Paid Clinical Trials in Springfield, IL
As of June 2026, 198 paid clinical trials are recruiting in Springfield, Illinois. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Springfield offers studies at sites including Southern Illinois University School of Medicine for conditions such as Acute Myeloid Leukemia, Malignant Solid Neoplasm, Stage IV Lung Cancer AJCC v8, Breast Cancer. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Springfield
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·Clear filters·↓ Download CSVAbout research studies in Springfield
Springfield has approximately 198 recruiting research studies across a wide range of therapeutic areas. Illinois's research base includes Northwestern Medicine, Rush University Medical Center, University of Chicago Medicine, and Ann & Robert H. Lurie Children's Hospital, covering oncology, cardiology, and pediatric specialties.
Top Research Study Locations in Springfield
Researchers run research studies in Springfield, IL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Southern Illinois University School of Medicine | Malignant Solid Neoplasm, Acute Myeloid Leukemia, Stage IV Lung Cancer AJCC v8 | 120 |
| Springfield Clinic | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 103 |
| Springfield Memorial Hospital | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Malignant Solid Neoplasm | 87 |
| Memorial Medical Center | Metastatic Malignant Neoplasm in the Brain, Acral Lentiginous Melanoma, Anatomic Stage IV Breast Cancer AJCC v8 | 8 |
| Springfield Clinic Main Campus | Carcinoma, Non-Small-Cell Lung, Carcinoma, Non-Small Cell Lung, Cutaneous Squamous Cell Cancer | 4 |
| Central Illinois Hematology Oncology Center | Head and Neck Squamous Cell Carcinoma, Hematopoietic and Lymphatic System Neoplasm, Hypopharyngeal Squamous Cell Carcinoma | 3 |
| Prairie Education and Research Cooperative | Aortic Stenosis, Aortic Stenosis, Severe, Heart Failure | 3 |
| Saint John's Hospital | Malignant Solid Neoplasm, Adrenal Gland Pheochromocytoma, Carcinoma In Situ | 3 |
| Southern Illinois University | Alzheimer Disease, Refractory Angina, Urothelial Carcinoma | 3 |
| Kailera Clinical Site | Obesity, Obesity With Diabetes, Overweight | 2 |
| Prairie Education & Research Cooperative | Atrial Fibrillation (AF), Heart Failure With Reduced Ejection Fraction, Hypertension, Pulmonary | 2 |
| Prairie Heart Institute | Cardiovascular Diseases, Functional Mitral Regurgitation, Generalized Myasthenia Gravis | 2 |
| Simmons Cancer Institute at SIU | Breast Neoplasms, Multiple Myeloma, Neoplasm Metastasis | 2 |
| Springfield Clinic - First | Diarrhea, Irritable Bowel Syndrome, Ulcerative Colitis (UC) | 2 |
| Springfield Clinic, LLP | Lung Cancer Diagnosis, Prostate Cancer | 2 |
| Clincial Research Site 49 | Non-healing Wound, Venous Insufficiency of Leg, Venous Leg Ulcer | 1 |
| Clinical Research Site 6 | Severe Hypertriglyceridemia | 1 |
| Clinical Trial Site | High Cardiovascular Risk, High Risk Cardiovascular Disease, Hypertension | 1 |
| Ep0162 50375 | Stereotypical Prolonged Seizures | 1 |
| Ep0165 50375 | Stereotypical Prolonged Seizures | 1 |
| HSHS St. John's Hospital | Multiple Myeloma | 1 |
| Home-based telemedicine | Chronic Granulomatous Disease (CGD) | 1 |
| Illinois Department of Corrections | Opioid Use, Opioid-use Disorder | 1 |
| Illinois Primary Health Care Association | Suicide | 1 |
| Independent Clincal Research LLC | Chronic Wound, Diabetic Foot Ulcer, Open Wound | 1 |
Active & Upcoming Studies in Springfield (2026)
Recruiting trials in Springfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (120 active studies)
- Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations · Phase 3 · SWOG Cancer Research Network
- A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer · Phase 3 · Incyte Corporation
Cardiovascular (14 active studies)
- Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease · Phase 3 · Alnylam Pharmaceuticals
- Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation · Arga Medtech SA
Diabetes & metabolic (5 active studies)
- A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes · Phase 3 · Novo Nordisk A/S
- Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes · Phase 3 · Kailera
Eye & vision (5 active studies)
- Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) · Phase 3 · AbbVie
- Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration · Phase 3 · 4D Molecular Therapeutics
Mental health & behavior (3 active studies)
- E-Mindfulness Approaches for Living After Breast Cancer · Phase 3 · NRG Oncology
- Reaching Rural Cancer Survivors Who Smoke Using Text-Based Program · Phase 3 · Alliance for Clinical Trials in Oncology
Pediatric (2 active studies)
- Supraglottic Airway for Resuscitation Trial · Children's Hospital of Philadelphia
- CNP-103 in Adolescent and Adult Subjects Ages 12-35 With Recently Diagnosed (Within 6 Months) Stage 3 Type 1 Diabetes (T1D) · Phase 1, Phase 2 · COUR Pharmaceutical Development Company, Inc.
Neurology & pain (1 active study)
- A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam) · Phase 2 · Alzheimer's Disease Cooperative Study (ADCS)
Common conditions studied in Springfield
- Acute Myeloid Leukemia (8 active studies). Leukemia trials evaluate targeted inhibitors, CAR-T cell therapies, and novel combinations for acute and chronic forms of the disease.
- Malignant Solid Neoplasm (8 active studies). Recruiting Malignant Solid Neoplasm studies evaluate investigational treatments, diagnostics, and supportive care approaches to improve patient outcomes.
- Stage IV Lung Cancer AJCC v8 (7 active studies). Lung cancer research focuses on targeted therapies for specific mutations such as EGFR, ALK, and KRAS, alongside immunotherapy regimens.
- Breast Cancer (6 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Anatomic Stage II Breast Cancer AJCC v8 (4 active studies). Breast cancer trials evaluate new hormone therapies, targeted drugs, and immunotherapy combinations aimed at improving survival and reducing recurrence.
- Hypertension (4 active studies). Hypertension research tests new antihypertensive drug classes, renal denervation devices, and fixed-dose combinations for resistant disease.
Leading research sponsors in Springfield
- National Cancer Institute (NCI)
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
- NRG Oncology
- Children's Oncology Group
Local regulations and guidelines
Clinical trials in Illinois are governed by U.S. Food and Drug Administration (FDA) regulations, Office for Human Research Protections (OHRP) standards, and federal HIPAA privacy rules. Every study is reviewed by an Institutional Review Board (IRB) to protect participant safety and ensure informed consent. Illinois studies must also comply with the Illinois Personal Information Protection Act (PIPA) and Biometric Information Privacy Act (BIPA) where applicable.
Compensation & what to expect
- How payment typically works
- Compensation is most often provided through reloadable electronic study cards or direct deposit, paid out per completed visit rather than as a lump sum. Amounts vary by the time required, the number of visits, and the study's complexity — overnight stays and inpatient pharmacology studies generally pay more than short outpatient surveys. The exact amount is disclosed in writing during informed consent before any visit.
- Healthy volunteers
- Healthy participants aged 18 and older can earn compensation by joining vaccine, pharmacology, and biomarker studies in Springfield. These trials check how a new drug or vaccine behaves in healthy bodies before later-phase testing. Many sites maintain a healthy-volunteer registry so you hear about new opportunities first.
- What's included beyond payment
- Most trials cover study-related medical care at no cost — physical exams, lab work, imaging, the investigational treatment itself, and follow-up visits with the research team. Insurance is not required to participate. Free check-ups and access to specialists are common reasons participants return for additional studies.
- Travel and time
- Many sponsors reimburse travel, parking, mileage, and lost wages for visit days. Long-running studies and trials that require frequent visits often raise stipends accordingly. Ask the study coordinator for the visit schedule and reimbursement policy before you commit.
- Asking about compensation
- Compensation is set per protocol and per site, so figures are not published in trial registries. The fastest way to confirm payment for a specific study is to contact the recruiting site listed on the study record. Coordinators are accustomed to this question and will quote the per-visit and total amounts up front.
How to find a clinical trial in Springfield
Hipa.ai aggregates every recruiting study in Springfield from ClinicalTrials.gov and refreshes the list daily. Use the filters above to narrow by condition, facility, age, phase, or healthy-volunteer eligibility, then click any study title to view full details — eligibility criteria, intervention, location, and sponsor contact information. To enroll, reach out to the central study contact listed on the study detail page; the research coordinator will walk you through the screening process.
Frequently asked questions
How many paid clinical trials are currently recruiting in Springfield?
There are approximately 198 recruiting clinical trials in Springfield, Illinois listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Springfield pay participants?
Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Springfield?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Springfield?
The most common conditions under active study in Springfield include Acute Myeloid Leukemia (8), Malignant Solid Neoplasm (8), Stage IV Lung Cancer AJCC v8 (7), Breast Cancer (6), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Springfield?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Springfield?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Springfield?
Recruiting research sites in Springfield include Southern Illinois University School of Medicine, Springfield Clinic, Springfield Memorial Hospital, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Springfield right now?
The largest active categories in Springfield are Cancer & tumors (120), Cardiovascular (14), Diabetes & metabolic (5). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.