Premature / preterm birth Clinical Trials

Recruiting premature / preterm birth studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat premature / preterm birth. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting premature / preterm birth studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting premature / preterm birth trials

Within

Periodontal Disease and Small Vulnerable Newborns in Rural Nepal: A Community-based Trial

for Preterm Birth

Sponsor: Johns Hopkins Bloomberg School of Public Health

Sex: Female·Age: 15 - 35·Accepts healthy volunteers

Code: NCT07553286·Phase 3

Antenatal Breastmilk Expression in Pregnant Women at High Risk of Preterm Birth

for Preterm Birth

Sponsor: Odense University Hospital

Sex: Female·Age: 18+

Code: NCT07191366

The Effect of Web-Based Counselling on Breastfeeding Experiences and Infant Care Competence Among Mothers of Preterm Babies

for Preterm Birth

Sponsor: Medipol University

Sex: Female·Age: All ages

Code: NCT07709663

The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health

for Preterm Birth

Sponsor: GrowBaby Life Project

Sex: Female·Age: 18+

Code: NCT07559773

Maternal Periodontal Inflammation and Pregnancy Outcomes: Salivary and Amniotic Biomarkers

for Periodontal Disease

Sponsor: Saglik Bilimleri Universitesi

Sex: Female·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07699978

Personalized Care for Prenatal Stress Reduction & Prevention of Preterm Birth (PTB) Disparities

for Preterm Birth Complication

1 site in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: Female·Age: 18+

Code: NCT06915428

Home Play-based Intervention for Parents and Infants

for Attention-Deficit/Hyperactivity Disorder (ADHD)

Sponsor: Nanyang Technological University

Sex: All·Age: 9 Months - 15 Months

Code: NCT07716072

Music Intervention for Preterm Birth

for Preterm Birth

2 sites in New York

Sponsor: Columbia University

Sex: Female·Age: 18 - 40

Code: NCT05945264

Systematic Screening of Lower Genital Tract Infections

for Neonatal Outcomes

Sponsor: Universidade Federal do Pampa

Sex: Female·Age: 12+

Code: NCT07592286

Initial Oxygen Concentration at Birth in Late-Preterm Infants

for Preterm Birth

Sponsor: University of Alberta

Sex: All·Age: 0 Minutes - 10 Minutes

Code: NCT07315594

DE-RESTRICT: Deimplementing Activity Restriction for Preterm Birth Prevention

for Preterm Birth

2 sites in Philadelphia

Sponsor: University of Pennsylvania

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07698483

Probiotics Supplementation for Neurodevelopment in Preterm Infants

for Premature Birth

Sponsor: Fudan University

Sex: All·Age: 23 Weeks - 25 Weeks

Code: NCT07617181

Milk Volume Outcomes Following Oral Nicotinamide Riboside Supplementation in Mothers of Extremely Preterm Infants

for Preterm Birth

1 site in Sacramento

Sponsor: University of California, Davis

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT04614714·Phase 2, Phase 3

Pharmacokinetics and Placental Transfer of Caffeine

for Preterm Labor With Preterm Delivery

1 site in Indianapolis

Sponsor: Indiana University

Sex: Female·Age: 18+

Code: NCT07570121·Phase 1

Apply to this trial

Healthy Expectancy Through Routine Antenatal STI Screening

for Antenatal Health

Sponsor: Adriane Wynn

Sex: Female·Age: 15+·Accepts healthy volunteers

Code: NCT07458802

Apply to this trial

Bed Rest With a Short Cervix on Preterm Birth

for Preterm Birth

Sponsor: Julie Glavind

Sex: Female·Age: 18+

Code: NCT07577388

Infant Massage for Lymphedema and Comfort in Preterm Newborns

for Lymphedema

Sponsor: Erzurum Technical University

Sex: All·Age: 28 Weeks - 37 Weeks

Code: NCT07418814

Caffeine for Infants Born at 28 to 34 Weeks Receiving Respiratory Support

for Preterm Birth

Sponsor: Queen's University

Sex: All·Age: 0 Days - 28 Days

Code: NCT07456670·Phase 2

Pivotal Study to Assess Safety and Performance of Neola®, a Novel Lung Monitoring Device for Neonates

for RDS of Prematurity

2 sites incl. Palo Alto

Sponsor: Neola Medical Inc

Sex: All·Age: 1 Day - 44 Weeks

Code: NCT07060911

Effectiveness of Targeted Cervical Length Screening Guided by a Preterm Birth Risk Scoring System in Reducing the Rate of Preterm Birth

for Preterm Birth

Sponsor: Ningbo University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT07415070

Xylitol and the Prevention of Periodontal Disease and Preterm Birth Trial

for Preterm Birth

Sponsor: University of Washington

Sex: Female·Age: All ages

Code: NCT07424846·Phase 2, Phase 3

Apply to this trial

Neonatal Data and Biobank to Study Factors Influencing Development in Preterm Infants Born at <32 Weeks' Gestation and/or <1500 g Birth Weight

for Preterm Infant Development

Sponsor: University Hospital of Cologne

Sex: All·Age: Up to 18

Code: NCT07490912

Apply to this trial

The Impact of Image Acquisition in Cervical Ultrasound on AI-Based Prediction of Preterm Birth in Clinical Practice

for Preterm Birth

Sponsor: Rigshospitalet, Denmark

Sex: Female·Age: 18+

Code: NCT07598097

Apply to this trial

Does AI Make Clinicians More Appropriately Confident? A Randomized Study in Preterm Birth Prediction

for Preterm Birth

Sponsor: Rigshospitalet, Denmark

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT07402668

Apply to this trial

Asymptomatic Bacteriuria in Pregnancy in Low- and Middle-IncomE Countries

for Preterm Birth

Sponsor: NICHD Global Network for Women's and Children's Health

Sex: Female·Age: 18 - 49·Accepts healthy volunteers

Code: NCT06723392·Phase 3

Apply to this trial

PLatform for Adaptive Trials In Perinatal UnitS - [Core Protocol]

for Preterm Birth

Sponsor: University of Melbourne

Sex: All·Age: All ages

Code: NCT06461429

Early Prediction of Lung Injury in Preterm Infants Score

for Respiratory Distress Syndrome RDS

Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia

Sex: All·Age: 26 Weeks - 32 Weeks

Code: NCT07265583

Apply to this trial

Involving Family Stakeholders in the NICU: a New Perspective to Improve Quality of Life. PAREN

for Premature Birth

Sponsor: Assistance Publique Hopitaux De Marseille

Sex: All·Age: Up to 6 Months

Code: NCT06811064

AI-POCUS for Maternal and Neonatal Health in Ethiopia

for Pregnancy

Sponsor: Tsinghua University

Sex: Female·Age: 15 - 49·Accepts healthy volunteers

Code: NCT07171086·Phase 4

Azithromycin and Ampicillin for Late PPROM

for Pregnancy Complications, Infectious

Sponsor: Sheba Medical Center

Sex: Female·Age: 18 - 50

Code: NCT07183462·Phase 4

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Impact of Colostrum Oropharyngeal Immunotherapy on Postnatal Growth in Preterm Infants

for Growth Failure

Sponsor: Suqian First Hospital

Sex: All·Age: 0 Days - 1 Day

Code: NCT07082881

Health-Related Quality-of-Life and Household Financial and Wellbeing Impacts of Prematurity and Necrotising Enterocolitis (NEC).

for Prematurity

Sponsor: Imperial College London

Sex: All·Age: Up to 30 Weeks

Code: NCT07192393

Apply to this trial

Reading-FREE Markers for Early Detection of Developmental Dyslexia

for Preterm Birth

Sponsor: Università Vita-Salute San Raffaele

Sex: All·Age: 6 - 9·Accepts healthy volunteers

Code: NCT07072104

Interest of Nurse Participation During Epicutaneous-cavity Catheter Placement in Neonatal Intensive Care

for Premature Birth

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: Up to 3 Months·Accepts healthy volunteers

Code: NCT06813326

Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)

for Preterm Birth

1 site in Philadelphia

Sponsor: Thomas Jefferson University

Sex: Female·Age: 16 - 55

Code: NCT06826859·Phase 1, Phase 2

Apply to this trial

Healing Tiny Minds: Rural Recovery Through Virtual and Lived Experience Care

for Hypoxic Ischaemic Encephalopathy (HIE)

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: Up to 5

Code: NCT06643598

Apply to this trial

Placental Organoids Development: Application in the Study of the Human Reproduction Pathophysiology.

for Preeclampsia

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: Female·Age: 18+

Code: NCT06893978

Biological Impacts of Rising Temperatures on Maternal, Fetal, and Newborn Health: A Cohort Study (BIRTH Cohort)

for Low Birth Weight Baby

Sponsor: Aga Khan University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06957769

Apply to this trial

Transition From Donor Milk: a Feasibility Study

for Preterm Birth

1 site in Augusta

Sponsor: Augusta University

Sex: All·Age: 28 Days+

Code: NCT06514014

Apply to this trial

Sodium Awareness in Lactation Trial

for Breastfeeding

2 sites in Seattle

Sponsor: The Hospital for Sick Children

Sex: Female·Age: All ages

Code: NCT06563726

Apply to this trial

The Effect of PIOMI and Chronobiological Nutrition on Readiness for Feeding, Full Transition to Oral Feeding and Body Weight

for Neonatal İntensive Care

Sponsor: Aydin Adnan Menderes University

Sex: All·Age: 29 Weeks - 33 Weeks·Accepts healthy volunteers

Code: NCT07306793

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Parental Stress and Attachment in Preterm Infants

for Premature Birth

Sponsor: Cardenal Herrera University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06813560

Optimal Timing of Routine Cervical Length Measurements During Anatomy Survey

for Cervical Insufficiency

1 site in Detroit

Sponsor: Henry Ford Health System

Sex: Female·Age: All ages

Code: NCT06822647

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Domperidone on the Composition of Preterm Breastmilk Using a Human Milk Mid-infrared Spectroscopy Analyzer

for Insufficient Breast Milk Syndrome

Sponsor: Centro Hospitalar de Lisboa Central

Sex: Female·Age: All ages

Code: NCT06830226

Pragmatic Evaluation of Respiratory Distress Syndrome Treatment in Africa

for Respiratory Distress Syndrome in Premature Infant

Sponsor: Indiana University

Sex: All·Age: 1 Hour - 24 Hours

Code: NCT06554522·Phase 4

Apply to this trial

Neuromotor Development and Motor Related Health Care in Children with a High Risk Neonatal Period

for Motor Disorders

Sponsor: Karolinska Institutet

Sex: All·Age: 2 - 14

Code: NCT06645717

The Social Determinants of Health Screening and Referral Project

for Preterm Birth

7 sites incl. Denver

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+

Code: NCT06582147

Preterm Newborn's Behavioral Responses During Feeding With Gastric Tube

for Premature Birth

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: All ages

Code: NCT06634329

Blood Glucose in Pregnant Non-diabetic Women During Treatment With Betamethasone for Fetal Lung Maturation

for Preterm Birth

Sponsor: University of Aarhus

Sex: Female·Age: 18+

Code: NCT06794307

Apply to this trial

The Benefit in Terms of Improvement in Haemoglobin Level at 6 Months in Premature Babies Receiving Alternate Iron Substitution 4 Times a Week Compared to a Daily Substitution

for Premature Birth

Sponsor: Riccardo Pfister

Sex: All·Age: 14 Days - 14 Days·Accepts healthy volunteers

Code: NCT06624709

Apply to this trial

Air Pollution and Pregnancy

for Premature Birth

Sponsor: Queen Mary University of London

Sex: Female·Age: 18+

Code: NCT06340971

Apply to this trial

COntact RElationship in Neonatal Intensive Care Unit

for Preterm Birth

Sponsor: Istituto per la Ricerca e l'Innovazione Biomedica

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06462638

Apply to this trial

Post-extubation Pressures in Preterm Neonates: A CER Study

for Respiratory Distress Syndrome

Sponsor: McMaster Children's Hospital

Sex: All·Age: All ages

Code: NCT06552455

Long-term Ophthalmic Outcomes in Ex-premature Infants

for Retinopathy of Prematurity (ROP)

Sponsor: Erasmus Medical Center

Sex: All·Age: 16+

Code: NCT06649513

Effect of Support for Low-Income Mothers of Preterm Infants

for Preterm Birth

4 sites incl. Atlanta

Sponsor: University of Massachusetts, Worcester

Sex: Female·Age: 18+

Code: NCT06362798

Apply to this trial

Hair Cortisol as Marker of Chronic Stress in Preterm and Term Fathers - Fathair-study

for Stress, Psychological

Sponsor: University of Cologne

Sex: All·Age: 1 Day - 7 Days·Accepts healthy volunteers

Code: NCT05969431

Apply to this trial

Postpartum Care in the NICU (PeliCaN) Transitions

for Stress Disorders, Post-Traumatic

1 site in Philadelphia

Sponsor: University of Pennsylvania

Sex: Female·Age: 16+

Code: NCT06521398

Apply to this trial

Growing Little PEAPODS Study

for Premature Birth

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 22 Weeks - 32 Weeks

Code: NCT06226051

Apply to this trial

Skincubator, a Novel Incubator for Skin to Skin Contact Feasibility Study

for Preterm

Sponsor: Itamar Nitzan

Sex: All·Age: 0 Days - 14 Days

Code: NCT06543433·Phase 2, Phase 3

Exercise in Prematurely Born Preadolescents to Mitigate Cardiovascular Risk and Improve Cognitive Impairment

for Preterm Birth

Sponsor: Henner Hanssen

Sex: All·Age: 6 - 12·Accepts healthy volunteers

Code: NCT06500910

Apply to this trial

Premature / preterm birth clinical trials — common questions

Are premature / preterm birth clinical trials free to join?

Yes. Participating in a premature / preterm birth clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a premature / preterm birth clinical trial?

Each premature / preterm birth study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a premature / preterm birth trial near me?

Use the location controls above. We'll show recruiting premature / preterm birth trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many premature / preterm birth trials are recruiting right now?

We're currently tracking roughly 42 recruiting premature / preterm birth trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Premature / preterm birth trials by city

Madison, WI Chicago, IL Columbus, OH Denver, CO San Diego, CA Seattle, WA Birmingham, AL Boston, MA Detroit, MI Evanston, IL Indianapolis, IN

Related specialties

Women's health Obstetrics