Continuous Monitoring of Microvascular Anastomoses: An Observational Trial
for Head and Neck Neoplasm
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07823283·Recruiting·Listed Sep 16, 2026
Clinical Trials at Mayo Clinic in Rochester
As of September 2026, 325 paid clinical trials are recruiting at Mayo Clinic in Rochester, located at 1216 2ND ST SW, ROCHESTER, MN 55902-1906, phone (507) 255-5123 in Rochester, Minnesota. Active studies at this site cover conditions such as Malignant Solid Neoplasm, Breast Cancer and Heart Failure. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
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Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Rochester
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
326 clinical trials at Mayo Clinic in Rochester
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AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis
for ALS
Sites in Rochester +9 more locations
Sponsor: Amylyx Pharmaceuticals Inc.
Sex: All·Age: 18+
Code: NCT06665165·Phase 1·Recruiting·Listed Oct 2024
Safety and Preliminary Efficacy of CTX112 in Adult Participants With Relapsed/Refractory Hematologic Autoimmune Disease
for Warm Autoimmune Hemolytic Anemia (WAIHA)
Sites in Rochester +1 more location
Sponsor: CRISPR Therapeutics AG
Sex: All·Age: 18+
Code: NCT07549698·Phase 1, Phase 2·Recruiting·Listed Apr 2026
Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.
for High-grade Glioma
Sites in Rochester +2 more locations
Sponsor: Tcelltech Inc.
Sex: All·Age: 18 - 75
Code: NCT06482905·Phase 1·Recruiting·Listed Jul 2024
First in Human Study of TORL-1-23 in Participants With Advanced Cancer
for Advanced Solid Tumor
Sites in Rochester, Minneapolis +7 more locations
Sponsor: TORL Biotherapeutics, LLC
Sex: All·Age: 18+
Code: NCT05103683·Phase 1·Recruiting·Listed Nov 2021
Acute Kidney Injury In Care Transitions (ACT): Pragmatic Clinical Trial
for Acute Kidney Injury
Sites in Rochester, Mankato +1 more location
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07670520·Recruiting·Listed Jun 2026
Virtual Group Resilient Living Program For Patients Living With Advanced Cancer
for Advanced Cancer
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07659158·Recruiting·Listed Jun 2026
Pharmacokinetics Of Emulsified Avacopan Applied By NG Tube
for Diffuse Alveolar Hemorrhage
Drug: Avacopan
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07556484·Phase 1·Recruiting·Listed Apr 2026
Acceptability of Testing DNA Markers in Vaginal Fluid for the Detection of Endometrial Cancer
for Endometrial Carcinoma
1 location in Rochester
Sponsor: Mayo Clinic
Sex: Female·Age: 45+·Accepts healthy volunteers
Code: NCT07527143·Recruiting·Listed Apr 2026
A Study Of Vagal Nerve Stimulation In Conjunction With NRT For Smoking Cessation
for Smoking Cessation
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07487818·Phase 2, Phase 3·Recruiting·Listed Mar 2026
Comparing Acoustic Resonance Therapy (ART) vs. Cognitive Behavioral Therapy for Insomnia (CBT-I)
for Chronic Insomnia Disorder
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 22+
Code: NCT07486882·Recruiting·Listed Mar 2026
VSV-IFNβ-NIS With Ipilimumab and Nivolumab for the Treatment of Advanced or Metastatic Clear Cell Renal Cell Carcinoma
for Advanced Clear Cell Renal Cell Carcinoma
Drug: Ipilimumab
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07510334·Phase 2·Recruiting·Listed Apr 2026
Evaluation of Alternative Site Goserelin Acetate Injection for Ovarian Function Suppression (OFS) in Local and Locally Advanced Premenopausal Hormone Receptor Positive Breast Cancer Patients
for Anatomic Stage I Breast Cancer AJCC v8
1 location in Rochester
Sponsor: Mayo Clinic
Sex: Female·Age: 18 - 50
Code: NCT07460752·Phase 2·Recruiting·Listed Mar 2026
A Study Of Clinical Implications Of Pulmonary Vascular Disease In Valvular Heart Disease
for Pulmonary Vascular Disease
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07483203·Recruiting·Listed Mar 2026
Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas
for Anaplastic Oligodendroglioma
Drug: Retifanlimab
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07468136·Phase 1, Phase 2·Recruiting·Listed Mar 2026
HEART: Pilot Randomized Controlled Trial
for Thoracic Aortic Aneurysm
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07483177·Phase 1, Phase 2·Recruiting·Listed Mar 2026
FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease
for Cushing Disease
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07460232·EARLY_Phase 1·Recruiting·Listed Mar 2026
Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction
for Heart Failure With Preserved Ejection Fraction
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18 - 80·Accepts healthy volunteers
Code: NCT07401771·Recruiting·Listed Feb 2026
Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy
for Malignant Digestive System Neoplasm
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07456852·Phase 1, Phase 2·Recruiting·Listed Mar 2026
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
for Breast Cancer
Sites in Rochester, Burnsville +1087 more locations
Sponsor: NRG Oncology
Sex: Female·Age: 18 - 60
Code: NCT05879926·Phase 3·Recruiting·Listed May 2023
A Study Of Heart Disease Using AI-Enabled Electrocardiography And Focused Cardiac Ultrasound
for Heart Disease
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07351656·Recruiting·Listed Jan 2026
ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab
for Anatomic Stage I Breast Cancer AJCC v8
Sites in Rochester, Saint Paul +594 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT06876714·Phase 3·Recruiting·Listed Mar 2025
Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects
for Hematopoietic and Lymphoid Cell Neoplasm
Sites in Rochester, Burnsville +392 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: All ages
Code: NCT04242095·Recruiting·Listed Jan 2020
Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors
for Bladder Adenocarcinoma
Drug: Cabozantinib
Sites in Rochester, Saint Paul +214 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT03866382·Phase 2·Recruiting·Listed Mar 2019
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
for Advanced Malignant Solid Neoplasm
Sites in Rochester, Saint Paul +427 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: All ages
Code: NCT05564377·Phase 2·Recruiting·Listed Oct 2022
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
for Adenocarcinoma of the Colon
Sites in Rochester, Burnsville +331 more locations
Sponsor: NRG Oncology
Sex: All·Age: 45 - 70
Code: NCT05080673·Recruiting·Listed Oct 2021
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
for Plasma Cell Myeloma
Sites in Rochester, Burnsville +303 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 18+
Code: NCT04566328·Phase 3·Recruiting·Listed Sep 2020
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
for Anatomic Stage II Breast Cancer AJCC v8
Sites in Rochester, Burnsville +777 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18+
Code: NCT05812807·Phase 3·Recruiting·Listed Apr 2023
Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia
for B Acute Lymphoblastic Leukemia
Sites in Rochester, Minneapolis +156 more locations
Sponsor: Alliance for Clinical Trials in Oncology
Sex: All·Age: 18 - 39
Code: NCT03150693·Phase 3·Recruiting·Listed May 2017
Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers
for Pancreatic Neoplasm
Sites in Rochester, Bemidji +333 more locations
Sponsor: ECOG-ACRIN Cancer Research Group
Sex: All·Age: 50 - 75
Code: NCT04239573·Recruiting·Listed Jan 2020
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
for Fallopian Tube Endometrioid Adenocarcinoma
Drug: Bevacizumab
Sites in Rochester, Burnsville +653 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT06580314·Phase 3·Recruiting·Listed Aug 2024
Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer
for Locally Advanced Cervical Adenocarcinoma
Sites in Rochester, Saint Paul +318 more locations
Sponsor: National Cancer Institute (NCI)
Sex: Female·Age: 18+
Code: NCT07061977·Phase 3·Recruiting·Listed Jul 2025
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
for Metastatic Renal Cell Carcinoma
Sites in Rochester, Saint Paul +278 more locations
Sponsor: NRG Oncology
Sex: All·Age: 18+
Code: NCT05327686·Phase 2·Recruiting·Listed Apr 2022
Studying Quality of Life Inclusive of Mental Health and Cognitive Behavioral Therapy for Cancer Distress for the Improvement of Quality of Life in Stage III-IV Melanoma Patients
for Melanoma
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+
Code: NCT07379138·Recruiting·Listed Jan 2026
BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
for Clinical Stage III Cutaneous Melanoma AJCC v8
Drug: Cabozantinib
Sites in Rochester, Burnsville +202 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT05136196·Phase 2·Recruiting·Listed Nov 2021
MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)
for Acute Myeloid Leukemia
Sites in Rochester, Saint Paul +324 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT05564390·Phase 2·Recruiting·Listed Oct 2022
Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma
for Classic Follicular Lymphoma
Drug: Mosunetuzumab
Sites in Rochester, Burnsville +258 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 18+
Code: NCT06337318·Phase 3·Recruiting·Listed Mar 2024
Ambient Sensing Room to Detect Early Signs of Adverse Events in Hospitalized Patients With Cancer
for Hematopoietic and Lymphatic System Neoplasm
1 location in Rochester
Sponsor: Mayo Clinic
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07477886·Recruiting·Listed Mar 2026
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
for Childhood Extracranial Germ Cell Tumor
Sites in Rochester, Minneapolis +380 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: All ages
Code: NCT03067181·Phase 3·Recruiting·Listed Mar 2017
Testing Whether High Dose Chemotherapy and Infusion of the Patients' Own Stem Cells Improves Survival in Patients With Peripheral T-cell Lymphoma Who Achieved a Complete Response at the End of the Initial Chemotherapy
for Anaplastic Large Cell Lymphoma, ALK-Negative
Sites in Rochester +141 more locations
Sponsor: Eastern Cooperative Oncology Group
Sex: All·Age: 18 - 75
Code: NCT06724237·Phase 3·Recruiting·Listed Dec 2024
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
Drug: Nivolumab
Sites in Rochester, Woodbury +382 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 5 - 60
Code: NCT05675410·Phase 3·Recruiting·Listed Jan 2023
Common conditions studied in Rochester
- Malignant Solid Neoplasm (20 active studies)
- Breast Cancer (15 active studies)
- Heart Failure (15 active studies)
- Ovarian Cancer (15 active studies)
- Multiple Myeloma (14 active studies)
- Healthy (13 active studies)
Leading research sponsors in Rochester
- Mayo Clinic
- National Cancer Institute (NCI)
- AstraZeneca
- Eli Lilly and Company
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Rochester?
There are approximately 1,222 recruiting clinical trials in Rochester, Minnesota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Rochester pay participants?
Most recruiting trials in Rochester compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Rochester?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Rochester?
The most common conditions under active study in Rochester include Malignant Solid Neoplasm (20), Breast Cancer (15), Heart Failure (15), Ovarian Cancer (15), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Rochester?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Rochester on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Rochester?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Rochester?
Recruiting research sites in Rochester include Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic Rochester, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Rochester right now?
The largest active categories in Rochester are Cancer & tumors (384), Cardiovascular (90), Neurology & pain (67). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Mayo Clinic in Rochester?
Mayo Clinic in Rochester is located at 1216 2ND ST SW, ROCHESTER, MN 55902-1906. Use the Google Maps link in the intro above to get directions.
How do I contact Mayo Clinic in Rochester?
You can reach Mayo Clinic in Rochester by phone at (507) 255-5123. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.
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