Paid Clinical Trials in San Luis Obispo, CA
As of August 2026, 43 paid clinical trials are recruiting in San Luis Obispo, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
San Luis Obispo offers studies at sites including Pacific Central Coast Health Center-San Luis Obispo for conditions such as Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8, Anatomic Stage IV Breast Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in San Luis Obispo
Trials by drug in San Luis Obispo
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Newly added in San Luis Obispo
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
Effects of Creatine and Carbohydrate Supplementation on Endurance Performance
42 clinical trials
This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.
A Study of Disitamab Vedotin Alone or With Pembrolizumab in Urothelial Cancer That Expresses HER2
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth
Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays
Sleep Well Firefighters: An App-based Program to Improve Sleep, Cognition, and Behavioral Health in Firefighters
Family Communications After Genetic Testing
Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Testing an Enhanced Digital Delivery Model for Inherited Cancer Genetic Testing in Young Adults With Cancer
Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer
Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
Comparing Impact of Treatment Before or After Surgery in Patients With Stage II-IIIB Resectable Non-small Cell Lung Cancer
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
Lenalidomide, and Dexamethasone With or Without Daratumumab in Treating Patients With High-Risk Smoldering Myeloma
Mobile Health for Adherence in Breast Cancer Patients
Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations
Immune Checkpoint Inhibitor Toxicity Risk Prediction in Solid Tumors
De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer
Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors
Early Intervention to Promote Cardiovascular Health of Mothers and Children
Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
Lifestyle Interventions to Prevent Diabetes in U.S. Home Visiting Programs
Investigating Baby Behavior and Family Technology Use Study
Adherence to Different Exercise Interventions
StandUPTV Habits: Feasibility Trial for Maintaining Reductions in Sedentary Screen Time
A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation
Top Research Study Locations in San Luis Obispo
Researchers run research studies in San Luis Obispo, CA at 10 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Pacific Central Coast Health Center-San Luis Obispo | Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8, Anatomic Stage IIIB Breast Cancer AJCC v8 | 29 |
| California Polytechnic State University | Blood Glucose Concentration, Blood Glucose Self Monitoring, Cardiovascular Health | 7 |
| UCLA Hematology/Oncology - San Luis Obispo | Cancer of the Prostate, Hormone Sensitive Prostate Cancer, Metastatic Castration Sensitive Prostate Cancer (mCSPC) | 2 |
| California Polytechnic University - San Luis Obispo | Anxiety, Cognition, Nutrition | 1 |
| California Polytechnic University San Luis Obispo | Glucose Metabolism, HbA1c Level, Physical Activity | 1 |
| Coastal Surgery Center | Lumbar Spinal Stenosis | 1 |
| Galileo Surgery Center | Lumbar Spinal Stenosis | 1 |
| Pain Management Specialists | Lumbar Spinal Stenosis | 1 |
| San Luis Obispo County Juvenile Hall | Anxiety Disorders, Depression Disorder, Emotional Dysregulation | 1 |
| Sierra Vista Regional Medical Center | Urothelial Carcinoma | 1 |
Active & Upcoming Studies in San Luis Obispo (2026)
Recruiting trials in San Luis Obispo grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (28 active studies)
- Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations · Phase 3 · SWOG Cancer Research Network
- Family Communications After Genetic Testing · Alliance for Clinical Trials in Oncology
Mental health & behavior (2 active studies)
- Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth · SoundHeal
- Sleep Well Firefighters: An App-based Program to Improve Sleep, Cognition, and Behavioral Health in Firefighters · California Polytechnic State University-San Luis Obispo
Neurology & pain (2 active studies)
- Sleep Well Firefighters: An App-based Program to Improve Sleep, Cognition, and Behavioral Health in Firefighters · California Polytechnic State University-San Luis Obispo
- StandUPTV Habits: Feasibility Trial for Maintaining Reductions in Sedentary Screen Time · Arizona State University
Diabetes & metabolic (1 active study)
- Lifestyle Interventions to Prevent Diabetes in U.S. Home Visiting Programs · California Polytechnic State University-San Luis Obispo
Pediatric (1 active study)
- Investigating Baby Behavior and Family Technology Use Study · California Polytechnic State University-San Luis Obispo
Common conditions studied in San Luis Obispo
- Anatomic Stage II Breast Cancer AJCC v8 (2 active studies)
- Anatomic Stage IIIA Breast Cancer AJCC v8 (2 active studies)
- Anatomic Stage IIIB Breast Cancer AJCC v8 (2 active studies)
- Anatomic Stage IV Breast Cancer AJCC v8 (2 active studies)
- Breast Carcinoma (2 active studies)
- Early Stage Triple-Negative Breast Carcinoma (2 active studies)
Leading research sponsors in San Luis Obispo
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- California Polytechnic State University-San Luis Obispo
- ECOG-ACRIN Cancer Research Group
- NRG Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in San Luis Obispo?
There are approximately 43 recruiting clinical trials in San Luis Obispo, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in San Luis Obispo pay participants?
Most recruiting trials in San Luis Obispo compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in San Luis Obispo?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in San Luis Obispo?
The most common conditions under active study in San Luis Obispo include Anatomic Stage II Breast Cancer AJCC v8 (2), Anatomic Stage IIIA Breast Cancer AJCC v8 (2), Anatomic Stage IIIB Breast Cancer AJCC v8 (2), Anatomic Stage IV Breast Cancer AJCC v8 (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in San Luis Obispo?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in San Luis Obispo on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in San Luis Obispo?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in San Luis Obispo?
Recruiting research sites in San Luis Obispo include Pacific Central Coast Health Center-San Luis Obispo, California Polytechnic State University, UCLA Hematology/Oncology - San Luis Obispo, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in San Luis Obispo right now?
The largest active categories in San Luis Obispo are Cancer & tumors (28), Mental health & behavior (2), Neurology & pain (2). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.