Oncology Clinical Trials in Rochester, MN
As of August 2026, 245 paid clinical trials are recruiting for Oncology in Rochester, Minnesota. Compensation typically covers time, travel, and study visits, and many studies also include study-related medical care at no cost.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
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Newly added in Rochester
Posted to ClinicalTrials.gov within the last 60 days — these studies are just starting to recruit.
246 clinical trials for Oncology
·Clear filters·Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer
Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer
A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence
A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer
A Study to Investigate Ronde-cel Versus Investigator's Choice CD19 CAR T-Cell Therapy
Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)
Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.
A Study to Evaluate the Safety and Efficacy of Tacabrutideg (BGB-16673) Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells
A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
A Long-term Study for Participants Previously Treated With Ciltacabtagene Autoleucel
SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)
A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/Refractory Mantle Cell Lymphoma (CELESTIAL-RRMCL)
A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
FOG-001 in Locally Advanced or Metastatic Solid Tumors
A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer
A First-in-Human Study of MEN2312 in Adults With Advanced Breast Cancer
A Study to Assess Adverse Events of Intravenously (IV) Infused Etentamig (ABBV-383) in Adult Participants With Relapsed or Refractory Multiple Myeloma
Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
A Dose-Escalation and Expansion Study of Tacabrutideg (BGB-16673) in Participants With B-Cell Malignancies
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)
A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors
Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation
Study of Arlocabtagene Autoleucel (BMS-986393) a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma
Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy
A Study to Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML
Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion
CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
Top Research Study Locations in Rochester
Researchers run research studies in Rochester, MN at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Mayo Clinic | Heart Failure, Breast Cancer, Ovarian Cancer | 462 |
| Mayo Clinic in Rochester | Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm, Breast Carcinoma | 397 |
| Mayo Clinic Rochester | CRC, Chronic Lymphocytic Leukemia, Colorectal Cancer | 78 |
| Mayo Clinic - Rochester | Endometrial Cancer, Epilepsy, Epilepsy (Treatment Refractory) | 31 |
| Mayo Clinic Minnesota | Healthy, Advanced Melanoma, Aging | 27 |
| Mayo Clinic in Rochester, Minnesota | Breast Neoplasms, Multiple Myeloma, Neoplasm Metastasis | 13 |
| Mayo Clinic, Rochester | Interstitial Lung Diseases, Acute Kidney Failure, Acute Kidney Insufficiency | 11 |
| Mayo Clinic Cancer Center | Lung Cancer, PDAC, PDAC - Pancreatic Ductal Adenocarcinoma | 7 |
| Clinical Trial Site | Advanced Hepatocellular Carcinoma, End Stage Renal Disease, Hereditary Transthyretin-Mediated Amyloidosis With Polyneuropathy | 5 |
| Mayo Clinic (Data Collection Only) | Adult T-cell Leukemia/Lymphoma, Aggressive NK-cell Leukemia, Anaplastic Large Cell Lymphoma, ALK-Positive | 4 |
| Mayo Clinic Cancer Center Outpatient Pharmacy | Colorectal Neoplasms, Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma | 4 |
| Mayo Clinic in Minnesota | Advanced Solid Tumor, Colorectal Cancer (CRC), Cutaneous Melanoma | 4 |
| GSK Investigational Site | Amyloidosis, Gastrointestinal Neoplasms, Neoplasms, Prostate | 3 |
| Mayo Clinic - PPDS | Alpha1-Antitrypsin Deficiency, Metastatic HER2-positive Breast Cancer, Uveal Melanoma | 3 |
| Mayo Clinic Comprehensive Cancer Center | Acute Myeloid Leukemia, Advanced Or Metastatic Merkel Cell Carcinoma, Clear Cell Renal Cell Carcinoma (ccRCC) | 3 |
| Mayo Clinic Hospital | ADA SCID, Glioblastoma, Glioblastoma (GBM) | 3 |
| Mayo Clinic- Rochester | Aneurysmal Subarachnoid Hemorrhage (aSAH), Cerebral Vasospasm, Crohns Disease | 3 |
| 89bio Clinical Study Site | Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis | 2 |
| Crinetics Study Site | Classic Congenital Adrenal Hyperplasia, Congenital Adrenal Hyperplasia, Neuroendocrine Neoplasm | 2 |
| Mayo Clinic - PIN | Crohn's Disease (CD), Obesity, Overweight | 2 |
| Mayo Clinic - Rochester Minnesota | Intermediate Risk Non-Muscle Invasive Bladder Cancer, Low-grade Upper Tract Urothelial Carcinoma | 2 |
| Mayo Clinic Children's - PIN | Developmental and Epileptic Encephalopathy, Dravet Syndrome | 2 |
| Mayo Clinic Department of Ophthalmology | Amblyopia | 2 |
| Mayo Clinic Foundation | Orthostatic Hypotension, Reflex Syncope, Weight Loss | 2 |
| Mayo Clinic Hospital, Methodist Campus, Research Pharmacy | Advanced Renal Cell Carcinoma, Advanced or Metastatic Renal Cell Carcinoma, Carcinoma, Renal Cell | 2 |
Active & Upcoming Studies in Rochester (2026)
Recruiting trials in Rochester grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (372 active studies)
Cardiovascular (94 active studies)
Neurology & pain (69 active studies)
- The Effect of Dry Needling With Electrical Stimulation on Individuals With Restless Legs Syndrome · Mayo Clinic
- COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" · Phase 3 · Yale University
Diabetes & metabolic (31 active studies)
- Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity · Mayo Clinic
- Evaluation of the Fully Closed Loop Omnipod® System in Type 2 Diabetes · Insulet Corporation
Mental health & behavior (13 active studies)
Pediatric (7 active studies)
- Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting · Mayo Clinic
- Supraglottic Airway for Resuscitation Trial · Children's Hospital of Philadelphia
Vaccines (6 active studies)
Eye & vision (4 active studies)
- 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension Patients · Phase 4 · Mayo Clinic
- Study to Assess the Injection Burden, Adverse Events, Change in Disease Activity, and Long-Term Preservation of Visual Acuity of Surabgene Lomparvovec in Adult Participants With Neovascular Age-Related Macular Degeneration (nAMD) · Phase 3 · AbbVie
HIV / STI (2 active studies)
- Liver Cirrhosis Network Rosuvastatin Efficacy and Safety for Cirrhosis in the United States · Phase 2 · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Analytic Treatment Interruption (ATI) to Assess HIV Cure · Mayo Clinic
Common conditions studied in Rochester
- Malignant Solid Neoplasm (19 active studies)
- Heart Failure (16 active studies)
- Ovarian Cancer (15 active studies)
- Breast Cancer (14 active studies)
- Healthy (14 active studies)
- Multiple Myeloma (14 active studies)
Leading research sponsors in Rochester
- Mayo Clinic
- National Cancer Institute (NCI)
- AstraZeneca
- Eli Lilly and Company
- Children's Oncology Group
Frequently asked questions
How many paid clinical trials are currently recruiting in Rochester?
There are approximately 1,209 recruiting clinical trials in Rochester, Minnesota listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Rochester pay participants?
Most recruiting trials in Rochester compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Rochester?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Rochester?
The most common conditions under active study in Rochester include Malignant Solid Neoplasm (19), Heart Failure (16), Ovarian Cancer (15), Breast Cancer (14), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Rochester?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Rochester on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Rochester?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Rochester?
Recruiting research sites in Rochester include Mayo Clinic, Mayo Clinic in Rochester, Mayo Clinic Rochester, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Rochester right now?
The largest active categories in Rochester are Cancer & tumors (372), Cardiovascular (94), Neurology & pain (69). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.