As of August 2026, 17 paid clinical trials are testing Methotrexate in Chicago, Illinois. Trials typically compensate participants for time, travel, and study visits, and many also provide study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Researchers run research studies in Chicago, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Northwestern University | Metastatic Malignant Solid Neoplasm, Prostate Adenocarcinoma, Stage IV Lung Cancer AJCC v8 | 345 |
| University of Chicago | Heart Failure, Peripheral Artery Disease, Gastric Cancer | 184 |
| Rush University Medical Center | Angelman Syndrome, Degenerative Disc Disease, Atrial Fibrillation | 157 |
| Ann & Robert H. Lurie Children's Hospital of Chicago | Diffuse Intrinsic Pontine Glioma, High Grade Glioma, WHO Grade III Glioma | 110 |
| University of Chicago Medical Center | Endometrial Cancer, Breast Cancer, Kidney Stone | 98 |
| University of Chicago Comprehensive Cancer Center | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome | 89 |
| Northwestern Memorial Hospital | Multiple Sclerosis, Heart Failure, Inguinal Hernia Bilateral | 85 |
| University of Illinois | Acute Myeloid Leukemia, Malignant Solid Neoplasm, Breast Cancer | 84 |
| University of Illinois at Chicago | Multiple Sclerosis, Carcinoma, Non-Small-Cell Lung, Chronic Stroke | 70 |
| Advocate Illinois Masonic Medical Center | Anatomic Stage II Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 48 |
| The University of Chicago | Head and Neck Cancer, Malnutrition, AML With Gene Mutations | 44 |
| Shirley Ryan AbilityLab | Stroke, Multiple Sclerosis, Spinal Cord Injuries | 36 |
| University of Illinois Chicago | Breast Cancer Early Stage Breast Cancer (Stage 1-3), Type 1 Diabetes (T1D), ASCVD | 34 |
| Lurie Children's Hospital-Chicago | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm | 32 |
| Northwestern University Feinberg School of Medicine | Peripheral Artery Disease, Aging, Depression | 29 |
| Rush MD Anderson Cancer Center | Stage IVB Prostate Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 25 |
| John H Stroger Jr Hospital of Cook County | Anatomic Stage II Breast Cancer AJCC v8, Malignant Solid Neoplasm, Anatomic Stage I Breast Cancer AJCC v8 | 24 |
| Northwestern Medicine | AML - Acute Myeloid Leukemia, Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS) | 23 |
| Rush University | Preterm, AV Block, Acute Kidney Injury | 22 |
| University of Illinois Cancer Center | Breast Cancer, Gastric Cancer, Cervical Cancer | 22 |
| The University of Chicago Medical Center | Systemic Sclerosis, Acute Myeloid Leukemia, Interstitial Lung Diseases | 21 |
| University of Chicago Medicine Comprehensive Cancer Center | Carcinoma, Squamous Cell, Prostate Cancer, Acute Leukemia | 20 |
| Lurie Children's Hospital | Congenital Heart Disease (CHD), ACL Injury, ACL Tear | 18 |
| University of Chicago Medicine | Advanced Solid Tumor, Lung Cancer, Ulcerative Colitis | 16 |
| Lurie Children's Hospital of Chicago | Acute Kidney Injury, Duchenne Muscular Dystrophy, Neurofibromatosis 1 | 14 |
Recruiting trials in Chicago grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 2,146 recruiting clinical trials in Chicago, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in Chicago compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in Chicago include Breast Cancer (35), Obesity (27), Stroke (25), Heart Failure (24), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Chicago on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in Chicago include Northwestern University, University of Chicago, Rush University Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in Chicago are Cancer & tumors (600), Neurology & pain (148), Cardiovascular (116). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.