Brain metastases Clinical Trials

Recruiting brain metastases studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat brain metastases. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting brain metastases studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting brain metastases trials

Within

ctDNA-Guided Intraventricular Therapy for CNS Malignancies

for Leptomeningeal Disease

Sponsor: Alireza Mansouri

Sex: All·Age: 18 - 120

Code: NCT07689721

MeDex: No Perioperative Dexamethasone in Brain Metastases

for Brain Metastases

1 site in Louisville

Sponsor: University of Louisville

Sex: All·Age: 18+

Code: NCT07044557

Apply to this trial

Memory Avoidance Whole Brain Radiotherapy vs Hippocampal Avoidance Whole Brain Radiotherapy (Athena 2 Trial)

for Brain Metastases

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT07248228·Phase 2

Apply to this trial

IL-8 Receptor Modified Patient-Derived Activated CD70 CAR T Cell Therapy in Adults With Brain Metastases

for Brain Metastases

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 18 - 80

Code: NCT07569263·Phase 1

Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases

for Breast Cancer

1 site in Miami

Sponsor: Baptist Health South Florida

Sex: Female·Age: 18+

Code: NCT07454668·Phase 1

Brain Radiotherapy Combined With Dalpiciclib and Endocrine Therapy in HR-Positive/HER2-Negative Advanced Breast Cancer With Brain Metastases

for Breast Cancer

Sponsor: Nanfang Hospital, Southern Medical University

Sex: Female·Age: 18 - 75

Code: NCT07539753·Phase 2

Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy.

for Short Time Examination

Sponsor: Centre Hospitalier Universitaire, Amiens

Sex: All·Age: 18+

Code: NCT07632092

Apply to this trial

Inflammation in Primary and Secondary Malignancies of the Central Nervous System Using [C-11]-CS1P1

for Central Nervous System Cancer

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07462507·Phase 2

Apply to this trial

Comparison of Molecular-Genetic Concordance of the Primary Tumor and Brain Metastases of Gastroesophageal Cancers

for Gastric Cancer

Sponsor: Blokhin's Russian Cancer Research Center

Sex: All·Age: 18+

Code: NCT07464470

Apply to this trial

Bevacizumab Plus FSRT Versus Hippocampus-Avoidant WBRT in Lung Adenocarcinoma With Extensive Brain Metastases

for Lung Adenocarcinoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07481786·Phase 3

Apply to this trial

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT)

for Brain Metastases

1 site in Charleston

Sponsor: Medical University of South Carolina

Sex: All·Age: 18+

Code: NCT07227610·Phase 2

Apply to this trial

Furmonertinib 160mg vs 80mg + Chemotherapy in EGFR-Mutated NSCLC With Brain Metastases: Efficacy and Safety Study

for Non-small Cell Lung Cancer (NSCLC)

Sponsor: Tianjin Medical University Cancer Institute and Hospital

Sex: All·Age: 18 - 75

Code: NCT07365410·Phase 2

Feasibility of a Cognitive Stepped Care Program for Adults With Brain Metastases

for Brain Metastases

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT07355348

Apply to this trial

Laser Interstitial Thermal Therapy (LITT) or Surgery and Adjuvant Reirradiation for Recurrent Brain Metastases (LaSAR BeaM)

for Brain Metastases

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT07053033·Phase 2

Apply to this trial

7T Brain MRI Scan for Micro-brain Metastasis (microBM) Detection for Patients With Small-cell Lung Cancer (SCLC), Who Decline Prophylactic Cranial Irradiation (PCI)

for Small-cell Lung Cancer

1 site in Columbia

Sponsor: University of Missouri-Columbia

Sex: All·Age: 18+

Code: NCT07175077

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Retrospective Multicenter Study of Patient-level T1CE/FLAIR MRI Deep Learning to Predict EGFR/ALK Driver Status in NSCLC Brain Metastases With External Validation and Survival Analysis

for Non-Small Cell Lung Cancer

Sponsor: Ming Yang

Sex: All·Age: 18+

Code: NCT07373951

Evolution of Hypofractionated Stereotactic Irradiation for Radio-Resistant Brain Metastases From D1-3-5 to D1-2-3

for Brain Metastases

Sponsor: Centre Paul Strauss

Sex: All·Age: 18+

Code: NCT07167134·Phase 3

Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)

for Small Cell Lung Cancer Extensive Stage

1 site in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18+

Code: NCT07139990·Phase 1

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A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)

for Lung Cancer

Sponsor: Latin American Cooperative Oncology Group

Sex: All·Age: 18+

Code: NCT06822543·Phase 2

Apply to this trial

A Two-cohort Study of SHR-A1811 in the Treatment of HER2-positive Breast Cancer With Brain Metastases

for Breast Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: Female·Age: 18 - 75

Code: NCT07177950·Phase 1, Phase 2

Dual Energy CT - a Tool for Delineation of Tumor and Organs at Risk in Radiotherapy

for Brain Metastases

Sponsor: Aalborg University Hospital

Sex: All·Age: 18+

Code: NCT07185958

Ex Vivo Drug Response Evaluation for Next Generation Care of Brain Metastases

for Brain Metastases

Sponsor: University of Zurich

Sex: All·Age: 18+

Code: NCT06620380·Phase 2

Apply to this trial

Trastuzumab Rezetecan Combined With Radiotherapy Versus Trastuzumab Rezetecan in the Treatment of HER2-positive Advanced Breast Cancer With Brain Metastases

for HER2-positive Advanced Breast Cancer

Sponsor: Henan Cancer Hospital

Sex: Female·Age: 18+

Code: NCT07100600·Phase 2

Apply to this trial

Trial of Relatlimab, Nivolumab, and Ipilimumab in Patients With Asymptomatic and Symptomatic Melanoma Brain Metastases

for Melanoma

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT06712927·Phase 2

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REPotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain mEtastasis

for NSCLC

Sponsor: MedSIR

Sex: All·Age: 18+

Code: NCT06315010·Phase 2

Apply to this trial

Neoadjuvant Stereotactic Radiotherapy for Brain Metastasis

for Brain Metastases

Sponsor: University Hospital Ostrava

Sex: All·Age: 18+

Code: NCT06933199

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Corticodependent or Corticoresistant Brain Radionecrosis After Radiotherapy for Brain Metastases

for Radionecrosis of Brain

Sponsor: Institut Cancerologie de l'Ouest

Sex: All·Age: 18+

Code: NCT06471465·Phase 3

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Trial of Differential Margins in Single Isocenter Radiosurgery of Brain Metastases

for Brain Metastases

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 19+

Code: NCT06857006

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EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active

for Brain Metastases

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06649058·Phase 2

Apply to this trial

Automated Detection of Brain Metastases on MRI

for Brain Metastases

Sponsor: Robovision BV

Sex: All·Age: 18+

Code: NCT06727032

ioMRI in the Surgery of Brain Metastases.

for Brain Metastases

Sponsor: Technical University of Munich

Sex: All·Age: 18+

Code: NCT07197632

Apply to this trial

BrAin Metastasis in tripLe Negateive Breast Cancer: IvoneScimab and Trop2 ADC

for Triple-Negative Breast Cancer (TNBC)

Sponsor: Fudan University

Sex: All·Age: 18 - 70

Code: NCT06793332·Phase 2

Apply to this trial

Cadonilimab Combined With Stereotactic Radiotherapy as Second-line Treatment for Brain Metastases

for Non Small Cell Lung Cancer

Sponsor: Rongrong Zhou

Sex: All·Age: 18 - 75

Code: NCT06702826·Phase 2

Apply to this trial

TIL Therapy Combined With Pembrolizumab for Advanced Brain Cancer Including Gliomas and Meningiomas

for Brain Tumor

Sponsor: Essen Biotech

Sex: All·Age: 16 - 90

Code: NCT06640582·Phase 1, Phase 2

Apply to this trial

Development of MRF for Characterization of Brain Tumors After Radiotherapy

for Brain Tumor

2 sites in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06101069

Apply to this trial

Efficacy of the Association of Fractionated SRS and Subsequent Surgery in Patients With Brain Metastases

for Brain Metastases

Sponsor: Regina Elena Cancer Institute

Sex: All·Age: 18+

Code: NCT06992973

Apply to this trial

Feasibility of 18F-Fluciclovine PET/CT to Identify Brain Metastasis

for Brain Metastases

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18 - 99

Code: NCT06055790·Phase 2

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Evaluation of the Efficacy and Safety of Furmonertinib Combined with Bevacizumab As First-Line Treatment for EGFR-Positive Non-Small Cell Lung Cancer with Brain Metastases: a Single-Arm, Open-Label, Prospective Phase II Clinical Study

for Non-small Cell Lung Cancer (NSCLC)

Sponsor: Li-kun Chen

Sex: All·Age: 15 - 75

Code: NCT06728865·Phase 2

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Evaluation of Brain Metastases Treated With Stereotactic Radiotherapy Using Dynamic [18F]FDG PET

for Brain Metastases

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT06511323

SRT Combined With Anlotinib for the Treatment of Brain Metastases From Non-small Cell Lung Cancer

for Non-Small-Cell Lung Cancer

Sponsor: The First People's Hospital of Lianyungang

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06476093

Apply to this trial

Cranial Radiotherapy Plus Chemoimmunotherapy in Untreated Driver-mutation Negative NSCLC With Stable Brain Metastasis

for NSCLC Stage IV

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT06501391·Phase 2

Apply to this trial

18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery

for Brain Metastases

1 site in Miami

Sponsor: Baptist Health South Florida

Sex: All·Age: 18+

Code: NCT06048094·Phase 1

Apply to this trial

Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma

for Cutaneous Melanoma

2 sites incl. Iowa City

Sponsor: University of Utah

Sex: All·Age: 18+

Code: NCT06194929·Phase 1, Phase 2

Apply to this trial

Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements

for Lung Cancer

3 sites incl. Stanford

Sponsor: Joshua Palmer

Sex: All·Age: 18+

Code: NCT05987644·Phase 1, Phase 2

Apply to this trial

Contribution of the CEST Sequence in the Characterization of Radionecrosis of Brain Metastases of Pulmonary Origin

for Brain Metastases

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT05977803

Apply to this trial

WBRT With Hippocampal-avoidance Technique Followed by SRT for Extensive-stage SCLC With Baseline Brain Metastases

for SCLC,Extensive Stage

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT06243003·Phase 1, Phase 2

Apply to this trial

Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer

for Breast Cancer

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: Female·Age: 18+

Code: NCT06072807·Phase 4

Apply to this trial

Imaging Features for the Risks for Recurrence After Stereotactic Radiosurgery in Brain Metastasis

for Brain Metastases

Sponsor: Asan Medical Center

Sex: All·Age: 18+

Code: NCT05868928

Apply to this trial

A Phase II Study of T-DXd Plus SRT in HER2-positive Breast Cancer Brain Metastases

for Breast Cancer

Sponsor: Fudan University

Sex: Female·Age: 18+

Code: NCT06088056·Phase 2

Cryoablation of Brain Neoplasm

for Brain Neoplasm

Sponsor: Erasmus Medical Center

Sex: All·Age: 18 - 80

Code: NCT06753617

Frameless Stereotactic Radiosurgery for Intact Brain Metastases

for Brain Metastases

1 site in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT02747303·Phase 2

Apply to this trial

SRS/SRT/Hypo-RT Versus HA-WBRT for No More Than 10 Brain Metastases in SCLC

for Small-cell Lung Cancer

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Sex: All·Age: 18 - 80

Code: NCT06457906·Phase 3

Apply to this trial

Reducing the Incidence of Symptomatic Brain Metastases With MRI Surveillance

for Brain Metastases

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT05692635·Phase 2

Apply to this trial

TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain Metastases

for NSCLC

Sponsor: TYK Medicines, Inc

Sex: All·Age: 18 - 80

Code: NCT05948813·Phase 2

Apply to this trial

Phase II Trial of the PARP Inhibitor Niraparib and PD-1 Inhibitor Dostarlimab in Patients With Advanced Cancers With Active Progressing Brain Metastases (STARLET)

for Brain Metastases

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05700721·Phase 2

Apply to this trial

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

for Head and Neck Squamous Cell Carcinoma

1 site in Nashville

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: 18+

Code: NCT05996432·EARLY_Phase 1

Apply to this trial

A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)

for Metastatic Solid Tumor

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT05673928·Phase 2

Apply to this trial

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

for Non-small Cell Lung Cancer

20 sites incl. Gilbert

Sponsor: Institut de Recherches Internationales Servier

Sex: All·Age: 18+

Code: NCT05786924·Phase 1, Phase 2

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Early or Delayed Intervention of Brain Radiotherapy Combined With Almonertinib in EGFR Mutated NSCLC With Brain Metastases

for Brain Metastases

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT05768490·Phase 3

Apply to this trial

Nitroglycerin Plus Radiotherapy Versus Conventional Radiotherapy in Patients With Lung Cancer.

for Non-small Cell Lung Cancer

Sponsor: Instituto Nacional de Cancerologia de Mexico

Sex: All·Age: 18 - 85

Code: NCT06238882

Apply to this trial

Brain metastases clinical trials — common questions

Are brain metastases clinical trials free to join?

Yes. Participating in a brain metastases clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a brain metastases clinical trial?

Each brain metastases study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a brain metastases trial near me?

Use the location controls above. We'll show recruiting brain metastases trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many brain metastases trials are recruiting right now?

We're currently tracking roughly 45 recruiting brain metastases trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Brain metastases trials by city

Miami, FL Boston, MA Cleveland, OH Birmingham, AL Chicago, IL Columbus, OH Gainesville, FL Los Angeles, CA Milwaukee, WI Palo Alto, CA Sacramento, CA Salt Lake City, UT

Related specialties

Oncology Neuro-oncology