Oncology Clinical Trials in Bethlehem, PA
As of September 2026, 25 paid clinical trials are recruiting for Oncology in Bethlehem, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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25 clinical trials for Oncology
·Clear filters·A Study to Compare Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) Versus Pembrolizumab Alone as Treatment in Participants With Mismatch Repair Proficient Endometrial Cancer (MK-2870-033/TroFuse-033/GOG-3119/ENGOT-en29)
A Study to Assess Anti-Tumor Activity of Intravenously (IV) Infused Carboplatin With Mirvetuximab Soravtansine in Participants With Newly Diagnosed Folate Receptor Alpha (FRα)Expressing Advanced-Stage Serous Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer.
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)
MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles
A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer
Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer
Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial
Abatacept in Immune Checkpoint Inhibitor Myocarditis
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Collection of Research Data and Samples From Patients Treated With Immunotherapy to Study Its Side Effects
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer
Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)
Top Research Study Locations in Bethlehem
Researchers run research studies in Bethlehem, PA at 23 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Lehigh Valley Hospital - Muhlenberg | Anatomic Stage II Breast Cancer AJCC v8, Lung Non-Small Cell Carcinoma, Malignant Solid Neoplasm | 43 |
| St. Luke's University Health Network | Abdominal Aortic Aneurysm, Adolescent Idiopathic Scoliosis, Advanced Breast Cancer | 14 |
| Saint Luke's University Hospital-Bethlehem Campus | Pancreatic Neoplasm, Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum | 7 |
| Lehigh University | Parent-Child Relations, Parenting, Attention Deficit Hyperactivity Disorder | 4 |
| Northeast Clinical Research Center | Autosomal Dominant Polycystic Kidney Disease, Diabetic Kidney Disease (DKD), Focal Segmental Glomerulosclerosis | 4 |
| Mid Atlantic Retina | Age-related Macular Degeneration (AMD), Geographic Atrophy (GA), Geographic Atrophy Secondary to Age-related Macular Degeneration | 4 |
| St. Luke's University Hospital | Chronic Limb-Threatening Ischemia, Population Genomic Screening Implementation Best Practices, Wound | 3 |
| St Luke's University Health Network | Computed Tomography, NSCLC, Non-small Cell Lung Cancer | 2 |
| St. Lukes University Hospital | Epithelial Ovarian Cancer, Fallopian Tube Cancer, Neoadjuvant | 2 |
| Center for Specialized Surgery LP | Lumbar Spinal Stenosis | 1 |
| Lehigh Valley Health Network | Cancer, Myocarditis Acute | 1 |
| Lehigh Valley Hospital- Muhlenberg | Advanced Solid Tumors, Lymphoma, Non-Hodgkin, Multiple Myeloma | 1 |
| Mid Atlantic Retina - Bethlehem | Geographic Atrophy | 1 |
| Northeast Clinical Research Center, LLC | End Stage Kidney Disease | 1 |
| Saint Luke's Hospital of Bethlehem Pennsylvania | Ischemic Stroke | 1 |
| St Luke's University Health Network, Bethlehem Campus | Cutaneous Melanoma, Stage II | 1 |
| St Luke's University Hospital | Acute Kidney Injury | 1 |
| St. Luke's Hospital | Breast Cancer | 1 |
| St. Luke's University Health Network (DNAanswers) | Genetic Predisposition to Disease, Genetics Disease | 1 |
| St. Lukes Hospital and Health Network | Carcinoma, Non-Small-Cell Lung | 1 |
| St. Lukes University Health Network | Ovarian Cancer | 1 |
| TG Therapeutics Investigational Trial Site | Multiple Sclerosis, Relapsing Multiple Sclerosis | 1 |
| Valley Surgical Ctr | Lumbar Spinal Stenosis | 1 |
Active & Upcoming Studies in Bethlehem (2026)
Recruiting trials in Bethlehem grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (51 active studies)
- A Trial to Evaluate Ovarian Suppression Following Subcutaneous ZOLADEX 10.8 mg in Premenopausal Women With Early-stage and Advanced HR+ Breast Cancer · Phase 1 · TerSera Therapeutics LLC
- A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer · Phase 3 · AbbVie
Cardiovascular (4 active studies)
- Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention · Phase 4 · Duke University
- DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD) · United Therapeutics
Eye & vision (4 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) · Phase 2, Phase 3 · EyeBiotech Ltd.
- A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA) · Complement Therapeutics
Neurology & pain (2 active studies)
- A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS) · TG Therapeutics, Inc.
- Strategy for Improving Stroke Treatment Response · Phase 2 · Translational Sciences, Inc.
Pediatric (2 active studies)
- Hands and Hearts Together · University of Maryland, College Park
- Advanced SPinal Innovations With Robotics and Enabling Technology Registry · Boston Children's Hospital
Mental health & behavior (1 active study)
- Testing ANSOS for Efficacy in Multi-Tribal Urban Communities · Lehigh University
Common conditions studied in Bethlehem
- Anatomic Stage II Breast Cancer AJCC v8 (3 active studies)
- Lung Non-Small Cell Carcinoma (3 active studies)
- Malignant Solid Neoplasm (3 active studies)
- Stage IIIB Lung Cancer AJCC v8 (3 active studies)
- Advanced Esophageal Adenocarcinoma (2 active studies)
- Advanced Gastric Adenocarcinoma (2 active studies)
Leading research sponsors in Bethlehem
- National Cancer Institute (NCI)
- Alliance for Clinical Trials in Oncology
- SWOG Cancer Research Network
- ECOG-ACRIN Cancer Research Group
- NRG Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Bethlehem?
There are approximately 96 recruiting clinical trials in Bethlehem, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Bethlehem pay participants?
Most recruiting trials in Bethlehem compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Bethlehem?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Bethlehem?
The most common conditions under active study in Bethlehem include Anatomic Stage II Breast Cancer AJCC v8 (3), Lung Non-Small Cell Carcinoma (3), Malignant Solid Neoplasm (3), Stage IIIB Lung Cancer AJCC v8 (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Bethlehem?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Bethlehem on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Bethlehem?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Bethlehem?
Recruiting research sites in Bethlehem include Lehigh Valley Hospital - Muhlenberg, St. Luke's University Health Network, Saint Luke's University Hospital-Bethlehem Campus, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Bethlehem right now?
The largest active categories in Bethlehem are Cancer & tumors (51), Cardiovascular (4), Eye & vision (4). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.