Rethinking Early Airway Clearence Therapies
for Cystic Fibrosis (CF)
Sites in Pittsburgh, Philadelphia +34 more locations
Sponsor: Nicole Hamblett
Sex: All·Age: 3 - 16
Code: NCT07696338·Not Yet Recruiting·Listed Jul 10, 2026
Clinical Trials at Children's Hospital of Pittsburgh of UPMC
As of September 2026, 55 paid clinical trials are recruiting at Children's Hospital of Pittsburgh of UPMC, located at 3705 5TH AVE, PITTSBURGH, PA 15213-2584, phone (412) 692-6207 in Pittsburgh, Pennsylvania. Active studies at this site cover conditions such as Breast Cancer, Melanoma and Stroke. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Pittsburgh
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
56 clinical trials at Children's Hospital of Pittsburgh of UPMC
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Safety Study of SMOFlipid to Evaluate the Risk of Developing EFAD and/or PNAC in Pediatric and Adult Patients
for Malnutrition, Child
Sites in Pittsburgh +4 more locations
Sponsor: Fresenius Kabi
Sex: All·Age: 1 Month - 17
Code: NCT06049680·Phase 4·Recruiting·Listed Sep 2023
Quality of End-of-Life Care for Children With Cancer
for Childhood Hematopoietic and Lymphatic System Neoplasm
Sites in Pittsburgh +14 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 18+·Accepts healthy volunteers
Code: NCT07412002·Recruiting·Listed Feb 2026
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
for Childhood Extracranial Germ Cell Tumor
Sites in Pittsburgh, Hershey +380 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: All ages
Code: NCT03067181·Phase 3·Recruiting·Listed Mar 2017
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
Drug: Nivolumab
Sites in Pittsburgh, Hershey +378 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 5 - 60
Code: NCT05675410·Phase 3·Recruiting·Listed Jan 2023
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
for Hematopoietic and Lymphatic System Neoplasm
Sites in Pittsburgh, Hershey +189 more locations
Sponsor: Children's Oncology Group
Sex: Female·Age: Up to 39
Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024
Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer
for Locally Advanced Adrenal Cortical Carcinoma
Drug: Cabozantinib
Sites in Pittsburgh +79 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 12+
Code: NCT06900595·Phase 2·Recruiting·Listed Mar 2025
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
for B Acute Lymphoblastic Leukemia
Sites in Pittsburgh, Hershey +185 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 365 Days - 25
Code: NCT03959085·Phase 3·Recruiting·Listed May 2019
A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)
for B Acute Lymphoblastic Leukemia
Sites in Pittsburgh, Hershey +136 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 366 Days - 46
Code: NCT06124157·Phase 2·Recruiting·Listed Nov 2023
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
for Acute Myeloid Leukemia
Sites in Pittsburgh, Hershey +167 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 21
Code: NCT04293562·Phase 3·Recruiting·Listed Mar 2020
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
for Acute Leukemia of Ambiguous Lineage
Drug: Venetoclax
Sites in Pittsburgh, Danville +110 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: Up to 365 Days
Code: NCT06317662·Phase 2·Recruiting·Listed Mar 2024
A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis
for Recurrent Langerhans Cell Histiocytosis
Sites in Pittsburgh, Danville +99 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 180 Days - 22
Code: NCT05828069·Phase 2·Recruiting·Listed Apr 2023
Project: Every Child for Younger Patients With Cancer
for Adrenal Gland Pheochromocytoma
Sites in Pittsburgh, Hershey +225 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 25
Code: NCT02402244·Recruiting·Listed Mar 2015
A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
for Stage I Mixed Cell Type Kidney Wilms Tumor
Sites in Pittsburgh, Hershey +151 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 30
Code: NCT06401330·Phase 3·Recruiting·Listed May 2024
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
for Anaplastic Kidney Wilms Tumor
Sites in Pittsburgh, Hershey +170 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 30
Code: NCT04322318·Phase 2·Recruiting·Listed Mar 2020
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
for Malignant Glioma
Drug: Selinexor
Sites in Pittsburgh, Danville +104 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 12 Months - 21
Code: NCT05099003·Phase 1, Phase 2·Recruiting·Listed Oct 2021
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
for Low Grade Astrocytoma
Drug: Selumetinib
Sites in Pittsburgh, Hershey +115 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 2 - 21
Code: NCT04166409·Phase 3·Recruiting·Listed Nov 2019
A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)
for Stage II Nasopharyngeal Carcinoma AJCC v8
Drug: Nivolumab
Sites in Pittsburgh, Hershey +73 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: Up to 21
Code: NCT06064097·Phase 2·Recruiting·Listed Oct 2023
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
for Acute Lymphoblastic Leukemia
Sites in Pittsburgh, Hershey +154 more locations
Sponsor: PedAL BCU, LLC
Sex: All·Age: Up to 22
Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021
Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
for Metastatic Malignant Neoplasm in the Lung
Sites in Pittsburgh, Hershey +200 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 50
Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
for Basal Ganglia Germinoma
Sites in Pittsburgh, Philadelphia +93 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 3 - 29
Code: NCT06368817·Phase 2·Recruiting·Listed Apr 2024
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
for Ganglioneuroblastoma, Nodular
Sites in Pittsburgh, Danville +152 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: Up to 30
Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)
for Ganglioneuroblastoma
Sites in Pittsburgh, Hershey +141 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 365 Days - 30
Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
for Central Nervous System Nongerminomatous Germ Cell Tumor
Sites in Pittsburgh, Hershey +139 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 3 - 29
Code: NCT04684368·Phase 2·Recruiting·Listed Dec 2020
Xylitol Dental Wipes for the Reduction of Bloodstream Infection Risk in Children With Acute Myeloid Leukemia
for Acute Myeloid Leukemia
Sites in Pittsburgh, Danville +34 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 1 - 25
Code: NCT07022678·Phase 3·Recruiting·Listed Jun 2025
A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia
for B Acute Lymphoblastic Leukemia Associated With Down Syndrome
Sites in Pittsburgh, Philadelphia +70 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 6 - 39
Code: NCT05702645·Recruiting·Listed Jan 2023
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss
for Childhood Medulloblastoma
Sites in Pittsburgh, Danville +100 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 4 - 21
Code: NCT05382338·Phase 3·Recruiting·Listed May 2022
Testing a Standardized Approach to Surgery and Chemotherapy for Type I Pleuropulmonary Blastoma or the Addition of an Anti-cancer Drug, Topotecan, to the Usual Treatment for Types II and III Pleuropulmonary Blastoma
for Pleuropulmonary Blastoma
Sites in Pittsburgh, Philadelphia +78 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 21
Code: NCT06647953·Phase 3·Recruiting·Listed Oct 2024
A Study About How Blood Cell Growth Patterns Relate to Heart Health After Treatment for Hodgkin Lymphoma
for Cardiovascular Disorder
Sites in Pittsburgh, Philadelphia +33 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 7+
Code: NCT05705531·Recruiting·Listed Jan 2023
Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma
for Embryonal Rhabdomyosarcoma
Sites in Pittsburgh, Hershey +162 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 21
Code: NCT05304585·Phase 3·Recruiting·Listed Mar 2022
Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children
for Cystic Fibrosis
Sites in Pittsburgh, Hershey +33 more locations
Sponsor: Sonya Heltshe
Sex: All·Age: Up to 10
Code: NCT04509050·Recruiting·Listed Aug 2020
A Study to Find the Highest Dose of Imetelstat in Combination With Fludarabine and Cytarabine for Patients With AML, MDS or JMML That Has Come Back or Does Not Respond to Therapy
for Recurrent Childhood Acute Myeloid Leukemia
Sites in Pittsburgh, Philadelphia +16 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 1 - 18
Code: NCT06247787·Phase 1·Recruiting·Listed Feb 2024
Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
for Cystic Fibrosis
Sites in Pittsburgh, Philadelphia +57 more locations
Sponsor: Chris Goss
Sex: All·Age: 6+
Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022
A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)
for Down Syndrome
Drug: Nivolumab
Sites in Pittsburgh, Hershey +148 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 1 - 30
Code: NCT04546399·Phase 2·Recruiting·Listed Sep 2020
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis
for Systemic Sclerosis
3 locations in Pittsburgh
Sponsor: Paul Szabolcs
Sex: All·Age: 8 - 60
Code: NCT03630211·Phase 2·Recruiting·Listed Aug 2018
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
for Colorectal Carcinoma
Sites in Pittsburgh, Philadelphia +17 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 12 Months - 30
Code: NCT04851119·Phase 1, Phase 2·Recruiting·Listed Apr 2021
Massive Transfusion in Children-2: A Trial Examining Life Threatening Hemorrhage in Children
for Hemorrhagic Shock
Sites in Pittsburgh +19 more locations
Sponsor: Philip Spinella
Sex: All·Age: Up to 17
Code: NCT06070350·Phase 3·Recruiting·Listed Oct 2023
A Study to Find the Highest Dose of Cedazuridine and Decitabine Combination With Filgrastim as a Treatment Option After Hematopoietic Stem Cell Transplant in Children With High-Risk Acute Myeloid Leukemia
for Acute Myeloid Leukemia Post Cytotoxic Therapy
Sites in Pittsburgh, Philadelphia +9 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: Up to 21
Code: NCT07012044·Phase 1·Recruiting·Listed Jun 2025
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
for Sickle Cell Anemia
1 location in Pittsburgh
Sponsor: Paul Szabolcs
Sex: All·Age: 5 - 40
Code: NCT03653338·Phase 1, Phase 2·Recruiting·Listed Aug 2018
Biomarkers in Transplant Recipients to Improve Outcomes
for Solid Organ Transplantation
1 location in Pittsburgh
Sponsor: University of Pittsburgh
Sex: All·Age: All ages
Code: NCT01163578·Recruiting·Listed Jul 2010
Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant
for Acute Biphenotypic Leukemia
Sites in Pittsburgh +7 more locations
Sponsor: Fred Hutchinson Cancer Center
Sex: All·Age: 6 Months - 26·Accepts healthy volunteers
Code: NCT03779854·Phase 2·Recruiting·Listed Dec 2018
Common conditions studied in Pittsburgh
- Breast Cancer (25 active studies)
- Cancer (19 active studies)
- Melanoma (17 active studies)
- Stroke (17 active studies)
- Endometrial Cancer (16 active studies)
- Ovarian Cancer (16 active studies)
Leading research sponsors in Pittsburgh
- University of Pittsburgh
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
- VA Office of Research and Development
Frequently asked questions
How many paid clinical trials are currently recruiting in Pittsburgh?
There are approximately 1,242 recruiting clinical trials in Pittsburgh, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Pittsburgh pay participants?
Most recruiting trials in Pittsburgh compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Pittsburgh?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Pittsburgh?
The most common conditions under active study in Pittsburgh include Breast Cancer (25), Cancer (19), Melanoma (17), Stroke (17), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Pittsburgh?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Pittsburgh on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Pittsburgh?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Pittsburgh?
Recruiting research sites in Pittsburgh include University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Pittsburgh right now?
The largest active categories in Pittsburgh are Cancer & tumors (397), Neurology & pain (82), Cardiovascular (73). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Children's Hospital of Pittsburgh of UPMC?
Children's Hospital of Pittsburgh of UPMC is located at 3705 5TH AVE, PITTSBURGH, PA 15213-2584. Use the Google Maps link in the intro above to get directions.
How do I contact Children's Hospital of Pittsburgh of UPMC?
You can reach Children's Hospital of Pittsburgh of UPMC by phone at (412) 692-6207. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.
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