Solid tumor Clinical Trials in Pittsburgh, PA
As of September 2026, 39 paid clinical trials are recruiting for Solid tumor in Pittsburgh, Pennsylvania. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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39 clinical trials for Solid tumor
·Clear filters·Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
FOG-001 in Locally Advanced or Metastatic Solid Tumors
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors
A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
A Study of 177Lu-FAP-2286 in Advanced Solid Tumors
XTX301 in Patients With Advanced Solid Tumors
ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
A First-In Human (FIH) Study to Find Out How Well REGN10597 Medicine Given Alone or in Combination With Cemiplimab Works in Adult Participants Who Have Cancer With Tumors That Have Spread in Their Body
An Open-label Dose Escalation/Expansion Trial to Evaluate the Safety and Anti-tumor Activity of TEV-56278 Alone or in Combination With Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
First In Human Study of CX-801 in Advanced Solid Tumors
Study to Evaluate IMGS-001 Treatment in Patients With Relapsed or Refractory Advanced Solid Tumors
Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation
A Study of VET3-TGI in Patients With Solid Tumors
PumaRx Registry Trial
Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.
Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab
A Clinical Study of Intratumoral MVR-T3011 (T3011) Given as a Single Agent and in Combination With Intravenous Pembrolizumab in Participants With Advanced or Metastatic Solid Tumors
Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)
Triptorelin for the Prevention of Ovarian Damage in Adolescents and Young Adults With Cancer
Project: Every Child for Younger Patients With Cancer
Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial
Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer
Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness
Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors
Indocyanine Green (ICG) Guided Sentinel Lymph Node Mapping for Pediatric Visceral Solid Tumors
Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid Tumors
Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors
Top Research Study Locations in Pittsburgh
Researchers run research studies in Pittsburgh, PA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| University of Pittsburgh | Stroke, Traumatic Brain Injury, Dementia | 155 |
| UPMC Hillman Cancer Center | Melanoma, Metastatic Malignant Solid Neoplasm, Acute Myeloid Leukemia | 147 |
| University of Pittsburgh Medical Center | Chronic Pancreatitis, Cystic Fibrosis, Advanced Solid Tumor | 132 |
| Allegheny General Hospital | Breast Cancer, Anatomic Stage II Breast Cancer AJCC v8, Heart Failure | 64 |
| Children's Hospital of Pittsburgh of UPMC | Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Neuroblastoma | 58 |
| UPMC Children's Hospital of Pittsburgh | Fabry Disease, Cerebral Palsy, Congenital Bone Marrow Failure Syndromes | 53 |
| Allegheny Health Network | Brain Tumor, Breast Cancer, Colorectal Cancer | 33 |
| UPMC-Passavant Hospital | Anatomic Stage II Breast Cancer AJCC v8, Recurrent Endometrial Carcinoma, Stage IV Renal Cell Cancer AJCC v8 | 31 |
| UPMC-Saint Clair Hospital Cancer Center | Anatomic Stage II Breast Cancer AJCC v8, Head and Neck Squamous Cell Carcinoma, Stage III Laryngeal Cancer AJCC v8 | 26 |
| UPMC-Saint Margaret | Stage III Laryngeal Cancer AJCC v8, Stage III Lip and Oral Cavity Cancer AJCC v8, Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | 24 |
| West Penn Hospital | Large B-cell Lymphoma, Stage IV Colorectal Cancer AJCC v8, Acute Lymphoblastic Leukemia (ALL) | 23 |
| UPMC Presbyterian | Acute Kidney Injuries, Aneurysm of Aorta, Thoracic, Aneurysmal Disease | 20 |
| UPMC-Magee Womens Hospital | Anatomic Stage II Breast Cancer AJCC v8, Recurrent Endometrial Carcinoma, Anatomic Stage I Breast Cancer AJCC v8 | 20 |
| UPMC Presbyterian Hospital | Abdominal Surgery, Acute Ischemic Stroke, Acute Myocardial Infarction | 19 |
| VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA | Cardiovascular Diseases, Stroke, Acute Kidney Injury | 19 |
| UPMC | Focal Epilepsy, ASD - Atrial Septal Defect, Advanced Melanoma | 18 |
| UPMC-Shadyside Hospital | Head and Neck Squamous Cell Carcinoma, Stage II Lip and Oral Cavity Cancer AJCC v8, Stage III Laryngeal Cancer AJCC v8 | 18 |
| University of Pittsburgh Cancer Institute (UPCI) | Head and Neck Squamous Cell Carcinoma, Metastatic Renal Cell Carcinoma, Oral Cavity Squamous Cell Carcinoma | 16 |
| Children's Hospital of Pittsburgh | Acute Lymphoblastic Leukemia (ALL), Acute Myelogenous Leukemia (AML or ANLL), Adolescent Congenital Heart Disease | 13 |
| University of Pittsburgh Medical Center (UPMC) | ALS, ALS (Amyotrophic Lateral Sclerosis), ALS - Amyotrophic Lateral Sclerosis | 9 |
| AHN Allegheny General Hospital | Breast Cancer, Cancer, Carcinoma, Non-Small-Cell Lung | 8 |
| AHN West Penn Hospital | Malignant Mesothelioma, Malignant Pleural Effusion, Metastasis to Pleura | 8 |
| UPMC Magee-Womens Hospital | ADHD, Behavioral Intervention, Cervical Cancer | 8 |
| University of Pittsburgh School of Medicine | Adolescents, Anorexia Nervosa, Bipolar Disorder (BD) | 8 |
| UPMC Shadyside Hospital | Abdominal Surgery, Dementia, Harm Reduction | 7 |
Active & Upcoming Studies in Pittsburgh (2026)
Recruiting trials in Pittsburgh grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (396 active studies)
- Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · University of Pittsburgh
- A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information · Children's Oncology Group
Neurology & pain (81 active studies)
- Collaborative Care Intervention for Cancer Patients and Their Family Caregivers -LITE · University of Pittsburgh
- Psilocybin After Trauma Surgery for Pain · Phase 1 · Trent Emerick
Cardiovascular (74 active studies)
- TEPH: Telaglenastat Efficacy in Pulmonary Hypertension · Phase 1, Phase 2 · Chan, Stephen, MD, PhD
- Precision Analgesia for Cardiac Surgery · Kathirvel Subramaniam
Diabetes & metabolic (39 active studies)
- Technology Knowledge Optimization for Type 1 Diabetes in Schools · University of Pittsburgh
- Network-Based Support to Help Community Coalition Members Choose and Use Strategies to Improve Child Health · University of Pittsburgh
Mental health & behavior (37 active studies)
Pediatric (19 active studies)
- Hypoxic Red Blood Cells in Sickle Cell Anemia · Hemanext
- A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients · Phase 2 · Costas Hadjipanayis
HIV / STI (8 active studies)
- Liver Transplantation From Donors With HIV: Impact on Opportunistic Infections, Cancer, and Long-Term Outcomes (Expanding HOPE Liver) · Johns Hopkins University
- Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults · Phase 1 · National Institute of Allergy and Infectious Diseases (NIAID)
Vaccines (7 active studies)
Eye & vision (3 active studies)
- A Study to Learn How Stargardt-type Eye Conditions Progress in Children and Adults · Astellas Pharma Global Development, Inc.
- The Effect of Rinsing on Ocular Inflammation and Symptoms in Patients With Dry Eye Disease · Rinsada
Common conditions studied in Pittsburgh
- Breast Cancer (24 active studies)
- Cancer (19 active studies)
- Ovarian Cancer (17 active studies)
- Endometrial Cancer (16 active studies)
- Stroke (16 active studies)
- Melanoma (15 active studies)
Leading research sponsors in Pittsburgh
- University of Pittsburgh
- National Cancer Institute (NCI)
- AstraZeneca
- Children's Oncology Group
- VA Office of Research and Development
Frequently asked questions
How many paid clinical trials are currently recruiting in Pittsburgh?
There are approximately 1,240 recruiting clinical trials in Pittsburgh, Pennsylvania listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Pittsburgh pay participants?
Most recruiting trials in Pittsburgh compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Pittsburgh?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Pittsburgh?
The most common conditions under active study in Pittsburgh include Breast Cancer (24), Cancer (19), Ovarian Cancer (17), Endometrial Cancer (16), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Pittsburgh?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Pittsburgh on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Pittsburgh?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Pittsburgh?
Recruiting research sites in Pittsburgh include University of Pittsburgh, UPMC Hillman Cancer Center, University of Pittsburgh Medical Center, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Pittsburgh right now?
The largest active categories in Pittsburgh are Cancer & tumors (396), Neurology & pain (81), Cardiovascular (74). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.