Sepsis Clinical Trials

Recruiting sepsis studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat sepsis. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting sepsis studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting sepsis trials

Within

The Extended Study of Prevalence of Infection in Intensive Care IV

for Sepsis

Sponsor: Universidad de la Sabana

Sex: All·Age: 18+

Code: NCT07309549

Biological Effects of Hemoadsorption in Septic Shock

for Septic Shock, Vasopressor Resistance

Sponsor: Miguel Sanchez Garcia

Sex: All·Age: 18+

Code: NCT07715110

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress

for Critical Illness

3 sites incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

for Sepsis

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 18+

Code: NCT01315782

STeroids and Enhanced Spectrum Antibiotics for the Treatment of Patients in Africa With Refractory Sepsis

for Sepsis

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT07332325·Phase 3

Extended vs. Intermittent Beta-Lactam Infusion in ICU Sepsis

for Sepsis

Sponsor: Assiut University

Sex: All·Age: 18 - 65

Code: NCT07398703

Ulinastatin on Systemic Immune-Inflammation in Patients With Complicated Intra-Abdominal Infection

for Complicated Intra-abdominal Infection (cIAI)

Sponsor: Fujian Medical University Union Hospital

Sex: All·Age: 18+

Code: NCT07672496

Evaluation of biomArkers for Quick SEpsis Diagnosis - ErASED Study

for Sepsis

Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia

Sex: All·Age: 18+

Code: NCT07655154

Monitoring of Septic Shock-induced Immunosuppression

for Sepsis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07698093

CBC Indices and Serum Lactate in Neonatal Sepsis

for Neonatal Sepsis

Sponsor: Assiut University

Sex: All·Age: 0 Days - 28 Days

Code: NCT07663084

Development of Context-Adapted Quality Indicators for Early Sepsis Care in Sub-Saharan Africa - A Modified Delphi Consensus Procedure

for Sepsis

Sponsor: Charite University, Berlin, Germany

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07711535

Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery

for Sepsis

Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07601256

Effects of Anisodamine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock

for Septic Shock

Sponsor: First Affiliated Hospital of Wannan Medical College

Sex: All·Age: 18 - 85

Code: NCT07657702

Effects of Dexmedetomidine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock

for Septic Shock

Sponsor: First Affiliated Hospital of Wannan Medical College

Sex: All·Age: 18 - 85

Code: NCT07657715

Effects of Esmolol on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock

for Septic Shock

Sponsor: First Affiliated Hospital of Wannan Medical College

Sex: All·Age: 18 - 85

Code: NCT07657754

Wearable Sweat Sensor for High-Concentration Lactate Monitoring in Critically Ill Patients

for Sepsis

Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University

Sex: All·Age: 16+

Code: NCT07716371

Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine

for Sepsis

Sponsor: Theis S. Itenov

Sex: All·Age: 18+

Code: NCT07273071·Phase 4

Evaluating the Diagnostic Performance and Impact on Clinical Outcomes of the NuRapid-CRISPR Pathogen Profile Assay in ICU Patients With Sepsis

for Sepsis

Sponsor: Shanghai 10th People's Hospital

Sex: All·Age: All ages

Code: NCT07580001

Integration of Wearable Sensor Devices Into a Single System to Predict the Onset of Sepsis

for Sepsis

Sponsor: Check Point R & D Ltd

Sex: All·Age: 18 - 100

Code: NCT07595848

Effect of Targeting Upper Normal Serum Magnesium Levels on Norepinephrine Requirements in Septic Shock Patients

for Septic Shock

Sponsor: Alexandria University

Sex: All·Age: 18+

Code: NCT07716956

Myeloid Bias in the Bone Marrow of Septic Patients and Its Correlation With Disease Severity and Prognosis: A Single-Center, Prospective Cohort Study

for Sepsis

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07667153

FMT for 90-Day Outcome of Clinical Use in ICU Sepsis

for Sepsis

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 70

Code: NCT07670299

Metabolic and Functional Study of γδ T Cells in Critically Ill Patients

for Sepsis

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07680816

Extracorporeal cfDNA Removal in Septic Shock Patients With Elevated DNA Levels

for Sepsis

Sponsor: Sergey Savko

Sex: All·Age: 18 - 65

Code: NCT07657767

NAI for Sepsis With Persistent Lymphopenia

for Sepsis

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18+

Code: NCT07578558·Phase 2

Outer Membrane Vesicle and Ferroptosis-Related Signatures in Sepsis-Associated Acute Lung Injury Caused by Extra-Pulmonary Hypervirulent Klebsiella Pneumoniae

for Sepsis

Sponsor: Southeast University, China

Sex: All·Age: 18 - 85

Code: NCT07686887

Blood Purification in Septic Children

for Sepsis

Sponsor: Children's Hospital of Fudan University

Sex: All·Age: 29 Days - 18

Code: NCT05595239

Study of Protection And Repair of Endothelial-glycocalyx in Sepsis (SPARES)

for Sepsis

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT07160426·Phase 2

T6A Biomarker for Detection of Bacterial Infection in Newborn Infants

for Sepsis

Sponsor: Salzburger Landeskliniken

Sex: All·Age: All ages

Code: NCT07670624

The Effect of Early Intervention on the Incidence of Posttraumatic Stress Disorder After Intensive Care Hospitalization Due to Sepsis

for PTSD - Post Traumatic Stress Disorder

Sponsor: Barzilai Medical Center

Sex: All·Age: 18 - 120

Code: NCT07707765

Apply to this trial

Comparison of Sepsis Prediction Algorithms

for Sepsis

7 sites incl. Atlanta

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT05943938

Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2

for Myocardial Injury After Noncardiac Surgery (MINS)

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 65+

Code: NCT07300579

Sepsis in Critically Ill Patients

for Sepsis

Sponsor: Beijing Chao Yang Hospital

Sex: All·Age: 18+

Code: NCT07707622

Nafamostat Mesylate Versus Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury

for Sepsis

Sponsor: Jianfeng Xie

Sex: All·Age: 18 - 90

Code: NCT07518303·Phase 4

Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury

for Acute Kidney Injury

Sponsor: Centre Hospitalier Universitaire de Nīmes

Sex: All·Age: 18+

Code: NCT07236463·Phase 1, Phase 2

Apply to this trial

Saudi Emergency Laparotomy Audit

for Laparotomy

Sponsor: King Faisal Specialist Hospital & Research Center

Sex: All·Age: 14+

Code: NCT07429929

The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)

for Infection

1 site in Cooperstown

Sponsor: Bassett Healthcare

Sex: All·Age: 18+

Code: NCT07556107·Phase 4

A Multicenter Clinical Study of Romiplostim N01 in the Treatment of Sepsis-related Thrombocytopenia

for Sepsis

Sponsor: Shanghai 10th People's Hospital

Sex: All·Age: 18+

Code: NCT07595133·Phase 1

Sepsis Multiomic Analysis & Risk sTratification in China

for Sepsis

Sponsor: Yuebei People's Hospital

Sex: All·Age: 18+

Code: NCT07599644

Apply to this trial

Clinical Study Evaluating the Efficacy and Safety of Fenofibrates Versus Silymarin in Adult Patients With Sepsis

for Sepsis

Sponsor: Tanta University

Sex: All·Age: 18+

Code: NCT07572552·Phase 2

TDAP in Burn Patients (Group 2)

for Sepsis

3 sites incl. Tampa

Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine

Sex: All·Age: 18 - 80

Code: NCT07223684

Surgical Critical Care Initiative (SC2i) Tissue and Data Acquisition Protocol (TDAP) in Burn Patients Improving the Robustness and Generalizability of Post-burn Sepsis Prediction With the Post-Burn Sepsis Digital Twin. Group 1

for Sepsis

3 sites incl. Tampa

Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine

Sex: All·Age: 18 - 80

Code: NCT07249762

Fluorescent Leukocytes as a Marker of Early Sepsis/Severity

for Sepsis

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07585942

Racecadotril for Organ Injury in Sepsis Patients

for Sepsis

Sponsor: Zhujiang Hospital

Sex: All·Age: 18 - 80

Code: NCT07454421·Phase 1, Phase 2

MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients

for Sepsis

3 sites incl. Rochester

Sponsor: Health Discovery Labs

Sex: All·Age: 18 - 85

Code: NCT07362862

Apply to this trial

Validation of SOFA-2 for Mortality and Sepsis-3 Prevalence in Turkey

for Sepsis

Sponsor: Marmara University

Sex: All·Age: 18+

Code: NCT07300306

Apply to this trial

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial

for Sepsis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 37 Weeks+

Code: NCT06381661·Phase 2

Phosphate-Containing Replacement Fluid for Patients Undergoing CRRT

for Acute Kidney Injury

Sponsor: Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07550894·Phase 3

Load Incorporating Cardiac Assessment by Echocardiography In Patients With SEpsis (LIAISE Study)

for Sepsis

Sponsor: The University of Queensland

Sex: All·Age: 18+

Code: NCT07562217

Cortisol Levels and Mortality in Septic Shock ICU Patients

for Sepsis

Sponsor: Ankara Etlik City Hospital

Sex: All·Age: 18+

Code: NCT07582926

Apply to this trial

Immunothrombosis With Septic Shock Undergoing Renal Replacement Therapy With the OXIRIS Membrane

for Sepsis

Sponsor: University Hospital, Bordeaux

Sex: All·Age: 18+

Code: NCT06440317

Apply to this trial

A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients

for Infection

Sponsor: Semmelweis University

Sex: All·Age: 0 Hours - 17

Code: NCT07484633·Phase 4

Performance and Impact of the Sepsis ImmunoScore

for Sepsis

Sponsor: Prenosis, Inc.

Sex: All·Age: 18+

Code: NCT07543497

Aminoglycosides in Early Sepsis

for Sepsis

Sponsor: University Hospital, Akershus

Sex: All·Age: 18+

Code: NCT06712641·Phase 4

Apply to this trial

Vancomycin and Acute Kidney Injury in Sepsis Treatment - Intervention

for Sepsis

1 site in Philadelphia

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 1 Month - 17

Code: NCT07084129·Phase 1

Apply to this trial

Corticosteroids in Hyperinflammatory Phenotype of Critical Illness

for Sepsis

Sponsor: Bin Du

Sex: All·Age: 18+

Code: NCT07511582·Phase 2

Apply to this trial

Cardiovascular Phenotypes in Sepsis

for Sepsis

Sponsor: Karolinska Institutet

Sex: All·Age: 18+

Code: NCT07442032

Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness

for Sepsis

Sponsor: Ain Shams University

Sex: All·Age: 18+

Code: NCT07507877

Apply to this trial

Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool

for Sepsis

1 site in Washington D.C.

Sponsor: Computer Technology Associates, Inc.

Sex: All·Age: 3 Months - 45

Code: NCT05311046

Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients.

for Sepsis

Sponsor: Region Örebro County

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07406750

Sepsis clinical trials — common questions

Are sepsis clinical trials free to join?

Yes. Participating in a sepsis clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a sepsis clinical trial?

Each sepsis study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a sepsis trial near me?

Use the location controls above. We'll show recruiting sepsis trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many sepsis trials are recruiting right now?

We're currently tracking roughly 48 recruiting sepsis trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Sepsis trials by city

Boston, MA Gainesville, FL Birmingham, AL San Francisco, CA Tampa, FL Aurora, CO Berkeley, CA Cleveland, OH Denver, CO

Related specialties

Infectious disease