Tactile Pre-Visit Imagery
for Dental Anxiety in Children
Sites in Santa Ana & Los Angeles
Sponsor: University of Southern California
Sex: All·Age: 4 - 10·Accepts healthy volunteers
Code: NCT07719205·Recruiting·Listed Jul 22, 2026
Paid Clinical Trials in Santa Ana, CA
As of August 2026, 49 paid clinical trials are recruiting in Santa Ana, California. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Santa Ana offers studies at sites including Syrentis Clinical Research for conditions such as Idiopathic Hypersomnia, Narcolepsy Type 1, Narcolepsy Type 2, Alzheimer Disease. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Santa Ana
Trials by drug in Santa Ana
Filter results
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Newly added in Santa Ana
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
43 clinical trials
A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT).
for Alzheimer Disease
Drug: Donanemab
Sites in Santa Ana, Huntington Beach +50 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 55+
Code: NCT07602582·Phase 3·Recruiting·Listed May 2026
Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
for Obesity or Overweight
Sites in Santa Ana, Rolling Hills Estates +41 more locations
Sponsor: Amgen
Sex: All·Age: 18 - 99
Code: NCT07575399·Phase 3·Recruiting·Listed May 2026
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)
for Cardiovascular Disease and Lipoprotein(a)
Drug: Pelacarsen
Sites in Santa Ana, Huntington Beach +110 more locations
Sponsor: Novartis Pharmaceuticals
Sex: All·Age: 18 - 100
Code: NCT07517263·Phase 3·Recruiting·Listed Apr 2026
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
for Macular Degeneration
Sites in Santa Ana, Encino +50 more locations
Sponsor: EyeBiotech Ltd.
Sex: All·Age: 50+
Code: NCT07496567·Phase 2, Phase 3·Recruiting·Listed Mar 2026
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
for Overweight
Drug: Eloralintide
Sites in Santa Ana, Tustin +57 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07392190·Phase 3·Recruiting·Listed Feb 2026
A 26-Wk Study to Assess Safety & Efficacy of Tenapanor for T/t of Chronic Idiopathic Constipation in Adults
for Chronic Idiopathic Constipation (CIC)
Drug: Tenapanor
Sites in Santa Ana, Inglewood +107 more locations
Sponsor: Ardelyx
Sex: All·Age: 18 - 80
Code: NCT07382167·Phase 3·Recruiting·Listed Feb 2026
A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows
for Moderate to Severe Glabellar Lines
Drug: IPN10200
Sites in Santa Ana, Newport Beach +39 more locations
Sponsor: Ipsen
Sex: All·Age: 18 - 80
Code: NCT07435428·Phase 3·Recruiting·Listed Feb 2026
Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight
for Osteoarthritis
Drug: Eloralintide
Sites in Santa Ana, Fountain Valley +36 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07353931·Phase 3·Recruiting·Listed Jan 2026
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
for Obesity
Drug: Eloralintide
Sites in Santa Ana, Tustin +39 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18+
Code: NCT07321886·Phase 3·Recruiting·Listed Jan 2026
A 16-Week Study to Learn About the Study Medicine Called Ritlecitinib in Adults With Long Lasting Painful Red Skin Lumps, Known by the Medical Term, Hidradenitis Suppurativa, or HS.
for Hidradenitis Suppurativa
Drug: Ritlecitinib
Sites in Santa Ana, Fountain Valley +38 more locations
Sponsor: Pfizer
Sex: All·Age: 18 - 75
Code: NCT07228390·Phase 2·Recruiting·Listed Nov 2025
A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular Degeneratio
for Geographic Atrophy Secondary to Age-related Macular Degeneration
Drug: Pegcetacoplan
Sites in Santa Ana, Huntington Beach +76 more locations
Sponsor: Apellis Pharmaceuticals, Inc.
Sex: All·Age: 60+
Code: NCT07215390·Phase 2·Recruiting·Listed Oct 2025
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
for Alzheimers Disease
Sites in Santa Ana, Irvine +66 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 50 - 90
Code: NCT07177352·Phase 3·Recruiting·Listed Sep 2025
A Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
for Alzheimers Disease
Drug: Trontinemab
Sites in Santa Ana, Irvine +33 more locations
Sponsor: Hoffmann-La Roche
Sex: All·Age: 50 - 90
Code: NCT07169578·Phase 3·Recruiting·Listed Sep 2025
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy
for Age-related Macular Degeneration (AMD)
Drug: Cemdisiran
Sites in Santa Ana, Huntington Beach +138 more locations
Sponsor: Regeneron Pharmaceuticals
Sex: All·Age: 50 - 85
Code: NCT06541704·Phase 3·Recruiting·Listed Aug 2024
Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7
for Advanced Non-Small Cell Lung Cancer
Drug: Adagrasib
Sites in Santa Ana, Fountain Valley +190 more locations
Sponsor: Mirati Therapeutics Inc.
Sex: All·Age: 18+
Code: NCT04613596·Phase 2, Phase 3·Recruiting·Listed Nov 2020
Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD)
for Neovascular Age-related Macular Degeneration
Drug: Surabgene Lomparvovec
Sites in Santa Ana, Huntington Beach +50 more locations
Sponsor: AbbVie
Sex: All·Age: 50+
Code: NCT07007065·Phase 3·Recruiting·Listed Jun 2025
A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)
for Early Alzheimer's Disease
Sites in Santa Ana, Irvine +34 more locations
Sponsor: Merck Sharp & Dohme LLC
Sex: All·Age: 50 - 85
Code: NCT07033494·Phase 2·Recruiting·Listed Jun 2025
MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
for Lumbar Spinal Stenosis
Sites in Santa Ana, Orange +2341 more locations
Sponsor: Stryker Instruments
Sex: All·Age: 18+
Code: NCT03072927·Recruiting·Listed Mar 2017
A Study Assessing Corneal Endothelial Cells in Participants With Neovascular Age-related Macular Degeneration (nAMD) Treated With the Port Delivery System With Ranibizumab (PDS)
for Neovascular Age-related Macular Degeneration
Drug: Ranibizumab
Sites in Santa Ana, Huntington Beach +31 more locations
Sponsor: Genentech, Inc.
Sex: All·Age: 50+
Code: NCT04853251·Phase 4·Recruiting·Listed Apr 2021
A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
for Type 2 Diabetes
Drug: Semaglutide
Sites in Santa Ana +24 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 18 - 75
Code: NCT06897475·Phase 2·Recruiting·Listed Mar 2025
A Study of Baricitinib (LY3009104) in Children From 6 Years to Less Than 18 Years of Age With Alopecia Areata
for Areata Alopecia
Drug: Baricitinib
Sites in Santa Ana, Los Angeles +39 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 6 - 17
Code: NCT05723198·Phase 3·Recruiting·Listed Feb 2023
A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO
for Neovascular Age-Related Macular Degeneration (NVAMD)
Sites in Santa Ana, Glendale +47 more locations
Sponsor: EyeBiotech Ltd.
Sex: All·Age: 18+
Code: NCT07205887·Phase 2·Recruiting·Listed Oct 2025
Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib
for Alopecia Areata
Drug: Ritlecitinib
Sites in Santa Ana, Oxnard +24 more locations
Sponsor: Pfizer
Sex: All·Age: 12+
Code: NCT06531109·Recruiting·Listed Jul 2024
AlloNK®, an Allogeneic Non-genetically Modified, Cord Blood-derived NK Cell Therapy, in Combination With Rituximab, Studied in Relapsing Forms of B-cell Dependent Rheumatologic Diseases.
for Refractory Rheumatoid Arthritis (RA)
Drug: Rituximab
Sites in Santa Ana, Tustin +29 more locations
Sponsor: Artiva Biotherapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06991114·Phase 2·Recruiting·Listed May 2025
A Study of TAK-360 in Adults With Narcolepsy Without Cataplexy (NT2)
for Narcolepsy Type 2
Sites in Santa Ana, Chula Vista +28 more locations
Sponsor: Takeda
Sex: All·Age: 18 - 70
Code: NCT06952699·Phase 2·Recruiting·Listed May 2025
A Study to Investigate the Treatment Effect of Subcutaneous Injections of Pentosan Polysulfate Sodium Compared With Placebo in Adult Participants With Knee Osteoarthritis Pain.
for Osteoarthritis, Knee
Sites in Santa Ana, Anaheim +38 more locations
Sponsor: Paradigm Biopharmaceuticals Ltd.
Sex: All·Age: 18+
Code: NCT06917404·Phase 3·Recruiting·Listed Apr 2025
A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
for Narcolepsy Type 1
Drug: ORX750
Sites in Santa Ana, Long Beach +27 more locations
Sponsor: Centessa Pharmaceuticals (UK) Limited
Sex: All·Age: 18 - 65
Code: NCT06752668·Phase 2·Recruiting·Listed Dec 2024
A Study to Evaluate the Efficacy and Safety of E2086 in Adults With Narcolepsy
for Narcolepsy
Sites in Santa Ana +16 more locations
Sponsor: Eisai Inc.
Sex: All·Age: 18+
Code: NCT07493265·Phase 2·Recruiting·Listed Mar 2026
A Study of TAK-360 in Adults With Idiopathic Hypersomnia
for Idiopathic Hypersomnia
Sites in Santa Ana, Redwood City +11 more locations
Sponsor: Takeda
Sex: All·Age: 18 - 70
Code: NCT06812078·Phase 2·Recruiting·Listed Feb 2025
A Study of TAK-861 for the Treatment of Selected Central Hypersomnia Conditions
for Narcolepsy Type 1
Sites in Santa Ana, Redwood City +17 more locations
Sponsor: Takeda
Sex: All·Age: 16 - 70
Code: NCT05816382·Phase 2, Phase 3·Recruiting·Listed Apr 2023
Efficacy in Controlling Myopia in Young Children Using a Novel Spectacle Lens
for Myopia
Sites in Santa Ana, San Diego +12 more locations
Sponsor: SightGlass Vision, Inc.
Sex: All·Age: 6 - 8·Accepts healthy volunteers
Code: NCT06034327·Recruiting·Listed Sep 2023
A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia
for Narcolepsy Type 1
Drug: ORX750
Sites in Santa Ana +18 more locations
Sponsor: Centessa Pharmaceuticals (UK) Limited
Sex: All·Age: 18 - 65
Code: NCT07096674·Phase 2·Recruiting·Listed Jul 2025
Clinical Study of SNK01 in Participants With Moderate Alzheimer's Disease
for Moderate Alzheimer Disease
Sites in Santa Ana, Glendale +4 more locations
Sponsor: NKGen Biotech, Inc.
Sex: All·Age: 40 - 85
Code: NCT06189963·Phase 1, Phase 2·Recruiting·Listed Jan 2024
EDX110 Randomized Control Trial for Treatment of DFUs
for Wound Heal
Sites in Santa Ana, Vista +2 more locations
Sponsor: ConvaTec Inc.
Sex: All·Age: 18 - 90
Code: NCT07209358·Recruiting·Listed Oct 2025
Clinical Protocol CERN Feasibility Study
for Bacterial Vaginosis
Sites in Santa Ana, Orange & Irvine
Sponsor: Cern Corporation
Sex: Female·Age: 18+
Code: NCT06933420·Recruiting·Listed Apr 2025
Dose Ranging Study of ORKA-002 in Patients With Moderate-to-Severe Plaque Psoriasis
for Plaque Psoriasis
Sites in Santa Ana, Fountain Valley +22 more locations
Sponsor: Oruka Therapeutics, Inc.
Sex: All·Age: 18 - 79
Code: NCT07474792·Phase 2·Recruiting·Listed Mar 2026
An Open-Label Extension Study of ORKA-001 in Participants With Plaque Psoriasis
for Plaque Psoriasis
Sites in Santa Ana, Fountain Valley +16 more locations
Sponsor: Oruka Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT07449702·Phase 2·Recruiting·Listed Mar 2026
Fibromyalgia Response With Esreboxetine Evaluated Using a Randomized Withdrawal Research Design
for Fibromyalgia
Sites in Santa Ana, Anaheim +49 more locations
Sponsor: Axsome Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT07398417·Phase 3·Recruiting·Listed Feb 2026
Elucidating TAAR-1, Dopamine, and Norepinephrine in Binge Eating Disorder Using Solriamfetol
for Binge-Eating Disorder
Drug: Solriamfetol
Sites in Santa Ana, Garden Grove +36 more locations
Sponsor: Axsome Therapeutics, Inc.
Sex: All·Age: 18 - 55
Code: NCT06413433·Phase 3·Recruiting·Listed May 2024
Studying Solriamfetol Modulation of TAAR-1, Dopamine, and Norepinephrine in Shift Work Disorder (SUSTAIN)
for Excessive Sleepiness
Drug: Solriamfetol
Sites in Santa Ana, Huntington Beach +39 more locations
Sponsor: Axsome Therapeutics, Inc.
Sex: All·Age: 18 - 65
Code: NCT06568367·Phase 3·Recruiting·Listed Aug 2024
Top Research Study Locations in Santa Ana
Researchers run research studies in Santa Ana, CA at 24 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Syrentis Clinical Research | Alzheimer Disease, Alzheimers Disease, AD | 6 |
| Southern California Clinical Research | Obesity, Overweight, Alopecia Areata | 4 |
| Orange County Retina Medical Group | Age-Related Macular Degeneration, Age-related Macular Degeneration (AMD), Choroidal Neovascularization | 4 |
| Santa Ana, California | Idiopathic Hypersomnia, Narcolepsy Type 1, Narcolepsy Type 2 | 3 |
| Wolverine Clinical Trials | Hidradenitis Suppurativa, Osteoarthritis, Overweight or Obesity | 3 |
| Oruka Therapeutics Investigative Site | Plaque Psoriasis | 2 |
| SDS Clinical Trials, Inc. | Narcolepsy Type 1, OSA | 2 |
| Southern California Dermatology, Inc. | Alopecia, Areata Alopecia, Hair Diseases | 2 |
| Takeda | Idiopathic Hypersomnia, Narcolepsy Type 2 | 2 |
| Akerman Med | Bacterial Vaginosis, Fungal Vaginal Infections | 1 |
| Altamed Dental Clinic | Behavior Change, Dental Anxiety in Children | 1 |
| Artiva Investigational Site Santa Ana | IIM, Idiopathic Inflammatory Myopathies (IIMs), Myositis | 1 |
| Clemente Clinical Research | Diabetic Foot Ulcer, Wound Heal | 1 |
| Helping Hands Medical Associates INC | Cardiovascular Disease and Lipoprotein(a) | 1 |
| Local Institution - 007-898-C | Advanced Non-Small Cell Lung Cancer, Metastatic Non-Small Cell Lung Cancer | 1 |
| Novartis Investigative Site | Atopic Dermatitis | 1 |
| Orange County Retina Med Group | Neovascular Age-related Macular Degeneration | 1 |
| Paje Optometric | Juvenile Myopia, Myopia, Myopia Progression | 1 |
| Paragon RX Clinical | Osteoarthritis, Knee | 1 |
| Paragon Rx Clinical, Inc. - Santa Ana | Chronic Idiopathic Constipation (CIC) | 1 |
| SDS Clinical Trials, Inc-California-Santa Ana | Narcolepsy | 1 |
| Southern California Dermatology | Dermatitis Atopic | 1 |
| UCI Health Family Health Center - Santa Ana | Early Detection of Cancer, Lung Cancer Screening, Lung Neoplasms | 1 |
| UCI Medical Center- Central Distribution Warehouse - Dyer | Lumbar Spinal Stenosis | 1 |
Active & Upcoming Studies in Santa Ana (2026)
Recruiting trials in Santa Ana grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Eye & vision (6 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) · Phase 3 · AbbVie
Diabetes & metabolic (5 active studies)
- Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH) · Phase 3 · Amgen
- A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin · Phase 3 · Eli Lilly and Company
Neurology & pain (3 active studies)
- A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT). · Phase 3 · Eli Lilly and Company
- Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015) · Cognito Therapeutics, Inc.
Mental health & behavior (2 active studies)
- Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+) · University of California, Irvine
- Tactile Pre-Visit Imagery · University of Southern California
Cancer & tumors (2 active studies)
- Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+) · University of California, Irvine
- Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7 · Phase 2, Phase 3 · Mirati Therapeutics Inc.
Pediatric (1 active study)
- Tactile Pre-Visit Imagery · University of Southern California
Common conditions studied in Santa Ana
- Idiopathic Hypersomnia (3 active studies)
- Narcolepsy Type 1 (3 active studies)
- Narcolepsy Type 2 (3 active studies)
- Alzheimer Disease (2 active studies)
- Alzheimers Disease (2 active studies)
- Binge-Eating Disorder (2 active studies)
Leading research sponsors in Santa Ana
- Eli Lilly and Company
- Axsome Therapeutics, Inc.
- Takeda
- Centessa Pharmaceuticals (UK) Limited
- EyeBiotech Ltd.
Frequently asked questions
How many paid clinical trials are currently recruiting in Santa Ana?
There are approximately 49 recruiting clinical trials in Santa Ana, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Santa Ana pay participants?
Most recruiting trials in Santa Ana compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Santa Ana?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Santa Ana?
The most common conditions under active study in Santa Ana include Idiopathic Hypersomnia (3), Narcolepsy Type 1 (3), Narcolepsy Type 2 (3), Alzheimer Disease (2), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Santa Ana?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Santa Ana on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Santa Ana?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Santa Ana?
Recruiting research sites in Santa Ana include Syrentis Clinical Research, Southern California Clinical Research, Orange County Retina Medical Group, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Santa Ana right now?
The largest active categories in Santa Ana are Eye & vision (6), Diabetes & metabolic (5), Neurology & pain (3). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
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