Paid Clinical Trials in Naperville, IL
As of August 2026, 65 paid clinical trials are recruiting in Naperville, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Naperville offers studies at sites including Edward Hospital/Cancer Center for conditions such as Heart Failure, Atrial Fibrillation, Bipolar Disorder, Breast Cancer. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Naperville
Trials by drug in Naperville
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Newly added in Naperville
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
59 clinical trials
A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine
A Study of PF-08653945 and PF-08653944 in Adults With Overweight or Obesity (SOLIS-1)
A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.
A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)
Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study
Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
The CONFORM Pivotal Trial
An Observational Study of Etrasimod in Adult Patients With Moderate to Severe Ulcerative Colitis
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression
Multicenter Study of Lumateperone for the Treatment of Irritability Associated With Autism Spectrum Disorder (ASD) in Pediatric Patients
LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC
Prevail Global Study
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
Zenith® Fenestrated+ Clinical Study
AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
Trial Comparing the Safety and Efficacy of Two Different Oral VPV Doses With Placebo as Treatment for RV in Participants With COPD
A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor
Prospective, Open-label, Non-significant Risk, Multicenter Study Comparing the Polyp Detection of the Study Device to That of the Colonoscopy Reference
Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare
Aspiration Thrombectomy Using the Symphony or Prodigy System
Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks
Real World Effectiveness of the Cordella Pulmonary Artery Sensor System in Patients With Chronic Heart Heart Failure
Hyrax Vs. Invisalign Palatal Expander Clinical Study
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
APOLLO: A Randomized Phase II Double-Blind Study of Olaparib Versus Placebo Following Curative Intent Therapy in Patients With Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation
A Study to Compare Two Surgical Procedures in Individuals With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer
Top Research Study Locations in Naperville
Researchers run research studies in Naperville, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Edward Hospital/Cancer Center | Breast Cancer, Metastatic Renal Cell Carcinoma, Ovarian Carcinoma | 18 |
| Midwest Cardiovascular Institute | Heart Failure, Atrial Fibrillation, Arterial Thromboembolism | 11 |
| Baber Research Group | Autism Spectrum Disorder, Bipolar Disorder, Depressive Disorder, Major | 3 |
| Edward Hospital | Aortic Aneurysm, Abdominal, Extent IV Thoracoabdominal, Juxtarenal Aortic Aneurysm | 3 |
| AMR-Baber Research Inc | Acute Treatment of Migraine, Pediatric Migraine | 2 |
| Bioluminux Clinical Research Illinois | Body Weight, Nutrition Disorders, Nutritional and Metabolic Diseases | 2 |
| Chicago Headache Center & Research Institute | Acute Migraine, Migraine | 2 |
| GSK Investigational Site | Colonic Neoplasms, Neoplasms, Colon | 1 |
| AMR- Baber Research, Inc. | Treatment Resistant Depression | 1 |
| Bioluminux Clinical Research | Acute Gout Flare, Acute Gouty Arthritis, Gout Flare | 1 |
| CIS Clinical Research Corporation | AV Block, Heart Failure, Heart Failure With Reduced Ejection Fraction | 1 |
| CON-10025, Naperville, IL | Heart Failure | 1 |
| Chicago Headache Center & Research Inst | Migraine | 1 |
| DuPage Medical Group | Degenerative Disc Disease, Degenerative Scoliosis, Degenerative Spondylolisthesis | 1 |
| Duly Health and Care | Cervical Disc Disease, Cervical Disc Herniation, Cervical Myelopathy | 1 |
| Dupage Medical Group Pain Management Surgical Center | Lumbar Spinal Stenosis | 1 |
| Edward Cancer Center | Metastatic Non-small Cell Lung Cancer | 1 |
| Edward-Elmhurst Healthcare, Edward Hospital-Edward Cancer Center | Metastatic Castration-resistant Prostate Cancer (mCRPC), Prostatic Neoplasms | 1 |
| Endeavor Health | Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small-Cell Lung (NSCLC), Non-Small Cell Lung Cancer | 1 |
| Endeavor Health Edward Hospital | Perinatal Decision Making | 1 |
| Endotronix | Heart Failure, Heart Failure NYHA Class III | 1 |
| Innovative Orthodontic Centers | Crowding, Malocclusions, Narrow Maxilla | 1 |
| Investigative | Solid Tumors | 1 |
| Midwest Cardiovascular Center | Heart Failure | 1 |
| Midwest Cardiovascular Institute (MCI) | Cardiovascular Diseases, Functional Mitral Regurgitation, Heart Diseases | 1 |
Active & Upcoming Studies in Naperville (2026)
Recruiting trials in Naperville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (22 active studies)
Cardiovascular (15 active studies)
- Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure · Boston Scientific Corporation
- Novel On-body Evaluation of Cardiac Health for Oncology · Skribe Medical
Neurology & pain (6 active studies)
- A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
- A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine · Phase 3 · Kallyope Inc.
Mental health & behavior (4 active studies)
- A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor · Phase 4 · Neurocrine Biosciences
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
Diabetes & metabolic (1 active study)
Pediatric (1 active study)
- Randomized Study in Children and Adolescents With Migraine: Acute Treatment · Phase 3 · Pfizer
Common conditions studied in Naperville
- Heart Failure (10 active studies)
- Atrial Fibrillation (2 active studies)
- Bipolar Disorder (2 active studies)
- Breast Cancer (2 active studies)
- Heart Failure With Reduced Ejection Fraction (2 active studies)
- Metastatic Renal Cell Carcinoma (2 active studies)
Leading research sponsors in Naperville
- NRG Oncology
- National Cancer Institute (NCI)
- Pfizer
- Alleviant Medical, Inc.
- Colorado Prevention Center
Frequently asked questions
How many paid clinical trials are currently recruiting in Naperville?
There are approximately 65 recruiting clinical trials in Naperville, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Naperville pay participants?
Most recruiting trials in Naperville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Naperville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Naperville?
The most common conditions under active study in Naperville include Heart Failure (10), Atrial Fibrillation (2), Bipolar Disorder (2), Breast Cancer (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Naperville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Naperville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Naperville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Naperville?
Recruiting research sites in Naperville include Edward Hospital/Cancer Center, Midwest Cardiovascular Institute, Baber Research Group, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Naperville right now?
The largest active categories in Naperville are Cancer & tumors (22), Cardiovascular (15), Neurology & pain (6). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.