Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
for Breast Neoplasms
Sites in Detroit, Grand Rapids +46 more locations
Sponsor: Natera, Inc.
Sex: All·Age: 18+
Code: NCT07214532·Recruiting·Listed Oct 2025
Breast oncology Clinical Trials in Detroit, MI
As of August 2026, 34 paid clinical trials are recruiting for Breast oncology in Detroit, Michigan. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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34 clinical trials for Breast oncology
·Clear filters· Email me when a new breast oncology trial opens in Detroit, MI.
A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
for HER2-positive Breast Cancer
Sites in Detroit +28 more locations
Sponsor: Jazz Pharmaceuticals
Sex: All·Age: 18+
Code: NCT07102381·Phase 2·Recruiting·Listed Aug 2025
ROSETTA Breast-01: The Effects and Safety of Pumitamig in Patients With Triple-Negative Breast Cancer
for Breast Neoplasms
Drug: Pumitamig
Sites in Detroit, Royal Oak +62 more locations
Sponsor: BioNTech SE
Sex: All·Age: 18+
Code: NCT07173751·Phase 3·Recruiting·Listed Sep 2025
A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer
for Breast Cancer
Sites in Detroit, Grand Rapids +57 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 18+
Code: NCT06790693·Phase 3·Recruiting·Listed Jan 2025
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
for Breast Neoplasms
Sites in Detroit +40 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 18+
Code: NCT06312176·Phase 3·Recruiting·Listed Mar 2024
A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)
for Breast Neoplasms
Sites in Detroit +37 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 18+
Code: NCT06926868·Phase 2, Phase 3·Recruiting·Listed Apr 2025
Rinatabart Sesutecan (Rina-S, PRO1184, GEN1184) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001)
for High Grade Epithelial Ovarian Cancer
Sites in Detroit, Grand Rapids +35 more locations
Sponsor: Genmab
Sex: All·Age: 18+
Code: NCT05579366·Phase 1, Phase 2·Recruiting·Listed Oct 2022
A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors
for Triple Negative Breast Cancer
Sites in Detroit +25 more locations
Sponsor: Day One Biopharmaceuticals, Inc.
Sex: All·Age: 18+
Code: NCT05377996·Phase 1, Phase 2·Recruiting·Listed May 2022
A Phase 1/1b Study of IAM1363 in HER2 Cancers
for HER2 Mutation-Related Tumors
Sites in Detroit, Ann Arbor +27 more locations
Sponsor: Iambic Therapeutics, Inc
Sex: All·Age: 18+
Code: NCT06253871·Phase 1·Recruiting·Listed Feb 2024
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
for Advanced Solid Tumor
Sites in Detroit +30 more locations
Sponsor: PMV Pharmaceuticals, Inc
Sex: All·Age: 12+
Code: NCT04585750·Phase 1, Phase 2·Recruiting·Listed Oct 2020
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
for Esophageal Squamous Cell Carcinoma
Sites in Detroit +14 more locations
Sponsor: IDEAYA Biosciences
Sex: All·Age: 18+
Code: NCT07503808·Phase 1·Recruiting·Listed Mar 2026
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
for Ovarian Neoplasms
Sites in Detroit, Grand Rapids +17 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07213791·Phase 1·Recruiting·Listed Oct 2025
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
for Breast Neoplasms
Sites in Detroit, Grand Rapids +13 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07114601·Phase 1·Recruiting·Listed Aug 2025
A Clinical Study to Find the Optimal Dose of an Investigational Treatment Called BNT323 When Used in Combination With Another Investigational Treatment, BNT327, and to Test if That Combination Treatment is Safe and Beneficial for Patients With Advanced Breast Cancer
for Locally Advanced Breast Cancer
Sites in Detroit, Grand Rapids +25 more locations
Sponsor: BioNTech SE
Sex: All·Age: 18+
Code: NCT06827236·Phase 1, Phase 2·Recruiting·Listed Feb 2025
A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer
for Metastatic Breast Cancer
Sites in Detroit +15 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 18+
Code: NCT05894239·Phase 3·Recruiting·Listed Jun 2023
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
for Breast Neoplasms
Sites in Detroit +8 more locations
Sponsor: Stemline Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT05386108·Phase 1, Phase 2·Recruiting·Listed May 2022
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
for Endometrial Cancer
Sites in Detroit +16 more locations
Sponsor: SystImmune Inc.
Sex: All·Age: 18+
Code: NCT06293898·Phase 1·Recruiting·Listed Mar 2024
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
for Breast Cancer
Sites in Detroit +21 more locations
Sponsor: Celcuity Inc
Sex: All·Age: 18+
Code: NCT06757634·Phase 3·Recruiting·Listed Jan 2025
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
for Breast Cancer
Sites in Detroit +14 more locations
Sponsor: Incyclix Bio
Sex: All·Age: 18+
Code: NCT05735080·Phase 1, Phase 2·Recruiting·Listed Feb 2023
Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer
for Metastatic Breast Cancer
Drug: Palazestrant
Sites in Detroit +13 more locations
Sponsor: Olema Pharmaceuticals, Inc.
Sex: All·Age: 18+
Code: NCT05508906·Phase 1·Recruiting·Listed Aug 2022
First-in-Human Study of ATX-295, an Oral Inhibitor of KIF18A, in Patients With Advanced or Metastatic Solid Tumors, Including Ovarian Cancer
for Advanced Solid Tumors
Sites in Detroit +8 more locations
Sponsor: Accent Therapeutics
Sex: All·Age: 18+
Code: NCT06799065·Phase 1·Recruiting·Listed Jan 2025
Phase 1/2 Study to Evaluate EP0062 as Monotherapy and in Combination in Patients With Advanced or Metastatic AR+/HER-2-/ER+ Breast Cancer
for Hormone Receptor-positive Breast Cancer
Sites in Detroit +5 more locations
Sponsor: Ellipses Pharma
Sex: Female·Age: 18+
Code: NCT05573126·Phase 1, Phase 2·Recruiting·Listed Oct 2022
A Beta-only IL-2 ImmunoTherapY Study
for Advanced Solid Tumor
Sites in Detroit +4 more locations
Sponsor: Medicenna Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT05086692·Phase 1, Phase 2·Recruiting·Listed Oct 2021
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Detroit, Dearborn +1098 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
for Acute Lymphoblastic Leukemia
Sites in Detroit, Dearborn +616 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 40 - 75·Accepts healthy volunteers
Code: NCT05334069·Recruiting·Listed Apr 2022
E-Mindfulness Approaches for Living After Breast Cancer
for Breast Cancer
Sites in Detroit, Dearborn +372 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18 - 50
Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
for Anatomic Stage IV Breast Cancer AJCC v8
Sites in Detroit, Livonia +255 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT06500455·Phase 3·Recruiting·Listed Jul 2024
Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial
for Anatomic Stage IV Breast Cancer AJCC v8
Sites in Detroit, Farmington Hills +56 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT06500481·Phase 3·Recruiting·Listed Jul 2024
The Vanguard Study: Testing a New Way to Screen for Cancer
for Bladder Carcinoma
Sites in Detroit, Dearborn +39 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 45 - 75·Accepts healthy volunteers
Code: NCT06995898·Recruiting·Listed May 2025
Comparison of Breast Cancer Screening With CESM to DBT in Women With Dense Breasts
for Breast Cancer
Sites in Detroit +10 more locations
Sponsor: American College of Radiology
Sex: Female·Age: 45 - 74·Accepts healthy volunteers
Code: NCT05625659·Recruiting·Listed Nov 2022
A Study of the TheraBionic P1 Device in Breast Cancer
for Breast Cancer Stage I
Sites in Detroit, Farmington Hills +6 more locations
Sponsor: Barbara Ann Karmanos Cancer Institute
Sex: Female·Age: 22+
Code: NCT07218432·Recruiting·Listed Oct 2025
F-Tryptophan PET/CT in Human Cancers
for Intracranial Glioma
1 location in Detroit
Sponsor: Barbara Ann Karmanos Cancer Institute
Sex: All·Age: 18+
Code: NCT05556473·Phase 1·Recruiting·Listed Sep 2022
A Ph II Study of the TheraBionic P1 Device in Subjects With Hormone Positive Breast Cancer
for HER2-negative Breast Cancer
Sites in Detroit, Mount Clemens +6 more locations
Sponsor: Barbara Ann Karmanos Cancer Institute
Sex: All·Age: 22+
Code: NCT07227831·Recruiting·Listed Nov 2025
A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
for Breast Cancer
Drug: Durvalumab
Sites in Detroit +35 more locations
Sponsor: AstraZeneca
Sex: All·Age: 18+
Code: NCT06103864·Phase 3·Recruiting·Listed Oct 2023
Top Research Study Locations in Detroit
Researchers run research studies in Detroit, MI at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Henry Ford Hospital | Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8, Heart Failure | 132 |
| Karmanos Cancer Institute | Ovarian Cancer, Advanced Solid Tumor, Endometrial Cancer | 89 |
| Henry Ford Health System | Advanced Solid Tumor, Brain Tumor, Breast Cancer | 68 |
| Henry Ford Health | Heart Failure, Advanced Solid Tumor, Amyotrophic Lateral Sclerosis | 58 |
| Children's Hospital of Michigan | Acute Myeloid Leukemia, Down Syndrome, Malignant Solid Neoplasm | 38 |
| Henry Ford Health Saint John Hospital | Anatomic Stage II Breast Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | 35 |
| Wayne State University/Karmanos Cancer Institute | Stage II Lip and Oral Cavity Cancer AJCC v8, Stage III Laryngeal Cancer AJCC v8, Stage III Lip and Oral Cavity Cancer AJCC v8 | 30 |
| Wayne State University | Asthma, Benign Prostatic Hyperplasia, Cancer Support | 20 |
| Barbara Ann Karmanos Cancer Institute | Breast Neoplasms, Colorectal Neoplasms, Esophageal Neoplasms | 14 |
| Henry Ford Cancer Institute | Metastatic Solid Tumor, Locally Advanced Solid Tumor, AML | 12 |
| John D. Dingell VA Medical Center, Detroit, MI | Obstructive Sleep Apnea, Sleep Apnea, Sleep Disordered Breathing | 12 |
| GSK Investigational Site | Neoplasms, Colonic Neoplasms, Liver Diseases, Alcoholic | 8 |
| Karmanos Cancer Center | Breast Neoplasms, Cancer Weight Loss, Chronic Lymphocytic Leukemia (CLL) | 7 |
| Henry Ford Health Hospital | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 6 |
| Tolan Park Medical Building | PTSD, Polysubstance Abuse, Adolescence | 6 |
| Detroit Medical Center | Diabetes (DM), Diabetic Ketoacidosis, Gastric Emptying | 5 |
| Henry Ford | ADHF, Atrial Fibrillation (AF), Brain Tumor - Metastatic | 5 |
| Detroit Receiving Hospital | Traumatic Brain Injury, Lumbar Spinal Stenosis, Status Epilepticus | 4 |
| Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion) | Advanced Colorectal Cancer (Part 1), Glioma, KRAS G12C-mutated Solid Tumors, Lung Cancer | 4 |
| Henry Ford Cancer Center | Locally Advanced Solid Tumor, Hemoglobinopathy, Metastatic Solid Tumor | 4 |
| Henry Ford Medical Center | Acute Kidney Injury, Coronary Artery Disease, Healthy | 4 |
| Henry Ford St. John Hospital | Cardiovascular Diseases, Hypertension, Vascular Diseases | 4 |
| Ascension Saint John Hospital | Anatomic Stage IV Breast Cancer AJCC v8, Elevated CA15-3 or CEA or CA27-29, Estrogen Receptor Positive | 3 |
| Ascension St. John Hospital | High-Risk Percutaneous Coronary Intervention, Pulmonary Embolism, Right Ventricular (RV) Dysfunction | 3 |
| Brigitte Harris Cancer Pavilion | Glioma, Melanoma, Thyroid Cancer | 3 |
Active & Upcoming Studies in Detroit (2026)
Recruiting trials in Detroit grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (304 active studies)
- Perioperative Cemiplimab for Resectable Non-Small Cell Lung Cancer With High PD-L1 · Phase 2 · Henry Ford Health System
- A Study of the TheraBionic P1 Device in Breast Cancer · Barbara Ann Karmanos Cancer Institute
Cardiovascular (51 active studies)
- Emergency Department-Initiated Team-Based Care for Severe Hypertension · Henry Ford Health System
- A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation · Phase 2 · Bayer
Neurology & pain (26 active studies)
- Behavioral Optimization to Overcome Obstructive Sleep Apnea Treatment Barriers · VA Office of Research and Development
- Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment · Phase 4 · VA Office of Research and Development
Diabetes & metabolic (15 active studies)
- Can Mindfulness and Virtual Reality Reduce Stress in Young Adults With Type 1 Diabetes? · Wayne State University
- Effects of Peanut Consumption on Adults With Metabolic Associated Fatty Liver Disease · Henry Ford Health System
Mental health & behavior (11 active studies)
- Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD · EARLY_Phase 1 · Wayne State University
- Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery · Phase 1, Phase 2 · Leslie Lundahl
HIV / STI (4 active studies)
- Implementation Study of Lenacapavir Pre-exposure Prophylaxis for HIV Prevention · Gilead Sciences
- A Clinical Study of Islatravir and Ulonivirine for People With HIV-1 Who Have Not Been Treated Before (MK-8591B-062) · Phase 2, Phase 3 · Merck Sharp & Dohme LLC
Vaccines (3 active studies)
- A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely Immunocompromised · Phase 3 · Pfizer
- Predictors of Post-COVID-19 Clinical and Cognitive Consequences · VA Office of Research and Development
Eye & vision (3 active studies)
- Comparison of Goniotomy Device Outcomes in Combined Phacoemulsification-goniotomy Surgeries · Henry Ford Health System
- Community Based Treatment for (ComBaT) Glaucoma · University of Michigan
Pediatric (3 active studies)
- Optimizing Pain Treatment in Children On Mechanical Ventilation · Phase 3 · Weill Medical College of Cornell University
- Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS · Phase 2, Phase 3 · Nationwide Children's Hospital
Common conditions studied in Detroit
- Endometrial Cancer (14 active studies)
- Advanced Solid Tumor (13 active studies)
- Breast Cancer (13 active studies)
- Heart Failure (13 active studies)
- Ovarian Cancer (12 active studies)
- Multiple Myeloma (11 active studies)
Leading research sponsors in Detroit
- Henry Ford Health System
- National Cancer Institute (NCI)
- AstraZeneca
- Wayne State University
- SWOG Cancer Research Network
Frequently asked questions
How many paid clinical trials are currently recruiting in Detroit?
There are approximately 718 recruiting clinical trials in Detroit, Michigan listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Detroit pay participants?
Most recruiting trials in Detroit compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Detroit?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Detroit?
The most common conditions under active study in Detroit include Endometrial Cancer (14), Advanced Solid Tumor (13), Breast Cancer (13), Heart Failure (13), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Detroit?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Detroit on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Detroit?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Detroit?
Recruiting research sites in Detroit include Henry Ford Hospital, Karmanos Cancer Institute, Henry Ford Health System, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Detroit right now?
The largest active categories in Detroit are Cancer & tumors (304), Cardiovascular (51), Neurology & pain (26). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
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