Non-small cell lung cancer (NSCLC) Clinical Trials in San Antonio, TX
As of July 2026, 50 paid clinical trials are recruiting for Non-small cell lung cancer (NSCLC) in San Antonio, Texas. Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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51 clinical trials for Non-small cell lung cancer (NSCLC)
·Clear filters·↓ Download CSVA Study to Evaluate Pumitamig Versus Durvalumab Following Concurrent Chemoradiation Therapy in Participants With Unresectable Stage III Non-small Cell Lung Cancer (NSCLC) (ROSETTA Lung-201)
A Study to Evaluate the Efficacy of Pumitamig Versus Pembrolizumab in Participants With Previously Untreated Advanced Non-Small Cell Lung Cancer and PD-L1 ≥ 50%. (ROSETTA Lung-202)
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
ONC-392 Versus Docetaxel in Metastatic NSCLC That Progressed on PD-1/PD-L1 Inhibitors
Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients
A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
A Study of SGN-CEACAM5C in Adults With Advanced Solid Tumors
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan
SLV-154 Treatment of Metastatic Solid Tumors
Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors
Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
BBO-11818 in Adult Subjects With KRAS Mutant Cancer
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC)
A First-in-human Study of PRTH-101 Monotherapy +/- Pembrolizumab in Subjects With Advanced Malignancies
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC
Study of RAS(ON) Inhibitors in Combination With Ivonescimab in Patients With Solid Tumors
Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors
A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors
A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies
Dose Escalation and Dose Expansion Study of MDX2001 in Patients With Advanced Solid Tumors
This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors
About research studies in San Antonio
San Antonio has approximately 986 recruiting research studies across a wide range of therapeutic areas. Texas hosts major cancer and cardiovascular research centers including MD Anderson Cancer Center, Baylor College of Medicine, UT Southwestern Medical Center, and the Texas Medical Center — the largest medical complex in the world.
Top Research Study Locations in San Antonio
Researchers run research studies in San Antonio, TX at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Texas Health Science Center at San Antonio | Cardiovascular Diseases, Type 2 Diabetes, Acute Myeloid Leukemia | 85 |
| NEXT Oncology | Advanced Solid Tumor, Advanced Solid Tumors, Colorectal Cancer | 56 |
| Children's Hospital of San Antonio | B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm, Acute Myeloid Leukemia | 32 |
| Methodist Children's Hospital of South Texas | B Acute Lymphoblastic Leukemia, Malignant Solid Neoplasm, Acute Myeloid Leukemia | 24 |
| START San Antonio | Advanced Solid Tumor, Breast Cancer, Colorectal Cancer | 22 |
| The University of Texas Health Science Center at San Antonio | Aging, Bladder Carcinoma, Blood Pressure | 21 |
| UT Health San Antonio | Focal Epilepsy, Colorectal Cancer, Pancreatic Cancer | 16 |
| GSK Investigational Site | Non-alcoholic Fatty Liver Disease, Neoplasms, Gastrointestinal Neoplasms | 13 |
| Texas Dermatology and Laser Specialists | Eczema, Plaque Psoriasis, Alopecia | 13 |
| Texas Oncology - San Antonio | Colorectal Neoplasms, Pancreatic Ductal Adenocarcinoma, Acinar Cell Carcinoma | 12 |
| Brooke Army Medical Center | Carpal Tunnel Syndrome, Chronic Pain, Combat Casualty Care | 11 |
| American Research Corporation at the Texas Liver Institute | Healthy, Hepatic Impairment, Liver Cirrhosis | 10 |
| Southern Star Research Institute | Colitis, Ulcerative, Crohn Disease, Irritable Bowel Syndrome | 9 |
| University Hospital | Hemorrhage, Surgical, Tonsillar Bleeding, CMV | 9 |
| Endeavor Clinical Trials | Obesity, Overweight, Cardiovascular Diseases | 8 |
| NEXT San Antonio | Advanced Solid Tumors, Endometrial Cancer, Cervical Cancer | 8 |
| Southern Star Research Institute, LLC | Colitis, Ulcerative, Crohn Disease, Crohn's Disease | 8 |
| South Texas Accelerated Research Therapeutics (START) | Advanced Solid Tumors, Head and Neck Squamous Cell Carcinoma, Non-small Cell Lung Cancer | 7 |
| Texas Transplant Institute | Large B-cell Lymphoma, Non-Hodgkin Lymphoma, Refractory Non-Hodgkin Lymphoma | 7 |
| Urology San Antonio | Prostate Cancer, FGFR Gene Alterations, FGFR Gene Amplification | 7 |
| IMA Clinical Research San Antonio | Obesity, Overweight, Cardiovascular Diseases | 6 |
| Methodist Hospital | AMI Cardiogenic Shock, Acute Kidney Injury, Aortic Stenosis | 6 |
| START - San Antonio | Advanced Solid Tumors, Advanced or Metastatic Castration-Resistant Prostate Cancer (mCRPC), Advanced or Metastatic ER+ HER2- Breast Cancer (mBC) | 6 |
| South Texas Health Care System, San Antonio, TX | Adult Growth Hormone Deficiency, Alcohol Use Disorder (AUD), Chronic Low Back Pain | 6 |
| South Texas Veterans Health Care System | Hearing Disability, Mobility Disability, Anxiety | 6 |
Active & Upcoming Studies in San Antonio (2026)
Recruiting trials in San Antonio grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (303 active studies)
- Genetic Investigation of Cancer Predisposition · The University of Texas Health Science Center at San Antonio
- SCIPI Implementation and Evaluation: A Multi-site Proof-of-Concept Pilot Trial · The University of Texas Health Science Center at San Antonio
Diabetes & metabolic (85 active studies)
- A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide · Phase 3 · Novo Nordisk A/S
- Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1) · Phase 3 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
Neurology & pain (47 active studies)
- SwallowFIT Study in Parkinson's Disease · The University of Texas Health Science Center at San Antonio
- DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea. · Phase 2 · Incannex Healthcare Ltd
Cardiovascular (33 active studies)
- A Comparative, Randomized, Investigator-blind, Active-controlled, Parallel-group, Multicenter, Clinical Endpoint Study · Phase 3 · YS Life Science Co., Ltd.
- PULSE - Patient Understanding and Learning Through Structured Education - Effectiveness and Implementation of Patient Education Videos in a New Pediatric Cardiology Clinic: A Stepped Wedge Cluster Randomized Trial · Driscoll Children's Hospital
Eye & vision (20 active studies)
- A Comparative, Randomized, Investigator-blind, Active-controlled, Parallel-group, Multicenter, Clinical Endpoint Study · Phase 3 · YS Life Science Co., Ltd.
- A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated · Phase 1, Phase 2 · Boehringer Ingelheim
Mental health & behavior (16 active studies)
Pediatric (12 active studies)
- MiniMed Fit Payload Wear Pediatric Study · Medtronic MiniMed, Inc.
- PULSE - Patient Understanding and Learning Through Structured Education - Effectiveness and Implementation of Patient Education Videos in a New Pediatric Cardiology Clinic: A Stepped Wedge Cluster Randomized Trial · Driscoll Children's Hospital
HIV / STI (4 active studies)
- Study of AHB-137 in Chronic Hepatitis B (CHB) Participants in North America and Europe Regions · Phase 2 · AusperBio Therapeutics Inc.
- Behavioral Economic Intervention to Improve HIV Behaviors in Sexual Minority Individuals · The University of Texas Health Science Center at San Antonio
Vaccines (3 active studies)
Common conditions studied in San Antonio
- Advanced Solid Tumor (39 active studies). Recruiting Advanced Solid Tumor studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Advanced Solid Tumors (30 active studies). Recruiting Advanced Solid Tumors studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Obesity (27 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
- Breast Cancer (26 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Ovarian Cancer (22 active studies). Ovarian cancer research examines PARP inhibitors, maintenance therapies, and antibody-drug conjugates for recurrent and platinum-resistant disease.
- Colorectal Cancer (21 active studies). Colorectal cancer trials explore novel chemotherapy combinations, targeted agents, and immunotherapy for microsatellite-instability-high tumors.
Leading research sponsors in San Antonio
- The University of Texas Health Science Center at San Antonio
- Eli Lilly and Company
- AstraZeneca
- Bristol-Myers Squibb
- Children's Oncology Group
Local regulations and guidelines
Clinical trials in Texas are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Trials run in Texas must also comply with the Texas Medical Privacy Act (TMPA), which extends federal HIPAA protections to a broader range of entities handling participant data.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in San Antonio. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in San Antonio
Hipa.ai aggregates every recruiting study in San Antonio from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in San Antonio?
There are approximately 986 recruiting clinical trials in San Antonio, Texas listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in San Antonio pay participants?
Most recruiting trials in San Antonio compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in San Antonio?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in San Antonio?
The most common conditions under active study in San Antonio include Advanced Solid Tumor (39), Advanced Solid Tumors (30), Obesity (27), Breast Cancer (26), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in San Antonio?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in San Antonio on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in San Antonio?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in San Antonio?
Recruiting research sites in San Antonio include University of Texas Health Science Center at San Antonio, NEXT Oncology, Children's Hospital of San Antonio, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in San Antonio right now?
The largest active categories in San Antonio are Cancer & tumors (303), Diabetes & metabolic (85), Neurology & pain (47). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.