Heart disease Clinical Trials in Pittsburgh, PA
As of August 2026, 37 paid clinical trials are recruiting for Heart disease in Pittsburgh, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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37 clinical trials for Heart disease
·Clear filters·OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
Assessment of CCM in HF With Higher Ejection Fraction
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Using the Sphere-9 Catheter and Affera Ablation System (Conquer-AF)
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels
A Pivotal Study to Evaluate the Effectiveness of Isometric Handgrip Therapy in Elevated Blood Pressure and Hypertensive Subjects
Abbott Structural Heart Device Registry
Feasibility of The Health Integrated Nutrition and Kidney Wellness Program
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation
The Fourth Left Atrial Appendage Occlusion Study
Pragmatic Evaluation of Events And Benefits of Lipid-lowering in Older Adults
Randomization of Single vs Multiple Arterial Grafts
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
Quantifying New Heart Muscle Cells
Treatment With Aspirin After Preeclampsia: TAP Trial
Brain Connections for Arm Movement After Stroke
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women
Deep Brain Stimulation Motor Ventral Thalamus (VOP/VIM) for Restoration of Speech and Upper-limb Function in People With Subcortical Stroke
Optimizing Prescribing Decisions for Hospitalized Older Adults With Chronic Conditions
Left vs Left Randomized Clinical Trial
Remote Ischemic Preconditioning for Renal and Cardiac Protection in Congestive Heart Failure (RICH) Trial
MCNAIR Study: coMparative effeCtiveness of iN-person and teleheAlth cardIac Rehabilitation
Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia
Transition to Cardiac Rehabilitation (T2CR) to Address Barriers of Multimorbidity and Frailty
Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With Congenital Heart Disease
Cerebrovascular Health and Resilience in Midlife
HeartBeam ECG Registry
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
Prospective Global Registry for the Study of Chronic Total Occlusion Intervention
Product Surveillance Registry
Top Research Study Locations in Pittsburgh
Researchers run research studies in Pittsburgh, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Pittsburgh | Stroke, Traumatic Brain Injury, Dementia | 159 |
| UPMC Hillman Cancer Center | Melanoma, Metastatic Malignant Solid Neoplasm, Acute Myeloid Leukemia | 147 |
| University of Pittsburgh Medical Center | Chronic Pancreatitis, Cystic Fibrosis, Advanced Solid Tumor | 130 |
| Allegheny General Hospital | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Pulmonary Hypertension | 62 |
| Children's Hospital of Pittsburgh of UPMC | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Mixed Phenotype Acute Leukemia | 58 |
| UPMC Children's Hospital of Pittsburgh | Fabry Disease, Cerebral Palsy, Congenital Bone Marrow Failure Syndromes | 52 |
| Allegheny Health Network | Brain Tumor, Breast Cancer, Colorectal Cancer | 32 |
| UPMC-Passavant Hospital | Anatomic Stage II Breast Cancer AJCC v8, Recurrent Endometrial Carcinoma, Stage IV Lung Cancer AJCC v8 | 32 |
| UPMC-Saint Clair Hospital Cancer Center | Anatomic Stage II Breast Cancer AJCC v8, Head and Neck Squamous Cell Carcinoma, Stage III Laryngeal Cancer AJCC v8 | 27 |
| UPMC-Saint Margaret | Stage III Laryngeal Cancer AJCC v8, Stage III Lip and Oral Cavity Cancer AJCC v8, Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | 25 |
| West Penn Hospital | Large B-cell Lymphoma, Stage IV Colorectal Cancer AJCC v8, Acute Lymphoblastic Leukemia (ALL) | 23 |
| UPMC-Magee Womens Hospital | Anatomic Stage II Breast Cancer AJCC v8, Recurrent Endometrial Carcinoma, Anatomic Stage I Breast Cancer AJCC v8 | 21 |
| UPMC | Focal Epilepsy, ASD - Atrial Septal Defect, Advanced Melanoma | 20 |
| UPMC Presbyterian | Acute Kidney Injuries, Aneurysm of Aorta, Thoracic, Aneurysmal Disease | 20 |
| UPMC-Shadyside Hospital | Head and Neck Squamous Cell Carcinoma, Metastatic Renal Cell Carcinoma, Stage II Lip and Oral Cavity Cancer AJCC v8 | 20 |
| UPMC Presbyterian Hospital | Abdominal Surgery, Acute Ischemic Stroke, Acute Myocardial Infarction | 19 |
| VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA | Cardiovascular Diseases, Stroke, Acute Kidney Injury | 19 |
| Children's Hospital of Pittsburgh | Diabetes Mellitus, Type 2, Hyperglycemia, Physical Inactivity | 16 |
| University of Pittsburgh Cancer Institute (UPCI) | Head and Neck Squamous Cell Carcinoma, Metastatic Renal Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma | 16 |
| UPMC Magee-Womens Hospital | ADHD, Behavioral Intervention, Breast Cancer | 9 |
| University of Pittsburgh School of Medicine | Adolescents, Anorexia Nervosa, Bipolar Disorder (BD) | 9 |
| AHN Allegheny General Hospital | Breast Cancer, Cancer, Carcinoma, Non-Small-Cell Lung | 8 |
| AHN West Penn Hospital | Malignant Mesothelioma, Malignant Pleural Effusion, Metastasis to Pleura | 8 |
| University of Pittsburgh Medical Center (UPMC) | ALS, ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis | 8 |
| UPMC Shadyside Hospital | Abdominal Surgery, Dementia, Harm Reduction | 7 |
Active & Upcoming Studies in Pittsburgh (2026)
Recruiting trials in Pittsburgh grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (396 active studies)
- Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · University of Pittsburgh
- Testing the Effect of Teclistamab on Recurrent Plasmablastic Lymphoma · Phase 1 · National Cancer Institute (NCI)
Neurology & pain (83 active studies)
- Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · University of Pittsburgh
- Psilocybin After Trauma Surgery for Pain · Phase 1 · Trent Emerick
Cardiovascular (73 active studies)
- Prediction and Prevention of Postoperative Mortality and Morbidity · University of Pittsburgh
- TEPH: Telaglenastat Efficacy in Pulmonary Hypertension · Phase 1, Phase 2 · Chan, Stephen, MD, PhD
Diabetes & metabolic (39 active studies)
- Technology Knowledge Optimization for Type 1 Diabetes in Schools · University of Pittsburgh
- A Study of Once-daily Oral ASC30 to Evaluate the Efficacy and Safety in Adult Participants With Obesity or Overweight With Type 2 Diabetes · Phase 3 · Ascletis Pharma (China) Co., Limited
Mental health & behavior (38 active studies)
Pediatric (19 active studies)
- Hypoxic Red Blood Cells in Sickle Cell Anemia · Hemanext
- A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients · Phase 2 · Costas Hadjipanayis
HIV / STI (10 active studies)
- Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver) · Johns Hopkins University
- A Trial to Evaluate the Safety and Tolerability of DV700P-RNA and DV701B1.1-RNA Immunization in Combination With Antiretroviral Analytical Treatment Interruption (ATI) in People Living With HIV for Elicitation of V3-glycan Antibodies · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Vaccines (7 active studies)
Eye & vision (3 active studies)
- A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults · Astellas Pharma Global Development, Inc.
- The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease · Rinsada
Common conditions studied in Pittsburgh
- Breast Cancer (25 active studies)
- Cancer (19 active studies)
- Melanoma (17 active studies)
- Stroke (17 active studies)
- Endometrial Cancer (16 active studies)
- Ovarian Cancer (16 active studies)
Leading research sponsors in Pittsburgh
- University of Pittsburgh
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
- VA Office of Research and Development
Frequently asked questions
How many paid clinical trials are currently recruiting in Pittsburgh?
There are approximately 1,242 recruiting clinical trials in Pittsburgh, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Pittsburgh pay participants?
Most recruiting trials in Pittsburgh compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Pittsburgh?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Pittsburgh?
The most common conditions under active study in Pittsburgh include Breast Cancer (25), Cancer (19), Melanoma (17), Stroke (17), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Pittsburgh?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Pittsburgh on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Pittsburgh?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Pittsburgh?
Recruiting research sites in Pittsburgh include University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Pittsburgh right now?
The largest active categories in Pittsburgh are Cancer & tumors (396), Neurology & pain (83), Cardiovascular (73). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.