Heart disease Clinical Trials in Jacksonville, FL
As of August 2026, 45 paid clinical trials are recruiting for Heart disease in Jacksonville, Florida. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Jacksonville
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
46 clinical trials for Heart disease
·Clear filters·A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
SELUTION 4 De Novo Small Vessel IDE Trial
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)
A Study of Assessment on Safety and Effectiveness of BWI Pulsed Field Ablation With OMNYPULSE Catheter for the Treatment of Paroxysmal Atrial Fibrillation (PAF)
AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation
A Study of VARIPULSE Catheter in Participants With Persistent Atrial Fibrillation Undergoing Pulmonary Vein and Superior Vena Cava Isolation
Transition to KPL-387 Monotherapy Dosing & Administration Study
Coherent Sine Burst Electroporation (CSE) Ablation System US IDE Study for Patients With Atrial Fibrillation
Artificial Intelligence Mapping and Ablation of Non-Pulmonary Vein Electrical Drivers of AF Study
MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels
PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm
NORM-HF Pivotal Study
A Safety and Tolerability Study of HJB647 in Heart Failure Participants With Reduced Ejection Fraction
Accuracy of a Cuffless Photoplethysmography (PPG) Chest-Patch Monitor for 24-hour Ambulatory Blood Pressure Monitoring (ABPM)
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
The Fourth Left Atrial Appendage Occlusion Study
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Comparison of Dual Antiplatelet Therapy De-escalation by Dose Reduction Versus Switching in Patients Undergoing PCI: The Switching Antiplatelet-8 (SWAP-8) Study
Tailoring Bleeding Reduction Approaches in Patients Undergoing PCI
Left vs Left Randomized Clinical Trial
Switching From Dual Antiplatelet Therapy to Monotherapy With Potent P2Y12 Inhibitors
Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention
A Precision Medicine Approach to Identify Patients Undergoing Elective PCI at Risk of Peri-PCI Myocardial Infarction
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
Barostim-Enabled NEurohormonal Intervention For Improving Treatment of Heart Failure
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
Top Research Study Locations in Jacksonville
Researchers run research studies in Jacksonville, FL at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Mayo Clinic in Florida | Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm, Anatomic Stage II Breast Cancer AJCC v8 | 170 |
| Mayo Clinic | Amyotrophic Lateral Sclerosis, Colorectal Cancer, Breast Cancer | 83 |
| Mayo Clinic Florida | Amyotrophic Lateral Sclerosis, Advanced Melanoma, CRC | 75 |
| Mayo Clinic Jacksonville | Non Small Cell Lung Cancer, Amyotrophic Lateral Sclerosis (ALS), Prostate Cancer | 47 |
| Nemours Children's Clinic-Jacksonville | Malignant Solid Neoplasm, Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia | 32 |
| Jacksonville Center for Clinical Research | Heart Failure, Obesity, Cardiovascular Disease | 22 |
| Baptist MD Anderson Cancer Center | Breast Cancer, Advanced Melanoma, Anatomic Stage II Breast Cancer AJCC v8 | 18 |
| Cancer Specialists of North Florida | Carcinoma, Non-Small-Cell Lung, Acinar Cell Carcinoma, Advanced Cancer | 14 |
| University of Florida | Coronary Artery Disease, Allergies, Arthropathy of Hip | 12 |
| Mayo Clinic - Jacksonville | Adenoid Cystic Carcinoma, Amyloid Cardiomyopathy, Amyloidosis | 10 |
| Brooks Rehabilitation | Spinal Cord Injuries, Spinal Cord Injury, Stroke | 9 |
| Ascension St. Vincent's | Atrial Fibrillation, Brain Tumor, Brain Tumor - Metastatic | 8 |
| Mayo Clinic - Florida | Epilepsy, Epilepsy (Treatment Refractory), Astrocytoma, Grade IV | 8 |
| University of Florida Jacksonville | Coronary Artery Disease, AV Block, Acute Stroke | 8 |
| Baptist Health Research Institute | Acute Ischemic Stroke, Alzheimer Disease, Aneurysm, Intracranial | 7 |
| UF Health Jacksonville | Atrial Fibrillation, Diabetes Mellitus, Type 2, Heart Failure | 7 |
| Baptist Medical Center Jacksonville | Intracranial Aneurysm, Chronic Subdural Hematoma, Intracranial Atherosclerotic Stenosis (ICAS) | 6 |
| Clinical Neuroscience Solutions, Inc. | Bipolar Depression, Bipolar Disorder, Bipolar I Disorder | 6 |
| Mayo Clinic Cancer Center | Acute Myeloid Leukemia, B-Cell Acute Lymphoblastic Leukaemia, CRC | 6 |
| First Coast Cardiovascular Institute | Heart Failure, Peripheral Arterial Disease, Chronic Limb-Threatening Ischemia | 5 |
| GSK Investigational Site | Non-alcoholic Fatty Liver Disease, Gastrointestinal Neoplasms, Irritable Bowel Syndrome | 5 |
| Nemours Children's Clinic | Cystic Fibrosis, Amblyopia, Cystic Fibrosis Pulmonary Exacerbation | 5 |
| Nemours Children's Health | Asthma (Diagnosis), Autosomal Dominant Hypocalcemia Type 1 (ADH1), Child | 5 |
| Clinical Trial Site | ATTR Amyloidosis, Advanced Hepatocellular Carcinoma, Generalized Myasthenia Gravis | 4 |
| Brooks Rehabilitation Hospital | Internuclear Ophthalmoplegia, Ischemic Stroke, Palsy, Abducens | 4 |
Active & Upcoming Studies in Jacksonville (2026)
Recruiting trials in Jacksonville grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (302 active studies)
Cardiovascular (68 active studies)
Neurology & pain (53 active studies)
- Magnesium Supplement for Sleep Quality in Women With Poor Sleep · Jacksonville University
- Arm Elevation for Prevention of Propofol Injection Pain · Mayo Clinic
Diabetes & metabolic (49 active studies)
- A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide · Phase 3 · Novo Nordisk A/S
- AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight · Phase 3 · Novo Nordisk A/S
Mental health & behavior (16 active studies)
- A Study to Evaluate the Efficacy and Safety of AXS-05 for Smoking Cessation in Adults · Phase 3 · Axsome Therapeutics, Inc.
- A Trial of the Efficacy and Safety of Fixed Doses of SEP-363856 in Adults With Generalized Anxiety Disorder · Phase 3 · Otsuka Pharmaceutical Development & Commercialization, Inc.
HIV / STI (8 active studies)
- Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver) · Johns Hopkins University
- Assessing Performance of a Hepatitis C Emergency Department (HepC-EnD) Screening Tool: IT Integration Process for Electronic Health Record System · University of Florida
Eye & vision (8 active studies)
- Ixoberogene Soroparvovec (Ixo-vec) Contralateral Dosing Study in Participants With Neovascular Age-related Macular Degeneration · Phase 2 · Adverum Biotechnologies, Inc.
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002) · Phase 2, Phase 3 · EyeBiotech Ltd.
Pediatric (6 active studies)
Vaccines (2 active studies)
Common conditions studied in Jacksonville
- Obesity (20 active studies)
- Malignant Solid Neoplasm (19 active studies)
- Breast Cancer (16 active studies)
- Heart Failure (16 active studies)
- Overweight (14 active studies)
- Prostate Cancer (13 active studies)
Leading research sponsors in Jacksonville
- Mayo Clinic
- AstraZeneca
- University of Florida
- Children's Oncology Group
- Eli Lilly and Company
Frequently asked questions
How many paid clinical trials are currently recruiting in Jacksonville?
There are approximately 925 recruiting clinical trials in Jacksonville, Florida listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Jacksonville pay participants?
Most recruiting trials in Jacksonville compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Jacksonville?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Jacksonville?
The most common conditions under active study in Jacksonville include Obesity (20), Malignant Solid Neoplasm (19), Breast Cancer (16), Heart Failure (16), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Jacksonville?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Jacksonville on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Jacksonville?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Jacksonville?
Recruiting research sites in Jacksonville include Mayo Clinic in Florida, Mayo Clinic, Mayo Clinic Florida, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Jacksonville right now?
The largest active categories in Jacksonville are Cancer & tumors (302), Cardiovascular (68), Neurology & pain (53). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.