Sepsis Clinical Trials

Recruiting sepsis studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat sepsis. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting sepsis studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting sepsis trials

Within

Extended vs. Intermittent Meropenem Infusion in Sepsis Patients in the ICU

for Sepsis

Sponsor: Assiut University

Sex: All·Age: 18 - 65

Code: NCT07398703

The Extended Study of Prevalence of Infection in Intensive Care IV

for Sepsis

Sponsor: Universidad de la Sabana

Sex: All·Age: 18+

Code: NCT07309549

Biological Effects of Hemoadsorption in Septic Shock

for Septic Shock, Vasopressor Resistance

Sponsor: Miguel Sanchez Garcia

Sex: All·Age: 18+

Code: NCT07715110

Self-directed Mobile Mindfulness to Address ICU Survivors' Psychological Distress

for Critical Illness

3 sites incl. Los Angeles

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT07634419

Immune Dysregulation During Sepsis: A Natural History Cohort

for Sepsis

1 site in Falls Church

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT07735741

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

for Sepsis

1 site in Houston

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 18+

Code: NCT01315782

STeroids and Enhanced Spectrum Antibiotics for the Treatment of Patients in Africa With Refractory Sepsis

for Sepsis

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT07332325·Phase 3

Ulinastatin on Systemic Immune-Inflammation in Patients With Complicated Intra-Abdominal Infection

for Complicated Intra-abdominal Infection (cIAI)

Sponsor: Fujian Medical University Union Hospital

Sex: All·Age: 18+

Code: NCT07672496

EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDS

for Acute Hypoxemic Respiratory Failure

Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Sex: All·Age: 18+

Code: NCT07281911

Evaluation of biomArkers for Quick SEpsis Diagnosis - ErASED Study

for Sepsis

Sponsor: Fondazione IRCCS Policlinico San Matteo di Pavia

Sex: All·Age: 18+

Code: NCT07655154

Relation of Serum Phosphate Level to the Duration of Mechanical Ventilation in Patient With Sepsis

for Sepsis

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07739251

Value of Biomarkers of Brain Injury for Predicting Psycho-cognitive Sequelae Secondary to Sepsis: a Prospective Multicenter Study

for Sepsis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 80

Code: NCT07746050

Validation of a Capillary Leak Index During Septic Shock, Based on Haemoglobin Level Variations Induced by Fluid Resuscitation. A Pilot Study.

for Sepsis

Sponsor: University Hospital Center of Martinique

Sex: All·Age: 18+

Code: NCT07733206

NAI (Nogapendekin Alfa Inbakicept) Plus Standard of Care in Critically Ill Adults With Sepsis

for Sepsis

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18+

Code: NCT07783789·Phase 1, Phase 2

T6A Biomarker for Detection of Bacterial Infection in Newborn Infants

for Sepsis

Sponsor: Salzburger Landeskliniken

Sex: All·Age: All ages

Code: NCT07670624

Monitoring of Septic Shock-induced Immunosuppression

for Sepsis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18+

Code: NCT07698093

ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers

for Acute Respiratory Failure

1 site in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99

Code: NCT07778004

CBC Indices and Serum Lactate in Neonatal Sepsis

for Neonatal Sepsis

Sponsor: Assiut University

Sex: All·Age: 0 Days - 28 Days

Code: NCT07663084

Development of Context-Adapted Quality Indicators for Early Sepsis Care in Sub-Saharan Africa - A Modified Delphi Consensus Procedure

for Sepsis

Sponsor: Charite University, Berlin, Germany

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07711535

Apply to this trial

Personalized Fluid Resuscitation in the Emergency Department: A Pilot Trial

for Sepsis

1 site in Murray

Sponsor: Intermountain Health Care, Inc.

Sex: All·Age: 18+

Code: NCT07779720

Apply to this trial

The Vancomycin Piperacillin/Tazobactam (VPT) Patient Safety Trial (VPS)

for Infection

3 sites incl. Cooperstown

Sponsor: Bassett Healthcare

Sex: All·Age: 18+

Code: NCT07556107·Phase 4

Apply to this trial

Discordance Between Capillary Refill Time and Oxygen Extraction Ratio in Septic Shock

for Septic Shock

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18+

Code: NCT07774962

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Inhalational Versus Intravenous Anesthesia on Postoperative Lung Injury in Septic Patients Undergoing Surgery

for Sepsis

Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

Sex: All·Age: 18+

Code: NCT07601256

Point of Care - Sepsis Study

for Neonate

Sponsor: Medical University of Graz

Sex: All·Age: All ages

Code: NCT07774013

EAA-Guided AN69-oXiris and PMX-HP Therapy in Septic Patients

for Hemoperfusion

Sponsor: Kyoung Moo Im

Sex: All·Age: 18+

Code: NCT07788144

Effects of Anisodamine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock

for Septic Shock

Sponsor: First Affiliated Hospital of Wannan Medical College

Sex: All·Age: 18 - 85

Code: NCT07657702

Effects of Dexmedetomidine on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock

for Septic Shock

Sponsor: First Affiliated Hospital of Wannan Medical College

Sex: All·Age: 18 - 85

Code: NCT07657715

Effects of Esmolol on Sublingual Microcirculation and Vascular Waterfall Phenomenon in Patients With Septic Shock

for Septic Shock

Sponsor: First Affiliated Hospital of Wannan Medical College

Sex: All·Age: 18 - 85

Code: NCT07657754

Wearable Sweat Sensor for High-Concentration Lactate Monitoring in Critically Ill Patients

for Sepsis

Sponsor: Second Affiliated Hospital of Xi'an Jiaotong University

Sex: All·Age: 16+

Code: NCT07716371

EEG Changes and Cognitive Profiles in Sepsis Patients With Different Inflammatory Phenotypes

for Sepsis

Sponsor: Xiangya Hospital of Central South University

Sex: All·Age: 18 - 90

Code: NCT07760415

Plasma Neprilysin for Predicting Sepsis Within 48 Hours in ICU Patients With Infection or Suspected Infection

for Sepsis

Sponsor: Zhujiang Hospital

Sex: All·Age: 18+

Code: NCT07796386

Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine

for Sepsis

Sponsor: Theis S. Itenov

Sex: All·Age: 18+

Code: NCT07273071·Phase 4

Evaluating the Diagnostic Performance and Impact on Clinical Outcomes of the NuRapid-CRISPR Pathogen Profile Assay in ICU Patients With Sepsis

for Sepsis

Sponsor: Shanghai 10th People's Hospital

Sex: All·Age: All ages

Code: NCT07580001

Integration of Wearable Sensor Devices Into a Single System to Predict the Onset of Sepsis

for Sepsis

Sponsor: Check Point R & D Ltd

Sex: All·Age: 18 - 100

Code: NCT07595848

Effect of Targeting Upper Normal Serum Magnesium Levels on Norepinephrine Requirements in Septic Shock Patients

for Septic Shock

Sponsor: Alexandria University

Sex: All·Age: 18+

Code: NCT07716956

Triage Performance and Physiological Predictors of Serious Illness in Febrile Children in the Pediatric Emergency Department

for Fever

Sponsor: TC Erciyes University

Sex: All·Age: 0 - 18

Code: NCT07739004

Apply to this trial

Personalized Nutritional Formula for ICU Patients: A Study on Prognosis and Multidimensional Health Markers

for Sepsis

Sponsor: Chinese Medical Association

Sex: All·Age: 18+

Code: NCT07755033

Myeloid Bias in the Bone Marrow of Septic Patients and Its Correlation With Disease Severity and Prognosis: A Single-Center, Prospective Cohort Study

for Sepsis

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07667153

FMT for 90-Day Outcome of Clinical Use in ICU Sepsis

for Sepsis

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 70

Code: NCT07670299

Metabolic and Functional Study of γδ T Cells in Critically Ill Patients

for Sepsis

Sponsor: Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT07680816

Dynamic Infection Kinetics for Early Diagnosis, Monitoring, and Prognostication of Sepsis in Adult Oncology Patients: Evaluating Serial Infection Biomarkers, Blood Culture Kinetics, Treatment Response, Disease Severity, and Clinical Outcomes

for Sepsis

Sponsor: Sohag University

Sex: All·Age: 18+

Code: NCT07795502

Apply to this trial

Extracorporeal cfDNA Removal in Septic Shock Patients With Elevated DNA Levels

for Sepsis

Sponsor: Sergey Savko

Sex: All·Age: 18 - 65

Code: NCT07657767

Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial

for Sepsis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 37 Weeks+

Code: NCT06381661·Phase 2

Apply to this trial

NAI for Sepsis With Persistent Lymphopenia

for Sepsis

Sponsor: ImmunityBio, Inc.

Sex: All·Age: 18+

Code: NCT07578558·Phase 2

Outer Membrane Vesicle and Ferroptosis-Related Signatures in Sepsis-Associated Acute Lung Injury Caused by Extra-Pulmonary Hypervirulent Klebsiella Pneumoniae

for Sepsis

Sponsor: Southeast University, China

Sex: All·Age: 18 - 85

Code: NCT07686887

Peripheral Perfusion Index Trajectory to Predict 28-Day Mortality in Patients With Sepsis in the Intensive Care Unit

for Sepsis

Sponsor: Trakya University

Sex: All·Age: 18+

Code: NCT07740304

Apply to this trial

Blood Purification in Septic Children

for Sepsis

Sponsor: Children's Hospital of Fudan University

Sex: All·Age: 29 Days - 18

Code: NCT05595239

Study of Protection And Repair of Endothelial-glycocalyx in Sepsis (SPARES)

for Sepsis

Sponsor: Beth Israel Deaconess Medical Center

Sex: All·Age: 18+

Code: NCT07160426·Phase 2

The Effect of Early Intervention on the Incidence of Posttraumatic Stress Disorder After Intensive Care Hospitalization Due to Sepsis

for PTSD - Post Traumatic Stress Disorder

Sponsor: Barzilai Medical Center

Sex: All·Age: 18 - 120

Code: NCT07707765

Apply to this trial

Comparison of Sepsis Prediction Algorithms

for Sepsis

7 sites incl. Atlanta

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT05943938

Vascular Events in Noncardiac Surgery Patients Cohort Evaluation Study 2

for Myocardial Injury After Noncardiac Surgery (MINS)

Sponsor: Hamilton Health Sciences Corporation

Sex: All·Age: 65+

Code: NCT07300579

Sepsis in Critically Ill Patients

for Sepsis

Sponsor: Beijing Chao Yang Hospital

Sex: All·Age: 18+

Code: NCT07707622

Immunity in Critical Sepsis

for Sepsis

Sponsor: Beijing Chao Yang Hospital

Sex: All·Age: 18+

Code: NCT07770347

Long-term Assessment of Patients Treated in the ICU for Sepsis

for Sepsis

Sponsor: Hospital Israelita Albert Einstein

Sex: All·Age: 18+

Code: NCT07502794

Apply to this trial

Call for Life Sepsis

for Sepsis

Sponsor: Makerere University

Sex: All·Age: 18+

Code: NCT07407868

Apply to this trial

Nafamostat Mesylate Versus Regional Citrate Anticoagulation for Continuous Renal Replacement Therapy in Sepsis-Associated Acute Kidney Injury

for Sepsis

Sponsor: Jianfeng Xie

Sex: All·Age: 18 - 90

Code: NCT07518303·Phase 4

Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury

for Acute Kidney Injury

Sponsor: Centre Hospitalier Universitaire de Nīmes

Sex: All·Age: 18+

Code: NCT07236463·Phase 1, Phase 2

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Saudi Emergency Laparotomy Audit

for Laparotomy

Sponsor: King Faisal Specialist Hospital & Research Center

Sex: All·Age: 14+

Code: NCT07429929

A Multicenter Clinical Study of Romiplostim N01 in the Treatment of Sepsis-related Thrombocytopenia

for Sepsis

Sponsor: Shanghai 10th People's Hospital

Sex: All·Age: 18+

Code: NCT07595133·Phase 1

Sepsis Multiomic Analysis & Risk sTratification in China

for Sepsis

Sponsor: Yuebei People's Hospital

Sex: All·Age: 18+

Code: NCT07599644

Apply to this trial

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Sepsis clinical trials — common questions

Are sepsis clinical trials free to join?

Yes. Participating in a sepsis clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a sepsis clinical trial?

Each sepsis study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a sepsis trial near me?

Use the location controls above. We'll show recruiting sepsis trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many sepsis trials are recruiting right now?

We're currently tracking roughly 48 recruiting sepsis trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Sepsis trials by city

Boston, MA Birmingham, AL Gainesville, FL San Francisco, CA Tampa, FL Aurora, CO Berkeley, CA Cleveland, OH Denver, CO

Related specialties

Infectious disease