Paid Clinical Trials in Springfield, IL
As of August 2026, 178 paid clinical trials are recruiting in Springfield, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Springfield offers studies at sites including Southern Illinois University School of Medicine for conditions such as Acute Myeloid Leukemia, Malignant Solid Neoplasm, Stage IV Lung Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Springfield
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·Clear filters·Top Research Study Locations in Springfield
Researchers run research studies in Springfield, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Southern Illinois University School of Medicine | Acute Myeloid Leukemia, Malignant Solid Neoplasm, Stage IV Lung Cancer AJCC v8 | 113 |
| Springfield Clinic | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8 | 97 |
| Springfield Memorial Hospital | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Anatomic Stage II Breast Cancer AJCC v8 | 76 |
| Springfield Clinic - First | Irritable Bowel Syndrome, Constipation, Diarrhea | 7 |
| Memorial Medical Center | Acral Lentiginous Melanoma, Anatomic Stage IV Breast Cancer AJCC v8, Castration-Resistant Prostate Carcinoma | 6 |
| Springfield Clinic Main Campus | Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer | 4 |
| Saint John's Hospital | Malignant Solid Neoplasm, Adrenal Gland Pheochromocytoma, Carcinoma In Situ | 3 |
| Prairie Education & Research Cooperative | Atrial Fibrillation (AF), Heart Failure With Reduced Ejection Fraction, Hypertension, Pulmonary | 2 |
| Simmons Cancer Institute at SIU | Breast Neoplasms, Multiple Myeloma, Neoplasm Metastasis | 2 |
| Southern Illinois University | Refractory Angina, Urothelial Carcinoma | 2 |
| Springfield Clinic Main Campus | Neovascular Age-related Macular Degeneration, Crohn's Disease | 2 |
| Clincial Research | Non-healing Wound, Venous Insufficiency of Leg, Venous Leg Ulcer | 1 |
| Clinical Research | Severe Hypertriglyceridemia | 1 |
| Clinical Trial Site | High Cardiovascular Risk, High Risk Cardiovascular Disease, Hypertension | 1 |
| Ep0162 50375 | Stereotypical Prolonged Seizures | 1 |
| Ep0165 50375 | Stereotypical Prolonged Seizures | 1 |
| HSHS St. John's Hospital | Multiple Myeloma | 1 |
| Home-based telemedicine | Chronic Granulomatous Disease (CGD) | 1 |
| Illinois Department of Corrections | Opioid Use, Opioid-use Disorder | 1 |
| Independent Clincal Research LLC | Chronic Wound, Diabetic Foot Ulcer, Open Wound | 1 |
| Independent Clinical Research, LLC | Diabetic Foot Ulcer (DFU), Lower Extremity | 1 |
| Investigative | Solid Tumors | 1 |
| Kailera Clinical Site | Obesity, Overweight | 1 |
| Local Institution - 0683 | Carcinoma, Non-Small-Cell Lung | 1 |
| Prairie Education and Research | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation, Ventricular Arrhythmia | 1 |
Active & Upcoming Studies in Springfield (2026)
Recruiting trials in Springfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (107 active studies)
- Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell Lung Cancer From Returning, AASI-NSCLC Trial · Phase 3 · National Cancer Institute (NCI)
- Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial · Phase 3 · National Cancer Institute (NCI)
Cardiovascular (12 active studies)
- A Phase 2b Clinical Trial of YN001 in Adults With Coronary Atherosclerosis · Phase 2 · Beijing Inno Medicine Co., Ltd.
- Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease · Phase 3 · Alnylam Pharmaceuticals
Eye & vision (6 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) · Phase 2, Phase 3 · EyeBiotech Ltd.
- Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) · Phase 3 · AbbVie
Diabetes & metabolic (4 active studies)
- A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes · Phase 3 · Novo Nordisk A/S
- Efficacy and Safety of Ribupatide in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes · Phase 3 · Kailera
Mental health & behavior (3 active studies)
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
- Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program · Phase 3 · Alliance for Clinical Trials in Oncology
Pediatric (2 active studies)
- Supraglottic Airway for Resuscitation Trial · Children's Hospital of Philadelphia
- CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D) · Phase 1, Phase 2 · COUR Pharmaceutical Development Company, Inc.
Common conditions studied in Springfield
- Acute Myeloid Leukemia (7 active studies)
- Malignant Solid Neoplasm (7 active studies)
- Stage IV Lung Cancer AJCC v8 (7 active studies)
- Anatomic Stage II Breast Cancer AJCC v8 (5 active studies)
- Stage IV Renal Cell Cancer AJCC v8 (5 active studies)
- Breast Cancer (4 active studies)
Leading research sponsors in Springfield
- National Cancer Institute (NCI)
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- NRG Oncology
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Springfield?
There are approximately 178 recruiting clinical trials in Springfield, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Springfield pay participants?
Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Springfield?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Springfield?
The most common conditions under active study in Springfield include Acute Myeloid Leukemia (7), Malignant Solid Neoplasm (7), Stage IV Lung Cancer AJCC v8 (7), Anatomic Stage II Breast Cancer AJCC v8 (5), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Springfield?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Springfield?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Springfield?
Recruiting research sites in Springfield include Southern Illinois University School of Medicine, Springfield Clinic, Springfield Memorial Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Springfield right now?
The largest active categories in Springfield are Cancer & tumors (107), Cardiovascular (12), Eye & vision (6). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.