Paid Clinical Trials in Plano, TX
As of June 2026, 179 paid clinical trials are recruiting in Plano, Texas. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Plano offers studies at sites including The Heart Hospital Baylor Plano for conditions such as Heart Failure, Coronary Artery Disease, Cardiovascular Diseases, Major Depressive Disorder. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Plano
Filter results
0 clinical trials
·Clear filters·↓ Download CSVAbout research studies in Plano
Plano has approximately 179 recruiting research studies across a wide range of therapeutic areas. Texas hosts major cancer and cardiovascular research centers including MD Anderson Cancer Center, Baylor College of Medicine, UT Southwestern Medical Center, and the Texas Medical Center — the largest medical complex in the world.
Top Research Study Locations in Plano
Researchers run research studies in Plano, TX at 50 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| The Heart Hospital Baylor Plano | Aortic Valve Stenosis, Abdominal Aortic Aneurysm, Abdominal Aortic Aneurysm >= 5.0 Centimeters in Female (Disorder) | 11 |
| Baylor Scott & White The Heart Hospital - Plano | ANOCA - Angina With Non-obstructive Coronary Arteries, Aneurysm of Aorta, Thoracic, Aneurysmal Disease | 8 |
| AIM Trials, LLC | Irritable Bowel Syndrome With Constipation (IBS-C), Acute Treatment of Migraine, Attention-Deficit/Hyperactivity Disorder | 8 |
| AIM Trials | Alzheimer Disease, Major Depressive Disorder, Migraine | 6 |
| Stryde Research | Focal Epilepsy, Heart Failure, SLE | 5 |
| Baylor Scott & White Research Institute | Heart Failure, Ascending Aorta Aneurysm, Ascending Aortic Aneurysm Enlargement | 4 |
| Baylor Scott and White | AAA - Abdominal Aortic Aneurysm, Aortic Aneurysm, Aortic Aneurysm, Abdominal | 4 |
| Baylor Scott & White | ADHF, Acute Aortic Dissection, Aortic Arch Aneurysm | 3 |
| Baylor Scott and White - The Heart Hospital Baylor Plano | Coronary Arterial Disease (CAD), Moderate Aortic Valve Stenosis, Transthyretin Amyloidosis (ATTR) With Cardiomyopathy | 3 |
| Baylor Scott and White Heart Hospital | Aortic Valve Disease, Aortic Valve Stenosis, Iliac Disease | 3 |
| Clinical Trial Site | AQP4+ NMOSD, High Cardiovascular Risk, High Risk Cardiovascular Disease | 3 |
| Delricht Research - Plano | Major Depressive Disorder, Depression, Major Depressive Disorder (MDD) | 3 |
| Texas Back Institute | Cervical Disc Disease, Chronic Lower Back Pain, Degenerative Disc Disease | 3 |
| Texas Oncology - DFW | Breast Cancer, Breast Neoplasms | 2 |
| ACRC Trials | Non-segmental Vitiligo, Nonsegmental Vitiligo | 2 |
| Baylor Research Institute | Aortic Dissection, Atrial Fibrillation, Bleeding | 2 |
| Baylor Scott & White - The Heart Hospital - Plano | Cardiovascular Diseases, Coronary Artery Disease, In-Stent Restenosis | 2 |
| Baylor Scott & White Medical Center - Plano | Cancer, Cardiovascular Diseases, Heart Diseases | 2 |
| Baylor Scott & White Res Inst | Acute Myocardial Infarction (AMI), Cardiovascular Risk, Heart Failure | 2 |
| Baylor Scott & White The Heart Hospital | Coronary Artery Disease, High Risk Percutaneous Coronary Intervention, Interventional Cardiology | 2 |
| Baylor Scott & White The Heart Hospital Plano | High-Risk Percutaneous Coronary Intervention, Obstructive Hypertrophic Cardiomyopathy | 2 |
| Baylor Scott & White The Heart Hospital- Plano | Coronary Atherosclerosis Due to Calcified Coronary Lesion, Radiation Protection | 2 |
| Clinical Investigations of Texas | Difficult to Control Hypertension, Psoriatic Arthritis | 2 |
| GSK Investigational Site | Asthma, Systemic Lupus Erythematosus | 2 |
| Medical City Plano | Avascular Necrosis, Dislocation, Hip, Femoral Neck Fractures | 2 |
| Research Your Health | Influenza, Obesity, Overweight | 2 |
| Texas Oncology - Plano West | Breast Cancer, Solid Tumours | 2 |
| Texas Retina Associates | DME, Diabetic Macular Edema, Diabetic Macular Edema (DME) | 2 |
| Texas Retina Associates (Plano) | Macular Edema Secondary to Inflammation | 2 |
| North Texas Institute of Neurology & Headache - Plano | Multiple Sclerosis | 2 |
| Research | Hypertriglyceridemia | 2 |
| Texas Oncology - Plano East | Breast Cancer, Non-Small Cell Lung Cancer | 2 |
| Texas Rheumatology Research Institute LLC | Lupus Erythematosus, Systemic, Rheumatoid Arthritis | 2 |
| Baylor | Aortic Insufficiency, Aortic Regurgitation, Aortic Valve Disease | 1 |
| Baylor Heart Hospital | Tricuspid Valve Regurgitation | 1 |
| Baylor Heart Hospital Plano | Pulmonary Embolism Acute | 1 |
| Baylor Scott & White - The Heart Hospital Plano | Aortic Valve Disease, Aortic Valve Stenosis, Heart Disease Structural Disorder | 1 |
| Baylor Scott & White Health | Aortic Insufficiency, Aortic Regurgitation, Aortic Valve Insufficiency | 1 |
| Baylor Scott & White Health - The Heart Hospital Plano | Coronary Artery Disease (CAD), Coronary Calcification, Coronary Calcified Disease | 1 |
| Baylor Scott & White Medical | Cardiovascular Diseases, Heart Failure, Heart Valve Diseases | 1 |
| Baylor Scott & White Medical Center | Abdominal Aortic Aneurysm | 1 |
| Baylor Scott & White Medical Center- The Hearth Hospital | Heart Failure, Heart Failure With Reduced Ejection Fraction | 1 |
| Baylor Scott & White Plano | Aortic Stenosis, Coronary Artery Disease, Coronary Stenosis | 1 |
| Baylor Scott & White Surgicare at Plano Alliance | Lumbar Spinal Stenosis | 1 |
| Baylor Scott & White, The Heart Hospital | Mitral Regurgitation | 1 |
| Baylor Scott & White, The Heart Hospital Plano | Coronary Artery Disease, Ischemic Heart Disease | 1 |
| Baylor Scott and White Plano | Coronary Artery Disease | 1 |
| Baylor Scott and White Research Institute | Abdominal Aortic Aneurysms (AAA) | 1 |
| Baylor Scott and White, Advanced Heart Care | Chronic Kidney Disease, Type 2 Diabetes | 1 |
| Baylor Scott and White- The Heart Hospital- Plano | Diastolic Heart Failure, Heart Failure, Heart Failure With Mid Range Ejection Fraction | 1 |
Active & Upcoming Studies in Plano (2026)
Recruiting trials in Plano grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cardiovascular (37 active studies)
Neurology & pain (20 active studies)
- Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis · Phase 3 · Sanofi
- A Study to Evaluate the Efficacy and Safety of Remibrutinib in Secondary Progressive Multiple Sclerosis · Phase 3 · Novartis Pharmaceuticals
Cancer & tumors (14 active studies)
- Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations · Phase 3 · AstraZeneca
- A Study of Disitamab Vedotin in Adults With HER2 Expressing Advanced Breast Cancer · Phase 1, Phase 2 · Pfizer
Mental health & behavior (8 active studies)
- A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD) · Phase 2 · Tonix Pharmaceuticals, Inc.
- RE104 Safety and Efficacy Study in Generalized Anxiety Disorder · Phase 2 · Reunion Neuroscience Inc
Eye & vision (6 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) · Phase 2, Phase 3 · EyeBiotech Ltd.
- COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
Diabetes & metabolic (4 active studies)
Vaccines (1 active study)
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Pediatric (1 active study)
- Randomized Study in Children and Adolescents With Migraine: Acute Treatment · Phase 3 · Pfizer
Common conditions studied in Plano
- Heart Failure (13 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Coronary Artery Disease (8 active studies). Coronary artery disease research evaluates lipid-lowering therapies, anti-inflammatory agents, and new revascularization devices.
- Cardiovascular Diseases (5 active studies). Recruiting Cardiovascular Diseases studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Major Depressive Disorder (5 active studies). Major depressive disorder research examines rapid-acting agents, augmentation strategies, and digital therapeutics for treatment-resistant cases.
- Aortic Valve Stenosis (4 active studies). Recruiting Aortic Valve Stenosis studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Aortic Dissection (3 active studies). Recruiting Aortic Dissection studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in Plano
- Baylor Research Institute
- AbbVie
- AstraZeneca
- Novartis Pharmaceuticals
- W.L.Gore & Associates
Local regulations and guidelines
Clinical trials in Texas are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Trials run in Texas must also comply with the Texas Medical Privacy Act (TMPA), which extends federal HIPAA protections to a broader range of entities handling participant data.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Plano. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Plano
Hipa.ai aggregates every recruiting study in Plano from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Plano?
There are approximately 179 recruiting clinical trials in Plano, Texas listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Plano pay participants?
Most recruiting trials in Plano compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Plano?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Plano?
The most common conditions under active study in Plano include Heart Failure (13), Coronary Artery Disease (8), Cardiovascular Diseases (5), Major Depressive Disorder (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Plano?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Plano on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Plano?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Plano?
Recruiting research sites in Plano include The Heart Hospital Baylor Plano, Baylor Scott & White The Heart Hospital - Plano, AIM Trials, LLC, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Plano right now?
The largest active categories in Plano are Cardiovascular (37), Neurology & pain (20), Cancer & tumors (14). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.