Fatigue Clinical Trials

Recruiting fatigue studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat fatigue. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting fatigue studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting fatigue trials

Within

Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE

for Cancer

2 sites in Pittsburgh

Sponsor: University of Pittsburgh

Sex: All·Age: 21 - 100·Accepts healthy volunteers

Code: NCT05601206

Home-Based High-Intensity Interval Training in Systemic Lupus Erythematosus

for Systemic Lupus Erthematosus

1 site in Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 18 - 65

Code: NCT07716462

Transcranial Direct Current Stimulation for Long COVID Brain Fog and Fatigue

for Long COVID

Sponsor: University of Las Palmas de Gran Canaria

Sex: All·Age: 18 - 70

Code: NCT07709234

The Safety and Efficacy of Redsenol-1 Plus on Cancer-related Fatigue in Adults

for Fatigue

Sponsor: Canada Royal Enoch Phytomedicine Co., Ltd.

Sex: All·Age: 18+

Code: NCT05664009

Non-Invasive Sleep Monitoring for Burnout and Retention Risk in Postgraduate Nurses

for Burnout

Sponsor: Kaohsiung Armed Forces General Hospital

Sex: All·Age: 20 - 65·Accepts healthy volunteers

Code: NCT07666633

Alterations in Spiking Following Muscle Fatigue in Volleyball Players

for Fatigue

Sponsor: National Yang Ming Chiao Tung University

Sex: All·Age: 18 - 35·Accepts healthy volunteers

Code: NCT07687550

Core Stability, Functional Capacity, Balance, Strength, and Fatigue in Pediatric Demyelinating Diseases

for Demyelinating Diseases of the Central Nervous System

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 6 - 18

Code: NCT07654738

Does Fatigue Coaching Improve Functioning and Fatigue in Resident Night Shifts

for Fatigue

1 site in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06100809

Effect of Virtual Reality-Guided Imagery on Pain, Anxiety, and Fatigue in Cancer Patients Undergoing Chemotherapy

for Virtual Reality

Sponsor: Thoalfokar Mohammed Al-Obaidi

Sex: Female·Age: 18+

Code: NCT07677436

Radicle Energy VBMTM: A Study Assessing the Impact of Health and Wellness Products on Fatigue and Related Health Outcomes

for Fatigue

1 site in Del Mar

Sponsor: Radicle Science

Sex: All·Age: 21 - 105·Accepts healthy volunteers

Code: NCT07653724

Cognitive Reserve and Post-Fatigue Recovery in Older Adults

for Cognitive Reserve

Sponsor: Uşak University

Sex: All·Age: 65 - 90·Accepts healthy volunteers

Code: NCT07667985

Apply to this trial

Transcranial Magnetic Stimulation for Depression in Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Calgary

Sex: All·Age: 18 - 65

Code: NCT07562074·Phase 1

A Phase 3 Efficacy and Safety Study of HBS-301 in Participants With Narcolepsy

for EDS

14 sites incl. Peoria

Sponsor: Harmony Biosciences Management, Inc.

Sex: All·Age: 18+

Code: NCT07675135·Phase 3

Apply to this trial

Bupropion for Fatigue in End-stage Kidney Disease Patients on Hemodialysis

for End Stage Renal Disease

1 site in San Antonio

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 25 - 74

Code: NCT06609343·Phase 1, Phase 2

The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT07504120

Reflexology Versus Progressive Muscle Relaxation for Fatigue in Hemodialysis Patients

for End Stage Renal Failure, Hemodialysis

Sponsor: Cairo University

Sex: All·Age: 50 - 70

Code: NCT07575607

Photobiomodulation Effects on Fatigue and Muscle Damage Induced by NMES

for Photobiomodulation

Sponsor: Federal University of Rio Grande do Sul

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07602933

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ROBO-PAWS: Robot-Dog-Assisted Walking

for Sleep Quality

Sponsor: Koç University

Sex: All·Age: 2 - 7

Code: NCT07603180

Association Between Sarcopenia, Fatigue and Orthostatic Intolerance in Geriatric Patients: A Case Control Study

for Sarcopenia

Sponsor: Ain Shams University

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07564830

The Effect of Art-Based Intervention on Fatigue, Anxiety, Perception of Nurse Presence, and Quality of Life in Patients With Hematological Cancers

for Art-based Intervention

Sponsor: Gazi University

Sex: All·Age: 18 - 65

Code: NCT07551817

Effect of Acupuncture on Psychoneurological Symptom Cluster in Breast Cancer Survivors

for Psychoneurological Symptom Cluster(Pain, Insomnia, Anxiety, Fatigue, Depression, Subjective Cognitive Decline)

Sponsor: First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

Sex: Female·Age: 18 - 75

Code: NCT07481903

Explanatory Factors and Predictors of Fatigue in Patients With Sjögren's Disease: A 3-month Longitudinal Study

for Sjogren's Disease

Sponsor: Kahramanmaras Sutcu Imam University

Sex: All·Age: 18+

Code: NCT07544394

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Laser Acupuncture for Fatigue in Hemodialysis Patients

for ESRD (End Stage Renal Disease)

Sponsor: Taipei City Hospital

Sex: All·Age: 18+

Code: NCT07538310

TESTING AN MTM THEORY-BASED INTERVENTION ON REDUCING DROWSY DRIVING BEHAVIOR, "STAY AWAKE, STAY ALIVE ©," AMONG COLLEGE STUDENTS

for Drowsiness

1 site in Las Vegas

Sponsor: University of Nevada, Las Vegas

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07434921

Virtual Patient Groups for Sarcoidosis Associated Fatigue

for Sarcoidosis

1 site in Cleveland

Sponsor: The Cleveland Clinic

Sex: All·Age: 18+

Code: NCT07073963

Apply to this trial

The Effects of Acupressure and Massage Following Cesarean Section

for Pain Management

Sponsor: Marmara University

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07432074

Investigation of the Relationship Between Periodontitis and Sleep Quality

for Periodontitis

Sponsor: Uskudar University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07421960

Apply to this trial

CF Wellness Program

for Cystic Fibrosis (CF)

3 sites incl. Denver

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT07071324

Apply to this trial

Modafinil For Fatigue in IBD: A Feasibility Randomised Controlled Trial

for Crohn Disease (CD)

Sponsor: Imperial College London

Sex: All·Age: 18+

Code: NCT07295834·Phase 2

The Impact of Fatigue on Quality of Life and Activities of Daily Living in Pediatric Oncology Patients

for Childhood Cancer

Sponsor: Medipol University

Sex: All·Age: 2 - 18

Code: NCT07606170

Modafinil to Improve Fatiguability

for Cancer-related Cognitive Difficulties

Sponsor: Ottawa Hospital Research Institute

Sex: All·Age: 18+

Code: NCT05333250·Phase 1, Phase 2

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The Effect of Progressive Muscle Relaxation and Deep Breathing Exercises Applied to Palliative Care Cancer Patients on Dyspnea, Fatigue, and Self-Care Behaviors

for Cancer

Sponsor: Ankara University

Sex: All·Age: 18+

Code: NCT07619209

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The Effects of an App-based Acupressure on Alleviating Fatigue, Pruritus, and Sleep Quality Among Hemodialysis Patients

for Hemodialysis Patient

Sponsor: Taipei Medical University

Sex: All·Age: 18+

Code: NCT07259369

Effect of Autogenic Training on Hemodialysis Patients

for Hemodialysis Patient

Sponsor: Cairo University

Sex: All·Age: 45 - 55

Code: NCT07276828

The Effect of a Passive Hip Exoskeleton on Daily-life Fatigue in Older Adults

for Fatigue

Sponsor: Vrije Universiteit Brussel

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT07359573

Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors

for Fatigue

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 65+·Accepts healthy volunteers

Code: NCT06819254·Phase 4

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Fatigue and Skeletal Muscle Impact in Severe Axial Spondyloarthritis

for Spondyloarthritis, Axial

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT03940911

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Lifting More Than Weights: Resistance Exercise Program Across Socioeconomic Groups for Cancer-Related Fatigue Management

for Breast Cancer

1 site in Morgantown

Sponsor: West Virginia University

Sex: Female·Age: 18+

Code: NCT06960720

Apply to this trial

Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS

for Fatigue

Sponsor: University Medical Center Groningen

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06432686

Randomized, Open-label, Safety Study of Subcutaneous and Intramuscular Injections of Niagen® Plus

for Healthy Volunteer

1 site in Miami

Sponsor: ChromaDex, Inc.

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07251608·Phase 1

Apply to this trial

Validation and Evaluation of the Mastication Function in Adults: The Functional Six-minute Mastication Test (F-6MMT).

for Mastication Disorder

Sponsor: Fundació Universitària del Bages

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06298786

Modafinil and Exercise for Post Stroke Fatigue

for Stroke

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT06354985·Phase 3

Effect of Agarwood (Aquilaria Sinensis) Inhalation Aromatherapy on Workplace Fatigue and Sleep Quality Among Hospital Employees: A Randomized Controlled Trial

for Fatigue

Sponsor: Da-Yeh University

Sex: All·Age: 20+

Code: NCT07188831

Effect of Adding Progressive Muscle Relaxation to Physical Therapy Program on Fatigue, Mobility and Stress Among Individuals With Traumatic Lower Limb Amputation in the Gaza Strip

for Traumatic Lower Limb Amputation

Sponsor: Marah Radi

Sex: All·Age: 18 - 59

Code: NCT07139145

Cancer-related Fatigue and Its Biological Contributors in Adolescent and Young Adult Brain Tumor Survivors: Effects of a Tele-exercise Intervention

for Cancer

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18 - 39

Code: NCT07186556

Apply to this trial

"Balance, Gait, and Motion Analysis in Multiple Sclerosis"

for Multiple Sclerosis

Sponsor: University of Patras

Sex: All·Age: 18+

Code: NCT07630311

Apply to this trial

Evaluation of NuvastaticTM in Reducing Cancer-Related Fatigue in Stage IV Colon Cancer Patients Undergoing First-Line Chemotherapy

for Fatigue

Sponsor: Natureceuticals Sdn Bhd

Sex: All·Age: 18 - 65

Code: NCT07669519·Phase 3

Apply to this trial

Clinical Trial of the Seaweed Supplement Fucoidan in Survivors of Cancer

for Fatigue

1 site in Rochester

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT06295588·Phase 2

Apply to this trial

Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2

for PASC Post Acute Sequelae of COVID 19

1 site in Baltimore

Sponsor: Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07278388

Apply to this trial

Exercise Therapy and Cognitive Behavioural Therapy for Fatigue in Female Cancer Patients in Singapore

for Fatigue

Sponsor: National Cancer Centre, Singapore

Sex: Female·Age: 21+

Code: NCT07116161

Apply to this trial

Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome

for Post-Acute COVID-19 Syndrome

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 50 - 94

Code: NCT05977179

Apply to this trial

Effects of Physical Fatigue on Cognitive Load and Performance Under Dual-Task Environments.

for Fatigue

Sponsor: Riphah International University

Sex: All·Age: 18 - 30·Accepts healthy volunteers

Code: NCT06941701

Apply to this trial

Pursuing Reduction in Fatigue After COVID-19 Via Exercise and Rehabilitation (PREFACER): A Randomized Feasibility Trial

for Long-COVID

Sponsor: Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT06156176

Apply to this trial

Test-retest Reliability of Myocene

for Reliability

Sponsor: University of Maia

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT06830447

Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury

for Fatigue Symptom

Sponsor: Rigshospitalet, Denmark

Sex: All·Age: 30 - 65·Accepts healthy volunteers

Code: NCT07135791

Apply to this trial

Capturing Key MG-symptoms Using Smartphone Recordings.

for Myasthenia Gravis

Sponsor: Leiden University Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06743490

Apply to this trial

Impact of Intermittent Fasting on Sleep and Quality of Life

for Sleep Quality

Sponsor: Université Libre de Bruxelles

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06959069

Apply to this trial

Patient Descriptors Of Cancer-Related Fatigue: A Mixed Methods Pilot Study Of Cancer Survivors

for Cancer

3 sites incl. Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06634381

Apply to this trial

Effect of Neuromuscular Electrical Stimulation of Lower Limbs on Improving Exercise Self-Efficacy, Dyspnea During Activity and Fatigue in Patients With Chronic Obstructive Pulmonary Disease

for Chronic Obstructive Pulmonary Disease (COPD)

Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Sex: All·Age: 18+

Code: NCT06851195

Functional and Performance Determinants in Climbers: Examining the Role of Mobility, Stability, and Fatigue Across Proficiency Levels

for Fatigue

Sponsor: Medical University of Gdansk

Sex: All·Age: 15 - 45·Accepts healthy volunteers

Code: NCT06830655

Fatigue clinical trials — common questions

Are fatigue clinical trials free to join?

Yes. Participating in a fatigue clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a fatigue clinical trial?

Each fatigue study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a fatigue trial near me?

Use the location controls above. We'll show recruiting fatigue trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many fatigue trials are recruiting right now?

We're currently tracking roughly 39 recruiting fatigue trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Fatigue trials by city

Birmingham, AL Boston, MA Chicago, IL Cincinnati, OH Cleveland, OH Denver, CO Gainesville, FL Miami, FL