Breast cancer Clinical Trials in St Louis, MO
As of September 2026, 46 paid clinical trials are recruiting for Breast cancer in St Louis, Missouri. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in St Louis
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
47 clinical trials for Breast cancer
·Clear filters·A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.
First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
A Phase 1 Study of LNCB74 in Advanced Solid Tumors
Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)
First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer
Phase 1b Study of OP-1250 (Palazestrant) in Combination With Ribociclib, Alpelisib, Everolimus, or Atirmociclib in ER+, HER2- Breast Cancer
An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors
FIH Study of RGT-419B Alone and With Endocrine Therapy in HR-Positive, HER2-Negative Advanced/Metastatic Breast Cancer
IDOV-Immune for Advanced Solid Tumors
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
E-Mindfulness Approaches for Living After Breast Cancer
The Vanguard Study: Testing a New Way to Screen for Cancer
Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer
Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer
Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score
Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Treatment Monitoring of Patients Receiving CDK 4/6 Inhibitors for Hormone Receptor (HR) Positive, HER2 Negative Metastatic Breast Cancer (MBC) With or Without the Addition of DiviTum® Serum Thymidine Kinase 1 (TK1) Activity Testing
ChatGPT & Surgeon Synergy: Redefining Breast Reconstruction Consultations for Enhanced Patient Engagement and Satisfaction
COOL-IT-PRO: Cryoablation of Breast Cancer in Non-surgical Patients
NeoTAILOR: ABiomarker-directed Approach to Guide Neoadjuvant Therapy for Patients With Stage II/III ER-positive, HER2-negative Breast Cancer
Cryoablation vs Lumpectomy in T1 Breast Cancers
Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors
Top Research Study Locations in St Louis
Researchers run research studies in St Louis, MO at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Washington University School of Medicine | Breast Cancer, Colorectal Cancer, Prostate Cancer | 458 |
| Washington University | Amyotrophic Lateral Sclerosis, CRC, Colorectal Cancer | 138 |
| Washington University in St. Louis | Cardiovascular Diseases, Dementia, Acute Stress Disorder | 88 |
| Mercy Hospital Saint Louis | Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8 | 86 |
| Missouri Baptist Medical Center | Anatomic Stage II Breast Cancer AJCC v8, Stage IV Lung Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8 | 77 |
| Mercy Hospital South | Stage IV Lung Cancer AJCC v8, Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8 | 76 |
| Siteman Cancer Center-South County | Acute Myeloid Leukemia, Stage IVB Prostate Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 68 |
| Siteman Cancer Center at Christian Hospital | Acute Myeloid Leukemia, Stage IVB Prostate Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 62 |
| Washington University School of Medicine in St. Louis | Ovarian Cancer, Lymphoma, Acute Myeloid Leukemia | 24 |
| Mercy Infusion Center - Chippewa | Malignant Solid Neoplasm, RISS Stage I Plasma Cell Myeloma, RISS Stage II Plasma Cell Myeloma | 23 |
| Cardinal Glennon Children's Medical Center | Neuroblastoma, Osteosarcoma, Ewing Sarcoma | 22 |
| St. Louis Children's Hospital | Adolescent Idiopathic Scoliosis, Advanced Solid Tumor, Autoimmune Hepatitis | 20 |
| Saint Louis University | Opioid Use, ACL Surgery, ALS | 19 |
| Barnes Jewish Hospital | Intracerebral Hemorrhage, Ischemic Stroke, Aortic Aneurysm, Abdominal | 14 |
| Siteman Cancer Center | Breast Cancer, Advanced Hepatocellular Carcinoma, Advanced/Metastatic Urothelial Cancer | 12 |
| Arch Clinical Trials | Schizophrenia, Bipolar Disorder, Bipolar Disorder Type I With Mania | 10 |
| Barnes-Jewish Hospital | Acute Ischemic Stroke, Advanced Hepatocellular Carcinoma, Advanced/Metastatic Urothelial Cancer | 10 |
| Washington University, St. Louis | Acute Myeloid Leukemia, Acute Stress Reaction, Alzheimer Disease | 10 |
| Washington University School of Medicine - Siteman Cancer Center | Advanced Hepatocellular Carcinoma, Advanced Solid Tumors, Adult, Advanced/Metastatic Urothelial Cancer | 9 |
| The Washington University | Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), Back Pain, Capsular Contracture Associated With Breast Implant | 8 |
| Washington University in St Louis | AML, Adult, Advanced Solid Tumor, Asymptomatic Bacteriuria | 8 |
| GSK Investigational Site | Non-alcoholic Fatty Liver Disease, Asthma, Bronchiectasis | 7 |
| St. Louis VA Medical Center John Cochran Division, St. Louis, MO | Anxiety, Carcinoma, Hepatocellular, Chronic Low Back Pain | 7 |
| Washington University Medical Center | ALK-Positive Lung Cancer, ALK-positive NSCLC, ALK-positive Non-small Cell Lung Cancer | 7 |
| Washington University St. Louis | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Advanced Solid Tumors | 7 |
Active & Upcoming Studies in St Louis (2026)
Recruiting trials in St Louis grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (546 active studies)
- TeamTalk: Improving Inter-professional Communication During Cancer Treatment · Washington University School of Medicine
- Testing the Addition of Venetoclax or Gemtuzumab Ozogamicin (GO) to Usual Treatment Regimen (Cytarabine and Daunorubicin, "7+3") for Core Binding Factor Acute Myeloid Leukemia (CBF-AML) to Improve Response (A MYELOMATCH Treatment Trial) · Phase 2 · National Cancer Institute (NCI)
Neurology & pain (98 active studies)
- Semaglutide for Low Back Pain · Phase 2 · Washington University School of Medicine
- An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD) · Phase 2 · Yale University
Cardiovascular (70 active studies)
- A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. · P+F Products + Features USA Inc.
- A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF · Phase 3 · AstraZeneca
Diabetes & metabolic (45 active studies)
- Semaglutide for Low Back Pain · Phase 2 · Washington University School of Medicine
- A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide · Phase 3 · Novo Nordisk A/S
Mental health & behavior (41 active studies)
- Substance Use in Pregnancy - Optimizing Retention in Treatment by Maximizing Opportunities for Management · Phase 2 · Washington University School of Medicine
- Relapse Prevention Trial Evaluating KarXT Treatment in Schizophrenia · Phase 3 · Karuna Therapeutics, Inc., a Bristol Myers Squibb company
Pediatric (22 active studies)
- TeamTalk: Improving Inter-professional Communication During Cancer Treatment · Washington University School of Medicine
- Weight Gain in Pediatric Leukemia Survivors · Washington University School of Medicine
HIV / STI (11 active studies)
- A Study of GS-3242 in Combination With Lenacapavir Versus Biktarvy in Virologically Suppressed People With HIV-1 · Phase 2 · Gilead Sciences
- Menopausal HT for Women Living With HIV (HoT) · Phase 4 · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Eye & vision (11 active studies)
- A Comparative, Randomized, Investigator-blind, Active-controlled, Parallel-group, Multicenter, Clinical Endpoint Study · Phase 3 · YS Life Science Co., Ltd.
- A Study to Evaluate Efficacy, Safety, and Immunogenicity With ABP 938 8 mg Versus EYLEA® HD (Aflibercept) in Participants With Neovascular Age-related Macular Degeneration · Phase 3 · Amgen
Vaccines (6 active studies)
- A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- Characterizing the Human Airway Immune Response to FluMist Vaccination · Phase 4 · Washington University School of Medicine
Common conditions studied in St Louis
- Breast Cancer (37 active studies)
- Prostate Cancer (32 active studies)
- Colorectal Cancer (24 active studies)
- Advanced Solid Tumor (20 active studies)
- Ovarian Cancer (20 active studies)
- Acute Myeloid Leukemia (19 active studies)
Leading research sponsors in St Louis
- Washington University School of Medicine
- National Cancer Institute (NCI)
- AstraZeneca
- Eli Lilly and Company
- SWOG Cancer Research Network
Frequently asked questions
How many paid clinical trials are currently recruiting in St Louis?
There are approximately 1,411 recruiting clinical trials in St Louis, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in St Louis pay participants?
Most recruiting trials in St Louis compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in St Louis?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in St Louis?
The most common conditions under active study in St Louis include Breast Cancer (37), Prostate Cancer (32), Colorectal Cancer (24), Advanced Solid Tumor (20), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in St Louis?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in St Louis on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in St Louis?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in St Louis?
Recruiting research sites in St Louis include Washington University School of Medicine, Washington University, Washington University in St. Louis, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in St Louis right now?
The largest active categories in St Louis are Cancer & tumors (546), Neurology & pain (98), Cardiovascular (70). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.