Solid tumor Clinical Trials in Cleveland, OH
As of August 2026, 44 paid clinical trials are recruiting for Solid tumor in Cleveland, Ohio. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Related specialties in Cleveland
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44 clinical trials for Solid tumor
·Clear filters·Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
FOG-001 in Locally Advanced or Metastatic Solid Tumors
Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers
A Study of ASP3082 in Adults With Advanced Solid Tumors
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations
A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
A Study of ASP1002 in Adults for Treatment of Solid Tumors
SLV-154 Treatment of Advanced Cancers
A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)
XTX301 in Patients With Advanced Solid Tumors
A Study of ZL-1310 in Participants With Selected Solid Tumors
First in Human Study of TUB-030 in Patients With Advanced Solid Tumors
A Phase 1 Clinical Study of NXP900 in Subjects With Advanced Cancers
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
A Phase 1 Study of XL309 (ISM3091) Alone and in Combination in Participants With Advanced Solid Tumors
A Study Assessing KB707 for the Treatment of Advanced Solid Tumor Malignancies Affecting the Lungs
A First-in-Human Study of YL217 in Patients With Advanced Solid Tumors
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
Study of AVZO-021 in Patients With Advanced Solid Tumors
Phase 1 Study of Intratumoral Administration of VAX014 With Expansion in Combination With a Checkpoint Inhibitor in Subjects With Advanced Solid Tumors
Safety and Preliminary Efficacy of SA53-OS in Patients With Locally Advanced or Metastatic Solid Tumors
SW-682 in Advanced Solid Tumors
A Study to Evaluate the Safety and Pharmacokinetics of Eflapegrastim in Pediatric Participants With Solid Tumors or Lymphomas and Treated With Myelosuppressive Chemotherapy
Study of ISM6331 in Participants With Advanced/Metastatic Malignant Mesothelioma or Other Solid Tumors
First in Human Study of TORL-1-23 in Participants With Advanced Cancer
JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration
ABL103 in Combination With Pembrolizumab, With or Without Taxane in Advanced or Metastatic Solid Tumors
Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab
A Study to Assess the Safety, Pharmacokinetics, and Antitumor Activity of BC3195 in Patients With Advanced or Metastatic Cancer
A Phase I/II, Open-label Study to Investigate the Safety, Tolerability, PK, and Preliminary Efficacy of FB849
A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain
Project: Every Child for Younger Patients With Cancer
The Vanguard Study: Testing a New Way to Screen for Cancer
Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies
Top Research Study Locations in Cleveland
Researchers run research studies in Cleveland, OH at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Cleveland Clinic | Heart Failure, Cardiovascular Diseases, Atrial Fibrillation | 354 |
| University Hospitals Cleveland Medical Center | ARDS, ARDS (Acute Respiratory Distress Syndrome), Acute Respiratory Distress Syndrome | 156 |
| Cleveland Clinic Foundation | COPD, Heart Failure, Recurrent Endometrial Carcinoma | 142 |
| Case Western Reserve University | Stage IV Lung Cancer AJCC v8, Acute Myeloid Leukemia, Metastatic Malignant Neoplasm in the Brain | 80 |
| MetroHealth Medical Center | Spinal Cord Injuries, Spinal Cord Injury Cervical, Stage IVB Prostate Cancer AJCC v8 | 37 |
| The Cleveland Clinic Foundation | Aortic Valve Insufficiency, Cardiovascular Diseases, Heart Diseases | 27 |
| Louis Stokes VA Medical Center, Cleveland, OH | Spinal Cord Injury, Diabetes, Parkinson's Disease | 24 |
| Rainbow Babies and Childrens Hospital | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Down Syndrome | 24 |
| Cleveland Clinic Main Campus | Breast Cancer, Abdominal Wall Hernia, Blood Pressure | 19 |
| The Cleveland Clinic | Depression / Major Depressive Disorder, Hopelessness, Suicidal Ideation | 17 |
| Cleveland Clinic Cancer Center/Fairview Hospital | Ovarian Carcinoma, Anatomic Stage IV Breast Cancer AJCC v8, Breast Cancer | 14 |
| University Hospitals | Chronic Pain, B Cell Lymphoma, Bladder Pain Syndrome | 13 |
| UH Cleveland Medical Center | Breast Cancer, Acute Decompensated Heart Failure, Atrial Fibrillation | 11 |
| University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center | Acute Lymphocytic Leukemia, Bile Duct Cancer, Brain Metastases | 11 |
| University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center | Pancreatic Cancer, Acute Lymphatic Leukemia, Acute Myelogenous Leukemia | 11 |
| Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center | Acute Myeloid Leukemia, Cyst of Pancreas, Cytokine Release Syndrome | 10 |
| University Hospitals of Cleveland | Advanced Solid Tumors, Aortic Aneurysm, Aortic Dissection | 9 |
| Case Comprehensive Cancer Center, Cleveland Clinic Foundation Taussig Cancer Institute | Amyloid Light-chain Amyloidosis, B-cell Non Hodgkin Lymphoma, Basal Cell Carcinoma | 8 |
| Cleveland Clinic Taussig Cancer Center | Glioma, Advanced Solid Tumor, Advanced or Metastatic Solid Tumors | 8 |
| The MetroHealth System | AV Block, COVID-19, Coronavirus Infections | 8 |
| University Hospitals Cleveland | 1st Line NSCLC, Abdominal Aortic Aneurysm, Advanced Solid Tumor | 8 |
| Cleveland Clinic Fairview Hospital | HPV Infection, Pre-Cancerous Dysplasia, Bleeding | 7 |
| Louis Stokes Cleveland VA Medical Center | Multiple Sclerosis, Stroke, Adenocarcinoma of the Colon | 7 |
| MetroHealth | Acute Kidney Injury, Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | 7 |
| Case Comprehensive Cancer Center, Cleveland Clinic Foundation | Head and Neck Cancer, Oral Cancer, Cancer | 6 |
Active & Upcoming Studies in Cleveland (2026)
Recruiting trials in Cleveland grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (384 active studies)
- TRANScriptional Pathways Of Surgical Pain Modulated by Music Therapy Exposure (TRANSPOSE) · Case Comprehensive Cancer Center
- A Study to Evaluate Adverse Events and Change in Disease Activity With Injected Etentamig Plus Oral Pomalidomide Versus Standard Therapies in Adults With Relapsed or Refractory Multiple Myeloma · Phase 3 · AbbVie
Cardiovascular (103 active studies)
- Metabolic Surgery for Atrial Fibrillation Elimination · Phase 4 · Ali Aminian
- A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. · P+F Products + Features USA Inc.
Neurology & pain (85 active studies)
- REstoring Flow by REvascularization With Submaximal Angioplasty in Hemodynamic IntraCranial Atherosclerotic Stenosis · Case Western Reserve University
- A Study of Remibrutinib Using MR Imaging in Relapsing or Progressive MS · Phase 2 · Moein Amin
Diabetes & metabolic (34 active studies)
- Whole Gut Motility Abnormalities Following GLP-1 Receptor Agonist (GLP-1RA) Initiation · The Cleveland Clinic
- PNS to Improve Vascular Function and Limb Health in Veterans · VA Office of Research and Development
Eye & vision (17 active studies)
- Study of Serine Supplementation to Protect Vision in MacTel · Phase 3 · The Lowy Medical Research Institute Limited
- A Study in People With Diabetic Macular Edema to Test How Well Different Doses of BI 3812465 Are Tolerated · Phase 1, Phase 2 · Boehringer Ingelheim
Mental health & behavior (15 active studies)
Pediatric (15 active studies)
- A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction · Phase 3 · Bayer
- Humidity Asthma Interventions for Low Socioeconomic Status Children · Case Western Reserve University
HIV / STI (6 active studies)
- Dasatinib for HIV-1 Reservoir Reduction · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
- Menopausal HT for Women Living With HIV (HoT) · Phase 4 · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
Vaccines (5 active studies)
- A Study on the Immune Response and Safety of an Investigational Combined Measles, Mumps, Rubella and Varicella Vaccine, When Given to Healthy Children 4 to 6 Years of Age · Phase 3 · GlaxoSmithKline
- A Study of S-337395 in Symptomatic Nonhospitalized Adults With Respiratory Syncytial Virus (RSV) Who Are at High Risk of Progression to Severe Disease · Phase 2 · Shionogi
Common conditions studied in Cleveland
- Heart Failure (28 active studies)
- Breast Cancer (19 active studies)
- Advanced Solid Tumor (18 active studies)
- Cardiovascular Diseases (17 active studies)
- Prostate Cancer (16 active studies)
- Acute Myeloid Leukemia (15 active studies)
Leading research sponsors in Cleveland
- The Cleveland Clinic
- Case Comprehensive Cancer Center
- National Cancer Institute (NCI)
- University Hospitals Cleveland Medical Center
- Case Western Reserve University
Frequently asked questions
How many paid clinical trials are currently recruiting in Cleveland?
There are approximately 1,259 recruiting clinical trials in Cleveland, Ohio listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Cleveland pay participants?
Most recruiting trials in Cleveland compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Cleveland?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Cleveland?
The most common conditions under active study in Cleveland include Heart Failure (28), Breast Cancer (19), Advanced Solid Tumor (18), Cardiovascular Diseases (17), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Cleveland?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Cleveland on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Cleveland?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Cleveland?
Recruiting research sites in Cleveland include Cleveland Clinic, University Hospitals Cleveland Medical Center, Cleveland Clinic Foundation, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Cleveland right now?
The largest active categories in Cleveland are Cancer & tumors (384), Cardiovascular (103), Neurology & pain (85). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.