Skin cancer Clinical Trials

Recruiting skin cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat skin cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting skin cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting skin cancer trials

Within

A Trial of Locoregionally Advanced Squamous Cell Carcinoma of The Head and Neck

for Squamous Cell Carcinoma

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT07346196·Phase 2

Phase 1 Study Of TROP2 CAR/IL-15 TGFBR2 KO NK Cell In Patients With Oral Premalignant Lesions

for Squamous Cell Carcinoma

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07631013·Phase 1

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

for Squamous Cell Carcinoma

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07513389·Phase 2

Apply to this trial

Combining Neo-adjuvant ATR-inhibition With Nodal SBRT for Early-stage Resectable HPV+ OPSCCs

for HPV Positive Oropharyngeal Squamous Cell Carcinoma

Sponsor: Abramson Cancer Center at Penn Medicine

Sex: All·Age: 18+

Code: NCT07578467·Phase 1, Phase 2

Cosibelimab for CSCC in Patients With Kidney Transplant or Hematologic Malignancy

for Cutaneous Squamous Cell Carcinoma

2 sites in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07426484·Phase 4

Impact of Dysport on PMFF Donor Scar

for Skin Cancer Excision Site

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT07720726·Phase 4

A Study of IDP-001 in Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

1 site in Edison

Sponsor: InduPro, Inc.

Sex: All·Age: 18+

Code: NCT07602842·Phase 1, Phase 2

Developing and Testing the Effectiveness of a Skin Cancer Self-Detection Educational Program

for Skin Cancer

Sponsor: National University Hospital, Singapore

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT07247123

Apply to this trial

AI-Assisted Endoscopy for Upper Aerodigestive Tract Lesions

for Upper Aerodigestive Tract Neoplasms

Sponsor: Istituto Italiano di Tecnologia

Sex: All·Age: 18+

Code: NCT07596355

CARES : Customized Aftercare Report for Evaluated Skin Cancer Patients

for Management

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18 - 80

Code: NCT07330323

Apply to this trial

A Randomized Controlled Trial of Topical 5% Niacinamide for Skin Cancer Prevention in Transplant Recipients

for Skin Cancer

2 sites in Pittsburgh

Sponsor: Marissa Lobl

Sex: All·Age: 18+

Code: NCT07286318·EARLY_Phase 1

Apply to this trial

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for Adenocarcinoma

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07628634·EARLY_Phase 1

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Cyclophosphamide and Etoposide as a Metronomic Therapy in Advanced Head and Neck Squamous Cell Cancer

for Squamous Cell Carcinoma

Sponsor: National Cancer Institute, Egypt

Sex: All·Age: 18+

Code: NCT07361133·Phase 2

PDT For Induction Therapy For Head And Neck Cancer

for Squamous Cell Carcinoma

2 sites in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07214987·Phase 2

Apply to this trial

Vitamin D Effects on Immune Microenvironment of Nonmelanoma Skin Cancer After Photodynamic Therapy (PDT)

for Nonmelanoma Skin Cancer

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07241585

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Neoadjuvant Chemotherapy and Programmed Cell Death Protein 1(PD-1) Inhibition for Head and Neck Cancer Treatment De-escalation (NeoScorch HN)

for Head and Neck Cancer

1 site in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT07209189·Phase 2

Apply to this trial

TIL Therapy in cSCC and MCC

for Cutaneous Squamous Cell Carcinoma

1 site in Boston

Sponsor: Karam Khaddour, MD, MS

Sex: All·Age: 18+

Code: NCT07288073·Phase 2

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Early Detection of Skin Tumors Using a Telemedicine Tool in Primary Care

for Skin Cancer Prevention

Sponsor: Institute of Health Information and Statistics of the Czech Republic

Sex: All·Age: 50+

Code: NCT07349940

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Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous SCC for Immunocompromised Patients

for Squamous Cell Carcinoma

10 sites incl. Gilbert

Sponsor: Alpha Tau Medical LTD.

Sex: All·Age: 18+

Code: NCT06615635

Apply to this trial

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

for Amyloidosis

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT07285044·Phase 2

Apply to this trial

The Florida ASCENT Study

for Cancer

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 100

Code: NCT07042243

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Optical Characterization and Multi-modality, Multi-scale Modeling of Human Skin Applied to Cancer Diagnosis.

for Skin Cancer

Sponsor: Centre Hospitalier Régional Metz-Thionville

Sex: All·Age: 18+

Code: NCT07406022

Apply to this trial

Early Phase Study of KESONOTIDE™in Participants With Solid Tumours

for Prostate Cancers

Sponsor: Filamon LTD

Sex: All·Age: 18+

Code: NCT06926075·Phase 1, Phase 2

Apply to this trial

Artificial Intelligent Decision Support for Skin Cancer Diagnostics in Primary Care

for Skin Cancer

Sponsor: Linkoeping University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06932172

Apply to this trial

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

for Renal Cell Carcinoma

1 site in Pittsburgh

Sponsor: Diwakar Davar

Sex: All·Age: 18+

Code: NCT07223424·Phase 2

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Negative Pressure Wound Therapy for Split Thickness Skin Grafting to the Lower Leg After Excision of Skin Tumour: A Multicentre Randomised Study

for Skin Transplantation

Sponsor: Region Skane

Sex: All·Age: 18+

Code: NCT07040683

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Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals

for Skin Cancer

Sponsor: University of Thessaly

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07510061

Apply to this trial

Meloxicam in Mohs Micrographic Surgery

for Postoperative Pain, Acute

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 110

Code: NCT07200544·Phase 4

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Hybrid Effectiveness-Implementation Trial to Integrate Precision Skin Cancer Risk Feedback in FQHCs

for Skin Cancer

1 site in Tampa

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07222995

Apply to this trial

Drug Screening of Cutaneous Lesions of Squamous Cell Carcinoma

for Squamous Cell Carcinoma of the Skin

1 site in Boston

Sponsor: Oliver Jonas

Sex: All·Age: 18+

Code: NCT06782399·EARLY_Phase 1

Screening for Anal Cancer in Men Who Have Sex With Men Using Pre-Exposure Prophylaxis

for Anal Cancer

Sponsor: Universitair Ziekenhuis Brussel

Sex: Male·Age: 35+

Code: NCT07029152

Apply to this trial

Defining TRPV4 Contribution of Schwann Cells to Oral Cancer Pain

for Oral Cancer

1 site in New York

Sponsor: New York University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07095608

Apply to this trial

Prospective Data Collection Initiative on Thoracic Malignancies

for Lung Cancer

Sponsor: Dutch Society of Physicians for Pulmonology and Tuberculosis

Sex: All·Age: 18+

Code: NCT06996249

Apply to this trial

Electrochemotherapy (ECT) in Patients With Primary Visceral Tumors and/or Secondary Visceral Localizations, of Any Histotype

for Primary Visceral Tumors of Any Histotype

Sponsor: Istituto Oncologico Veneto IRCCS

Sex: All·Age: 18 - 99

Code: NCT06753136

Apply to this trial

Mechanisms for Laser-Induced Rejuvenation

for Skin Cancer

1 site in Fairborn

Sponsor: Wright State University

Sex: All·Age: 18+

Code: NCT06489301

Apply to this trial

Toripalimab With Chemotherapy for Sinus Cancer

for Sinonasal Cancer

2 sites in Boston

Sponsor: Glenn J. Hanna

Sex: All·Age: 18+

Code: NCT06940180·Phase 2

Apply to this trial

Treating Basal and Squamous Cell Carcinomas With Fractional Laser and Tirbanibulin Ointment

for Keratinocyte Carcinoma

1 site in New York

Sponsor: Bruce Robinson, MD

Sex: All·Age: 18+

Code: NCT07010692·Phase 1, Phase 2

Apply to this trial

Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery

for Oropharyngeal Squamous Cell Carcinoma (OPSCCA)

1 site in Philadelphia

Sponsor: Ryan Carey

Sex: All·Age: 18+

Code: NCT06747390·Phase 1

Apply to this trial

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

for Cancer

8 sites incl. Fort Smith

Sponsor: Elephas

Sex: All·Age: 18+

Code: NCT07327489

Apply to this trial

Impact of COL7A1 Gene Therapy on SCC Recurrence in RDEB Skin

for Squamous Cell Carcinoma

1 site in Redwood City

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT06731933·Phase 2

Apply to this trial

Brodalumab in the Treatment of Immune-Related Adverse Events

for Breast Cancer

1 site in New York

Sponsor: Brian Henick, MD

Sex: All·Age: 18+

Code: NCT06673329·Phase 1

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Use of SPY Imaging System to Minimize Fistulas After Hypopharyngeal Reconstruction

for Squamous Cell Carcinoma

1 site in Pittsburgh

Sponsor: Matthew Spector

Sex: All·Age: 18+

Code: NCT06831149·Phase 2

Apply to this trial

Raman Spectroscopy and Skin Cancer

for Skin Cancer

1 site in Stony Brook

Sponsor: Tiezhi Zhang

Sex: All·Age: 18+

Code: NCT06384924

Apply to this trial

A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision

for Skin Cancer

2 sites in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06664151·EARLY_Phase 1

Apply to this trial

CHG0521 Oral Coating in Patients with Solid Tissue Tumor/Recurrent/Metastatic TSCC

for Squamous Cell Carcinoma

Sponsor: Guangzhou University of Traditional Chinese Medicine

Sex: All·Age: 18 - 80

Code: NCT06609070

A Study of VET3-TGI in Patients With Solid Tumors

for Solid Tumor, Adult

7 sites incl. Los Angeles

Sponsor: KaliVir Immunotherapeutics

Sex: All·Age: 18+

Code: NCT06444815·Phase 1

Apply to this trial

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

for Advanced Cancer

4 sites incl. Aurora

Sponsor: 7 Hills Pharma, LLC

Sex: All·Age: 18+

Code: NCT06362369·Phase 1, Phase 2

Apply to this trial

Patient Perspectives in Squamous Cell Carcinoma Clinical Trials

for Squamous Cell Carcinoma

1 site in San Francisco

Sponsor: Power Life Sciences Inc.

Sex: All·Age: 18+

Code: NCT05929547

Stratification of Cutaneous Squamous Cell Carcinomas According to Its Transcriptomic, Metabolic and Inflammatory Characteristics

for Skin Cancer

Sponsor: University Hospital, Bordeaux

Sex: All·Age: 18+

Code: NCT06476964

Apply to this trial

High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

for Melanoma (Skin)

1 site in Seattle

Sponsor: Fred Hutchinson Cancer Center

Sex: All·Age: 18+

Code: NCT06298734

Apply to this trial

Early Detection of Esophageal Squamous Cancer With the Capsule Sponge Device

for Esophageal Cancer

Sponsor: Centre of Postgraduate Medical Education

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06418516

Hyperthermia Enhanced Re-irradiation of Loco-regional Recurrent Tumors

for Recurrent Cancer

Sponsor: Charite University, Berlin, Germany

Sex: All·Age: 18+

Code: NCT04889742·Phase 2

BAI-BACE for Advanced Lung Squamous Cell Carcinoma

for Squamous Cell Carcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06377735

Apply to this trial

Rural Adult and Youth Sun Protection Study

for Melanoma (Skin)

2 sites incl. Salt Lake City

Sponsor: University of Utah

Sex: All·Age: 3 - 7·Accepts healthy volunteers

Code: NCT06439979

Apply to this trial

A Phase Ib/II Study of an Anti-HER3 Antibody, HMBD-001, With Cetuximab +/- Docetaxel in Advanced Squamous Cell Cancers

for Advanced or Metastatic Squamous Non-Small Cell Lung Cancer

Sponsor: Hummingbird Bioscience

Sex: All·Age: 18+

Code: NCT05910827·Phase 1, Phase 2

Apply to this trial

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

for Squamous Cell Carcinoma

1 site in Tampa

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Sex: All·Age: 18+

Code: NCT06137274·Phase 2

Apply to this trial

Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis

for Diffuse Astrocytoma, IDH-Mutant

7 sites incl. Beverly Hills

Sponsor: Neonc Technologies, Inc.

Sex: All·Age: 18+

Code: NCT06047379·Phase 1, Phase 2

Apply to this trial

A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

for Triple Negative Breast Cancer

Sponsor: OncoNano Medicine, Inc.

Sex: All·Age: 18+

Code: NCT06022029·Phase 1

Apply to this trial

Cryoablation+Ipilimumab+Nivolumab in Melanoma

for Metastatic Melanoma

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT05779423·Phase 2

Apply to this trial

High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins

for Breast Carcinoma

Sponsor: Algemeen Ziekenhuis Maria Middelares

Sex: All·Age: 18+

Code: NCT06835426

Apply to this trial

Skin cancer clinical trials — common questions

Are skin cancer clinical trials free to join?

Yes. Participating in a skin cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a skin cancer clinical trial?

Each skin cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a skin cancer trial near me?

Use the location controls above. We'll show recruiting skin cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many skin cancer trials are recruiting right now?

We're currently tracking roughly 54 recruiting skin cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Skin cancer trials by city

Boston, MA Los Angeles, CA Salt Lake City, UT San Francisco, CA Tampa, FL Aurora, CO Beverly Hills, CA Chicago, IL Cleveland, OH Fort Smith, AR Gainesville, FL Indianapolis, IN

Related specialties

Oncology Skin cancer Dermatology