Chronic pain Clinical Trials

Recruiting chronic pain studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat chronic pain. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting chronic pain studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting chronic pain trials

Within

Personalizing Veteran Pain Care: Adapting Coaching Interventions to Support Maintenance of Self-Care

for Chronic Pain

1 site in Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07456150·Phase 1

Mindfulness Therapy for Chronic Pain After Intimate Partner Violence

for Chronic Pain

1 site in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT07700355

Internet-Delivered ACT Targeting Emotional Distress and Chronic Pain

for Chronic Pain

Sponsor: Skane University Hospital

Sex: All·Age: 18 - 65

Code: NCT07426367

Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain

for Stress Disorders, Post-Traumatic

1 site in San Diego

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07725588

Digital Treatment for Chronic Pain and Addiction in Veterans With Opioid Use Disorder Receiving Buprenorphine

for Opioid Use Disorder

4 sites incl. West Haven

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT07361432·Phase 3

Pediatric Electrocutaneous Analgesia for Children Experiencing Neuropathic Pain

for Neuropathic Pain

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: All·Age: 5 - 26

Code: NCT07264920

Empowered Relief for Caregivers

for Chronic Pain

1 site in Palo Alto

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07636980

Mindfulness-Based Cognitive Therapy Vs. the Health Enhancement Program for Chronic Pain and Early Cognitive Decline; The Feeling of Being Pilot RCT

for Chronic Pain

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 50 - 120·Accepts healthy volunteers

Code: NCT07785648

The Women Veteran's Health Mission

for Chronic Pain

Sponsor: McGill University Health Centre/Research Institute of the McGill University Health Centre

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07608952

Development of a Pain Rehabilitation Program for Chronic Pain After SCI

for Spinal Cord Injuries

Sponsor: Umeå University

Sex: All·Age: 18+

Code: NCT07634796

Perioperative Yoga Therapy and Endometriosis Surgery

for Endometriosis

Sponsor: University Hospital, Lille

Sex: Female·Age: 18+

Code: NCT07765680

Harmonized Healing: Personalized Music Interventions to Address Chronic Pain in People Living With HIV

for Chronic Pain

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07214077

Evaluation of Chronic Postsurgical Pain Risk in Patients Undergoing CIED Implantation Using an AID Support System

for Pain Measurement

Sponsor: Istanbul University - Cerrahpasa

Sex: All·Age: 18+

Code: NCT07322900

Personalized Care Management Model (GAP-421) for Chronic Pain in Primary Care Physiotherapy

for Chronic Pain

Sponsor: Universidad Autonoma de Madrid

Sex: All·Age: 18+

Code: NCT07451587

Analgesic Efficacy of Multisite rTMS in Fibromyalgia Patients

for Fibromyalgia

Sponsor: Hospital Ambroise Paré Paris

Sex: All·Age: 18 - 80

Code: NCT07642882

Apply to this trial

Human Pain Atlas for Sensory Neurons

for Chronic Pain

Sponsor: King's College Hospital NHS Trust

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07740681

S1R Imaging-Based Cryoneurolysis in Chronic Pain

for Chronic Pain

Sponsor: Davidzon, Guido, M.D.

Sex: All·Age: 18+

Code: NCT07768501·EARLY_Phase 1

BurstDR Spinal Cord Stimulation Versus Sham in Established Responders

for Chronic Pain

Sponsor: Umeå University

Sex: All·Age: All ages

Code: NCT07779733

Tai Chi Intervention for Geriatric Pain Syndrome

for Chronic Pain

Sponsor: University of Massachusetts, Boston

Sex: All·Age: 65+

Code: NCT03705598

Validation of the Turkish Brief Inventory of Treatment Expectations in Chronic Pain

for Chronic Pain

Sponsor: Hacettepe University

Sex: All·Age: 18 - 70

Code: NCT07673874

Turkish Adaptation of the Pain and Smoking Inventory

for Chronic Pain

Sponsor: Hacettepe University

Sex: All·Age: 18 - 65

Code: NCT07673926

Full-Spectrum Cannabis Extract for Chronic Pain and Bone Health Biomarkers in Women

for Chronic Pain

Sponsor: Associação Pan-Americana Multidisciplinar de Endocanabinologia

Sex: Female·Age: 45 - 80

Code: NCT07783295·Phase 2

Exercise, Insulin Resistance, and Chronic Pain in Postmenopausal Women.

for Chronic Pain

Sponsor: São Paulo State University

Sex: Female·Age: All ages

Code: NCT07407699

The BRIDGE Pain Study

for Juvenile Idiopathic Arthritis (JIA)

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 14 - 26

Code: NCT07602595

Apply to this trial

Outcomes Registry After Ketamine Infusions for Chronic Pain: A Longitudinal Evaluation

for Chronic Pain

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07648771

LIFU for Chronic Pain and Generalized Anxiety Disorder

for Chronic Pain

1 site in Roanoke

Sponsor: Virginia Polytechnic Institute and State University

Sex: All·Age: 18 - 65

Code: NCT07686354

Multimodal Lifestyle Approach for Chronic Pain With Nociplastic Pain Features

for Chronic Pain

Sponsor: Prefectural University of Hiroshima

Sex: All·Age: 20 - 75

Code: NCT07693062

Personalized Analgesia Through Central Nervous System Engagement to Unlock Performance

for Knee Osteoarthritis (Knee OA)

1 site in Pittsburgh

Sponsor: Benedict Alter

Sex: All·Age: 45 - 80

Code: NCT07759336·Phase 4

Pain Reprocessing Therapy (PRT) in a Specialist Pain Clinic: A Feasibility Study

for Chronic Pain

Sponsor: Karolinska Institutet

Sex: All·Age: 18+

Code: NCT07791355

Apply to this trial

Action Observation and Motor Imagery Training in Cervical Disc Herniation

for Cervical Disc Herniation

Sponsor: İrem Çetinkaya

Sex: All·Age: 18 - 65

Code: NCT07781982

Effect of Rebound Pain on Chronic Postsurgical Pain After Total Knee Arthroplasty

for Acute Pain, Postoperative

Sponsor: Konya City Hospital

Sex: All·Age: 18+

Code: NCT07511985

Apply to this trial

Pain Phenotypes in Individuals With Multiple Sclerosis

for Multiple Sclerosis

Sponsor: Kutahya Health Sciences University

Sex: All·Age: 18+

Code: NCT07766213

National Survey of Chronic Occupational Pain in Thai Anesthesia Providers

for Chronic Pain

Sponsor: Mahidol University

Sex: All·Age: 25 - 60·Accepts healthy volunteers

Code: NCT07778381

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain

for Chronic Pain

36 sites incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT07641504·Phase 2

Apply to this trial

PREDICT-DOLOR VE: Validation of a Structured Triage Protocol for Chronic Pain

for Chronic Pain

Sponsor: Universidad Central de Venezuela

Sex: All·Age: 18 - 100

Code: NCT07696676

Comparison of Transcatheter Arterial Microembolization and Corticosteroid Injection and for Treatment of Frozen Shoulder

for Frozen Shoulder

Sponsor: Shin Kong Wu Ho-Su Memorial Hospital

Sex: All·Age: 18 - 80

Code: NCT07696923

Apply to this trial

Feasibility and Acceptability of Empowered Relief for American Indians With Pain During and After Cancer Treatment

for Cancer

1 site in Tulsa

Sponsor: University of Oklahoma

Sex: All·Age: 18+

Code: NCT07742449

VETERANS AFFAIRS AUGUSTA

for Chronic Pain

1 site in Augusta

Sponsor: Companion IQ, Inc

Sex: All·Age: 18+

Code: NCT07776600

Apply to this trial

Safety and Preliminary Efficacy of Endoscopic Submucosal Injection of Hyaluronic Acid Into the Bladder Wall in Patients With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)

for Cystitis, Interstitial

Sponsor: Sverdlovsk Regional Clinical Hospital No.1

Sex: All·Age: 18+

Code: NCT07658118·Phase 1

Assessment of Prolonged Pain in Infants With Excessive Crying: the Role of Thermal Imaging

for Chronic Pain

Sponsor: Centre Hospitalier de Saint-Denis

Sex: All·Age: 3 Weeks - 9 Weeks·Accepts healthy volunteers

Code: NCT07693179

A Study to Evaluate the Drug-Drug Interaction Between KL0011034 Injection and Alfentanil Hydrochloride Injection in Participants With Moderate-to-Severe Non-Cancer Chronic Pain

for Chronic Pain

Sponsor: The Third Xiangya Hospital of Central South University

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07751094·Phase 1

POP SINGER Randomized Clinical Trial

for Chronic Pain

1 site in Cleveland

Sponsor: University Hospitals Cleveland Medical Center

Sex: All·Age: 18+

Code: NCT07756541

Apply to this trial

Virtual Pain Education for Spinal Cord Stimulation Patients

for Chronic Pain

Sponsor: University of Arkansas

Sex: All·Age: 18+

Code: NCT07743905

DockTales for Chronic Pain

for Chronic Pain

1 site in Baltimore

Sponsor: University of Maryland, Baltimore

Sex: All·Age: 18 - 88

Code: NCT07680894

A Study Evaluating the Drug-Drug Interaction Between KL0011034 Injection and Alfentanil Hydrochloride Injection

for Chronic Pain

Sponsor: Hunan Kelun Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 55

Code: NCT07710560·Phase 1

Building a Swiss Pain Registry: A National Framework for Acute and Chronic Pain Assessment

for Chronic Pain

Sponsor: Insel Gruppe AG, University Hospital Bern

Sex: All·Age: All ages

Code: NCT07717762

Conventional Sacroiliac Joint Injection Versus Pulsed Radiofrequency in SIJ Pain

for Chronic Pain

Sponsor: National Cancer Institute, Egypt

Sex: All·Age: 18 - 65

Code: NCT07709689

RUTISS-Diary and RUTISS-65 Study

for Urology

Sponsor: Katherine Finlay

Sex: All·Age: 18+

Code: NCT07698041

Multimodal Telerehabilitation Versus Face-to-Face Care for Adults With Hemophilia and Chronic Pain

for Hemophilia

Sponsor: University of Chile

Sex: Male·Age: 18 - 60

Code: NCT07682519

Apply to this trial

ARPA-H Smart Band-Aid to Measure Chronic Pain in Women

for Chronic Pain

2 sites incl. Chicago

Sponsor: Northwestern University

Sex: Female·Age: 18+·Accepts healthy volunteers

Code: NCT06994988

Apply to this trial

Comorbidity Between Attention Deficit Hyperactivity Disorder and Fibromyalgia

for ADHD - Attention Deficit Disorder With Hyperactivity

Sponsor: University Hospital, Tours

Sex: All·Age: 18 - 100

Code: NCT07443800

Ketamine-Assisted Psychotherapy for Treatment-Resistant Depression

for Treatment Resistant Depression (TRD)

1 site in Rochester

Sponsor: University of Rochester

Sex: All·Age: 18+

Code: NCT07247006·Phase 2

Ultrasound for Peripheral Nerve Modulation

for Neuropathic Pain

1 site in Stanford

Sponsor: Stanford University

Sex: All·Age: 18+

Code: NCT07572591

Virtual Reality for Pain and Well-Being in Older Adults

for Chronic Pain

Sponsor: Laval University

Sex: All·Age: 65+

Code: NCT07607899

A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

for Osteoarthritis, Knee

36 sites incl. Birmingham

Sponsor: Eli Lilly and Company

Sex: All·Age: 40+

Code: NCT07641517·Phase 2

Apply to this trial

Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain

for Chronic Pain

1 site in Old Saybrook

Sponsor: Yale University

Sex: All·Age: 18+

Code: NCT07639060

Apply to this trial

Culturally Adapted Pain Management for Indigenous Peoples

for Chronic Pain

1 site in Yakima

Sponsor: University of California, San Diego

Sex: All·Age: 18+

Code: NCT07524751

Apply to this trial

Cannabis Vs Opioids Pain Management Objective Testing Comparisons

for Chronic Pain

Sponsor: American Association of Sensory Electrodiagnostic Medicine

Sex: All·Age: Up to 90

Code: NCT03734731

EmpowerSpine Program

for Internet Delivered Treatment

Sponsor: Lawson Research Institute of St. Joseph's

Sex: All·Age: 18+

Code: NCT07419646

Evaluation of Alexithymia in Chronic Pain Patients With Spinal Cord Stimulation

for Chronic Pain

Sponsor: Marmara University

Sex: All·Age: 18+

Code: NCT07696286

Apply to this trial

New trials in Boston, MA?

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Chronic pain clinical trials — common questions

Are chronic pain clinical trials free to join?

Yes. Participating in a chronic pain clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a chronic pain clinical trial?

Each chronic pain study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a chronic pain trial near me?

Use the location controls above. We'll show recruiting chronic pain trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many chronic pain trials are recruiting right now?

We're currently tracking roughly 193 recruiting chronic pain trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Chronic pain trials by city

Boston, MA Chicago, IL Palo Alto, CA Birmingham, AL Cleveland, OH San Diego, CA San Francisco, CA Seattle, WA Stanford, CA Ann Arbor, MI Aurora, CO Indianapolis, IN

Related specialties

Pain management