As of July 2026, 197 paid clinical trials are recruiting in Springfield, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Springfield offers studies at sites including Southern Illinois University School of Medicine for conditions such as Acute Myeloid Leukemia, Malignant Solid Neoplasm, Stage IV Lung Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Springfield has approximately 197 recruiting research studies across a wide range of therapeutic areas. Illinois's research base includes Northwestern Medicine, Rush University Medical Center, University of Chicago Medicine, and Ann & Robert H. Lurie Children's Hospital, covering oncology, cardiology, and pediatric specialties.
Researchers run research studies in Springfield, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Southern Illinois University School of Medicine | Malignant Solid Neoplasm, Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8 | 121 |
| Springfield Clinic | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8 | 102 |
| Springfield Memorial Hospital | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8 | 85 |
| Memorial Medical Center | Metastatic Malignant Neoplasm in the Brain, Acral Lentiginous Melanoma, Anatomic Stage IV Breast Cancer AJCC v8 | 8 |
| Springfield Clinic - First | Irritable Bowel Syndrome, Constipation, Diarrhea | 8 |
| Springfield Clinic Main Campus | Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer | 4 |
| Central Illinois Hematology Oncology Center | Head and Neck Squamous Cell Carcinoma, Hematopoietic and Lymphatic System Neoplasm, Hypopharyngeal Squamous Cell Carcinoma | 3 |
| Prairie Education and Research Cooperative | Aortic Stenosis, Aortic Stenosis, Severe, Heart Failure | 3 |
| Saint John's Hospital | Malignant Solid Neoplasm, Adrenal Gland Pheochromocytoma, Carcinoma In Situ | 3 |
| Kailera Clinical Site | Obesity, Obesity With Diabetes, Overweight | 2 |
| Prairie Education & Research Cooperative | Atrial Fibrillation (AF), Heart Failure With Reduced Ejection Fraction, Hypertension, Pulmonary | 2 |
| Prairie Heart Institute | Cardiovascular Diseases, Functional Mitral Regurgitation, Generalized Myasthenia Gravis | 2 |
| Simmons Cancer Institute at SIU | Breast Neoplasms, Multiple Myeloma, Neoplasm Metastasis | 2 |
| Southern Illinois University | Refractory Angina, Urothelial Carcinoma | 2 |
| Springfield Clinic, LLP | Lung Cancer Diagnosis, Prostate Cancer | 2 |
| St. John's Hospital | Atrial Fibrillation, Atrial Fibrillation (AF), Intracerebral Hemorrhage | 2 |
| Springfield Clinic Main Campus | Neovascular Age-related Macular Degeneration, Crohn's Disease | 2 |
| Clincial Research | Non-healing Wound, Venous Insufficiency of Leg, Venous Leg Ulcer | 1 |
| Clinical Research | Severe Hypertriglyceridemia | 1 |
| Clinical Trial Site | High Cardiovascular Risk, High Risk Cardiovascular Disease, Hypertension | 1 |
| Ep0162 50375 | Stereotypical Prolonged Seizures | 1 |
| Ep0165 50375 | Stereotypical Prolonged Seizures | 1 |
| HSHS St. John's Hospital | Multiple Myeloma | 1 |
| Home-based telemedicine | Chronic Granulomatous Disease (CGD) | 1 |
| Illinois Department of Corrections | Opioid Use, Opioid-use Disorder | 1 |
Recruiting trials in Springfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Clinical trials in Illinois are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Illinois studies must also comply with the Illinois Personal Information Protection Act (PIPA) and Biometric Information Privacy Act (BIPA) where applicable.
Hipa.ai aggregates every recruiting study in Springfield from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
There are approximately 197 recruiting clinical trials in Springfield, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Springfield include Acute Myeloid Leukemia (8), Malignant Solid Neoplasm (8), Stage IV Lung Cancer AJCC v8 (7), Anatomic Stage II Breast Cancer AJCC v8 (5), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Springfield include Southern Illinois University School of Medicine, Springfield Clinic, Springfield Memorial Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Springfield are Cancer & tumors (119), Cardiovascular (15), Diabetes & metabolic (5). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.