Small cell lung cancer Clinical Trials

Recruiting small cell lung cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat small cell lung cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting small cell lung cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting small cell lung cancer trials

Within

SMARCA4/2 Inhibitor for POU2F3-Positive SCLC

for Small Cell Lung Cancer

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT07551635·Phase 2

A Study to Test Obrixtamig in Combination With ZL-1310 in People With Advanced Small Cell Lung Cancer or Other Neuroendocrine Cancers

for Small Cell Lung Cancer

2 sites incl. Washington D.C.

Sponsor: Boehringer Ingelheim

Sex: All·Age: 18+

Code: NCT07707895·Phase 1, Phase 2

QL1706 Plus Anlotinib as a Later-line Treatment for Patients With Advanced Lung Cancer

for Small Cell Lung Cancer

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 80

Code: NCT07636226·Phase 2, Phase 3

Epigenomic Profiling of Circulating Cell-Free DNA (cfDNA) to Characterize the Dynamic Evolution of Molecular Subtypes in Extensive-Stage Small Cell Lung Cancer During First-Line Chemoimmunotherapy

for Small Cell Lung Cancer

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07670442

A Study of DXC006 With Immune Checkpoint Inhibitors or Platinum for Small Cell Lung Cancer.

for Small Cell Lung Cancer

Sponsor: Hangzhou DAC Biotechnology Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07559929·Phase 1, Phase 2

Tarlatamab for SCLC Brain Metastases

for Small Cell Lung Cancer

Sponsor: Maastricht University Medical Center

Sex: All·Age: 18+

Code: NCT07402343·Phase 2

Symbiotic-Lung-14: A Study to Learn About the Study Medicine Called PF08634404 in Combination With Chemotherapy in Adult Participants With Transformed Small Cell Lung Cancer

for Small Cell Lung Cancer

4 sites incl. Duarte

Sponsor: Pfizer

Sex: All·Age: 18+

Code: NCT07476287·Phase 2

Apply to this trial

Limertinib Plus Carboplatin and Etoposide for EGFR-mutant NSCLC With SCLC Transformation After EGFR-TKI Progression

for Small Cell Lung Cancer

Sponsor: Hunan Province Tumor Hospital

Sex: All·Age: 18 - 80

Code: NCT07001995·Phase 2

Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck Oncology

for Small Cell Lung Cancer

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18+

Code: NCT07550049

18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors

for Clear Cell Renal Cell Cancer (ccRCC)

Sponsor: Peking University First Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07557225

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Study of ZG006 in Combination With PD-1/PD-L1 Immune Checkpoint Inhibitors as First-Line Standard Therapy in Participants With Extensive Stage Small-Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Sex: All·Age: 18 - 75

Code: NCT07231445·Phase 1

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Study of Tarlatamab + ZL-1310 +/- Anti-programmed Death Ligand 1 (Anti-PD-L1) in Small Cell Lung Cancer (SCLC)

for Small Cell Lung Cancer

3 sites incl. New York

Sponsor: Amgen

Sex: All·Age: 18 - 99

Code: NCT07531095·Phase 1

Apply to this trial

A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07365241·Phase 3

Nab-Paclitaxel Combined With Local Therapy in Relapsed SCLC

for Small Cell Lung Cancer

Sponsor: Shanghai Pulmonary Hospital, Shanghai, China

Sex: All·Age: 18 - 75

Code: NCT07547332·Phase 2

A Study of DXC014 in Patients With Advanced Solid Tumors.

for Small Cell Lung Cancer

Sponsor: Hangzhou DAC Biotechnology Co., Ltd.

Sex: All·Age: 18+

Code: NCT07177937·Phase 1

Apply to this trial

Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors

for Cancer

5 sites incl. Plantation

Sponsor: Conjupro Biotherapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07424547·Phase 1

Apply to this trial

SYS6090 Combination Therapy in Advanced Lung Cancer

for Non-Small Cell Lung Cancer

Sponsor: Shanghai JMT-Bio Inc.

Sex: All·Age: 18 - 75

Code: NCT07472647·Phase 1, Phase 2

A Phase II Clinical Study to Evaluate HLX43 in Combination With Serplulimab in Subjects With Advanced Lung Cancer

for Non Small Cell Lung Cancer

Sponsor: Shanghai Henlius Biotech

Sex: All·Age: 18 - 75

Code: NCT07253142·Phase 2

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Adebrelimab Combined With Oral Etoposide for Elderly Patients and Patients With Poor Performance Status in Small Cell Lung Cancer: An Exploratory Clinical Study

for Small Cell Lung Cancer

Sponsor: The Third Affiliated Hospital of Harbin Medical University

Sex: All·Age: 18 - 99

Code: NCT07398560·Phase 2

SKB500 Combinations in Patients With Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07296809·Phase 2

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Prospective, Single-arm, Phase II Clinical Study of Irinotecan Hydrochloride Liposome Injection Combined With Platinum and Immune Checkpoint Inhibitors Combined With Anlotinib for the Maintenance of Extensive Small Cell Lung Cancer After First-line Induction

for Small Cell Lung Cancer

Sponsor: China Medical University, China

Sex: All·Age: 18+

Code: NCT07376499·Phase 2

Small Cell Lung Cancer Irinotecan and CDC2-like Kinase Inhibition Trial (SLICK Trial)

for Small-cell Lung Cancer

1 site in St Louis

Sponsor: Washington University School of Medicine

Sex: All·Age: 18+

Code: NCT07155200·Phase 1, Phase 2

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Phase 1 Trial of ST-001 nanoFenretinide in Relapsed/ Refractory Small Cell Lung Cancer

for Small Cell Lung Cancer

1 site in Los Angeles

Sponsor: SciTech Development, Inc.

Sex: All·Age: 18+

Code: NCT06922539·Phase 1

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A Study to Evaluate the Optimal Dose, Adverse Events and Change in Disease Activity of Intravenous ABBV-706 in Combination With Atezolizumab Versus Standard of Care as First-Line Treatment in Adult Participants With Previously Untreated Extensive Stage Small Cell Lung Cancer

for Small Cell Lung Cancer

10 sites incl. New Haven

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT07155174·Phase 2

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A Study of YL201 and Ivonescimab (AK112) in Advanced Solid Tumors

for Advanced Solid Tumors

Sponsor: MediLink Therapeutics (Suzhou) Co., Ltd.

Sex: All·Age: 18+

Code: NCT07208773·Phase 1, Phase 2

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68Ga-PFD3 PET Imaging for the Diagnosis and Evaluation of Small Cell Lung Cancer

for SCLC

Sponsor: Peking University First Hospital

Sex: All·Age: 18+

Code: NCT07508852·Phase 1, Phase 2

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A Prospective, Single-Arm, Single-Center Phase II Study Evaluating the Efficacy and Safety of Chidamide Combined With PD-L1 Inhibitor, Carboplatin, and Etoposide as First-Line Treatment in Patients With Extensive-Stage Small-Cell Lung Cancer (ES-SCLC)

for Small Cell Lung Cancer

Sponsor: China Medical University, China

Sex: All·Age: 18 - 75

Code: NCT07373964·Phase 2

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Prophylactic Proton Pump Inhibition for Esophageal Protection in Lung Radiation Therapy

for Primary Lung Cancer

Sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07076914·Phase 2

Prospective Observational Study on ES-SCLC

for Extensive-stage Small-cell Lung Cancer

Sponsor: Peking Union Medical College Hospital

Sex: All·Age: 18+

Code: NCT07173946

ZG006 and ZG005 in Participants With Small Cell Lung Cancer or Neuroendocrine Carcinoma

for Small Cell Lung Cancer

Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Sex: All·Age: 18 - 70

Code: NCT07038096·Phase 1, Phase 2

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DESTINY-PANTUMOUR04

for Adenocarcinoma (NOS)

18 sites incl. Birmingham

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT07124000

Apply to this trial

A Real-world Study of Adebrelimab-based Combination Regimens in the Treatment of Advanced Solid Tumors

for Non-Small Cell Lung Cancer

Sponsor: Tianjin First Central Hospital

Sex: All·Age: 18 - 80

Code: NCT07173244

A Study on the First-line Treatment of Small Cell Lung Cancer With Adebrelimab and Vunakizumab and Chemotherapy

for Vunakizumab

Sponsor: Fujian Cancer Hospital

Sex: All·Age: 18 - 75

Code: NCT07069270·Phase 2

A Clinical Study of BT02 in Treating Patients With Advanced Lung Cancer

for Advanced Malignant Solid Tumor

Sponsor: Biotroy Therapeutics

Sex: All·Age: 18 - 75

Code: NCT07110363·Phase 1

Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

2 sites incl. Boston

Sponsor: Nerviano Medical Sciences

Sex: All·Age: 18+

Code: NCT06931626·Phase 1

Apply to this trial

A Phase II/III Study of IBB0979 in Combination With Topotecan Versus Topotecan in Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: SUNHO（China）BioPharmaceutical CO., Ltd.

Sex: All·Age: 18 - 75

Code: NCT07076095·Phase 2

Study of GV20-0251 in Participants With Solid Tumor Malignancies

for Solid Tumor Cancer

Sponsor: GV20 Therapeutics

Sex: All·Age: 18+

Code: NCT07070518·Phase 1, Phase 2

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A Study of AK112 as Consolidation Treatment for Patients With Limited Stage Small-cell Lung Cancer Who Have Not Progressed Following Concurrent Chemoradiation Therapy

for Small Cell Lung Cancer

Sponsor: Akeso

Sex: All·Age: 18+

Code: NCT07010263·Phase 3

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Efficacy and Biomarkers of the Second-line Treatment of Adebelizumab Combined With Irinotecan Liposome in Advanced Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Peking University Cancer Hospital & Institute

Sex: All·Age: 18 - 75

Code: NCT07004712·Phase 2

Prospective, Single-arm, Phase II Clinical Study of Irinotecan Hydrochloride Liposome Injection Combined With Platinum and Immune Checkpoint Inhibitors Combined With Anlotinib for the Maintenance of Extensive Small Cell Lung Cancer After First-line Induction

for Small Cell Lung Cancer

Sponsor: China Medical University, China

Sex: All·Age: 18+

Code: NCT06951841·Phase 4

A Study of SYS6040 for Injection in Patients With Advanced Solid Tumors

for Small Cell Lung Cancer

Sponsor: CSPC Megalith Biopharmaceutical Co.,Ltd.

Sex: All·Age: 18+

Code: NCT06970795·Phase 1

Apply to this trial

A Phase 1 Dose Escalation Study of ZG006 in Patients With Small Cell Lung Cancer

for Small Cell Lung Cancer

6 sites incl. Orange

Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Sex: All·Age: 18 - 75

Code: NCT06592638·Phase 1

Apply to this trial

A Study to Evaluate the Safety and Efficacy of Gocatamig (MK-6070) and Ifinatamab Deruxtecan (I-DXd) in Participants With Relapsed/Refractory Extensive-Stage Small Cell Lung Cancer (MK-6070-002)

for Small Cell Lung Cancer

9 sites incl. Aurora

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06780137·Phase 1, Phase 2

Apply to this trial

Immunonutrition Reduces Acute Esophagitis After Thoracic Radiotherapy in Lung Cancer

for Non Small Cell Lung Cancer

Sponsor: Hunan Cancer Hospital

Sex: All·Age: 18+

Code: NCT06840704·Phase 3

Apply to this trial

Genomic and Methylation Markers in SCLC and LCNEC for Chemo-Immunotherapy Resistance Prediction (STRATUS)

for Small Cell Lung Cancer

1 site in New York

Sponsor: Oncology Center of Biochemical Education And Research

Sex: All·Age: 18 - 85

Code: NCT06717243

Apply to this trial

Phase II Study of Ivonescimab and Cadonilimab in Combination with Chemotherapy in Patients with ES-SCLC

for Small Cell Lung Cancer

Sponsor: Sichuan University

Sex: All·Age: 18 - 75

Code: NCT06769971·Phase 2

Apply to this trial

A Multi-omics Sequencing-based Model for Predicting Efficacy and Dynamic Monitoring of Treatment in Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Sex: All·Age: 18+

Code: NCT07026669

Apply to this trial

A Multicenter, Open-label Phase IIa Clinical Study to Evaluate the Efficacy and Safety of B1962 Injection in the Treatment of Advanced Malignant Solid Tumors

for Recurrent Platinum-resistant Epithelial Ovarian Cancer

Sponsor: Tasly Biopharmaceuticals Co., Ltd.

Sex: All·Age: 18+

Code: NCT06724263·Phase 2

Study of IBI3009 in Participants with Unresectable, Metastatic or Extensive-Stage Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Innovent Biologics (Suzhou) Co. Ltd.

Sex: All·Age: 18 - 75

Code: NCT06613009·Phase 1

Apply to this trial

INK Cells As Maintenance Therapy After Chemoradiotherapy for Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Guangzhou Ruixin Biotechnological Co., LTD

Sex: All·Age: 18 - 75

Code: NCT06747832·EARLY_Phase 1

A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors

for Solid Tumor

15 sites incl. Little Rock

Sponsor: NiKang Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06586957·Phase 1

Apply to this trial

JK-1201I Compared with Topotecan in Patients with Relapsed Extensive Stage Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: JenKem Technology Co., Ltd.

Sex: All·Age: 18 - 70

Code: NCT06581380·Phase 3

A Study of DC05F01 in Chinese Patients with Recurrent/Refractory Ovarian Cancer and Other Advanced Solid Tumors

for Solid Tumors

Sponsor: Heronova Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06873555·Phase 1, Phase 2

Apply to this trial

Dose Escalation Study of ZG006 in Participants With Advanced Small Cell Lung Cancer or Neuroendocrine Carcinoma, Followed by Dose Expansion Study in Participants With Advanced Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Sex: All·Age: 18 - 75

Code: NCT06283719·Phase 1, Phase 2

Apply to this trial

Adebrelimab Plus Apatinib for Maintenance Therapy of Extensive Stage Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Yunpeng Liu

Sex: All·Age: 18+

Code: NCT06480864

Apply to this trial

A Study of BL-M14D1 in Patients With Locally Advanced or Metastatic Small Cell Lung Cancer, Neuroendocrine Tumors and Other Solid Tumors

for Small Cell Lung Cancer

Sponsor: Sichuan Baili Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT06505824·Phase 1

Apply to this trial

Liposomal Irinotecan Combination Regimen for First-line Treatment of Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Zhou Chengzhi

Sex: All·Age: 18 - 75

Code: NCT06462105

ARTEMIS-008：HS-20093 Compared With Topotecan in Subjects With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

Sponsor: Hansoh BioMedical R&D Company

Sex: All·Age: 18+

Code: NCT06498479·Phase 3

Apply to this trial

A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

for Small Cell Lung Cancer

30 sites incl. Springdale

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06203210·Phase 3

Apply to this trial

Serplulimab Combined With CCRT for LS-SCLC.

for Small Cell Lung Cancer

Sponsor: Peking Union Medical College Hospital

Sex: All·Age: 18+

Code: NCT06295926·Phase 2

Apply to this trial

Small cell lung cancer clinical trials — common questions

Are small cell lung cancer clinical trials free to join?

Yes. Participating in a small cell lung cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a small cell lung cancer clinical trial?

Each small cell lung cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a small cell lung cancer trial near me?

Use the location controls above. We'll show recruiting small cell lung cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many small cell lung cancer trials are recruiting right now?

We're currently tracking roughly 24 recruiting small cell lung cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Small cell lung cancer trials by city

Aurora, CO Beverly Hills, CA Birmingham, AL Boston, MA Indianapolis, IN Duarte, CA La Jolla, CA Little Rock, AR Los Angeles, CA Orange, CA Plantation, FL Springdale, AR

Related specialties

Oncology Lung oncology