Paid Clinical Trials in Springfield, MA
As of July 2026, 74 paid clinical trials are recruiting in Springfield, Massachusetts. Compensation typically covers time, travel, and study visits, with stipends ranging from modest amounts for short outpatient studies to several thousand dollars for long or inpatient protocols.
Springfield offers studies at sites including Baystate Medical Center for conditions such as Alzheimer Disease, Coronary Artery Disease, Major Depressive Disorder, Opioid Use Disorder. Both patients with specific conditions and healthy volunteers can qualify. Most trials offer free study-related medical care alongside compensation.
Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: .
Trials by specialty in Springfield
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·Clear filters·Top Research Study Locations in Springfield
Researchers run research studies in Springfield, MA at 25 active sites. The clinics below currently host the largest number of recruiting studies — each name is followed by the conditions they focus on most.
| Site | Specializes in | Active trials |
|---|---|---|
| Baystate Medical Center | Stroke, Anatomic Stage II Breast Cancer AJCC v8, Atrial Fibrillation | 39 |
| Baystate Health | Coronary Artery Disease, Heart Diseases, Chronic Obstructive Pulmonary Disease | 4 |
| Elixia MA | Alzheimer Disease, Bipolar Disorder, Treatment Resistant Depression | 3 |
| Elixia Health - Springfield - Elixia - PPDS | Alzheimer Disease, Type II Diabetes Mellitus | 2 |
| New England Retina Consultants | DME, Diabetic Macular Edema, Diabetic Macular Edema (DME) | 2 |
| Elixia - Springfield | Generalized Anxiety Disorder (GAD), Bipolar I or II Disorder | 2 |
| Baystate Children's Hospital | Bronchiolitis Acute | 1 |
| Baystate Clinical Trials Unit | OSA | 1 |
| Baystate Pain Management Center | Lumbar Spinal Stenosis | 1 |
| Behavioral Health Network | Mental Health Disorder, Opioid Use Disorder | 1 |
| Caring Health Center | Breast Cancer Screening, Cervical Cancer Screening, Colon Cancer Screening | 1 |
| Direct Biologics Investigational Site | ARDS, Acute Respiratory Distress Syndrome | 1 |
| ELIXIA | Major Depressive Disorder | 1 |
| Elixia Health | Major Depressive Disorder | 1 |
| Elixia MA, LLC | Major Depressive Disorder | 1 |
| Elixia SISU BHR - Sprinfield | Chronic Idiopathic Constipation (CIC) | 1 |
| Elixia SISU BHR - Springfield | Cortisol Excess, Type 2 Diabetes | 1 |
| Kidney Care and Transplant Services of NE | Arteriovenous Fistula, End-stage Renal Disease, Kidney Disease, End-Stage | 1 |
| Local Institution - 1239 | Psychosis Associated With Alzheimer's Disease | 1 |
| New England Retina Consultants, PC | Age-related Macular Degeneration (AMD), Geographic Atrophy (GA) | 1 |
| RAYUS Radiology | Knee Arthritis, Osteoarthritis | 1 |
| Retina Research Institute at New England Retina Consultants | Age - Related Macular Degeneration (AMD), Geographic Atrophy (GA) | 1 |
| Retina Research Institute at New England Retina Consultants, PC | Age-Related Macular Degeneration, Choroidal Neovascularization, Macular Degeneration | 1 |
| Sisu BHR, LLC | AD, Alzheimer Disease, Cognitive Impairment | 1 |
| Site 0263 - Baystate Medical Center | High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer | 1 |
Active & Upcoming Studies in Springfield (2026)
Recruiting trials in Springfield grouped by therapeutic area, drawn from ClinicalTrials.gov. Each bucket shows the most recent example studies.
Cancer & tumors (22 active studies)
- Community Gateway to Health Study · Harvard School of Public Health (HSPH)
- ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab · Phase 3 · Alliance for Clinical Trials in Oncology
Mental health & behavior (8 active studies)
- Community Gateway to Health Study · Harvard School of Public Health (HSPH)
- A Type I Hybrid Effectiveness-Implementation Trial of MIO · Baystate Medical Center
Neurology & pain (6 active studies)
- Telerehabilitation In The Home After Stroke · University of California, Los Angeles
- A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1) · Phase 3 · Bristol-Myers Squibb
Cardiovascular (6 active studies)
- SELUTION 4 De Novo Small Vessel IDE Trial · M.A. Med Alliance S.A.
- Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial · Phase 2 · Baystate Medical Center
Eye & vision (5 active studies)
- A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003) · Phase 2, Phase 3 · EyeBiotech Ltd.
- COMO: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME · Phase 3 · EyePoint Pharmaceuticals, Inc.
Diabetes & metabolic (2 active studies)
- A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus · Phase 2 · Corxel Pharmaceuticals
- Trial Against INtractable Type 2 Diabetes (CAPTAIN-T2D) · Phase 2 · Sparrow Pharmaceuticals
HIV / STI (1 active study)
Common conditions studied in Springfield
- Alzheimer Disease (3 active studies)
- Coronary Artery Disease (3 active studies)
- Major Depressive Disorder (3 active studies)
- Opioid Use Disorder (3 active studies)
- Stroke (3 active studies)
- Anatomic Stage II Breast Cancer AJCC v8 (2 active studies)
Leading research sponsors in Springfield
- Baystate Medical Center
- Children's Oncology Group
- National Cancer Institute (NCI)
- SWOG Cancer Research Network
- Alliance for Clinical Trials in Oncology
Frequently asked questions
How many paid clinical trials are currently recruiting in Springfield?
There are approximately 74 recruiting clinical trials in Springfield, Massachusetts listed on ClinicalTrials.gov. The number changes weekly as new studies open and others close enrollment.
Do clinical trials in Springfield pay participants?
Most recruiting trials in Springfield compensate participants for their time, travel, and study visits. Compensation varies by sponsor, study phase, and visit requirements — the exact amount is disclosed by the study team during the informed consent process.
Who can participate in a clinical trial in Springfield?
Eligibility depends on the specific study. Each trial defines its own inclusion criteria (age, diagnosis, medical history, prior treatments) and exclusion criteria. Both patients with specific conditions and healthy volunteers can qualify, depending on the study design.
What conditions are most commonly studied in Springfield?
The most common conditions under active study in Springfield include Alzheimer Disease (3), Coronary Artery Disease (3), Major Depressive Disorder (3), Opioid Use Disorder (3), among many others. Browse the list above to explore every recruiting trial.
Are there clinical trials for healthy volunteers in Springfield?
Yes. Healthy-volunteer studies — often early-phase pharmacology or vaccine trials — recruit in Springfield on an ongoing basis. Use the "Healthy volunteers only" filter above to view trials that accept participants without the study's target condition.
How do I enroll in a clinical trial in Springfield?
Click any study title above to see the full study record, including eligibility criteria, visit schedule, and the study team's contact information. Reach out to the central contact or recruiting site directly — they will guide you through screening and informed consent.
Where can I take part in paid clinical trials in Springfield?
Recruiting research sites in Springfield include Baystate Medical Center, Baystate Health, Elixia MA, among others. Each site lists its open studies and contact information on the study record above — call or email the site coordinator to ask about screening for a specific protocol.
What kinds of studies are recruiting in Springfield right now?
The largest active categories in Springfield are Cancer & tumors (22), Mental health & behavior (8), Neurology & pain (6). Use the filters above to narrow by therapeutic area, phase, age, or healthy-volunteer eligibility.