Amputation Clinical Trials

Recruiting amputation studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat amputation. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting amputation studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting amputation trials

Within

The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation

for Low Back Pain

Sponsor: Ukrainian Society of Regional Anesthesia and Pain Therapy

Sex: All·Age: 18 - 50

Code: NCT07626294

Comparing the Attentional Demands and Functional Outcomes in People With Transradial Amputation

for Amputation

2 sites incl. Austin

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18+

Code: NCT07075042

Apply to this trial

Influence Of A Slope Adaptive Foot On Participation Of Veterans With Lower-Limb Amputations

for Amputation

1 site in Minneapolis

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 89

Code: NCT07266077

Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation

for Amputation

1 site in Richmond

Sponsor: Virginia Commonwealth University

Sex: All·Age: 18 - 85

Code: NCT07387744

Apply to this trial

Bio Leg: Advancing Mobility (BAM)

for Amputation of Lower Limb Above Knee

1 site in Jacksonville

Sponsor: University of Florida

Sex: All·Age: 40 - 70

Code: NCT07613502

Apply to this trial

TOE Study: Treatment and Gait Analysis fOllowing an Excised Lesser Toe

for Diabetes Mellitus

Sponsor: University of Huddersfield

Sex: All·Age: 18 - 105

Code: NCT07441772

Prosthetic Socket Fit Testing System

for Amputation

Sponsor: University of Washington

Sex: All·Age: 18 - 70

Code: NCT07491614

Evacuation Time and Tourniquet Use as Risk Factors for PTSD in Combat-Related Amputation

for Amputation

Sponsor: Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)

Sex: All·Age: 18 - 60

Code: NCT07502313

Advancing Antimicrobial Photodynamic Therapy to Prevent Infection in Osseointegrated Prosthesis Patients

for Amputation

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18+

Code: NCT06777511

Amputations in Childhood and Neuropathic Pain

for Pediatric

Sponsor: Hopitaux de Saint-Maurice

Sex: All·Age: 5 - 18

Code: NCT07401966

Apply to this trial

Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation

for Amputation

1 site in Pittsburgh

Sponsor: Boninger, Michael, MD

Sex: All·Age: 22 - 70

Code: NCT05768802

Apply to this trial

Neuromusculoskeletal Interface for Bionic Arms

for Amputation

1 site in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 70

Code: NCT07032753

Pilot Feasibility Trial of a Peer Support Program for Trauma Survivors

for Traumatic Injury

Sponsor: Sunnybrook Health Sciences Centre

Sex: All·Age: 18+

Code: NCT07275892

Combined Local Anesthetic Blockade and Neuromodulation vs Local Anesthetic Blockade Only for Analgesia After Below-knee Amputation: RCT

for Amputation

3 sites incl. Stanford

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT06964347

Impact Evaluation of Breizh Fabribus Intervention for Personalized Assistive Technology Creation or Adaptation

for Amputation

Sponsor: Fondation Ildys

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07314099

Apply to this trial

Gait Training and Artificial Intelligence

for Above Knee Amputation

Sponsor: South Valley University

Sex: All·Age: 16 - 50

Code: NCT07265154

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Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes

for Amputation

1 site in Aurora

Sponsor: University of Colorado, Denver

Sex: All·Age: 18+

Code: NCT07263945·Phase 1

Apply to this trial

A Comparison of Myoelectric and Bionic Hands

for Amputation

Sponsor: Gulhane School of Medicine

Sex: All·Age: 18 - 65

Code: NCT07347561

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Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control

for Amputation

2 sites incl. Chicago

Sponsor: Liberating Technologies, Inc.

Sex: All·Age: 18+

Code: NCT07011420

Apply to this trial

Operative Treatment vs Treatment With Semi-occlusive Dressing for Single Finger Amputations

for Fingertips Traumatic Amputations

Sponsor: Tampere University Hospital

Sex: All·Age: 18+

Code: NCT07175675

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Evaluation of a Powered Ankle Prosthesis Capable of Bidirectional Control Via Neural Recording and Cutaneous Stimulation in Free-Space and Walking Tasks

for Amputation

1 site in Cambridge

Sponsor: Massachusetts Institute of Technology

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT07645729

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Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators

for Amputation

1 site in Austin

Sponsor: Hanger Institute for Clinical Research and Education, LLC

Sex: All·Age: 18+

Code: NCT06937242

Apply to this trial

3-Dimensional Evaluation of Body Perception

for Body Image

Sponsor: Trakya University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06985329

Prosthetic Performance Enhancement Trial

for Amputation

1 site in Las Vegas

Sponsor: University of Nevada, Las Vegas

Sex: All·Age: 18+

Code: NCT06419920

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Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment

for Phantom Pain Following Amputation of Lower Limb

3 sites incl. Philadelphia

Sponsor: Albert Einstein Healthcare Network

Sex: All·Age: 18 - 100

Code: NCT07044323

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Quantification of Motor Compensation Following Biomechanical, Proprioceptive and Physiological Alterations Post-lower Limb Amputation.

for Amputation

Sponsor: Centre Hospitalier Universitaire de Nīmes

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06780943

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Personalizing Thromboprophylaxis for Patients With Peripheral Artery Disease

for Peripheral Arterial Disease (PAD)

2 sites incl. Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07613840

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New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI)

for Wheelchair Users

Sponsor: Nova Scotia Health Authority

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06831240

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

for Amputation

5 sites incl. Pittsfield

Sponsor: AtriCure, Inc.

Sex: All·Age: 18+

Code: NCT06908538

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Regenerative Peripheral Nerve Interface for Control of Lower Limb Prostheses

for Amputation

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18 - 75

Code: NCT06275282

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Effect of Music During Toe Amputation

for Amputation

Sponsor: Afyonkarahisar Health Sciences University

Sex: All·Age: 18+

Code: NCT06776809

Promoting Physical Activity Following Dysvascular Amputation

for Amputation

Sponsor: West Park Healthcare Centre

Sex: All·Age: 18+

Code: NCT06667739

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Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA

for Amputation

1 site in Pittsburgh

Sponsor: Sara Peterson-Snyder

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT06830876

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Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses

for Amputation

1 site in Redondo Beach

Sponsor: Infinite Biomedical Technologies

Sex: All·Age: 18+

Code: NCT06539936

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Thermoregulation in Individuals With a Leg Amputation

for Amputation

1 site in Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT06458426

Studies Into Touch in Healthy Humans to Provide Sensory Feedback in Prostheses

for Somatosensory Disorders

Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Sex: All·Age: 20 - 70·Accepts healthy volunteers

Code: NCT05548322

Apply to this trial

Usability of the Smart Hallway System in Clinical Setting

for Amputation

Sponsor: University Rehabilitation Institute, Republic of Slovenia

Sex: All·Age: 18+

Code: NCT06645054

Apply to this trial

A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations

for Amputation

2 sites incl. Minneapolis

Sponsor: Seattle Institute for Biomedical and Clinical Research

Sex: All·Age: 18 - 89

Code: NCT05473065

Apply to this trial

Study of Efficacy of the MyoTrain System in a Population of Individuals With Trans-radial Limb Loss

for Amputation

1 site in Grand Rapids

Sponsor: Infinite Biomedical Technologies

Sex: All·Age: 18+

Code: NCT05888428

Apply to this trial

Powered Prosthesis for Use With TF Osseointegration Recipients

for Amputation

1 site in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 70

Code: NCT06160882

Apply to this trial

Pro APP Prosthetic Outcome Registry

for Amputation

1 site in Irvine

Sponsor: Össur Iceland ehf

Sex: All·Age: 18+

Code: NCT06210620

Apply to this trial

TITAN Trial: Reducing Phantom Limb Pain in People with Amputations

for Phantom Limb Pain

Sponsor: Neuroscience Research Australia

Sex: All·Age: 18+

Code: NCT06167330

Apply to this trial

Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs

for Amputation

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06138977

Apply to this trial

Downstream Effects of Personalized 'Top-down' Participation-based Interventions Among Youth With Physical Disabilities

for Spinal Cord Injuries

Sponsor: McGill University

Sex: All·Age: 12 - 18

Code: NCT05784285

Sonomyographic Upper Limb Prosthetics: A New Paradigm

for Amputation

1 site in Fairfax

Sponsor: George Mason University

Sex: All·Age: 18 - 65

Code: NCT05376332

Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees

for Amputation

1 site in Austin

Sponsor: Liberating Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06194838

Apply to this trial

Impact of Improving Footwear Options

for Amputation

1 site in Minneapolis

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 89

Code: NCT05601869

Apply to this trial

Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis

for Amputation

3 sites incl. Tampa

Sponsor: University of Washington

Sex: All·Age: 16+

Code: NCT06214026

Apply to this trial

Enhancing Motor Function in Individuals with Lower Limb Amputation

for Amputation

1 site in Las Vegas

Sponsor: University of Nevada, Las Vegas

Sex: All·Age: 18+

Code: NCT06638723

Apply to this trial

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

for Infections

13 sites incl. Indianapolis

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18+

Code: NCT05699174·Phase 3

Apply to this trial

Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait

for Amputation

1 site in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 95

Code: NCT06433648

Apply to this trial

Clinical Feasibility of the IMES Transradial Prosthesis

for Amputation

Sponsor: Össur Iceland ehf

Sex: All·Age: 18 - 65

Code: NCT04936789

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Self-Management for Amputee Rehabilitation Using Technology.

for Behavior

Sponsor: University of British Columbia

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT04953364

Apply to this trial

Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.

for Amputation

1 site in Baltimore

Sponsor: Major Extremity Trauma Research Consortium

Sex: All·Age: 18 - 75

Code: NCT04839497·Phase 2

Apply to this trial

MultiSENSory Stimulation to TArgeT Sensory Loss and ChronIc Pain in NeurOpathic PatieNts

for Neuropathy

Sponsor: ETH Zurich

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05483816

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Early Evaluation of the Introduction of Pre- and Post-operative Psychological and Physiotherapeutic Follow-up in Vascular Surgery in Amputee Patients

for Amputation

Sponsor: Centre Hospitalier Departemental Vendee

Sex: All·Age: 18+

Code: NCT04750876

Apply to this trial

Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Feedback?

for Amputation

1 site in Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 18 - 65

Code: NCT05505513

Apply to this trial

Evaluating the Experience of Upper Limb Prosthesis Use

for Prosthesis User

1 site in Cleveland

Sponsor: Louis Stokes VA Medical Center

Sex: All·Age: 18+

Code: NCT04855214

Apply to this trial

Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation

for Amputation

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06840262

Apply to this trial

AMI Construction in Lower Extremity Residual Limbs

for Amputation

3 sites incl. Bethesda

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT04063592

Apply to this trial

Amputation clinical trials — common questions

Are amputation clinical trials free to join?

Yes. Participating in a amputation clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a amputation clinical trial?

Each amputation study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a amputation trial near me?

Use the location controls above. We'll show recruiting amputation trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many amputation trials are recruiting right now?

We're currently tracking roughly 44 recruiting amputation trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Amputation trials by city

Chicago, IL Ann Arbor, MI Cleveland, OH Salt Lake City, UT Aurora, CO Boston, MA Grand Rapids, MI Indianapolis, IN Irvine, CA Jacksonville, FL Stanford, CA Tampa, FL