Paid Clinical Trials in Bethlehem, PA
As of August 2026, 101 paid clinical trials are recruiting in Bethlehem, Pennsylvania. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Bethlehem offers studies at sites including Lehigh Valley Hospital - Muhlenberg for conditions such as Anatomic Stage IV Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma, Stage IIIB Lung Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Bethlehem
Trials by drug in Bethlehem
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Newly added in Bethlehem
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
A Phase IIb Study to Evaluate AZD8965 in Participants With IPF.
99 clinical trials
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
PODOMOUNT-Basket, a Study to Test Whether BI 764198 Helps Adults and Adolescents With Different Types of Kidney Disease
Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease
A Study to Find Out if BI 764198 Helps Adults and Adolescents With a Kidney Condition Called Focal Segmental Glomerulosclerosis (FSGS)
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
ANCHOR Study: A Study to Assess the Safety and Efficacy of ABBV-CLS-628 in Adult Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
Strategy for Improving Stroke Treatment Response
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
Nectero EAST System Clinical Study
Neutrophil and Monocyte Deactivation Via the SeLective CytopheretIc Device - A Randomized Clinical Trial in Acute Kidney Injury
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With HR+, HER2- Advanced Breast Cancer
A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
A Study to Test Whether BI 1815368 Helps People With an Eye Condition Called Diabetic Macular Edema
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
INHANCE Stemless Reverse Shoulder IDE
Helix Research Network
4D-150 in Patients With Neovascular (Wet) Age-Related Macular Degeneration
A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)
A Study Evaluating the Safety and Efficacy of the 3M™ V.A.C. Peel and Place Dressing
A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin PDT
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
Family Communications After Genetic Testing
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer
Top Research Study Locations in Bethlehem
Researchers run research studies in Bethlehem, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Lehigh Valley Hospital - Muhlenberg | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma | 46 |
| St. Luke's University Health Network | Abdominal Aortic Aneurysm, Adolescent Idiopathic Scoliosis, Advanced Breast Cancer | 15 |
| Saint Luke's University Hospital-Bethlehem Campus | Pancreatic Neoplasm, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum | 8 |
| Lehigh University | Parent-Child Relations, Parenting, Attention Deficit Hyperactivity Disorder | 4 |
| Northeast Clinical Research Center | Autosomal Dominant Polycystic Kidney Disease, Diabetic Kidney Disease (DKD), Focal Segmental Glomerulosclerosis | 4 |
| Mid Atlantic Retina | Age-related Macular Degeneration (AMD), Geographic Atrophy (GA), Geographic Atrophy Secondary to Age-related Macular Degeneration | 4 |
| St. Luke's University Hospital | Chronic Limb-Threatening Ischemia, Wound | 2 |
| St Luke's University Health Network | Computed Tomography, NSCLC, Non-small Cell Lung Cancer | 2 |
| Center for Specialized Surgery LP | Lumbar Spinal Stenosis | 1 |
| Lehigh Valley Health Network | Cancer, Myocarditis Acute | 1 |
| Lehigh Valley Hospital- Muhlenberg | Advanced Solid Tumors, Lymphoma, Non-Hodgkin, Multiple Myeloma | 1 |
| Mid Atlantic Retina - Bethlehem | Macular Edema | 1 |
| Mid Atlantic Retina - Bethlehem | Geographic Atrophy | 1 |
| Northeast Clinical Research Center, LLC | End Stage Kidney Disease | 1 |
| Saint Luke's Hospital of Bethlehem Pennsylvania | Ischemic Stroke | 1 |
| St Luke's University Health Network, Bethlehem Campus | Cutaneous Melanoma, Stage II | 1 |
| St Luke's University Hospital | Acute Kidney Injury | 1 |
| St. Luke's Hospital | Breast Cancer | 1 |
| St. Luke's University Health Network (DNAanswers) | Genetic Predisposition to Disease, Genetics Disease | 1 |
| St. Luke's University Health Network - 1179 | Non Small Cell Lung Cancer | 1 |
| St. Lukes Hospital and Health Network | Carcinoma, Non-Small-Cell Lung | 1 |
| St. Lukes University Health Network | Ovarian Cancer | 1 |
| St. Lukes University Hospital | Epithelial Ovarian Cancer, Fallopian Tube Cancer, Neoadjuvant | 1 |
| TG Therapeutics Investigational Trial Site | Multiple Sclerosis, Relapsing Multiple Sclerosis | 1 |
| Valley Surgical Ctr | Lumbar Spinal Stenosis | 1 |
Active & Upcoming Studies in Bethlehem (2026)
Recruiting trials in Bethlehem grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (55 active studies)
- A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With HR+, HER2- Advanced Breast Cancer · Phase 1 · TerSera Therapeutics LLC
- Family Communications After Genetic Testing · Alliance for Clinical Trials in Oncology
Eye & vision (5 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) · Phase 2, Phase 3 · EyeBiotech Ltd.
- A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA) · Complement Therapeutics
Cardiovascular (3 active studies)
Neurology & pain (2 active studies)
- A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS) · TG Therapeutics, Inc.
- Strategy for Improving Stroke Treatment Response · Phase 2 · Translational Sciences, Inc.
Pediatric (2 active studies)
- Hands and Hearts Together · University of Maryland, College Park
- Advanced SPinal Innovations With Robotics and Enabling Technology Registry · Boston Children's Hospital
Mental health & behavior (1 active study)
- Testing ANSOS for Efficacy in Multi-Tribal Urban Communities · Lehigh University
Common conditions studied in Bethlehem
- Anatomic Stage IV Breast Cancer AJCC v8 (4 active studies)
- Anatomic Stage II Breast Cancer AJCC v8 (3 active studies)
- Lung Non-Small Cell Carcinoma (3 active studies)
- Stage IIIB Lung Cancer AJCC v8 (3 active studies)
- Stage IV Renal Cell Cancer AJCC v8 (3 active studies)
- Advanced Esophageal Adenocarcinoma (2 active studies)
Leading research sponsors in Bethlehem
- National Cancer Institute (NCI)
- Alliance for Clinical Trials in Oncology
- SWOG Cancer Research Network
- ECOG-ACRIN Cancer Research Group
- NRG Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Bethlehem?
There are approximately 101 recruiting clinical trials in Bethlehem, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Bethlehem pay participants?
Most recruiting trials in Bethlehem compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Bethlehem?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Bethlehem?
The most common conditions under active study in Bethlehem include Anatomic Stage IV Breast Cancer AJCC v8 (4), Anatomic Stage II Breast Cancer AJCC v8 (3), Lung Non-Small Cell Carcinoma (3), Stage IIIB Lung Cancer AJCC v8 (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Bethlehem?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Bethlehem on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Bethlehem?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Bethlehem?
Recruiting research sites in Bethlehem include Lehigh Valley Hospital - Muhlenberg, St. Luke's University Health Network, Saint Luke's University Hospital-Bethlehem Campus, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Bethlehem right now?
The largest active categories in Bethlehem are Cancer & tumors (55), Eye & vision (5), Cardiovascular (3). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.