A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors
for Advanced/Metastatic Solid Tumors
21 locations incl. Duarte
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07090499·Phase 1·Recruiting
Head and neck cancer Clinical Trials in Newton, MA
As of June 2026, 1 paid clinical trial is recruiting for Head and neck cancer in Newton, Massachusetts. Recruiting Head and neck cancer studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Related specialties in Newton
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1 clinical trial for Head and neck cancer
·Clear filters·↓ Download CSVAbout research studies in Newton
Newton has approximately 32 recruiting research studies across a wide range of therapeutic areas. Massachusetts is a global epicenter of biomedical research, anchored by Harvard-affiliated hospitals (MGH, Brigham and Women's, Dana-Farber), Boston Children's Hospital, and the Kendall Square biotech corridor in Cambridge.
Top Research Study Locations in Newton
Researchers run research studies in Newton, MA at 20 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Boston Center for Memory | Alzheimer Disease, Alzheimers Disease, AD | 7 |
| Dana-Farber Cancer Institute - Chestnut Hill | Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Gastroesophageal Junction Adenocarcinoma | 3 |
| Newton-Wellesley Hospital | C. Diff Infection, C.Difficile Diarrhea, CDI | 3 |
| Dana Farber Cancer Institute- Chestnut Hill | Advanced Breast Cancer, Advanced Gastric Cancer, Breast Neoplasms | 2 |
| Newton Wellesley Hospital | Breast Cancer, HER2-positive Breast Cancer, Inflammatory Arthritis | 2 |
| Boston Center for Memory ( Site 1008) | Early Alzheimer's Disease | 1 |
| Brigham & Women's Hospital | Attention, Healthy, Vision | 1 |
| DFCI Chestnut Hill | Advanced Colorectal Cancer (Part 1), Glioma, Melanoma | 1 |
| Dana Farber Cancer Institute | Metastatic Castration-resistant Prostate Cancer | 1 |
| Dynocardia Inc | Healthy, Hypertension | 1 |
| Mass General Cancer Center Newton-Wellesley Hospital | Non Metastatic Rectal Cancer, Rectal Cancer | 1 |
| Mass General Cancer Center at Newton-Wellesley Hospital's Vernon Cancer Center | Breast Cancer | 1 |
| Mass General at Newton Wellesley Hospital | Cancer, Caregiver Burden, Coping Skills | 1 |
| Massachusetts General Hospital at Newton Wellesley Hospital | Esophagogastric Cancer, Gastroesophageal Junction Adenocarcinoma | 1 |
| Massachusetts General Hospital at Newton-Wellesley Hospital | ER-Negative Breast Cancer, HER2-negative Breast Cancer, Invasive Breast Cancer | 1 |
| Neurocare Inc | Narcolepsy Type 1 | 1 |
| Neurocare, Inc. | OSA | 1 |
| Newton Wellesley Hospital Ambulatory Care Center | Lumbar Spinal Stenosis | 1 |
| Newton, Massachusetts | Idiopathic Hypersomnia, Narcolepsy Type 1, Narcolepsy Type 2 | 1 |
| The Spiegel Center | Neck Muscle Issue | 1 |
Active & Upcoming Studies in Newton (2026)
Recruiting trials in Newton grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (14 active studies)
- ctDNA and Organ Preservation/Pathologic CR in Rectal Cancer · Massachusetts General Hospital
- A Study of Valemetostat (DS-3201b) in Combination With Darolutamide in Metastatic Castration Resistant Prostate Cancer (mCRPC) · Phase 1 · Daiichi Sankyo
Neurology & pain (4 active studies)
- A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT). · Phase 3 · Eli Lilly and Company
- A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3) · Phase 3 · Bristol-Myers Squibb
Cardiovascular (2 active studies)
Common conditions studied in Newton
- Alzheimer Disease (4 active studies). Alzheimer's research investigates anti-amyloid antibodies, tau-targeted therapies, and lifestyle interventions aimed at slowing cognitive decline.
- Gastroesophageal Junction Adenocarcinoma (4 active studies). Recruiting Gastroesophageal Junction Adenocarcinoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Alzheimers Disease (2 active studies). Alzheimer's research investigates anti-amyloid antibodies, tau-targeted therapies, and lifestyle interventions aimed at slowing cognitive decline.
- Breast Cancer (2 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Esophageal Adenocarcinoma (2 active studies). Recruiting Esophageal Adenocarcinoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Esophageal Squamous Cell Carcinoma (2 active studies). Recruiting Esophageal Squamous Cell Carcinoma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in Newton
- Massachusetts General Hospital
- Pfizer
- Bristol-Myers Squibb
- Hoffmann-La Roche
- Seagen, a wholly owned subsidiary of Pfizer
Local regulations and guidelines
Clinical trials in Massachusetts are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Massachusetts trials follow additional state privacy requirements enforced under 201 CMR 17.00 and oversight from the Massachusetts Department of Public Health.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Newton. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Newton
Hipa.ai aggregates every recruiting study in Newton from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Newton?
There are approximately 32 recruiting clinical trials in Newton, Massachusetts listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Newton pay participants?
Most recruiting trials in Newton compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Newton?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Newton?
The most common conditions under active study in Newton include Alzheimer Disease (4), Gastroesophageal Junction Adenocarcinoma (4), Alzheimers Disease (2), Breast Cancer (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Newton?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Newton on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Newton?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Newton?
Recruiting research sites in Newton include Boston Center for Memory, Dana-Farber Cancer Institute - Chestnut Hill, Newton-Wellesley Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Newton right now?
The largest active categories in Newton are Cancer & tumors (14), Neurology & pain (4), Cardiovascular (2). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
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