Pulmonary hypertension Clinical Trials

Recruiting pulmonary hypertension studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat pulmonary hypertension. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting pulmonary hypertension studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting pulmonary hypertension trials

Within

Withdrawal of Prostacyclin Pathway Therapy in Patients With Pulmonary Arterial Hypertension Receiving Sotatercept (WATERLOO)

for Pulmonary Arterial Hypertension

Sponsor: University of Alberta

Sex: All·Age: 18+

Code: NCT07700303

Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension

for Pulmonary Arterial Hypertension

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18+

Code: NCT06176118·Phase 2

Dynamic Changes in Right Ventricle and Pulmonary Artery Coupling Among COPD Patients With Acute Exacerbation

for COPD Exacerbation (AECOPD)

Sponsor: Assiut University

Sex: All·Age: 40+

Code: NCT07694713

Extracellular Vesicle Dynamics Predicting Vascular Complications and Treatment Response in Systemic Sclerosis

for Systemic Sclerosis

Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Sex: All·Age: 45 - 75·Accepts healthy volunteers

Code: NCT07717060

TEPH: Telaglenastat Efficacy in Pulmonary Hypertension

for Pulmonary Hypertension

1 site in Pittsburgh

Sponsor: Chan, Stephen, MD, PhD

Sex: All·Age: 18 - 75

Code: NCT07223528·Phase 1, Phase 2

A Study of Sotatercept (MK-7962) in Japanese Children With Pulmonary Arterial Hypertension (PAH) (MK-7962-032)

for Pulmonary Arterial Hypertension

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 1 - 17

Code: NCT07646860·Phase 2

Pulmonary Hypertension (PH) Biorepository for Translational Research

for Pulmonary Hypertension

3 sites incl. Baltimore

Sponsor: National Institutes of Health Clinical Center (CC)

Sex: All·Age: 18 - 100

Code: NCT07647549

Effect of Vasopressin Versus Norepinephrine on Post-operative Mean Pulmonary Arterial Pressure Following Pulmonary Endarterectomy Surgery,

for Anesthesia

Sponsor: Fondation Hôpital Saint-Joseph

Sex: All·Age: 18+

Code: NCT07614438·Phase 2

Wearable Assessment of Thoracic, Cardiac Health and Exercise Performance Trial Prospective

for Congenital Heart Disease

Sponsor: The University of Hong Kong

Sex: All·Age: 20 - 70

Code: NCT07663799

MedlyPeds Feasibility Study

for Pediatric Heart Failure

Sponsor: The Hospital for Sick Children

Sex: All·Age: 8 - 18

Code: NCT07556185

Apply to this trial

A Comparison of a Medication Adherence Platform (FORTISKAP™) vs. Usual Care in Subjects on Oral Medications for the Treatment of Interstitial Lung Disease, Sarcoid and Pulmonary Hypertension

for Idiopathic Pulmonary Fibrosis (IPF)

1 site in Norfolk

Sponsor: Cosmos Rx, Inc

Sex: All·Age: 21+

Code: NCT07613216

A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease

for Pulmonary Hypertension

3 sites incl. Houma

Sponsor: Pulnovo Medical, Inc.

Sex: All·Age: 18 - 85

Code: NCT07214376

Apply to this trial

Fibrotic Disease Activity in Cardiopulmonary Disorders Using 18F-Fibroblast Activation Protein Inhibitor (18F-FAPI-74) PET/CT Imaging

for Allogeneic Stem Cell Transplantation

1 site in Bethesda

Sponsor: National Heart, Lung, and Blood Institute (NHLBI)

Sex: All·Age: 18 - 100

Code: NCT07613099·Phase 3

Apply to this trial

Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants

for Bronchopulmonary Dysplasia

2 sites incl. Birmingham

Sponsor: University of Alabama at Birmingham

Sex: All·Age: 1 Month - 5 Months·Accepts healthy volunteers

Code: NCT06373289

Apply to this trial

A Study of Sotatercept (MK-7962) in People With Pulmonary Arterial Hypertension (PAH) in India (MK-7962-037)

for Pulmonary Arterial Hypertension

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT07600723·Phase 4

A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia

for Pulmonary Hypertension

11 sites incl. Durham

Sponsor: Duke University

Sex: All·Age: 18+

Code: NCT06327373·Phase 1, Phase 2

Clinical Trial of NS-863 in Participants With Pulmonary Arterial Hypertension (PAH)

for Pulmonary Arterial Hypertension

Sponsor: NS Pharma, Inc.

Sex: All·Age: 18 - 75

Code: NCT07441200·Phase 2

Correlation Between CT Pulmonary Angiography Metrics and Right Heart Catheterization Parameters in Pre-Capillary Pulmonary Hypertension

for Pulmonary Hypertension

Sponsor: Assiut University

Sex: All·Age: 18+

Code: NCT07667595

A Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH)

for Pulmonary Arterial Hypertension

2 sites incl. Santa Barbara

Sponsor: Insmed Incorporated

Sex: All·Age: 18 - 75

Code: NCT07481981·Phase 3

Apply to this trial

Risk Factor Assessment for Acute Pulmonary Hypertension Crisis

for Pulmonary Hypertension

Sponsor: Peking Union Medical College Hospital

Sex: All·Age: All ages

Code: NCT07653958

Apply to this trial

Bridge to Lung Transplant With Trans-septal Extra-corporeal Membrane Oxygenation (ECMO) for Right Heart Failure From Pulmonary Hypertension

for Lung Transplant

1 site in Jacksonville

Sponsor: Mayo Clinic

Sex: All·Age: 18 - 80

Code: NCT06770023·Phase 1

Apply to this trial

Percutaneous Pulmonary Artery Denervation (PADN) for the Treatment of Pulmonary Hypertension After Transcatheter Mitral Valve Edge-to-Edge Repair (M-TEER): A Prospective Cohort Study

for Pulmonary Hypertension

Sponsor: Xiamen Cardiovascular Hospital, Xiamen University

Sex: All·Age: 18 - 80

Code: NCT07662655·EARLY_Phase 1

Apply to this trial

An Open-Label Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

for Pulmonary Hypertension

Sponsor: Insmed Incorporated

Sex: All·Age: 18+

Code: NCT07234032·Phase 3

DIAG723 in Adults With Hereditary Hemorrhagic Telangiectasia

for Hereditary Hemorrhagic Telangiectasia

Sponsor: Diagonal Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07623525·Phase 1, Phase 2

Apply to this trial

Evolution of Hypoxic Burden and Sympathetic/Parasympathetic Balance in Patients With Pulmonary Hypertension

for Precapillary Pulmonary Hypertension

Sponsor: University Hospital, Rouen

Sex: All·Age: 18+

Code: NCT07464184

Pulmonary Artery Pressure in Predicting Pulmonary Embolism in Patients Presenting To The Emergency Department With Dyspnea

for Emergency Department Patients

Sponsor: Antalya Health Sciences University

Sex: All·Age: 18+

Code: NCT07641400

The Benefits of Home Exercise in Pulmonary Hypertension Interstitial Lung Disease

for Pulmonary Hypertension

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT07561034

A Phase 3 Study of Extended-release Tacrolimus in Subjects With Pulmonary Arterial Hypertension and Functional Limitations

for Pulmonary Arterial Hypertension

Sponsor: VIVUS LLC

Sex: All·Age: 18 - 75

Code: NCT07612657·Phase 3

Multimodality RV Phenotyping for Risk Stratification and Short-Term Outcomes in Group 1 PAH

for Pulmonary Hypertension

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18+

Code: NCT07667673

Apply to this trial

An Adaptive Program of IKT-001 in Pulmonary Arterial Hypertension (PAH)

for Pulmonary Arterial Hypertension

2 sites incl. Louisville

Sponsor: Inhibikase Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07365332·Phase 3

Apply to this trial

Mechanistic Study of Nicotinamide Riboside on NAD+ Biology in Individuals With Combined Pulmonary Hypertension

for Pulmonary Hypertension

1 site in Nashville

Sponsor: Vanderbilt University Medical Center

Sex: All·Age: 18 - 85

Code: NCT07563322

Apply to this trial

Exercise Intervention as an Adjunct to Medical Therapy in Newly Diagnosed Patients With Pulmonary Arterial Hypertension

for Pulmonary Arterial Hypertension

Sponsor: Golden Jubilee National Hospital

Sex: All·Age: 18+

Code: NCT07366879

Apply to this trial

Portosystemic Shunt-associated Pulmonary Hypertension Multi-center Prospective Cohort Study

for Portosystemic Shunt

Sponsor: Chinese Pulmonary Vascular Disease Research Group

Sex: All·Age: 18+

Code: NCT07481877

Reverse Remodeling of the Pulmonary Vasculature: a Longitudinal, Investigational Study of the Effects of Sotatercept.

for Pulmonary Arterial Hypertension (PAH)

1 site in Tucson

Sponsor: Franz Rischard, DO

Sex: All·Age: 18 - 65

Code: NCT07487441

Riociguat in Triple Therapy for Pulmonary Arterial Hypertension in Real-World Practice

for Pulmonary Arterial Hypertension

Sponsor: Caio Júlio César dos Santos Fernandes

Sex: All·Age: 18+

Code: NCT07374302

A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

for Hypertensive Disorder of Pregnancy

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: Female·Age: 18 - 45·Accepts healthy volunteers

Code: NCT07312227

Apply to this trial

The Impact of IV Iron on Exercise Capacity and Quality of Life in Pulmonary Hypertension

for Pulmonary Hypertension

Sponsor: Ziekenhuis Oost-Limburg

Sex: All·Age: 18+

Code: NCT07359599·Phase 4

Apply to this trial

Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

for Pulmonary Hypertension

8 sites incl. Los Angeles

Sponsor: Insmed Incorporated

Sex: All·Age: 18+

Code: NCT07179380·Phase 3

Apply to this trial

A Multicenter Study on the Normal Reference Range and Clinical Significance of the Right Atrioventricular Coupling Index Assessed by Artificial Intelligence-Based Three-Dimensional Echocardiography

for Healthy Adults

Sponsor: First Hospital of China Medical University

Sex: All·Age: 18 - 79·Accepts healthy volunteers

Code: NCT07292896

A Study of Mosliciguat in Combination With Inhaled Treprostinil in PH-ILD

for Pulmonary Hypertension

1 site in Kissimmee

Sponsor: Pulmovant, Inc.

Sex: All·Age: 18 - 85

Code: NCT07333183·Phase 2

Apply to this trial

Accuracy of Smartwatches in Measuring Oxygen Levels in Patients With Pulmonary Hypertension: A Pilot Study

for Pulmonary Hypertension

Sponsor: Golden Jubilee National Hospital

Sex: All·Age: 18+

Code: NCT07311135

Apply to this trial

European Registry of Acutely Decompensated Pulmonary Arterial Hypertension

for Pulmonary Hypertension

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: All ages

Code: NCT06923917

Observational Study of Patients Undergoing Diagnostic Right Heart Catheterization

for Pulmonary Hypertension

1 site in Boulder

Sponsor: HemoCept Inc.

Sex: All·Age: 18+

Code: NCT07224906

Apply to this trial

Efficacy of Inhaled Nitric Oxide in Congenital Diaphragmatic Hernia

for Congenital Diaphragmatic Hernia

Sponsor: Asan Medical Center

Sex: All·Age: 1 Minute - 14 Days

Code: NCT07247240·Phase 4

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

for Pulmonary Hypertension

13 sites incl. Sacramento

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07073820·Phase 2

Apply to this trial

A Study of HS235 for Treatment of Pulmonary Arterial Hypertension (PAH) in Adults

for Pulmonary Arterial Hypertension

Sponsor: 35Pharma Inc

Sex: All·Age: 18+

Code: NCT07143448·Phase 1

Echocardiographic Assessment of Pulmonary Hypertension in Obstructive Sleep Apnea

for Obstructive Sleep Apnea (OSA)

Sponsor: Assiut University

Sex: All·Age: 18 - 65

Code: NCT07184060

129 Xenon Imaging in Patients Treated With Sotatercept

for Pulmonary Hypertension

1 site in Durham

Sponsor: Bastiaan Driehuys

Sex: All·Age: 18 - 75

Code: NCT06351345·Phase 2

Apply to this trial

Pulmonary Hypertension Inspiratory Training

for Pulmonary Hypertension

1 site in Tucson

Sponsor: University of Arizona

Sex: All·Age: 18+

Code: NCT06931886

A Study to Observe the Safety, Tolerability, and Efficacy of Remodulin

for Pulmonary Arterial Hypertension

Sponsor: Excelsior

Sex: All·Age: All ages

Code: NCT06603285

Efficacy and Tolerance of Treatment With Bevacizumab for Severe Liver Involvement With High Cardiac Output in Hereditary Hemorrhagic Telangiectasia Within the French Hereditary Hemorrhagic Telangiectasia Network

for Hereditary Hemorrhagic Telangiectasia (HHT)

Sponsor: Poitiers University Hospital

Sex: All·Age: 18+

Code: NCT07445347

Effects of Inhaled Treprostinil on Exercise Performance in Exercise Induced Pulmonary Hypertension

for Pulmonary Hypertension

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT07116681·EARLY_Phase 1

Pulmonary Arterial Hypertension and Associated Cardiovascular Disease Detection Using Artificial Intelligence

for Pulmonary Hypertension

Sponsor: Imperial College London

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07147725

Study of HS235 in Obese Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)

for Pulmonary Hypertension

Sponsor: 35Pharma Inc

Sex: All·Age: 18+

Code: NCT07123779·Phase 1

Clinical, Radiological, Tissue and Biological Phenotyping for the Analysis of the Transition From Physiology to Pathology in Pulmonary Diseases With Pulmonary Hypertension

for Pulmonary Hypertension

Sponsor: Assistance Publique Hopitaux De Marseille

Sex: All·Age: 18+

Code: NCT07184671

Safety and Efficacy of FETO in CDH Phase III

for Congenital Diaphragmatic Hernia

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: Female·Age: 18 - 50·Accepts healthy volunteers

Code: NCT07187206·Phase 3

Apply to this trial

Cardiovascular Complications in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

for Cardiotoxicity

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 15+

Code: NCT07157670

A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of MN-08 Tablets

for Pulmonary Arterial Hypertension

Sponsor: Guangzhou Magpie Pharmaceuticals Co., Ltd.

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT05660863·Phase 1

Neuromodulation in Patients With Pulmonary Arterial Hypertension

for Pulmonary Hypertension

1 site in Oklahoma City

Sponsor: University of Oklahoma

Sex: All·Age: 18 - 90

Code: NCT06802380·Phase 1, Phase 2

Clinical Registry for the Characterization of the 'Pulmonary Vascular Phenotype' in Patients With Chronic Obstructive Pulmonary Disease

for Chronic Obstructive Pulmonary Disease (COPD)

Sponsor: Medical University of Graz

Sex: All·Age: 18+

Code: NCT07102823

Apply to this trial

Pulmonary hypertension clinical trials — common questions

Are pulmonary hypertension clinical trials free to join?

Yes. Participating in a pulmonary hypertension clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a pulmonary hypertension clinical trial?

Each pulmonary hypertension study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a pulmonary hypertension trial near me?

Use the location controls above. We'll show recruiting pulmonary hypertension trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many pulmonary hypertension trials are recruiting right now?

We're currently tracking roughly 71 recruiting pulmonary hypertension trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Pulmonary hypertension trials by city

Aurora, CO Birmingham, AL Los Angeles, CA Cincinnati, OH Palo Alto, CA Boston, MA Boulder, CO Jacksonville, FL Kissimmee, FL Little Rock, AR

Related specialties

Cardiology Pulmonology Lung disease