Randomized Study in Children and Adolescents With Migraine: Acute Treatment
for Pediatric Migraine
Sites in Orange, Fountain Valley +76 more locations
Sponsor: Pfizer
Sex: All·Age: 6 - 17
Code: NCT04649242·Phase 3·Recruiting·Listed Dec 2020
Clinical Trials at Children's Hospital of Orange County
As of September 2026, 65 paid clinical trials are recruiting at Children's Hospital of Orange County, located at 1201 W LA VETA AVE, ORANGE, CA 92868-4203, phone (714) 997-3000 in Orange, California. Active studies at this site cover conditions such as Breast Cancer, Ovarian Cancer and Acute Myeloid Leukemia. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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65 clinical trials at Children's Hospital of Orange County
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A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
for Neoplasms
Sites in Orange, Los Angeles +23 more locations
Sponsor: Eli Lilly and Company
Sex: All·Age: 1 - 39
Code: NCT05999994·Phase 2·Recruiting·Listed Aug 2023
Pompe Disease Registry Protocol
for Glycogen Storage Disease Type II
Sites in Orange, Irvine +72 more locations
Sponsor: Genzyme, a Sanofi Company
Sex: All·Age: All ages
Code: NCT00231400·Recruiting·Listed Oct 2005
Fabry Disease Registry & Pregnancy Sub-registry
for Fabry Disease
Sites in Orange, Irvine +72 more locations
Sponsor: Genzyme, a Sanofi Company
Sex: All·Age: All ages
Code: NCT00196742·Recruiting·Listed Sep 2005
International Collaborative Gaucher Group (ICGG) Gaucher Disease Registry & Pregnancy Sub-registry
for Gaucher Disease
Sites in Orange, Irvine +68 more locations
Sponsor: Genzyme, a Sanofi Company
Sex: All·Age: All ages
Code: NCT00358943·Recruiting·Listed Aug 2006
Study to Evaluate the Maximal Use of Ruxolitinib Cream in Adult and Adolescent Participants With Hidradenitis Suppurativa
for Hidradenitis Suppurativa
Drug: Ruxolitinib
Sites in Orange, Northridge +17 more locations
Sponsor: Incyte Corporation
Sex: All·Age: 12 - 75
Code: NCT07049575·Phase 1·Recruiting·Listed Jul 2025
A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Adult and Pediatric Participants With Spinal Muscular Atrophy (PIERRE-PK)
for Muscular Atrophy, Spinal
Sites in Orange, Palo Alto +8 more locations
Sponsor: Biogen
Sex: All·Age: 3+
Code: NCT06555419·Phase 1·Recruiting·Listed Aug 2024
A Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis or Crohn's Disease
for Ulcerative Colitis
Sites in Orange +5 more locations
Sponsor: Takeda
Sex: All·Age: 2 - 17
Code: NCT06100289·Phase 3·Recruiting·Listed Oct 2023
A Long-Term Extension Study of Vedolizumab in Children and Teenagers With Ulcerative Colitis (UC) or Crohn's Disease (CD)
for Ulcerative Colitis
Sites in Orange, Loma Linda +12 more locations
Sponsor: Takeda
Sex: All·Age: 2 - 17
Code: NCT06405087·Phase 3·Recruiting·Listed May 2024
A Study to Learn About the Study Medicine Aztreonam-Avibactam (ATM-AVI) in Infants and Newborns Admitted in Hospitals With Bacterial Infection (CHERISH)
for Gram-negative Bacterial Infection
Sites in Orange +10 more locations
Sponsor: Pfizer
Sex: All·Age: Up to 39 Weeks
Code: NCT06462235·Phase 2·Recruiting·Listed Jun 2024
An Open Label Clinical Study to Evaluate Tanruprubart (Also Commonly Known as ANX005) in Participants With Guillain-Barré Syndrome (FORWARD Study)
for Guillain-Barre Syndrome
Sites in Orange, Carlsbad +10 more locations
Sponsor: Annexon, Inc.
Sex: All·Age: 12 - 85
Code: NCT07020819·Phase 3·Recruiting·Listed Jun 2025
Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps
for Chronic Rhinosinusitis Without Nasal Polyps
Sites in Orange, Torrance +18 more locations
Sponsor: Optinose US Inc.
Sex: All·Age: 12 - 17
Code: NCT06850805·Phase 3·Recruiting·Listed Feb 2025
A Long-Term Observational Study of Patients With Fucosidosis
for Fucosidosis
Sites in Orange +1 more location
Sponsor: JCR Pharmaceuticals Co., Ltd.
Sex: All·Age: All ages
Code: NCT07615400·Recruiting·Listed May 2026
Glycogen Storage Disease Type Ia (GSDIa) Disease Monitoring Program
for Glycogen Storage Disease Type Ia
Sites in Orange +8 more locations
Sponsor: Ultragenyx Pharmaceutical Inc
Sex: All·Age: 2+
Code: NCT06636383·Recruiting·Listed Oct 2024
Mucopolysaccharidosis VII Disease Monitoring Program
for Mucopolysaccharidosis VII
Sites in Orange +5 more locations
Sponsor: Ultragenyx Pharmaceutical Inc
Sex: All·Age: All ages
Code: NCT03604835·Recruiting·Listed Jul 2018
A Study to Evaluate the Safety and Tolerability of Eravacycline in Pediatric Patients Aged 8 to 17 With Complicated Intra-abdominal Infections (cIAI)
for Complicated Intra-abdominal Infections (cIAI)
Sites in Orange, Los Angeles +3 more locations
Sponsor: Tetraphase Pharmaceuticals, Inc
Sex: All·Age: 8 - 17
Code: NCT06794541·Phase 2·Recruiting·Listed Jan 2025
Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).
for IGF1 Deficiency
Sites in Orange +4 more locations
Sponsor: Esteve Pharmaceuticals, S.A.
Sex: All·Age: 2 - 18
Code: NCT00903110·Recruiting·Listed May 2009
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
for Epileptic Encephalopathy
Sites in Orange +4 more locations
Sponsor: Institut de Recherches Internationales Servier
Sex: All·Age: 2 - 12
Code: NCT07227857·Phase 1, Phase 2·Recruiting·Listed Nov 2025
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
for Childhood Extracranial Germ Cell Tumor
Sites in Orange, Anaheim +380 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: All ages
Code: NCT03067181·Phase 3·Recruiting·Listed Mar 2017
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
for Advanced Malignant Solid Neoplasm
Sites in Orange, Los Angeles +429 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: All ages
Code: NCT05564377·Phase 2·Recruiting·Listed Oct 2022
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
Drug: Nivolumab
Sites in Orange, Costa Mesa +378 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 5 - 60
Code: NCT05675410·Phase 3·Recruiting·Listed Jan 2023
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
for Hematopoietic and Lymphatic System Neoplasm
Sites in Orange, Duarte +189 more locations
Sponsor: Children's Oncology Group
Sex: Female·Age: Up to 39
Code: NCT06513962·Phase 3·Recruiting·Listed Jul 2024
Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy
for B Acute Lymphoblastic Leukemia
Sites in Orange, Long Beach +185 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 365 Days - 25
Code: NCT03959085·Phase 3·Recruiting·Listed May 2019
A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)
for B Acute Lymphoblastic Leukemia
Sites in Orange, Long Beach +136 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 366 Days - 46
Code: NCT06124157·Phase 2·Recruiting·Listed Nov 2023
A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations
for Acute Myeloid Leukemia
Sites in Orange, Long Beach +167 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 21
Code: NCT04293562·Phase 3·Recruiting·Listed Mar 2020
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
for Acute Leukemia of Ambiguous Lineage
Drug: Venetoclax
Sites in Orange, Long Beach +110 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: Up to 365 Days
Code: NCT06317662·Phase 2·Recruiting·Listed Mar 2024
A Study With Tovorafenib (DAY101) as a Treatment Option for Progressive, Relapsed, or Refractory Langerhans Cell Histiocytosis
for Recurrent Langerhans Cell Histiocytosis
Sites in Orange, Long Beach +99 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 180 Days - 22
Code: NCT05828069·Phase 2·Recruiting·Listed Apr 2023
Project: Every Child for Younger Patients With Cancer
for Adrenal Gland Pheochromocytoma
Sites in Orange, Long Beach +225 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 25
Code: NCT02402244·Recruiting·Listed Mar 2015
A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)
for Stage I Mixed Cell Type Kidney Wilms Tumor
Sites in Orange, Long Beach +151 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 30
Code: NCT06401330·Phase 3·Recruiting·Listed May 2024
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT
for Anaplastic Kidney Wilms Tumor
Sites in Orange, Long Beach +170 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 30
Code: NCT04322318·Phase 2·Recruiting·Listed Mar 2020
A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)
for Malignant Glioma
Drug: Selinexor
Sites in Orange, Long Beach +104 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 12 Months - 21
Code: NCT05099003·Phase 1, Phase 2·Recruiting·Listed Oct 2021
A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma
for Low Grade Astrocytoma
Drug: Selumetinib
Sites in Orange, Long Beach +115 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: 2 - 21
Code: NCT04166409·Phase 3·Recruiting·Listed Nov 2019
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
for Acute Lymphoblastic Leukemia
Sites in Orange, Long Beach +154 more locations
Sponsor: PedAL BCU, LLC
Sex: All·Age: Up to 22
Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021
Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma
for Metastatic Malignant Neoplasm in the Lung
Sites in Orange, Anaheim +200 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: Up to 50
Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022
A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma
for Basal Ganglia Germinoma
Sites in Orange, Los Angeles +93 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 3 - 29
Code: NCT06368817·Phase 2·Recruiting·Listed Apr 2024
Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma
for Ganglioneuroblastoma, Nodular
Sites in Orange, Long Beach +152 more locations
Sponsor: National Cancer Institute (NCI)
Sex: All·Age: Up to 30
Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)
for Ganglioneuroblastoma
Sites in Orange, Downey +141 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 365 Days - 30
Code: NCT03126916·Phase 3·Recruiting·Listed Apr 2017
A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT
for Central Nervous System Nongerminomatous Germ Cell Tumor
Sites in Orange, Long Beach +139 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 3 - 29
Code: NCT04684368·Phase 2·Recruiting·Listed Dec 2020
Cardiac Structure and Function in MPS
for MPS I
Sites in Orange +2 more locations
Sponsor: Children's Hospital of Orange County
Sex: All·Age: 0 - 99·Accepts healthy volunteers
Code: NCT07361536·Recruiting·Listed Jan 2026
A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss
for Childhood Medulloblastoma
Sites in Orange, Long Beach +100 more locations
Sponsor: Children's Oncology Group
Sex: All·Age: 4 - 21
Code: NCT05382338·Phase 3·Recruiting·Listed May 2022
Common conditions studied in Orange
- Breast Cancer (10 active studies)
- Ovarian Cancer (9 active studies)
- Acute Myeloid Leukemia (8 active studies)
- Hepatocellular Carcinoma (8 active studies)
- Major Depressive Disorder (8 active studies)
- Endometrial Cancer (7 active studies)
Leading research sponsors in Orange
- University of California, Irvine
- National Cancer Institute (NCI)
- Children's Oncology Group
- NRG Oncology
- Alliance for Clinical Trials in Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Orange?
There are approximately 511 recruiting clinical trials in Orange, California listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Orange pay participants?
Most recruiting trials in Orange compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Orange?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Orange?
The most common conditions under active study in Orange include Breast Cancer (10), Ovarian Cancer (9), Acute Myeloid Leukemia (8), Hepatocellular Carcinoma (8), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Orange?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Orange on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Orange?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Orange?
Recruiting research sites in Orange include Children's Hospital of Orange County, UC Irvine Health/Chao Family Comprehensive Cancer Center, University of California Irvine, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Orange right now?
The largest active categories in Orange are Cancer & tumors (216), Neurology & pain (19), Cardiovascular (19). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.
What is the address of Children's Hospital of Orange County?
Children's Hospital of Orange County is located at 1201 W LA VETA AVE, ORANGE, CA 92868-4203. Use the Google Maps link in the intro above to get directions.
How do I contact Children's Hospital of Orange County?
You can reach Children's Hospital of Orange County by phone at (714) 997-3000. For questions about a specific trial, use the study coordinator contact listed on the individual study record — click any trial title above to open it.
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