Study of DONQ52 in Active Celiac Disease
for Celiac Disease
Drug: DONQ52
Sites in Harrisburg +56 more locations
Sponsor: Chugai Pharmaceutical
Sex: All·Age: 18 - 75
Code: NCT07239336·Phase 2·Recruiting·Listed Nov 2025
Paid Clinical Trials in Harrisburg, PA
As of August 2026, 60 paid clinical trials are recruiting in Harrisburg, Pennsylvania. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Harrisburg offers studies at sites including UPMC Pinnacle Cancer Center/Community Osteopathic Campus for conditions such as Anatomic Stage II Breast Cancer AJCC v8, Breast Cancer, Head and Neck Squamous Cell Carcinoma, Stage IV Lung Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Harrisburg
Trials by drug in Harrisburg
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56 clinical trials
A Study of Icotrokinra in Participants With Moderately to Severely Active Crohn's Disease
for Crohn Disease
Sites in Harrisburg, Hershey +52 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 18+
Code: NCT07196722·Phase 2, Phase 3·Recruiting·Listed Sep 2025
A Protocol of Icotrokinra Therapy in Adult and Adolescent Participants With Moderately to Severely Active Ulcerative Colitis
for Colitis, Ulcerative
Sites in Harrisburg, Hershey +48 more locations
Sponsor: Janssen Research & Development, LLC
Sex: All·Age: 12+
Code: NCT07196748·Phase 3·Recruiting·Listed Sep 2025
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
for Colorectal Neoplasms
Sites in Harrisburg, Mechanicsburg +106 more locations
Sponsor: Seagen, a wholly owned subsidiary of Pfizer
Sex: All·Age: 18+
Code: NCT05253651·Phase 3·Recruiting·Listed Feb 2022
Phase IIIb Study of Ribociclib + ET in Early Breast Cancer
for Early Breast Cancer
Drug: Ribociclib
Sites in Harrisburg, Drexel Hill +83 more locations
Sponsor: Novartis Pharmaceuticals
Sex: All·Age: 18 - 100
Code: NCT05827081·Phase 3·Recruiting·Listed Apr 2023
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
for Lumbar Spinal Stenosis
Sites in Harrisburg, Hershey +2366 more locations
Sponsor: Stryker Instruments
Sex: All·Age: 18+
Code: NCT03072927·Recruiting·Listed Mar 2017
Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.
for Mitral Valve Regurgitation
Sites in Harrisburg, Wynnewood +65 more locations
Sponsor: Medtronic Cardiovascular
Sex: All·Age: 18+
Code: NCT03242642·Recruiting·Listed Aug 2017
VE303 for Prevention of Recurrent Clostridioides Difficile Infection
for Clostridium Difficile
Sites in Harrisburg, Philadelphia +54 more locations
Sponsor: Vedanta Biosciences, Inc.
Sex: All·Age: 12+
Code: NCT06237452·Phase 3·Recruiting·Listed Feb 2024
Global Paradise System US Post Approval Study
for Hypertension
Sites in Harrisburg, Phildelphia +41 more locations
Sponsor: ReCor Medical, Inc.
Sex: All·Age: 18+
Code: NCT06297291·Recruiting·Listed Mar 2024
Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System
for Pulmonary Embolism
Sites in Harrisburg, Hershey +53 more locations
Sponsor: Penumbra Inc.
Sex: All·Age: 18+
Code: NCT04798261·Recruiting·Listed Mar 2021
Efficacy and Safety of Obefazimod in Subjects With Moderately to Severely Active Crohn's Disease
for Moderately to Severely Active Crohn Disease
Sites in Harrisburg, Uniontown +41 more locations
Sponsor: Abivax S.A.
Sex: All·Age: 18 - 75
Code: NCT06456593·Phase 2·Recruiting·Listed Jun 2024
Prevail Global Study
for Coronary Artery Disease
Sites in Harrisburg, Allentown +49 more locations
Sponsor: Medtronic Vascular
Sex: All·Age: 18+
Code: NCT06535854·Recruiting·Listed Aug 2024
EXActDNA-003 / NSABP B-64: Study of Molecular Residual Disease Detection in Breast Cancer (MRD)
for Breast Cancer
Sites in Harrisburg, Hershey +51 more locations
Sponsor: Exact Sciences Corporation
Sex: All·Age: 18+
Code: NCT06401421·Recruiting·Listed May 2024
Prospective Study to Assess a Diagnostic Aid for Cancer
for Cancer
Sites in Harrisburg, York +33 more locations
Sponsor: Harbinger Health
Sex: All·Age: 45+
Code: NCT07046260·Recruiting·Listed Jul 2025
Prevalence of Antibodies and Cytokines in Participants With Chronic Granulomatous Disease
for Chronic Granulomatous Disease (CGD)
Sites in Harrisburg +49 more locations
Sponsor: Ensoma
Sex: All·Age: All ages
Code: NCT06605378·Recruiting·Listed Sep 2024
TRIcvalve biCAVal Valve System for Severe Tricuspid Regurgitation (TRICAV-I)
for Tricuspid Regurgitation
Sites in Harrisburg, York +34 more locations
Sponsor: P+F Products + Features USA Inc.
Sex: All·Age: 18+
Code: NCT06137807·Recruiting·Listed Nov 2023
EFS of the DUO System for Tricuspid Regurgitation
for Tricuspid Regurgitation
Sites in Harrisburg +11 more locations
Sponsor: CroiValve Limited
Sex: All·Age: 18+
Code: NCT05913908·Recruiting·Listed Jun 2023
A Study to Investigate the Efficacy and Safety of SAR442970 in Adult Participants With Ulcerative Colitis
for Ulcerative Colitis
Sites in Harrisburg +20 more locations
Sponsor: Sanofi
Sex: All·Age: 18 - 75
Code: NCT06975722·Phase 2·Recruiting·Listed May 2025
A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease
for Crohn's Disease
Sites in Harrisburg +19 more locations
Sponsor: Sanofi
Sex: All·Age: 18 - 75
Code: NCT06958536·Phase 2·Recruiting·Listed May 2025
A Biospecimen Collection Study to Identify the Targets of Disease-Reactive T Cells in Patients With Autoimmune Disease
for Autoimmune Diseases
Sites in Harrisburg +10 more locations
Sponsor: TScan Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06587828·Recruiting·Listed Sep 2024
The Half Moon Transcatheter Mitral Valve Repair (TMVr) Pilot Study
for Mitral Valve Insufficiency
Sites in Harrisburg +4 more locations
Sponsor: Half Moon Medical
Sex: All·Age: 21 - 95
Code: NCT04343313·Recruiting·Listed Apr 2020
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Harrisburg, Mechanicsburg +1098 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
for Lung Non-Small Cell Carcinoma
Sites in Harrisburg, Mechanicsburg +633 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04267848·Phase 3·Recruiting·Listed Feb 2020
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
for Stage III Colon Cancer
Sites in Harrisburg, Mechanicsburg +913 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05174169·Phase 2, Phase 3·Recruiting·Listed Dec 2021
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
for Anatomic Stage I Breast Cancer AJCC v8
Sites in Harrisburg, Mechanicsburg +591 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
for Head and Neck Squamous Cell Carcinoma
Sites in Harrisburg, Mechanicsburg +464 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT02734537·Phase 2·Recruiting·Listed Apr 2016
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
for Locally Advanced Cervical Adenocarcinoma
Sites in Harrisburg, Mechanicsburg +303 more locations
Sponsor: National Cancer Institute (NCI)
Sex: Female·Age: 18+
Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025
Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
for Anatomic Stage II Breast Cancer AJCC v8
Drug: Durvalumab
Sites in Harrisburg, Mechanicsburg +525 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06058377·Phase 3·Recruiting·Listed Sep 2023
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
for Extensive Stage Lung Small Cell Carcinoma
Drug: Atezolizumab
Sites in Harrisburg, Mechanicsburg +268 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT04402788·Phase 2, Phase 3·Recruiting·Listed May 2020
Testing the Addition of the Anti-Cancer Drug Tivozanib to Immunotherapy (Pembrolizumab) After Surgery to Remove All Known Sites of Kidney Cancer
for Clear Cell Renal Cell Carcinoma
Sites in Harrisburg, Mechanicsburg +406 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT06661720·Phase 3·Recruiting·Listed Oct 2024
Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study
for Muscle Invasive Bladder Urothelial Carcinoma
Sites in Harrisburg, Mechanicsburg +445 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT05987241·Phase 2, Phase 3·Recruiting·Listed Aug 2023
E-Mindfulness Approaches for Living After Breast Cancer
for Breast Cancer
Sites in Harrisburg, Mechanicsburg +372 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18 - 50
Code: NCT06748222·Phase 3·Recruiting·Listed Dec 2024
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
for Plasma Cell Myeloma
Sites in Harrisburg, Reading +226 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT04566328·Phase 3·Recruiting·Listed Sep 2020
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial
for Lung Non-Small Cell Carcinoma
Sites in Harrisburg, Mechanicsburg +259 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06498635·Phase 3·Recruiting·Listed Jul 2024
Adding Nivolumab to Usual Treatment for People With Advanced Stomach or Esophageal Cancer, PARAMUNE Trial
for Advanced Esophageal Adenocarcinoma
Drug: Nivolumab
Sites in Harrisburg, Mechanicsburg +341 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06203600·Phase 2, Phase 3·Recruiting·Listed Jan 2024
A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer
for Locally Advanced Urothelial Carcinoma
Sites in Harrisburg, Mechanicsburg +155 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06524544·Phase 3·Recruiting·Listed Jul 2024
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer
for Previously Treated Non-Small Cell Lung Cancer
Sites in Harrisburg, Mechanicsburg +948 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT03851445·Phase 2, Phase 3·Recruiting·Listed Feb 2019
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
for Metastatic Renal Cell Carcinoma
Sites in Harrisburg, Mechanicsburg +278 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05327686·Phase 2·Recruiting·Listed Apr 2022
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
for Biochemically Recurrent Prostate Carcinoma
Drug: Apalutamide
Sites in Harrisburg, Mechanicsburg +276 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: Male·Age: 18+
Code: NCT04423211·Phase 3·Recruiting·Listed Jun 2020
Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)
for Recurrent Lung Non-Small Cell Carcinoma
Sites in Harrisburg, Mechanicsburg +370 more locations
Sponsor: SWOG Cancer Research Network
Sex: All·Age: 18+
Code: NCT05642572·Phase 2·Recruiting·Listed Dec 2022
Top Research Study Locations in Harrisburg
Researchers run research studies in Harrisburg, PA at 24 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| UPMC Pinnacle Cancer Center/Community Osteopathic Campus | Anatomic Stage II Breast Cancer AJCC v8, Head and Neck Squamous Cell Carcinoma, Stage IV Lung Cancer AJCC v8 | 28 |
| Susquehanna Research Group | Ankylosing Spondylitis, Autoimmune Diseases, Birdshot Chorioretinitis | 4 |
| Pennsylvania Psychiatric Institute | Anxiety, Chemically-Induced Disorders, Chronic Stress | 2 |
| Pinnacle Health Cardiovascular Institute | Heart Failure | 2 |
| Susquehanna Research Group, LLC | Celiac Disease, Moderately to Severely Active Crohn Disease | 2 |
| UPMC Harrisburg | Cardiovascular Diseases, Hypertension, Pulmonary Embolism | 2 |
| UPMC Pinnacle Harrisburg | Heart Valve Diseases, Previously Treated Non-Small Cell Lung Cancer, Tricuspid Regurgitation | 2 |
| UPMC Pinnacle Harrisburg Campus | Coronary Artery Disease, Mitral Valve Regurgitation | 2 |
| Investigational | Crohn's Disease, Ulcerative Colitis | 2 |
| GSK Investigational Site | Irritable Bowel Syndrome | 1 |
| Home-based telemedicine | Chronic Granulomatous Disease (CGD) | 1 |
| Parents and Children Together (PACT) Lab Space | Anxiety Symptoms, Conduct Problems, Depressive Symptoms | 1 |
| Penn State Health Medical Group - Andrews Patel | Breast Cancer | 1 |
| Penn State Health Medical Group - Andrews Patel Hematology/Oncology East | Plasma Cell Myeloma, RISS Stage I Plasma Cell Myeloma, RISS Stage II Plasma Cell Myeloma | 1 |
| Penn State Hershey Medical Center-TLC Research and Treatment Center | Problematic Sexual Behavior Among Preteen Children | 1 |
| PennState Hershey Medical Center--PennState Health Children's Hospital | Hypoplastic Left Heart Syndrome (HLHS) | 1 |
| Susquehanna Research Group - Gastroenterology | C. Diff Infection, C.Difficile Diarrhea, CDI | 1 |
| Susquehanna Valley Pain Management | Lumbar Spinal Stenosis | 1 |
| UPMC Heart & Vascular Institute | Mitral Valve Insufficiency | 1 |
| UPMC Hillman Cancer Center - Pinnacle (Community Osteopathic / Medical Sciences Pavillion) | Colorectal Neoplasms | 1 |
| UPMC Pinnacle | Tricuspid Regurgitation, Tricuspid Valve Disease | 1 |
| Univ of Pittsburg Med Ctr Pinnacle | Early Breast Cancer | 1 |
| University of Pittsburg Medical Center - Harrisburg | Distal Femur Fracture | 1 |
| University of Pittsburgh Medical Center | Kidney Transplant Rejection | 1 |
Active & Upcoming Studies in Harrisburg (2026)
Recruiting trials in Harrisburg grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (32 active studies)
- A Study Comparing the Combination of Pembrolizumab and Sacituzumab Govitecan-hziy Versus Standard of Care in the Treatment of Advanced Urothelial Cancer · Phase 3 · National Cancer Institute (NCI)
- Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer · Phase 3 · National Cancer Institute (NCI)
Cardiovascular (6 active studies)
- Alleviant ALLAY-HFrEF Study · Alleviant Medical, Inc.
- Prevail Global Study · Medtronic Vascular
Mental health & behavior (4 active studies)
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
- Video-feedback Intervention to Promote Racial-Ethnic Socialization Competency (VIP-RACE) · Penn State University
Neurology & pain (1 active study)
Pediatric (1 active study)
- Treatment for Problematic Sexual Behavior of Preteen Children · Milton S. Hershey Medical Center
Common conditions studied in Harrisburg
- Anatomic Stage II Breast Cancer AJCC v8 (3 active studies)
- Breast Cancer (3 active studies)
- Head and Neck Squamous Cell Carcinoma (3 active studies)
- Stage IV Lung Cancer AJCC v8 (3 active studies)
- Anatomic Stage I Breast Cancer AJCC v8 (2 active studies)
- Celiac Disease (2 active studies)
Leading research sponsors in Harrisburg
- NRG Oncology
- National Cancer Institute (NCI)
- ECOG-ACRIN Cancer Research Group
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Harrisburg?
There are approximately 60 recruiting clinical trials in Harrisburg, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Harrisburg pay participants?
Most recruiting trials in Harrisburg compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Harrisburg?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Harrisburg?
The most common conditions under active study in Harrisburg include Anatomic Stage II Breast Cancer AJCC v8 (3), Breast Cancer (3), Head and Neck Squamous Cell Carcinoma (3), Stage IV Lung Cancer AJCC v8 (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Harrisburg?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Harrisburg on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Harrisburg?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Harrisburg?
Recruiting research sites in Harrisburg include UPMC Pinnacle Cancer Center/Community Osteopathic Campus, Susquehanna Research Group, Pennsylvania Psychiatric Institute, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Harrisburg right now?
The largest active categories in Harrisburg are Cancer & tumors (32), Cardiovascular (6), Mental health & behavior (4). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
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