Gastrointestinal cancer Clinical Trials

Recruiting gastrointestinal cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat gastrointestinal cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting gastrointestinal cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting gastrointestinal cancer trials

Within

GutCheck: Optimization of a Personalized Mobile Health App for Survivors of Gastrointestinal Cancer

for Gastrointestinal

Sponsor: Masonic Cancer Center, University of Minnesota

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07661017

A Study of Selective Internal Radiation Therapy for the Management of Chemotherapy-induced Thrombocytopenia With Splenomegaly in Adult Subjects With Gastrointestinal Cancer

for Gastrointestinal Cancer

Sponsor: Centre Georges Francois Leclerc

Sex: All·Age: 18+

Code: NCT07575854

EAT-ING: Enhancing Anticancer Treatment Safety Via Immunomodulatory Nutritional Support in Advanced Gastrointestinal Cancers

for Gastrointestinal Cancer

Sponsor: IRCCS San Raffaele

Sex: All·Age: 18+

Code: NCT07590622

Digitally Supported Prehabilitation Before Major Visceral Cancer Surgery

for Gastrointestinal Neoplasms

Sponsor: Ludwig Boltzmann Institute for Digital Health and Prevention

Sex: All·Age: 18+

Code: NCT07658313

Non-Operative Management and Following Immunotherapy for Colorectal Cancer and Other GI Cancers

for Gastrointestinal Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: All·Age: All ages

Code: NCT07656740

Food-related Quality of Life in Patients With Cancer

for Breast Cancer

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07437326

Study of High-Precision Evaluation of Molecular ResiduaL Disease Through a PlatfOrm for Cancer TracKing and Interception (SHERLOCK)

for Breast Cancer

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT07524114

Apply to this trial

Safety, Tolerance and Preliminary Efficacy of XH001 Injection Combined With Neoantigen Vaccine-induced Tumor-specific T-cell Injection in Advanced Gastrointestinal Cancer

for Gastrointestinal Cancer

Sponsor: Beijing GoBroad Hospital

Sex: All·Age: 18 - 70

Code: NCT07329894·Phase 1

Apply to this trial

DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.

for Haematological Malignancy

Sponsor: Cancer Research UK

Sex: All·Age: 1+

Code: NCT07440290·Phase 2, Phase 3

A Study of DB-1324 in Advanced/Metastatic Gastrointestinal Tumors

for Gastrointestinal Cancer

4 sites incl. Port Saint Lucie

Sponsor: DualityBio Inc.

Sex: All·Age: 18+

Code: NCT07263594·Phase 1, Phase 2

Apply to this trial

Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)

for Gastrointestinal Cancer

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18+

Code: NCT07124351·Phase 4

Apply to this trial

Hyperthermia Combined With Immune Checkpoint Inhibitors in the Treatment of Advanced Gastrointestinal Malignancies With Liver Metastases

for Gastrointestinal Cancer

Sponsor: China Medical University, China

Sex: All·Age: 18 - 75

Code: NCT07118566·Phase 2

Evaluating Microarray Pharmacogenetic Testing in Cancer Patients

for Cancer

1 site in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT06489041

Apply to this trial

Postbiotics for Mitigation of Postoperative Dysbiosis in Gastrointestinal Cancer Surgery

for Colon Cancer

2 sites in Tampa

Sponsor: University of South Florida

Sex: All·Age: 18+

Code: NCT07050485

BOLSTER: Learning New Skills to Thrive

for Gastrointestinal Cancer

2 sites incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT06936878

Apply to this trial

Total Neoadjuvant FLOT Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Cancer

for Gastric Cancer

Sponsor: Ukrainian Society of Clinical Oncology

Sex: All·Age: 18 - 80

Code: NCT06028737·Phase 2, Phase 3

Apply to this trial

Evaluation of the Preliminary Efficacy and Safety of DR30206 in Combination With Standard Therapy in Patients With Gastrointestinal Cancer

for Gastrointestinal Cancer

Sponsor: Zhejiang Doer Biologics Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07056777·Phase 1, Phase 2

Apply to this trial

Extracellular Vesicles and Chemotherapy-Induced Peripheral Neuropathy

for Chemotherapy-Induced Peripheral Neuropathy

Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Sex: All·Age: 18+

Code: NCT07558447

Apply to this trial

Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT

for Cancer

1 site in San Francisco

Sponsor: University of California, San Francisco

Sex: All·Age: 18+

Code: NCT06633224

Apply to this trial

Palliative Radiotherapy in Symptomatic Pelvic Soft Tissue Tumors

for Gastrointestinal Cancer

Sponsor: Sykehuset Telemark

Sex: All·Age: 18+

Code: NCT06398314

Apply to this trial

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

for Gastrointestinal Cancer

1 site in Cleveland

Sponsor: Case Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT06263088

Apply to this trial

Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy

for Gastrointestinal Cancer

1 site in Detroit

Sponsor: Henry Ford Health System

Sex: All·Age: 18+

Code: NCT06065371·Phase 1

Apply to this trial

PhI Pilot Study Pafolacianine Inject for Intraoperative Imaging on Outcomes of GI Cancer Peritoneal Carcinomatosis

for Gastrointestinal Cancer

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT06511037·EARLY_Phase 1

Apply to this trial

Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)

for Gastrointestinal Cancer

8 sites incl. Aurora

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06596694·Phase 1, Phase 2

Apply to this trial

Dyadic Sleep Study

for Gastrointestinal Cancer

1 site in Coral Gables

Sponsor: University of Miami

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06569693

Apply to this trial

Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple Myeloma

for Ovarian Cancer

10 sites incl. Los Angeles

Sponsor: Nammi Therapeutics Inc

Sex: All·Age: 18+

Code: NCT06582017·Phase 1

Apply to this trial

REmote Symptom COllection to improVE postopeRative Care

for Gastrointestinal Cancer

2 sites incl. Baltimore

Sponsor: Medstar Health Research Institute

Sex: All·Age: 18+

Code: NCT06190730

Apply to this trial

A Study of GC203 TIL in Advanced Malignant Solid Tumors

for Solid Tumor

Sponsor: Shanghai Juncell Therapeutics

Sex: All·Age: 18 - 75

Code: NCT06375187·Phase 1

Apply to this trial

Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors

for Colorectal Cancer

32 sites incl. Chandler

Sponsor: Revolution Medicines, Inc.

Sex: All·Age: 18+

Code: NCT06445062·Phase 1, Phase 2

Apply to this trial

Goals of Care Discussion for Patients With Advanced Lung and Gastrointestinal Cancer in the Emergency Department of a Comprehensive Cancer Center

for Lung Cancer

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 18+

Code: NCT06420206

Apply to this trial

EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope

for Pancreatic Disease

1 site in Orlando

Sponsor: Orlando Health, Inc.

Sex: All·Age: 18 - 100

Code: NCT06340620

Apply to this trial

BGT007 Cells for the Treatment of Refractory Digestive System Tumors

for Gastrointestinal Cancer

Sponsor: The Affiliated Hospital of Xuzhou Medical University

Sex: All·Age: 18 - 70

Code: NCT06104241·EARLY_Phase 1

Apply to this trial

JUMP_START - Optimization of Care for Young Cancer Patients with Gastrointestinal Tumors

for Gastrointestinal Cancer

Sponsor: University Hospital Heidelberg

Sex: All·Age: 18+

Code: NCT06621277

Apply to this trial

A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue

for Invasive Ductal Breast Carcinoma

7 sites incl. Basking Ridge

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT05837767

Apply to this trial

Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor Microenvironment

for Solid Tumors

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT05600933

A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

for Gastrointestinal Cancer

8 sites incl. Hartford

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT05789485·Phase 2

Apply to this trial

SURGE: Supporting UnderRepresented Minorities in Genomics-based Cancer Trial Enrollment (Intervention)

for Gastrointestinal Cancer

3 sites incl. Boston

Sponsor: Nadine McCleary, MD, MPH

Sex: All·Age: 18+

Code: NCT05375643

Apply to this trial

Disease Outcomes and Toxicities in Patients With Gastrointestinal and Sarcomatous Malignancies

for Sarcoma

1 site in Chapel Hill

Sponsor: UNC Lineberger Comprehensive Cancer Center

Sex: All·Age: 18+

Code: NCT05743426

Apply to this trial

Frailty in Patients With Gastrointestinal Cancer Who Are Undergoing Major Surgery

for Gastrointestinal Cancer

2 sites incl. East Corning

Sponsor: The Guthrie Clinic

Sex: All·Age: 18+

Code: NCT05694338

Apply to this trial

Quality of Care in Relationship to Aborted Cancer Surgery

for Cancer

Sponsor: Linkoeping University

Sex: All·Age: 18+

Code: NCT05808712

Apply to this trial

Optimizing and Personalising Azacitidine Combination Therapy for Treating Solid Tumours QPOP and CURATE.AI

for Solid Tumor

Sponsor: National University Hospital, Singapore

Sex: All·Age: 21 - 99

Code: NCT05381038·Phase 1, Phase 2

Apply to this trial

Pemigatinib in the Advanced Gastrointestinal Cancer With FGFR 1-3 Alterations

for Gastrointestinal Cancer

Sponsor: Tianjin Medical University Cancer Institute and Hospital

Sex: All·Age: 18+

Code: NCT05651672·Phase 2

Apply to this trial

PSMA in Gastroenterologic Tumors (GIPSMA)

for Gastrointestinal Cancer

Sponsor: Wuerzburg University Hospital

Sex: All·Age: 18+

Code: NCT05547919

Apply to this trial

Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer Patients

for Gastric Cancer

3 sites incl. Palo Alto

Sponsor: Fox Chase Cancer Center

Sex: All·Age: 18+

Code: NCT05274048·Phase 1

Apply to this trial

Improving Comprehensive Care of Cancer Patients

for Breast Cancer

1 site in Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05323409

Apply to this trial

Resilience and Equity in Aging, Cancer, and Health (REACH)

for Gastric Cancer

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 70+

Code: NCT04674267

Apply to this trial

Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies

for Peritoneal Mesothelioma

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 120

Code: NCT04847063·Phase 1

Apply to this trial

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

for Brain Cancer

2 sites in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT04899908·Phase 2

Apply to this trial

Electroporation for Cancer Treatment Real World Registry

for Skin Cancer

Sponsor: Mirai Medical

Sex: All·Age: All ages

Code: NCT04929912

Apply to this trial

EUS Guided HVA and PVA for Circulating Tumor DNA in Patients

for Circulating Tumor Cell

Sponsor: Chinese University of Hong Kong

Sex: All·Age: All ages

Code: NCT04782557

Apply to this trial

Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity

for Breast Cancer

Sponsor: British Columbia Cancer Agency

Sex: All·Age: 18+

Code: NCT04273061·Phase 2

Apply to this trial

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

for Healthy Volunteer

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04354064

Apply to this trial

OH2 Oncolytic Viral Therapy in Solid Tumors

for Solid Tumor

Sponsor: Binhui Biopharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT03866525·Phase 1, Phase 2

Apply to this trial

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

for Pancreatic Cancer

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18 - 72

Code: NCT03190941·Phase 1, Phase 2

Apply to this trial

Ontario-wide Cancer TArgeted Nucleic Acid Evaluation

for Breast Cancer

Sponsor: University Health Network, Toronto

Sex: All·Age: 18+

Code: NCT02906943

Apply to this trial

Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies

for Head and Neck Cancer

1 site in Baltimore

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: 18+

Code: NCT05995821

Apply to this trial

Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal Cancer

for Non-GI Cancers

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT01313442

Apply to this trial

Harvesting Cells for Experimental Cancer Treatments

for Melanoma

1 site in Bethesda

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT00068003

Gastrointestinal cancer clinical trials — common questions

Are gastrointestinal cancer clinical trials free to join?

Yes. Participating in a gastrointestinal cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a gastrointestinal cancer clinical trial?

Each gastrointestinal cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a gastrointestinal cancer trial near me?

Use the location controls above. We'll show recruiting gastrointestinal cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many gastrointestinal cancer trials are recruiting right now?

We're currently tracking roughly 32 recruiting gastrointestinal cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Gastrointestinal cancer trials by city

Boston, MA Los Angeles, CA Aurora, CO Cleveland, OH Coral Gables, FL Detroit, MI Orange, CA Orlando, FL Palo Alto, CA San Francisco, CA Tampa, FL

Related specialties

Oncology GI oncology