Prediabetes Clinical Trials

Recruiting prediabetes studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat prediabetes. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting prediabetes studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting prediabetes trials

Within

Cardiometabolic & Cognitive Effects of Peanut Butter in Prediabetes

for Prediabetes

1 site in University Park

Sponsor: Penn State University

Sex: All·Age: 40 - 65

Code: NCT07714096

Time to Healthy Lifestyle Habit Using Digital Health Tools in Adults at Risk of Diabetes

for Prediabetes

Sponsor: Imam Abdulrahman Bin Faisal University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07667361

Exocrine-Endocrine Pancreatic Crosstalk: Precision Pathways to Reframe Diabetes Pathophysiology

for Type 2 Diabetes Mellitus (T2DM)

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 20 - 78

Code: NCT07670871

Fiber mHealth Intervention for Prediabetes

for Prediabetes

1 site in Tulsa

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 39

Code: NCT07491653

Apply to this trial

Trial of CGM Technology in Persons Living With Prediabetes

for Prediabetes

1 site in Winston-Salem

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 18+

Code: NCT07639593

Mediterranean Diet and Blood Sugar Study

for Prediabetes

Sponsor: Penn State University

Sex: All·Age: 25 - 65

Code: NCT07229781

Risk-informed Shared-decision Making Engagement Strategy for Patients With Prediabetes

for Prediabetes

1 site in Frederick

Sponsor: Johns Hopkins University

Sex: All·Age: 18 - 75

Code: NCT07553325

Community Dining, Walking, and Glucose in Older Adults

for Prediabetes

Sponsor: Yang Zhang

Sex: All·Age: 60 - 79

Code: NCT07695675

Apply to this trial

Training Induced Muscle-Adipose EV Communication

for Prediabetes

1 site in Lexington

Sponsor: Yuan Wen

Sex: All·Age: 30 - 55·Accepts healthy volunteers

Code: NCT07106450

Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)

for Prediabetes

Sponsor: Shandong Provincial Hospital

Sex: All·Age: 18 - 75

Code: NCT07654062·Phase 4

Human Pilot Study for the Investigation of the Role of Bilberry and Olive Bioactives on Oxidative Stress Parameters and Inflammatory Markers.

for Prediabetes

Sponsor: National and Kapodistrian University of Athens

Sex: All·Age: 30 - 50·Accepts healthy volunteers

Code: NCT07659028

Safety and Dose-Response of Bletilla Formosana in Prediabetic Subjects

for Prediabetes

Sponsor: Chang Gung Memorial Hospital

Sex: All·Age: 30 - 70

Code: NCT07704944·Phase 1, Phase 2

Effects of Postprandial Walking and Resistance Snacking on Glucose Responses in Adults With Metabolic Syndrome

for Metabolic Syndrome

Sponsor: Seoul National University

Sex: All·Age: 40 - 65

Code: NCT07620886

Food and Metabolism Study

for Prediabetes

1 site in Chicago

Sponsor: Clinical Nutrition Research Center, Illinois Institute of Technology

Sex: All·Age: 40 - 70·Accepts healthy volunteers

Code: NCT07624500

Apply to this trial

Optimizing Implementation of the Intensive Diabetes Prevention Program

for Prediabetes

Sponsor: The Hong Kong Polytechnic University

Sex: All·Age: 18+

Code: NCT07412912

Pharmacist-Led Continuous Glucose Monitoring for Prediabetes

for Prediabetes

2 sites in Tampa

Sponsor: University of South Florida

Sex: All·Age: 18 - 70

Code: NCT07529366

Apply to this trial

Personalized Meal Timing and Walking Based on Glucose Patterns in Adults With Prediabetes

for Prediabetes

Sponsor: Shifa International Hospital

Sex: All·Age: 30 - 70

Code: NCT07618663

Apply to this trial

Vitamin D and Type 2 Diabetes - Treat-To-Target

for Prediabetes

1 site in Boston

Sponsor: Tufts Medical Center

Sex: All·Age: 30 - 74

Code: NCT07448974·Phase 3

Nested Pilot Study Comparing Two Treatments to Reduce Type 2 Diabetes Risk in At-Risk Delawareans

for Prediabetes

1 site in Newark

Sponsor: University of Delaware

Sex: All·Age: 18+

Code: NCT07450118

Apply to this trial

Study EHR Risk Stratification Tools

for Prediabetes

1 site in Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 65+

Code: NCT06995378

Apply to this trial

Cardiometabolic Effects of Pecan Snacking in Prediabetes

for Prediabetes

1 site in University Park

Sponsor: Penn State University

Sex: All·Age: 25 - 65

Code: NCT07235358

Apply to this trial

Food Sequencing in Food Insecurity

for Prediabetes

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 75

Code: NCT07488767

Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients

for PreDiabetes

Sponsor: Riphah International University

Sex: All·Age: 35 - 54·Accepts healthy volunteers

Code: NCT07713030

Apply to this trial

Early Precise Identification and Intervention Strategies for Individuals at High Risk of Prediabetes

for Prediabetes

Sponsor: Peking Union Medical College Hospital

Sex: All·Age: 35 - 75·Accepts healthy volunteers

Code: NCT07386756

Basic Carbohydrate Counting in Prediabetes

for Prediabetes

Sponsor: Hamide Sahin

Sex: All·Age: 18+

Code: NCT07525622

Apply to this trial

Effects of Dried Whole Fruits on Metabolism in Diabetes

for Prediabetes

Sponsor: University of Manitoba

Sex: All·Age: 18 - 74

Code: NCT07354386

Argus 2.0 Adoption Study

for Diabetes

1 site in San Mateo

Sponsor: KOS Inc.

Sex: All·Age: 18 - 75

Code: NCT07425236

Evaluation of Chiglitazar Sodium With Lifestyle Intervention for Reversing Prediabetes

for Prediabetes

Sponsor: Second Xiangya Hospital of Central South University

Sex: All·Age: 18 - 70

Code: NCT07558525

CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes

for PreDiabetes

1 site in Buffalo

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18+

Code: NCT07140848

Apply to this trial

Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being

for Chronic Disease

1 site in Waianae

Sponsor: Waianae Coast Comprehensive Health Center

Sex: All·Age: 12 - 25

Code: NCT07536256

Apply to this trial

Behavioral Approach for Latinas Addressing Nutrition, Cravings, and Eating Patterns to Prevent Type 2 Diabetes

for Prediabetes

1 site in La Jolla

Sponsor: University of California, San Diego

Sex: Female·Age: 18 - 55

Code: NCT07478263

Apply to this trial

BETA: Study in Prediabetes Type 2 Diabetes

for Prediabetes

1 site in San Francisco

Sponsor: 4YouandMe

Sex: All·Age: 18+

Code: NCT07598773

Smartwatch-based Intervention for Cardiovascular Health (SWITCH)

for Prehypertension

Sponsor: Beijing Anzhen Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07372729

Apply to this trial

Continuous Glucose Monitoring in Prediabetes

for Prediabetes

Sponsor: University of Hartford

Sex: All·Age: 18 - 65

Code: NCT07455435

Blood Glucose Screening in Patients With Advanced Periodontits: the Role of Specialist Periodontal Care in Identifying Hyperglycaemia and Supporting Patient Centered Treatment

for Periodontitis Stage III

Sponsor: Folktandvården Stockholms län AB

Sex: All·Age: 18+

Code: NCT07426224

Exercise, Chronotype, and Prediabetes

for Prediabetes

Sponsor: German Diabetes Center

Sex: All·Age: 19 - 75

Code: NCT07389005

Reversal to Normoglycemia by Treating Prediabetes

for Prediabetes

Sponsor: Michael Mæng

Sex: All·Age: 18 - 80

Code: NCT07392151·Phase 3

Continuous Glucose Monitoring (CGM) in Prediabetes With Community Based Recruitment

for Prediabetes

1 site in Los Angeles

Sponsor: David S Black, PhD

Sex: All·Age: 35+·Accepts healthy volunteers

Code: NCT07477249

Apply to this trial

Effect of Chronic Exposure to Nextida GC-B on Glycemic Control in Adults With Normoglycemia or Prediabetes

for Normoglycemia

Sponsor: Rousselot BVBA

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07149064

Apply to this trial

Crocus Sativus Tepals Water Extract in Obesity and Prediabetes

for Prediabetes

Sponsor: University of Primorska

Sex: All·Age: 40 - 65

Code: NCT07261475·EARLY_Phase 1

Apply to this trial

MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/Obesity

for Prediabetes

Sponsor: Hudson Biotech

Sex: All·Age: 18 - 65

Code: NCT07505745·Phase 2

Apply to this trial

Mobile Health Dietary Intervention for Stroke Survivors With Prediabetes or Type 2 Diabetes

for Stroke Recurrence

1 site in Honolulu

Sponsor: University of Hawaii

Sex: All·Age: 30 - 65

Code: NCT07120334

Apply to this trial

Effect of a Nutritional Product Containing Carob Extract on Carbohydrate Metabolism in Glucose-intolerant Subjects

for Prediabetes

Sponsor: Universidad Católica San Antonio de Murcia

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07420998

Apply to this trial

Effects of LP-LDL® on Lipid Metabolism, Glycemic Control, Inflammatory Markers, and Cognitive Function in Individuals With Prediabetes and Diabetes Mellitus

for Diabete Type 1

Sponsor: Aalborg University

Sex: All·Age: 18+

Code: NCT07373392

Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects

for Prediabetic State

Sponsor: Charite University, Berlin, Germany

Sex: All·Age: 18 - 75

Code: NCT07377097

Bromocriptine for Patients With Schizophrenia and Prediabetes

for Schizophrenia

1 site in Pittsburgh

Sponsor: VA Pittsburgh Healthcare System

Sex: All·Age: 18+

Code: NCT03575000·Phase 4

Interaction Between Inorganic Nitrate Supplementation and Metformin in Individuals With Prediabetes

for Males

1 site in Charlottesville

Sponsor: University of Virginia

Sex: All·Age: 18 - 60

Code: NCT07131384

Apply to this trial

Efficacy of Diacylglycerol Oil on Metabolic Risk Factors in Prediabetes

for Prediabetes

Sponsor: The First Affiliated Hospital of Guangdong Pharmaceutical University

Sex: All·Age: 40 - 75·Accepts healthy volunteers

Code: NCT07289880

Effectiveness of a Virtual Health Management Community (VHMC) for Pre-diabetes in China

for Prediabetes

Sponsor: Third Affiliated Hospital, Sun Yat-Sen University

Sex: All·Age: 18 - 80

Code: NCT07338552

Multicenter Study on Early Arterial Changes in Prediabetic Patients Evaluated by Ultra-High-Frequency Ultrasound

for Prediabetes

Sponsor: Chunyan Ma

Sex: All·Age: 18 - 79·Accepts healthy volunteers

Code: NCT07271745

Effects of a Mediterranean Diet With Cycling and Rowing Exercise on Blood Sugar in Women With Prediabetes

for Prediabetes

Sponsor: Begüm Yücesoy Güneysu

Sex: Female·Age: 22 - 55

Code: NCT07326891

Feasibility of a Nutrition Intervention for Patients With Prediabetes at a Federally Qualified Health Center

for Prediabetic State

1 site in Los Angeles

Sponsor: Cedars-Sinai Medical Center

Sex: All·Age: 18 - 99

Code: NCT06897982

Apply to this trial

Prediabetes and Metabolic Parameters Among Young Adults at Assiut University Hospital

for PreDiabetes

Sponsor: Assiut University

Sex: All·Age: 18 - 40·Accepts healthy volunteers

Code: NCT07259954

Artificial-Intelligence-based Early Detection of Diabetic Retinopathy (FUNDUS AI)

for Diabetes (DM)

Sponsor: University Hospital Tuebingen

Sex: All·Age: 18 - 80

Code: NCT07378891

The Role of Islet GLP-1 in the Pathogenesis of Prediabetes

for PreDiabetes

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 25 - 70·Accepts healthy volunteers

Code: NCT06967558·Phase 2

Apply to this trial

Pilot Study of "Bottarga" Supplementation: A Little-known, Sustainable "Blue" Food

for Prediabetes

1 site in Sommerville

Sponsor: Cambridge Health Alliance

Sex: All·Age: 18 - 60

Code: NCT06988462

Apply to this trial

New T-UP: Engaging Vulnerable Students in Diabetes Prevention

for Prediabetes

1 site in Los Angeles

Sponsor: University of California, Los Angeles

Sex: All·Age: 17 - 25

Code: NCT07225218

Apply to this trial

Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 Diabetes

for PreDiabetes

1 site in Nashville

Sponsor: Vanderbilt University

Sex: All·Age: 6 - 59

Code: NCT06482944

Apply to this trial

Post Prandial Individual Responses to Different Foods

for PreDiabetes

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 18 - 80

Code: NCT06989164

Apply to this trial

Truway Diagnostic Tools in Primary Care

for Chronic Disease

1 site in New York

Sponsor: Truway Health, Inc.

Sex: All·Age: All ages

Code: NCT07209527·EARLY_Phase 1

Prediabetes clinical trials — common questions

Are prediabetes clinical trials free to join?

Yes. Participating in a prediabetes clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a prediabetes clinical trial?

Each prediabetes study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a prediabetes trial near me?

Use the location controls above. We'll show recruiting prediabetes trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many prediabetes trials are recruiting right now?

We're currently tracking roughly 57 recruiting prediabetes trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Prediabetes trials by city

Los Angeles, CA Boston, MA Stanford, CA Ann Arbor, MI Birmingham, AL Chicago, IL Columbus, OH Indianapolis, IN Jacksonville, FL La Jolla, CA

Related specialties

Endocrinology