As of August 2026, 10 paid clinical trials are testing Methotrexate in St Louis, Missouri. Trials typically compensate participants for time, travel, and study visits, and many also provide study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Researchers run research studies in St Louis, MO at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Washington University School of Medicine | Breast Cancer, Colorectal Cancer, Prostate Cancer | 459 |
| Washington University | Amyotrophic Lateral Sclerosis, CRC, Colorectal Cancer | 138 |
| Washington University in St. Louis | Cardiovascular Diseases, Dementia, Acute Stress Disorder | 87 |
| Mercy Hospital Saint Louis | Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8 | 86 |
| Missouri Baptist Medical Center | Anatomic Stage II Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8 | 77 |
| Mercy Hospital South | Stage IV Lung Cancer AJCC v8, Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8 | 76 |
| Siteman Cancer Center-South County | Acute Myeloid Leukemia, Stage IVB Prostate Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 68 |
| Siteman Cancer Center at Christian Hospital | Acute Myeloid Leukemia, Stage IVB Prostate Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 62 |
| Washington University School of Medicine in St. Louis | Ovarian Cancer, Lymphoma, Acute Myeloid Leukemia | 24 |
| Mercy Infusion Center - Chippewa | Malignant Solid Neoplasm, RISS Stage I Plasma Cell Myeloma, RISS Stage II Plasma Cell Myeloma | 23 |
| Cardinal Glennon Children's Medical Center | Neuroblastoma, Osteosarcoma, Ewing Sarcoma | 22 |
| St. Louis Children's Hospital | Adolescent Idiopathic Scoliosis, Advanced Solid Tumor, Autoimmune Hepatitis | 20 |
| Saint Louis University | Opioid Use, ACL Surgery, ALS | 19 |
| Barnes Jewish Hospital | Intracerebral Hemorrhage, Ischemic Stroke, Aortic Aneurysm, Abdominal | 14 |
| Siteman Cancer Center | Breast Cancer, Advanced Hepatocellular Carcinoma, Advanced/Metastatic Urothelial Cancer | 12 |
| Arch Clinical Trials | Schizophrenia, Bipolar Disorder, Bipolar Disorder Type I With Mania | 10 |
| Barnes-Jewish Hospital | Acute Ischemic Stroke, Advanced Hepatocellular Carcinoma, Advanced/Metastatic Urothelial Cancer | 10 |
| Washington University, St. Louis | Acute Myeloid Leukemia, Acute Stress Reaction, Alzheimer Disease | 10 |
| Washington University School of Medicine - Siteman Cancer Center | Advanced Hepatocellular Carcinoma, Advanced Solid Tumors, Adult, Advanced/Metastatic Urothelial Cancer | 9 |
| The Washington University | Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), Back Pain, Capsular Contracture Associated With Breast Implant | 8 |
| Washington University in St Louis | AML, Adult, Advanced Solid Tumor, Asymptomatic Bacteriuria | 8 |
| GSK Investigational Site | Non-alcoholic Fatty Liver Disease, Asthma, Bronchiectasis | 7 |
| St. Louis VA Medical Center John Cochran Division, St. Louis, MO | Anxiety, Carcinoma, Hepatocellular, Chronic Low Back Pain | 7 |
| Washington University Medical Center | ALK-Positive Lung Cancer, ALK-positive NSCLC, ALK-positive Non-small Cell Lung Cancer | 7 |
| Washington University St. Louis | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Advanced Solid Tumors | 7 |
Recruiting trials in St Louis grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
There are approximately 1,413 recruiting clinical trials in St Louis, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Most recruiting trials in St Louis compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
The most common conditions under active study in St Louis include Breast Cancer (37), Prostate Cancer (32), Colorectal Cancer (24), Advanced Solid Tumor (20), among many others. Browse the list above to explore every recruiting trial.
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in St Louis on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Recruiting research sites in St Louis include Washington University School of Medicine, Washington University, Washington University in St. Louis, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
The largest active categories in St Louis are Cancer & tumors (546), Neurology & pain (98), Cardiovascular (69). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.