in Naperville, Chicago +111 more locations
Sponsor: Kallyope Inc.
Sex: All·Age: 18 - 75
Code: NCT07645924·Phase 3·Recruiting·Listed Jun 2026
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
for Solid Tumors
Drug: INCB161734
Sites in Naperville, Chicago +67 more locations
Sponsor: Incyte Corporation
Sex: All·Age: 18+
Code: NCT07522073·Phase 3·Recruiting·Listed Apr 2026
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
for Triple Negative Breast Cancer
Sites in Naperville, Chicago +119 more locations
Sponsor: Gilead Sciences
Sex: All·Age: 18+
Code: NCT05633654·Phase 3·Recruiting·Listed Dec 2022
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
for Pediatric Migraine
Sites in Naperville, Chicago +76 more locations
Sponsor: Pfizer
Sex: All·Age: 6 - 17
Code: NCT04649242·Phase 3·Recruiting·Listed Dec 2020
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
for Acute Treatment of Migraine
Drug: Rimegepant
Sites in Naperville, Chicago +59 more locations
Sponsor: Pfizer
Sex: All·Age: 6 - 17
Code: NCT04743141·Phase 3·Recruiting·Listed Feb 2021
A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)
for Diffuse Large B-Cell Lymphoma
Drug: Rituximab
Sites in Naperville, O'Fallon +48 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT06717347·Phase 3·Recruiting·Listed Dec 2024
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
for Lumbar Spinal Stenosis
Sites in Naperville, Bolingbrook +2386 more locations
Sponsor: Stryker Instruments
Sex: All·Age: 18+
Code: NCT03072927·Recruiting·Listed Mar 2017
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
for Depressive Disorder, Major
Drug: Seltorexant
Sites in Naperville, Chicago +42 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18 - 74
Code: NCT06559306·Phase 3·Recruiting·Listed Aug 2024
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
for Schizophrenia
Sites in Naperville +46 more locations
Sponsor: Intra-Cellular Therapies, Inc.
Sex: All·Age: 5 - 17
Code: NCT06229210·Phase 3·Recruiting·Listed Jan 2024
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
for Non-Small Cell Lung Cancer
Drug: sigvotatug vedotin
Sites in Naperville, Hinsdale +73 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT06758401·Phase 3·Recruiting·Listed Jan 2025
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
for Cutaneous Squamous Cell Carcinoma (CSCC)
Drug: Cemiplimab
Sites in Naperville, Chicago +43 more locations
Sponsor: Regeneron Pharmaceuticals
Sex: All·Age: 18+
Code: NCT06585410·Phase 3·Recruiting·Listed Sep 2024
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
for Heart Failure
Sites in Naperville +80 more locations
Sponsor: Cytokinetics
Sex: All·Age: 18 - 85
Code: NCT06736574·Phase 3·Recruiting·Listed Dec 2024
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
for Heart Failure - NYHA II - IV
Sites in Naperville, Hinsdale +38 more locations
Sponsor: Boston Scientific Corporation
Sex: All·Age: 18+
Code: NCT07069738·Recruiting·Listed Jul 2025
Zenith® Fenestrated+ Clinical Study
for Aortic Aneurysm, Abdominal
Sites in Naperville, Maywood +28 more locations
Sponsor: Cook Research Incorporated
Sex: All·Age: 18+
Code: NCT04875429·Recruiting·Listed May 2021
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
for Moderate Aortic Valve Stenosis
Drug: Ataciguat
Sites in Naperville, Elk Grove Village +67 more locations
Sponsor: Kardigan, Inc.
Sex: All·Age: 50+
Code: NCT07001800·Phase 2, Phase 3·Recruiting·Listed Jun 2025
Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients
for Irritability Associated With Autism Spectrum Disorder
Sites in Naperville, Chicago +26 more locations
Sponsor: Intra-Cellular Therapies, Inc.
Sex: All·Age: 5 - 17
Code: NCT06706674·Phase 3·Recruiting·Listed Nov 2024
An Observational Study of Etrasimod in Adult Patients With Moderate to Severe Ulcerative Colitis
for Colitis, Ulcerative
Sites in Naperville, Chicago +25 more locations
Sponsor: Pfizer
Sex: All·Age: 18 - 64
Code: NCT06398626·Recruiting·Listed May 2024
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
for Treatment Resistant Depression
Sites in Naperville, Chicago +51 more locations
Sponsor: LivaNova
Sex: All·Age: 18+
Code: NCT03887715·Recruiting·Listed Mar 2019
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
for Metastatic Non-small Cell Lung Cancer
Sites in Naperville, Elmhurst +35 more locations
Sponsor: NovoCure GmbH
Sex: All·Age: 18+
Code: NCT06216301·Phase 3·Recruiting·Listed Jan 2024
Prevail Global Study
for Coronary Artery Disease
Sites in Naperville, Chicago +49 more locations
Sponsor: Medtronic Vascular
Sex: All·Age: 18+
Code: NCT06535854·Recruiting·Listed Aug 2024
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
for Functional Mitral Regurgitation
Sites in Naperville, Downers Grove +49 more locations
Sponsor: Cardiac Dimensions, Inc.
Sex: All·Age: 18+
Code: NCT03142152·Recruiting·Listed May 2017
AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
for Heart Failure
Sites in Naperville, Downers Grove +35 more locations
Sponsor: Cordio Medical
Sex: All·Age: 22+
Code: NCT06378632·Recruiting·Listed Apr 2024
Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
for Rhinovirus Infection
Sites in Naperville +31 more locations
Sponsor: Altesa Biosciences, Inc.
Sex: All·Age: 40 - 85
Code: NCT07610395·Phase 2·Recruiting·Listed May 2026
A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System
for Atrial Fibrillation
Sites in Naperville +21 more locations
Sponsor: Biosense Webster, Inc.
Sex: All·Age: 22+
Code: NCT07227532·Recruiting·Listed Nov 2025
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
for Schizophrenia
Sites in Naperville +18 more locations
Sponsor: Neurocrine Biosciences
Sex: All·Age: 18+
Code: NCT07105111·Phase 4·Recruiting·Listed Aug 2025
Prospective, Open-label, Non-significant Risk, Multicenter Study Comparing the Polyp Detection of the Study Device to That of the Colonoscopy Reference
for Colonic Polyps
Sites in Naperville, Downers Grove +9 more locations
Sponsor: Capso Vision, Inc.
Sex: All·Age: 45 - 75
Code: NCT07089615·Recruiting·Listed Jul 2025
Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare
for Acute Gouty Arthritis
Sites in Naperville +13 more locations
Sponsor: Atom Therapeutics Co., Ltd
Sex: All·Age: 18 - 70
Code: NCT07145229·Phase 2·Recruiting·Listed Aug 2025
Aspiration Thrombectomy Using the Symphony or Prodigy System
for Arterial Thromboembolism
Sites in Naperville +7 more locations
Sponsor: Imperative Care, Inc.
Sex: All·Age: 18+
Code: NCT07350499·Recruiting·Listed Jan 2026
Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks
for Migraine
Drug: Ubrogepant
Sites in Naperville +2 more locations
Sponsor: AbbVie
Sex: All·Age: 18+
Code: NCT07310290·Recruiting·Listed Dec 2025
Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure
for Heart Failure NYHA Class III
1 location in Naperville
Sponsor: Endotronix, Inc.
Sex: All·Age: 18+
Code: NCT06783335·Recruiting·Listed Jan 2025
Hyrax Vs. Invisalign Palatal Expander Clinical Study
for Malocclusions
Sites in Naperville +3 more locations
Sponsor: Align Technology, Inc.
Sex: All·Age: 6 - 11
Code: NCT06662279·Recruiting·Listed Oct 2024
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Naperville, Lisle +1087 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
for Stage III Colon Cancer
Sites in Naperville, Lisle +923 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
for Chronic Lymphocytic Leukemia
Sites in Naperville, Warrenville +290 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04269902·Phase 3·Recruiting·Listed Feb 2020
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
for Pancreatic Acinar Cell Carcinoma
Drug: Olaparib
Sites in Naperville, Plainfield +256 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04858334·Phase 2·Recruiting·Listed Apr 2021
Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
for Pancreatic Neoplasm
Sites in Naperville, Warrenville +333 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 50 - 75
Code: NCT04239573·Recruiting·Listed Jan 2020
Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
for Clear Cell Renal Cell Carcinoma
Sites in Naperville, Warrenville +401 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT06661720·Phase 3·Recruiting·Listed Oct 2024
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
for Fallopian Tube Endometrioid Adenocarcinoma
Drug: Bevacizumab
Sites in Naperville, Aurora +653 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024
Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma
for Classic Follicular Lymphoma
Drug: Mosunetuzumab
Sites in Naperville, Plainfield +258 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06337318·Phase 3·Recruiting·Listed Mar 2024
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
Drug: Nivolumab
Sites in Naperville, Warrenville +382 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 5 - 60
Code: NCT05675410·Phase 3·Recruiting·Listed Jan 2023
Top Research Study Locations in Naperville
Researchers run research studies in Naperville, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Edward Hospital/Cancer Center | Breast Cancer, Ovarian Carcinoma, Chronic Lymphocytic Leukemia | 16 |
| Midwest Cardiovascular Institute | Heart Failure, Arterial Thromboembolism, Atrial Fibrillation | 10 |
| Baber Research Group | Autism Spectrum Disorder, Bipolar Disorder, Depressive Disorder, Major | 3 |
| Edward Hospital | Aortic Aneurysm, Abdominal, Extent IV Thoracoabdominal, Juxtarenal Aortic Aneurysm | 3 |
| AMR-Baber Research Inc | Acute Treatment of Migraine, Pediatric Migraine | 2 |
| Chicago Headache Center & Research Institute | Acute Migraine, Migraine | 2 |
| Duly Health and Care | Cervical Disc Disease, Cervical Disc Herniation, Cervical Myelopathy | 2 |
| GSK Investigational Site | Colonic Neoplasms, Neoplasms, Colon | 1 |
| AMR- Baber Research, Inc. | Treatment Resistant Depression | 1 |
| Bioluminux Clinical Research | Acute Gout Flare, Acute Gouty Arthritis, Gout Flare | 1 |
| Bioluminux Clinical Research Illinois | Rhinovirus Infection | 1 |
| CIS Clinical Research Corporation | AV Block, Heart Failure, Heart Failure With Reduced Ejection Fraction | 1 |
| CON-10025, Naperville, IL | Heart Failure | 1 |
| Chicago Headache Center & Research Inst | Migraine | 1 |
| DuPage Medical Group | Degenerative Disc Disease, Degenerative Scoliosis, Degenerative Spondylolisthesis | 1 |
| Dupage Medical Group Pain Management Surgical Center | Lumbar Spinal Stenosis | 1 |
| Edward Cancer Center | Metastatic Non-small Cell Lung Cancer | 1 |
| Edward Cancer Center | Diffuse Large B-Cell Lymphoma | 1 |
| Edward Hospital Midwest Cardiovascular Institute | Atrial Fibrillation | 1 |
| Endeavor Health | Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC), Non-Small Cell Lung Cancer | 1 |
| Endeavor Health Edward Hospital | Perinatal Decision Making | 1 |
| Endotronix | Heart Failure, Heart Failure NYHA Class III | 1 |
| Innovative Orthodontic Centers | Crowding, Malocclusions, Narrow Maxilla | 1 |
| Investigative | Solid Tumors | 1 |
| Midwest Cardiovascular Center | Heart Failure | 1 |
Active & Upcoming Studies in Naperville (2026)
Recruiting trials in Naperville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (20 active studies)
Cardiovascular (15 active studies)
- Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure · Boston Scientific Corporation
- A Study Assessing Long-Term Safety and Effectiveness in Treatment Management of Atrial Fibrillation With VARIPULSE Catheter System · Biosense Webster, Inc.
Neurology & pain (5 active studies)
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
- A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
Mental health & behavior (4 active studies)
- A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor · Phase 4 · Neurocrine Biosciences
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
Pediatric (1 active study)
- Randomized Study in Children and Adolescents With Migraine: Acute Treatment · Phase 3 · Pfizer
Common conditions studied in Naperville
- Heart Failure (10 active studies)
- Atrial Fibrillation (2 active studies)
- Bipolar Disorder (2 active studies)
- Breast Cancer (2 active studies)
- Heart Failure With Reduced Ejection Fraction (2 active studies)
- Migraine (2 active studies)
Leading research sponsors in Naperville
- NRG Oncology
- National Cancer Institute (NCI)
- Pfizer
- Alleviant Medical, Inc.
- Colorado Prevention Center
Frequently asked questions
How many paid clinical trials are currently recruiting in Naperville?
There are approximately 63 recruiting clinical trials in Naperville, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Naperville pay participants?
Most recruiting trials in Naperville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Naperville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Naperville?
The most common conditions under active study in Naperville include Heart Failure (10), Atrial Fibrillation (2), Bipolar Disorder (2), Breast Cancer (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Naperville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Naperville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Naperville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Naperville?
Recruiting research sites in Naperville include Edward Hospital/Cancer Center, Midwest Cardiovascular Institute, Baber Research Group, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Naperville right now?
The largest active categories in Naperville are Cancer & tumors (20), Cardiovascular (15), Neurology & pain (5). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
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