Low back pain Clinical Trials

Recruiting low back pain studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat low back pain. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting low back pain studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting low back pain trials

Within

Therapeutic Exercise and Education for Low Back Pain

for Low Back Pain

Sponsor: University of Valladolid

Sex: All·Age: 18+

Code: NCT07713082

Effect of Kinesio Taping Versus Myofascial Release on Menstrual Low Back Pain

for Low Back Pain

Sponsor: Cairo University

Sex: Female·Age: 18 - 25·Accepts healthy volunteers

Code: NCT06280989

Impact of the Receptive Music Intervention Tool (MUSIC CARE©) on Changes in the Functional Abilities of Patients With Chronic Low Back Pain

for Low Back Pain

Sponsor: LNA SANTE

Sex: All·Age: 18+

Code: NCT07731204

Virtual Tai Chi for Chronic Low Back Pain (Spine 2027)

for Low Back Pain

1 site in Valhalla

Sponsor: New York Medical College

Sex: All·Age: 18+

Code: NCT07772154

Effect of Dry Needling Plus Vibration on Myofascial Trigger Points in Individuals With Nonspecific Low Back Pain

for Low Back Pain

Sponsor: Universidad de Zaragoza

Sex: All·Age: 35 - 65

Code: NCT06527339

Spinery Basivertebral Nerve Ablation for Vertebrogenic Chronic Low Back Pain

for Low Back Pain

Sponsor: Axon srl

Sex: All·Age: 25+

Code: NCT07696507

The Association Between Amputation Level and Chronic Low Back Pain After Combat-Related Amputation

for Low Back Pain

Sponsor: Ukrainian Society of Regional Anesthesia and Pain Therapy

Sex: All·Age: 18 - 50

Code: NCT07626294

Brain Connectivity and Perceptive Surfaces in Chronic Low Back Pain (SUPER-RMNf)

for Low Back Pain

Sponsor: G. d'Annunzio University

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07568353

EFFICACY OF ARTIFICIAL INTELLIGENCE DRIVEN PROGRAM VERSUS TRADITIONAL PHYSICAL THERAPY PROGRAM IN PATIENTS WITH LOW BACK DYSFUNCTION

for Low Back Pain

Sponsor: Cairo University

Sex: All·Age: 18 - 45

Code: NCT07749833

Biologic Injection For Adults With Lumbar Disc Herniation

for Degenerative Disc Disease

1 site in Manhattan

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18+

Code: NCT07386548

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Comparing Yoga Nidra, Yoga, and Control Condition on Pain in Individuals With Chronic Low Back Pain

for Low Back Pain

1 site in Orlando

Sponsor: University of Central Florida

Sex: All·Age: 18 - 65

Code: NCT07543835

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Dual-Task Neuromuscular Warm-Up Exercises in Chronic Low Back Pain

for Low Back Pain

Sponsor: Istinye University

Sex: All·Age: 18 - 50

Code: NCT07761247

Acceptance and Commitment Therapy Plus Physiotherapy for Chronic Low Back Pain

for Low Back Pain

Sponsor: Al-Azhar University

Sex: All·Age: 18 - 55

Code: NCT07766616

Device-Based vs Manual Sensory Training in Low Back Pain

for Low Back Pain

Sponsor: Medipol University

Sex: All·Age: 25 - 45

Code: NCT07277803

Core Endurance Versus Segmental Stabilization Exercise in Recreational Athletes With Low Back Pain

for Low Back Pain

Sponsor: Uskudar University

Sex: All·Age: 18 - 45

Code: NCT07760103

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Multichannel Neuromuscular Electrical Stimulation With Core Exercise for Chronic Low Back Pain

for Chronic Low-back Pain

Sponsor: Uskudar University

Sex: All·Age: 18 - 55

Code: NCT07760142

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A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain

for Chronic Pain

36 sites incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07641504·Phase 2

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Comparison of Traditional, Synchronous, and Asynchronous Telerehabilitation in Office Workers With Chronic Nonspecific Low Back Pain

for Chronic Non-Specific Low Back Pain

Sponsor: Istanbul Aydın University

Sex: All·Age: 18 - 65

Code: NCT07700589

Neuroscience Education and Spinal Manipulation on Health Locus of Control in Low Back Pain

for Low Back Pain

Sponsor: Centro Universitário Augusto Motta

Sex: All·Age: 18 - 60

Code: NCT07639216

Neurolyser XR for the Treatment of Sacroiliitis

for Sacroiliitis

Sponsor: Federico II University

Sex: All·Age: 18 - 80

Code: NCT07647757

Algorithm-informed Decision-making to Advance Pain Treatment

for Chronic Low-back Pain

1 site in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 25+

Code: NCT07731750

Kinetic Control Training Versus Core Stability Exercises on Proprioception and Spatiotemporal Gait Parameters in Chronic Non-specific Low Back Pain

for Low Back Pain

Sponsor: Cairo University

Sex: All·Age: 18 - 45

Code: NCT07683676

The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients

for Ehlers-Danlos Syndrome

1 site in New Orleans

Sponsor: Tulane University

Sex: All·Age: 18 - 75

Code: NCT05279937·Phase 3

Comparison Of Early Mobilization And Electrical Stimulation On Functional Recovery After Lumbar Disc Herniation Surgery

for Lumbar Disc Herniation

Sponsor: Istanbul Medipol University Hospital

Sex: All·Age: 18 - 65

Code: NCT07575477

Foam Roller Versus Self-Performed Neurodynamic Sliding in People With Hamstring Tightness and Low Back Pain History

for Low Back Pain

Sponsor: Universidad Pontificia de Salamanca

Sex: All·Age: 18 - 65

Code: NCT07627581

Spray and Stretch Technique Versus Strain Counter Strain in Patients With Non Specific Low Back Pain

for Low Back Pain

Sponsor: Riphah International University

Sex: All·Age: 35 - 50

Code: NCT07729774

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Sciatic Neural Mobilization in Lumbar-Related Leg Pain

for Low Back Pain

Sponsor: Istinye University

Sex: All·Age: 18 - 50

Code: NCT07588919

Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings

for Low Back Pain

Sponsor: Bahçeşehir University

Sex: All·Age: 18 - 65

Code: NCT07648927

Pre-Visit AI Symptom-Checking and Shared Decision-Making in Spine Physical Therapy

for Low Back Pain

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07733752

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Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain

for Spine

1 site in Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06987786

Back to Life - Early Rehabilitation Therapy for Patients Undergoing Lumbar Spinal Fusion

for Low Back Pain

Sponsor: Rigshospitalet, Denmark

Sex: All·Age: 18+

Code: NCT07378735

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Effectiveness of the SelfBack-App in Preventing and Treating Low Back Pain Versus no Intervention: a Non-randomized Clinical Trial

for Low Back Pain

Sponsor: Universitair Ziekenhuis Brussel

Sex: All·Age: 18 - 18·Accepts healthy volunteers

Code: NCT07785804

Multi-Omics Characterization of Percutaneous Electrolysis in Low Back Pain

for Low Back Pain

Sponsor: Universidad Europea de Madrid

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07524010

Comparative Effects Of Post Isometric Relaxation Versus Active Isolated Stretch In Patients With Piriformis Syndrome

for Piriformis Syndrome

Sponsor: Foundation University Islamabad

Sex: All·Age: 20 - 55

Code: NCT07526012

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Sensorimotor Training With a Mobilized Balance Platform in Patients With Chronic Low Back Pain

for Low Back Pain

Sponsor: Gaziler Physical Medicine and Rehabilitation Education and Research Hospital

Sex: All·Age: 18 - 55

Code: NCT07603609

Apply to this trial

Low Blood Flow Restriction Training on Low Back Pain

for Low Back Pain

Sponsor: Riphah International University

Sex: All·Age: 18 - 45

Code: NCT07576101

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Potential of Virtual Reality in Primary Chronic Low Back Pain

for Low Back Pain

Sponsor: Aveiro University

Sex: All·Age: 18+

Code: NCT07742111

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Psoas Muscle Release in Non-specific Mechanical Low Back Pain

for Low Back Pain

Sponsor: Escola Superior de Tecnologia da Saúde do Porto

Sex: All·Age: 18 - 30

Code: NCT06994364

Clinical and MRI Findings in Lumbar Disc Disease

for Lumbar Disc Disease

Sponsor: Assiut University

Sex: All·Age: 18 - 70

Code: NCT07516613

The Effectiveness of Aquatherapy on Physical Performance and Fear of Falling in Geriatric Individuals With Low Back Pain

for Low Back Pain

Sponsor: Kirsehir Ahi Evran Universitesi

Sex: All·Age: 65+

Code: NCT07531017

COMPARATIVE EFFECTIVENESS OF EXERCISE, COGNITIVE BEHAVIOURAL THERAPY, AND THEIR COMBINATION FOR PEOPLE WITH CHRONIC MUSCULOSKELETAL PAIN AND POOR SLEEP: SLEEPFIT TRIAL

for Osteo Arthritis Knee and Hip

2 sites incl. San Antonio

Sponsor: University of Sydney

Sex: All·Age: 18+

Code: NCT07532070

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Effect of Lumbar Spine Correction Training on Postural Awareness and Stability in Patients With Low Back Pain

for Low Back Pain

Sponsor: October 6 University

Sex: All·Age: 25 - 45

Code: NCT07552064

High-intensity Laser Therapy and Mulligan Mobilization for Patients With Chronic Nonspecific Low Back Pain

for Low Back Pain

Sponsor: Anas Radi Hassan Alashram

Sex: All·Age: 18 - 60

Code: NCT07556926

Common Pain Mechanisms in Migraine, Migraine-Related Neck Pain, and Lower Back Pain: A Cross Sectional Study

for Neck Pain

Sponsor: Bozok University

Sex: All·Age: 18 - 65

Code: NCT07567300

Apply to this trial

Safety and Effectiveness of Ultrasound-guided Pharmacopuncture for Spinal Diseases

for Spinal Disease

Sponsor: Jaseng Medical Foundation

Sex: All·Age: 19 - 69

Code: NCT07543692

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Contextual Effects on Inflammatory Biomarkers and Pain Relief After Spinal Joint Manipulation

for Low Back Pain

Sponsor: John Paul II University in Biała Podlaska

Sex: All·Age: 18 - 65

Code: NCT07507604

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Motivating Core-muscle Exercises With Wearable Sensors, Haptics and Interactive Gaming

for Non-specific Low Back Pain

Sponsor: Imperial College London

Sex: All·Age: 18+

Code: NCT07555795

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How Patient Education Helps Patients With Chronic Musculoskeletal Disorders Stick to Home Exercise for Pain Relief.

for Low Back Pain

Sponsor: Imam Abdulrahman Bin Faisal University

Sex: All·Age: All ages

Code: NCT07764354

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Placebo-Induced Hypoalgesia During Transcutaneous Electrical Nerve Stimulation Application in Low Back Pain

for Low Back Pain (LBP)

Sponsor: Cairo University

Sex: All·Age: 18 - 65

Code: NCT07535047

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AI-Based Phenome Data Analysis for Predicting the Onset of Major Diseases

for Diabetes Mellitus Type 2

Sponsor: Jae Yong Jeon, MD

Sex: All·Age: 30 - 60·Accepts healthy volunteers

Code: NCT07595718

Apply to this trial

Low Back and Neck Pain in Nursing Students at The University of The West Indies

for Back Pain

Sponsor: The University of The West Indies

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07167888

Neck and Low Back Pain in Physical Therapy Students at The University of the West Indies, Mona, Jamaica

for Back Pain

Sponsor: The University of The West Indies

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07177001

The Prevalence of Neck and Low Back Pain in FMSTRC Staff At the UWI Mona

for Neck Pain

Sponsor: The University of The West Indies

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07194746

Evaluation of Stabilization Training With Biofeedback in Lumbosacral Spine Pain Syndrome

for Low Back Pain

Sponsor: University of Rzeszow

Sex: All·Age: 30 - 65

Code: NCT07463729

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The Relationship Between Transversus Abdominis Muscle Architecture and Upper Extremity Function in Patients With Chronic Low Back Pain

for Low Back Pain

Sponsor: Ilayda Dilan Isik

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07474610

Apply to this trial

Office Program Effects on Pain, Posture, Muscle Physiology, Stress, Ergonomics, and Quality of Life in LBP Workers

for Low Back Pain

Sponsor: Suci Wahyu Ismiyasa

Sex: All·Age: 18 - 58

Code: NCT07250568

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The Effects of Eight-Week Baduanjin Exercise on Chronic Low Back Pain and Disability Among Office Workers.

for Low Back Pain

Sponsor: Universiti Sains Malaysia

Sex: All·Age: 20 - 55

Code: NCT07338045

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Catgut Embedding for Lumbar Spondylosis With Blood Stasis Syndrome

for Lumbar Spondylosis

Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City

Sex: All·Age: 18 - 65

Code: NCT07590050

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Effectiveness of Pilates on Postural Correction, Core Strength and Flexibility in Younger Individuals With Non-specific Low Backache

for Low Back Pain

Sponsor: University of Health Sciences Lahore

Sex: All·Age: 18 - 25

Code: NCT07467070

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Chronic Low Back Pain and Osteopathic Manipulation Treatment

for Chronic Low Back Pain (CLBP)

1 site in Hines

Sponsor: Edward Hines Jr. VA Hospital

Sex: All·Age: 18+

Code: NCT07161661

Apply to this trial

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Low back pain clinical trials — common questions

Are low back pain clinical trials free to join?

Yes. Participating in a low back pain clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a low back pain clinical trial?

Each low back pain study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a low back pain trial near me?

Use the location controls above. We'll show recruiting low back pain trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many low back pain trials are recruiting right now?

We're currently tracking roughly 58 recruiting low back pain trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Low back pain trials by city

Birmingham, AL Chicago, IL La Jolla, CA Los Angeles, CA San Diego, CA Ann Arbor, MI Boston, MA Cincinnati, OH Columbus, OH Gainesville, FL

Related specialties

Pain management Musculoskeletal disorders