Paid Clinical Trials in Santa Ana, CA
As of June 2026, 64 paid clinical trials are recruiting in Santa Ana, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Santa Ana offers studies at sites including Syrentis Clinical Research for conditions such as Obesity, Idiopathic Hypersomnia, Narcolepsy Type 1, Narcolepsy Type 2. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Santa Ana
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5 clinical trials
·Clear filters·↓ Download CSVFibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design
Open-Label Safety Study of Solriamfetol in Subjects With Binge Eating Disorder
Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)
Elucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using Solriamfetol
About research studies in Santa Ana
Santa Ana has approximately 64 recruiting research studies across a wide range of therapeutic areas. California hosts a dense network of world-class research institutions, including UC San Diego Health, Stanford Medicine, UCLA Health, UCSF, City of Hope, and Scripps Research. The state's thriving biotech corridor and diverse patient population make it a national hub for both early-phase and late-phase clinical research.
Top Research Study Locations in Santa Ana
Researchers run research studies in Santa Ana, CA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Syrentis Clinical Research | Alzheimer Disease, Alzheimers Disease, AD | 9 |
| Southern California Clinical Research | Obesity, Overweight, Alopecia Areata | 4 |
| Orange County Retina Medical Group | Age-related Macular Degeneration (AMD), Geographic Atrophy (GA), Geographic Atrophy Secondary to Age-related Macular Degeneration | 4 |
| Santa Ana, California | Idiopathic Hypersomnia, Narcolepsy Type 1, Narcolepsy Type 2 | 3 |
| Wolverine Clinical Trials | Hidradenitis Suppurativa, Osteoarthritis, Overweight or Obesity | 3 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 2 |
| Orange County Retina Med Group | Neovascular Age-Related Macular Degeneration, Neovascular Age-related Macular Degeneration | 2 |
| Oruka Therapeutics Investigative Site | Plaque Psoriasis | 2 |
| Paje Optometric | Myopia, Juvenile Myopia, Myopia Progression | 2 |
| SDS Clinical Trials, Inc. | Narcolepsy Type 1, OSA | 2 |
| Southern California Dermatology, Inc. | Alopecia, Areata Alopecia, Hair Diseases | 2 |
| Takeda | Idiopathic Hypersomnia, Narcolepsy Type 2 | 2 |
| Southern California Dermatology | Dermatitis, Atopic, Dermatitis Atopic | 2 |
| Akerman Med | Bacterial Vaginosis, Fungal Vaginal Infections | 1 |
| Anthos Investigative | Atrial Fibrillation (AF) | 1 |
| Artiva Investigational Site Santa Ana | IIM, Idiopathic Inflammatory Myopathies (IIMs), Myositis | 1 |
| Clemente Clinical Research | Diabetic Foot Ulcer, Wound Heal | 1 |
| Clinical Study Site | Non-Small Cell Lung Cancer | 1 |
| Helping Hands Medical Associates INC | Cardiovascular Disease and Lipoprotein(a) | 1 |
| Investigative | Hidradenitis Suppurativa | 1 |
| Kailera Clinical Site | Obesity | 1 |
| Local Institution - 007-898-C | Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer | 1 |
| Local Institution - 0136 | Bipolar Disorder Type I With Mania | 1 |
| Novartis Investigative Site | Atopic Dermatitis | 1 |
| Paragon RX Clinical | Osteoarthritis, Knee | 1 |
Active & Upcoming Studies in Santa Ana (2026)
Recruiting trials in Santa Ana grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Diabetes & metabolic (8 active studies)
Eye & vision (7 active studies)
- Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) · Phase 3 · AbbVie
- A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO · Phase 2 · EyeBiotech Ltd.
Neurology & pain (4 active studies)
- A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT). · Phase 3 · Eli Lilly and Company
- Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015) · Cognito Therapeutics, Inc.
Mental health & behavior (2 active studies)
- A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3) · Phase 3 · Bristol-Myers Squibb
- A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression · LivaNova
Cancer & tumors (2 active studies)
- Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1 · Phase 3 · Summit Therapeutics
- Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 · Phase 2, Phase 3 · Mirati Therapeutics Inc.
Cardiovascular (2 active studies)
- Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function · Phase 3 · AstraZeneca
- Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76) · Phase 3 · Anthos Therapeutics, Inc.
Common conditions studied in Santa Ana
- Obesity (4 active studies). Obesity trials evaluate GLP-1 and GIP receptor agonists, novel metabolic drugs, and combined lifestyle interventions for sustainable weight loss.
- Idiopathic Hypersomnia (3 active studies). Recruiting Idiopathic Hypersomnia studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Narcolepsy Type 1 (3 active studies). Recruiting Narcolepsy Type 1 studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Narcolepsy Type 2 (3 active studies). Recruiting Narcolepsy Type 2 studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Overweight (3 active studies). Recruiting Overweight studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Alzheimer Disease (2 active studies). Alzheimer's research investigates anti-amyloid antibodies, tau-targeted therapies, and lifestyle interventions aimed at slowing cognitive decline.
Leading research sponsors in Santa Ana
- Eli Lilly and Company
- Axsome Therapeutics, Inc.
- AstraZeneca
- Hoffmann-La Roche
- Pfizer
Local regulations and guidelines
Clinical trials in California are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. In addition, California-specific protections such as the California Consumer Privacy Act (CCPA) and the Confidentiality of Medical Information Act (CMIA) impose stringent data-privacy requirements on research involving California residents.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Santa Ana. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Santa Ana
Hipa.ai aggregates every recruiting study in Santa Ana from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Santa Ana?
There are approximately 64 recruiting clinical trials in Santa Ana, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Santa Ana pay participants?
Most recruiting trials in Santa Ana compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Santa Ana?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Santa Ana?
The most common conditions under active study in Santa Ana include Obesity (4), Idiopathic Hypersomnia (3), Narcolepsy Type 1 (3), Narcolepsy Type 2 (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Santa Ana?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Santa Ana on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Santa Ana?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Santa Ana?
Recruiting research sites in Santa Ana include Syrentis Clinical Research, Southern California Clinical Research, Orange County Retina Medical Group, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Santa Ana right now?
The largest active categories in Santa Ana are Diabetes & metabolic (8), Eye & vision (7), Neurology & pain (4). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.