Paid Clinical Trials in St Louis, MO
As of June 2026, 1,463 paid clinical trials are recruiting in St Louis, Missouri. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
St Louis offers studies at sites including Washington University School of Medicine for conditions such as Breast Cancer, Prostate Cancer, Heart Failure, Colorectal Cancer. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in St Louis
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St Louis has approximately 1,463 recruiting research studies across a wide range of therapeutic areas. Missouri hosts Washington University School of Medicine in St. Louis and University of Kansas Medical Center's Missouri partners, known for oncology, genomics, and rare-disease research.
Top Research Study Locations in St Louis
Researchers run research studies in St Louis, MO at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Washington University School of Medicine | Breast Cancer, Multiple Myeloma, Prostate Cancer | 468 |
| Washington University | NSCLC, Heart Failure, Ovarian Cancer | 145 |
| Mercy Hospital Saint Louis | Malignant Solid Neoplasm, Anatomic Stage II Breast Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8 | 95 |
| Mercy Hospital South | Stage IV Lung Cancer AJCC v8, Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8 | 85 |
| Siteman Cancer Center-South County | Stage IV Lung Cancer AJCC v8, Stage IVB Prostate Cancer AJCC v8, Acute Myeloid Leukemia | 85 |
| Washington University in St. Louis | Cardiovascular Diseases, Dementia, Acute Stress Disorder | 82 |
| Missouri Baptist Medical Center | Stage IV Lung Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Breast Cancer | 80 |
| Siteman Cancer Center at Christian Hospital | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Metastatic Malignant Solid Neoplasm | 78 |
| Mercy Infusion Center - Chippewa | Malignant Solid Neoplasm, Stage IIIB Lung Cancer AJCC v8, Anatomic Stage I Breast Cancer AJCC v8 | 35 |
| Cardinal Glennon Children's Medical Center | Neuroblastoma, Acute Myeloid Leukemia, Metastatic Osteosarcoma | 25 |
| Washington University School of Medicine in St. Louis | Ovarian Cancer, Lymphoma, Acute Myeloid Leukemia | 25 |
| St. Louis Children's Hospital | Acute Liver Failure, Acute Liver Injury, Acute Respiratory Distress Syndrome | 22 |
| Saint Louis University | Chronic Cutaneous Lupus Erythematosus, Chronic Kidney Diseases, Opioid Use | 20 |
| Barnes Jewish Hospital | Intracerebral Hemorrhage, Ischemic Stroke, Aortic Aneurysm, Abdominal | 13 |
| Barnes-Jewish Hospital | Acute Ischemic Stroke, Advanced Breast Cancer, Advanced Gastric Cancer | 12 |
| Arch Clinical Trials | Schizophrenia, Bipolar 1 Disorder, Bipolar Disorder | 11 |
| Washington University St. Louis | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Advanced Solid Tumors | 11 |
| GSK Investigational Site | Gastrointestinal Neoplasms, Non-alcoholic Fatty Liver Disease, Asthma | 10 |
| Washington University School of Medicine - Siteman Cancer Center | Advanced Breast Cancer, Advanced Gastric Cancer, Breast Neoplasms | 10 |
| Washington University, St. Louis | Alzheimer Disease, Acute Myeloid Leukemia, Acute Stress Reaction | 10 |
| Siteman Cancer Center | Breast Cancer, Neoplasms, Carcinoma, Non-Small-Cell Lung | 9 |
| The Washington University | Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP), Alzheimer's Disease, Amyloid Plaque | 9 |
| Saint Louis Cancer and Breast Institute-South City | Metastatic Malignant Neoplasm in the Brain, Acral Lentiginous Melanoma, Anatomic Stage IV Breast Cancer AJCC v8 | 8 |
| Washington University in St Louis | AML, Adult, Advanced Solid Tumor, Asymptomatic Bacteriuria | 8 |
| Cardinal Glennon Children's Hospital | Neuroblastoma, Acute Respiratory Distress Syndrome, Alpha1-Antitrypsin Deficiency | 7 |
Active & Upcoming Studies in St Louis (2026)
Recruiting trials in St Louis grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (550 active studies)
- TeamTalk: Improving Inter-professional Communication During Cancer Treatment · Washington University School of Medicine
- Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer · Phase 1 · National Cancer Institute (NCI)
Neurology & pain (97 active studies)
Cardiovascular (67 active studies)
- A Study of LY3971297 in Participants With Heart Failure · Phase 1 · Eli Lilly and Company
- An International Multicenter, Multivendor Evaluation of the Free-Running Framework for Cardiac Function · Matthias Stuber
Mental health & behavior (42 active studies)
- Psilocybin-Assisted Therapy as a Treatment for Depression · Phase 2 · Washington University School of Medicine
- A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers · RAI Services Company
Diabetes & metabolic (41 active studies)
- Weight Gain in Pediatric Leukemia Survivors · Washington University School of Medicine
- A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight · Phase 3 · Novo Nordisk A/S
Pediatric (23 active studies)
- TeamTalk: Improving Inter-professional Communication During Cancer Treatment · Washington University School of Medicine
- A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction · Phase 3 · Bayer
HIV / STI (13 active studies)
- Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disorder (MND) in Persons With HIV · Phase 2 · National Institute of Allergy and Infectious Diseases (NIAID)
- Menopausal HT for Women Living With HIV (HoT) · Phase 4 · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Eye & vision (13 active studies)
- CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
- Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) · Phase 3 · AbbVie
Vaccines (9 active studies)
- A Safety and Immunogenicity Trial of OCU500, ChAd36 Vector Encoding SARS-CoV-2 Spike Vaccine Via Intranasal and Inhalational Routes in Previously Vaccinated Adults · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- A Study to Evaluate the Safety and Efficacy of CD388 for Prevention of Influenza · Phase 3 · Cidara Therapeutics Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Common conditions studied in St Louis
- Breast Cancer (36 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Prostate Cancer (28 active studies). Prostate cancer studies test next-generation hormone therapies, PARP inhibitors, and radioligand treatments for both localized and advanced disease.
- Heart Failure (23 active studies). Heart failure trials explore SGLT-2 inhibitors, novel myosin modulators, and device-based therapies for both reduced and preserved ejection fraction.
- Colorectal Cancer (22 active studies). Colorectal cancer trials explore novel chemotherapy combinations, targeted agents, and immunotherapy for microsatellite-instability-high tumors.
- Advanced Solid Tumor (21 active studies). Recruiting Advanced Solid Tumor studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Multiple Myeloma (21 active studies). Recruiting Multiple Myeloma studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
Leading research sponsors in St Louis
- Washington University School of Medicine
- National Cancer Institute (NCI)
- AstraZeneca
- Eli Lilly and Company
- Children's Oncology Group
Local regulations and guidelines
Clinical trials in Missouri are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Missouri research additionally follows state public health department oversight and any applicable state privacy statutes.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in St Louis. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in St Louis
Hipa.ai aggregates every recruiting study in St Louis from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in St Louis?
There are approximately 1,463 recruiting clinical trials in St Louis, Missouri listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in St Louis pay participants?
Most recruiting trials in St Louis compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in St Louis?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in St Louis?
The most common conditions under active study in St Louis include Breast Cancer (36), Prostate Cancer (28), Heart Failure (23), Colorectal Cancer (22), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in St Louis?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in St Louis on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in St Louis?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in St Louis?
Recruiting research sites in St Louis include Washington University School of Medicine, Washington University, Mercy Hospital Saint Louis, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in St Louis right now?
The largest active categories in St Louis are Cancer & tumors (550), Neurology & pain (97), Cardiovascular (67). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.