GLP-1 Agonists for Lung Function Improvement and Muscle Restoration in COPD
for COPD
1 location in Cleveland
Sponsor: The Cleveland Clinic
Sex: All·Age: 40 - 80
Code: NCT07747805·Phase 2·Not Yet Recruiting·Listed Aug 5, 2026
Lung disease Clinical Trials in Cleveland, OH
As of August 2026, 25 paid clinical trials are recruiting for Lung disease in Cleveland, Ohio. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Cleveland
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
26 clinical trials for Lung disease
·Clear filters· Email me when a new lung disease trial opens in Cleveland, OH.
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
for Advanced Non-Small Cell Lung Cancer
Drug: PF-08634404
Sites in Cleveland, North Canton +204 more locations
Sponsor: Pfizer
Sex: All·Age: 18+
Code: NCT07222566·Phase 3·Recruiting·Listed Oct 2025
DeciPHer-ILD: A Real-world Patient Registry in Group 3 Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
for Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Sites in Cleveland, Columbus +68 more locations
Sponsor: United Therapeutics
Sex: All·Age: 18+
Code: NCT06388421·Recruiting·Listed Apr 2024
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
for Pulmonary Hypertension
Sites in Cleveland +31 more locations
Sponsor: Tempus AI
Sex: All·Age: 18+
Code: NCT06911632·Recruiting·Listed Apr 2025
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
for Heart Failure
Sites in Cleveland, Cincinnati +55 more locations
Sponsor: Abbott Medical Devices
Sex: All·Age: 18+
Code: NCT06526195·Recruiting·Listed Jul 2024
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
for Advanced Solid Tumor
Sites in Cleveland +30 more locations
Sponsor: PMV Pharmaceuticals, Inc
Sex: All·Age: 12+
Code: NCT04585750·Phase 1, Phase 2·Recruiting·Listed Oct 2020
A Study to Evaluate the Safety, Tolerability, Drug Levels, and Preliminary Efficacy of BMS-986507 Combinations in Adult Participants With Advanced Solid Tumors
for Lung Cancer
Sites in Cleveland, Columbus +11 more locations
Sponsor: Bristol-Myers Squibb
Sex: All·Age: 18+
Code: NCT06618287·Phase 1, Phase 2·Recruiting·Listed Oct 2024
Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis
for Cystic Fibrosis
Sites in Cleveland +11 more locations
Sponsor: Arcturus Therapeutics, Inc.
Sex: All·Age: 18+
Code: NCT06747858·Phase 2·Recruiting·Listed Dec 2024
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
for COPD
Sites in Cleveland, Columbus +16 more locations
Sponsor: Apreo Health, Inc.
Sex: All·Age: 40 - 84
Code: NCT06891755·Recruiting·Listed Mar 2025
cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease
for Brain Cancer
Sites in Cleveland +15 more locations
Sponsor: Adela, Inc
Sex: All·Age: 40+·Accepts healthy volunteers
Code: NCT05366881·Recruiting·Listed May 2022
A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
for Pulmonary Hypertension
Sites in Cleveland +5 more locations
Sponsor: Pulnovo Medical, Inc.
Sex: All·Age: 18 - 85
Code: NCT07214376·Recruiting·Listed Oct 2025
Real World Treatment Experience of Patients With Breast, Lung, Ovarian, Multiple Myeloma, or Acute Myelogenous Leukemia Using Remote Symptom Monitoring
for Breast Cancer
Sites in Cleveland, Massillon +2 more locations
Sponsor: Carevive Systems, Inc.
Sex: All·Age: 18+
Code: NCT05974150·Recruiting·Listed Aug 2023
The Vanguard Study: Testing a New Way to Screen for Cancer
for Bladder Carcinoma
Sites in Cleveland +40 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 45 - 75·Accepts healthy volunteers
Code: NCT06995898·Recruiting·Listed May 2025
Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study
for Cystic Fibrosis
Sites in Cleveland, Akron +57 more locations
Sponsor: Chris Goss
Sex: All·Age: 6+
Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022
45th Multicenter Airway Research Collaboration
for Asthma Acute
1 location in Cleveland
Sponsor: Massachusetts General Hospital
Sex: All·Age: 18 - 54
Code: NCT07166939·Phase 4·Recruiting·Listed Sep 2025
Pulmonary Rehabilitation in Advanced Lung Cancer Survivors
for Non-small Cell Lung Cancer Stage III
1 location in Cleveland
Sponsor: Case Comprehensive Cancer Center
Sex: All·Age: 18+
Code: NCT07104630·Phase 2·Recruiting·Listed Aug 2025
A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators
for Cystic Fibrosis
Sites in Cleveland, Columbus +66 more locations
Sponsor: Nicole Hamblett
Sex: All·Age: 12+
Code: NCT06504589·Recruiting·Listed Jul 2024
Implementation of a Sarcopenia Clinic to Diagnose and Treat Skeletal Muscle Loss Due to COPD
for COPD
1 location in Cleveland
Sponsor: The Cleveland Clinic
Sex: All·Age: 40+
Code: NCT07059637·Recruiting·Listed Jul 2025
myAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home
for COPD
Sites in Cleveland, Columbus +23 more locations
Sponsor: Temple University
Sex: All·Age: 30+
Code: NCT05204888·Recruiting·Listed Jan 2022
PRagmatic EVAluation of a Quality Improvement Program for People Living With Modifiable High-risk COPD.
for Chronic Obstructive Pulmonary Disease
Sites in Cleveland +2 more locations
Sponsor: Observational and Pragmatic Research Institute
Sex: All·Age: 18+
Code: NCT05306743·Recruiting·Listed Apr 2022
Roll-over Study for Participants Who Have Completed a Previous Clinical Study With Benralizumab (Fasenra) and Benefit From Continued Treatment
for Asthma
Sites in Cleveland +7 more locations
Sponsor: AstraZeneca
Sex: All·Age: 6+
Code: NCT07444567·Phase 3·Recruiting·Listed Mar 2026
PEP Buddy in Pulmonary Rehabilitation
for COPD
Sites in Cleveland & Cincinnati
Sponsor: VA Office of Research and Development
Sex: All·Age: 40 - 89
Code: NCT07404826·Recruiting·Listed Feb 2026
Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension
for Pulmonary Arterial Hypertension
Drug: Empagliflozin
Sites in Cleveland +2 more locations
Sponsor: Gustavo A Heresi, MD, MS
Sex: All·Age: 18+
Code: NCT06992440·Phase 2·Recruiting·Listed May 2025
A Study to Investigate the Efficacy and Safety of Tezepelumab Compared With Placebo in Children 5 to < 12 Years Old With Severe Asthma
for Asthma
Sites in Cleveland, Toledo +19 more locations
Sponsor: AstraZeneca
Sex: All·Age: 5 - 11
Code: NCT06023589·Phase 3·Recruiting·Listed Sep 2023
A Study to Compare the Efficacy, Safety and Tolerability of FF/UMEC/VI With FF/VI in 12-17-year-olds With Asthma
for Asthma
Sites in Cleveland, Cincinnati +16 more locations
Sponsor: GlaxoSmithKline
Sex: All·Age: 12 - 17
Code: NCT05757102·Phase 3·Recruiting·Listed Mar 2023
Study to Evaluate the Efficacy, Safety, and Tolerability of Efzofitimod in Patients With Systemic Sclerosis (SSc)-Related Interstitial Lung Disease (ILD) (SSc-ILD)
for Interstitial Lung Disease
Sites in Cleveland +14 more locations
Sponsor: aTyr Pharma, Inc.
Sex: All·Age: 18+
Code: NCT05892614·Phase 2·Recruiting·Listed Jun 2023
Top Research Study Locations in Cleveland
Researchers run research studies in Cleveland, OH at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Cleveland Clinic | Heart Failure, Cardiovascular Diseases, Atrial Fibrillation | 354 |
| University Hospitals Cleveland Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 156 |
| Cleveland Clinic Foundation | COPD, Heart Failure, Recurrent Endometrial Carcinoma | 142 |
| Case Western Reserve University | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Metastatic Malignant Neoplasm in the Brain | 80 |
| MetroHealth Medical Center | Spinal Cord Injuries, Spinal Cord Injury Cervical, Stage IVB Prostate Cancer AJCC v8 | 37 |
| The Cleveland Clinic Foundation | Aortic Valve Insufficiency, Cardiovascular Diseases, Heart Diseases | 27 |
| Louis Stokes VA Medical Center, Cleveland, OH | Spinal Cord Injury, Diabetes, Parkinson's Disease | 24 |
| Rainbow Babies and Childrens Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Down Syndrome | 24 |
| Cleveland Clinic Main Campus | Breast Cancer, Abdominal Wall Hernia, Blood Pressure | 19 |
| The Cleveland Clinic | Depression / Major Depressive Disorder, Hopelessness, Suicidal Ideation | 17 |
| Cleveland Clinic Cancer Center/Fairview Hospital | Ovarian Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8, Breast Cancer | 14 |
| University Hospitals | Chronic Pain, B Cell Lymphoma, Bladder Pain Syndrome | 13 |
| UH Cleveland Medical Center | Breast Cancer, Acute Decompensated Heart Failure, Atrial Fibrillation | 11 |
| University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center | Acute Lymphocytic Leukemia, Bile Duct Cancer, Brain Metastases | 11 |
| University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center | Pancreatic Cancer, Acute Lymphatic Leukemia, Acute Myelogenous Leukemia | 11 |
| Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center | Acute Myeloid Leukemia, Cyst of Pancreas, Cytokine Release Syndrome | 10 |
| University Hospitals of Cleveland | Advanced Solid Tumors, Aortic Aneurysm, Aortic Dissection | 9 |
| Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute | Amyloid Light-chain Amyloidosis, B-cell Non Hodgkin Lymphoma, Basal Cell Carcinoma | 8 |
| Cleveland Clinic Taussig Cancer Center | Glioma, Advanced Solid Tumor, Advanced or Metastatic Solid Tumors | 8 |
| The MetroHealth System | AV Block, COVID-19, Coronavirus Infections | 8 |
| University Hospitals Cleveland | 1st Line NSCLC, Abdominal Aortic Aneurysm, Advanced Solid Tumor | 8 |
| Cleveland Clinic Fairview Hospital | HPV Infection, Pre-Cancerous Dysplasia, Bleeding | 7 |
| Louis Stokes Cleveland VA Medical Center | Multiple Sclerosis, Stroke, Adenocarcinoma of the Colon | 7 |
| MetroHealth | Acute Kidney Injury, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 7 |
| Case Comprehensive Cancer Center, Cleveland Clinic Foundation | Head and Neck Cancer, Oral Cancer, Cancer | 6 |
Active & Upcoming Studies in Cleveland (2026)
Recruiting trials in Cleveland grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (384 active studies)
- TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE) · Case Comprehensive Cancer Center
- A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma · Phase 3 · AbbVie
Cardiovascular (103 active studies)
- Metabolic Surgery for Atrial Fibrillation Elimination · Phase 4 · Ali Aminian
- A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. · P+F Products + Features USA Inc.
Neurology & pain (85 active studies)
- REstoring Flow by REvascularization With Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis · Case Western Reserve University
- A Study of Remibrutinib Using MR Imaging in Relapsing or Progressive MS · Phase 2 · Moein Amin
Diabetes & metabolic (34 active studies)
- Whole Gut Motility Abnormalities Following GLP-1 Receptor Agonist (GLP-1RA) Initiation · The Cleveland Clinic
- PNS to Improve Vascular Function and Limb Health in Veterans · VA Office of Research and Development
Eye & vision (17 active studies)
- Study of Serine Supplementation to Protect Vision in MacTel · Phase 3 · The Lowy Medical Research Institute Limited
- A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated · Phase 1, Phase 2 · Boehringer Ingelheim
Mental health & behavior (15 active studies)
Pediatric (15 active studies)
- A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction · Phase 3 · Bayer
- Humidity Asthma Interventions for Low Socioeconomic Status Children · Case Western Reserve University
HIV / STI (6 active studies)
- Dasatinib for HIV-1 Reservoir Reduction · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- Menopausal HT for Women Living With HIV (HoT) · Phase 4 · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Vaccines (5 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- A Study of S-337395 in Symptomatic Nonhospitalized Adults With Respiratory Syncytial Virus (RSV) Who Are at High Risk of Progression to Severe Disease · Phase 2 · Shionogi
Common conditions studied in Cleveland
- Heart Failure (28 active studies)
- Breast Cancer (19 active studies)
- Advanced Solid Tumor (18 active studies)
- Cardiovascular Diseases (17 active studies)
- Prostate Cancer (16 active studies)
- Acute Myeloid Leukemia (15 active studies)
Leading research sponsors in Cleveland
- The Cleveland Clinic
- Case Comprehensive Cancer Center
- National Cancer Institute (NCI)
- University Hospitals Cleveland Medical Center
- Case Western Reserve University
Frequently asked questions
How many paid clinical trials are currently recruiting in Cleveland?
There are approximately 1,259 recruiting clinical trials in Cleveland, Ohio listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Cleveland pay participants?
Most recruiting trials in Cleveland compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Cleveland?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Cleveland?
The most common conditions under active study in Cleveland include Heart Failure (28), Breast Cancer (19), Advanced Solid Tumor (18), Cardiovascular Diseases (17), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Cleveland?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Cleveland on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Cleveland?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Cleveland?
Recruiting research sites in Cleveland include Cleveland Clinic, University Hospitals Cleveland Medical Center, Cleveland Clinic Foundation, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Cleveland right now?
The largest active categories in Cleveland are Cancer & tumors (384), Cardiovascular (103), Neurology & pain (85). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
Browse more clinical trials
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