Colon cancer Clinical Trials

Recruiting colon cancer studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat colon cancer. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting colon cancer studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting colon cancer trials

Within

Improving Prognostication in Colon Cancer

for Colon Cancer

Sponsor: Universitaire Ziekenhuizen KU Leuven

Sex: All·Age: 18+

Code: NCT07673393

ctDNA and TEP Levels in Colon Cancer

for Colon Cancer

Sponsor: Institute of Oncology Ljubljana

Sex: All·Age: 18+

Code: NCT07701408

QL1706 Combined With Standard Therapy for Conversion Therapy of Synchronous Liver Metastases From Colon Cancer: a Multicenter, Single-arm, Exploratory Study

for Colon Cancer

Sponsor: Fujian Medical University

Sex: All·Age: 18 - 70

Code: NCT07649473·Phase 2

COLOFLOW: Laser Speckle Contrast Imaging Versus Near-infrared Fluorescence Imaging With Indocyanine Green

for Leakage, Anastomotic

Sponsor: Leiden University Medical Center

Sex: All·Age: 18+

Code: NCT07720505

Cemiplimab With Fianlimab for Resectable Non-Metastatic Colon Cancer

for Colon Cancer

Sponsor: John Strickler, M.D.

Sex: All·Age: 18+

Code: NCT07224022·Phase 2

Distribution and Analysis of Metastatic Lymph Nodes in Colorectal Cancer Patients (DIAMOND)

for Colon Cancer

Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Sex: All·Age: 18 - 80

Code: NCT07306390

Statewide Unified Network for Remote Intervention of Strength and Exercise

for Gastric Cancer (Diagnosis)

Sponsor: AdventHealth Translational Research Institute

Sex: All·Age: 18+

Code: NCT07596732

A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors

for Advanced or Metastatic Solid Tumors

3 sites incl. Denver

Sponsor: SHY Therapeutics

Sex: All·Age: 18+

Code: NCT07705334·Phase 1

Apply to this trial

Frequency of Care for Peripherally Inserted Central Vascular Access In the Prevention of Marsi

for Colon Cancer

Sponsor: Institut Català d'Oncologia

Sex: All·Age: 18+

Code: NCT07697170

Six Versus Twelve Month Index Follow-up After Large Colon Polyp Resection

for Colon Cancer

8 sites incl. Birmingham

Sponsor: Indiana University

Sex: All·Age: 18+

Code: NCT07198945

ICG in Colon Cancer

for Colon Cancer

Sponsor: Tanta University

Sex: All·Age: 18+

Code: NCT07638956

Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer

for Breast Cancer

Sponsor: Gustave Roussy, Cancer Campus, Grand Paris

Sex: All·Age: 18+

Code: NCT07436312

Apply to this trial

Fruquintinib In Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies in South Korea Patients (FIRST-K)

for Colon Cancer

Sponsor: Korea University Anam Hospital

Sex: All·Age: 19+

Code: NCT07510932·Phase 2

Mainstreaming Genetics: Evaluation of a Digital Application to Scale and Spread Oncologist-initiated Genetic Testing

for Cancer

Sponsor: Unity Health Toronto

Sex: All·Age: 18+

Code: NCT07387263

Apply to this trial

Precision Physical Exercise for Personalized Onco-Hematology.

for Hematologic Cancer

Sponsor: University of Salamanca

Sex: All·Age: 18+

Code: NCT07286539

An Open-label, Single-arm Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetic Profile, and Preliminary Efficacy of KT032 Cell Injection in Patients With Mesothelin-positive Advanced Solid Tumors.

for Ovarian Cancer

Sponsor: Weijia Fang, MD

Sex: All·Age: 18 - 75

Code: NCT07420010·EARLY_Phase 1

Effectiveness of Health Education as a Nursing Intervention in Improving Quality of Life and Reducing Symptoms of Anxiety and Depression in Ostomy Patients Following Digestive Surgery: A Quasi-Experimental Study.

for Colon Cancer

Sponsor: Hospital Clinico Universitario de Santiago

Sex: All·Age: 18+

Code: NCT07347158

Distance-Based Exercise to Preserve Function and Prevent Disability

for Localized Malignant Solid Neoplasm

18 sites incl. Dublin

Sponsor: Alliance for Clinical Trials in Oncology

Sex: All·Age: 18+

Code: NCT07059884

Apply to this trial

Cancer Loyalty Card Study 2 (CLOCS-2)

for Pancreatic Cancer

Sponsor: Imperial College London

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06447064

Apply to this trial

Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study

for Colon Cancer

Sponsor: Institute of Oncology Ljubljana

Sex: All·Age: 18 - 80

Code: NCT06923787·Phase 2

Apply to this trial

Analysis of the Presence and Cardiac Functional Effects of Anti-NaV1.5 Autoantibodies in Patients With Metastatic Tumors

for Brugada Syndrome (BrS)

Sponsor: IRCCS Policlinico S. Donato

Sex: All·Age: All ages

Code: NCT07364656

Leakage Rate of Ileo-COlic Sutured Anastomosis After Right Hemicolectomy

for Anastomotic Leak

Sponsor: Aesculap AG

Sex: All·Age: 18+

Code: NCT07132970

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A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

for Colorectal Cancer

8 sites incl. Duarte

Sponsor: Cartography Biosciences

Sex: All·Age: 18+

Code: NCT07321106·Phase 1

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Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)

for Rectal Cancer

Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle

Sex: All·Age: 18+

Code: NCT07098182

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Node-Sparing Low-Dose Radiotherapy Concurrent With Chemotherapy and PD-1 Inhibitor in pMMR/MSS High-Risk Locally Advanced Colon Cancer: A Prospective, Single-Arm, Phase II Trial

for Colon Cancer

Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT07279077·Phase 2

Apply to this trial

Chronic Loose Stools Following Right-sided Hemicolectomy for Colon Cancer and the Association With Bile Acid Malabsorption and Small Intestinal Bacterial Overgrowth Using a Novel Sampling Device

for Colon Cancer

1 site in Houston

Sponsor: M.D. Anderson Cancer Center

Sex: All·Age: 20 - 85

Code: NCT06927011

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Study to Evaluate the Use of Surgical Gloves for the Prevention of Oxaliplatin-Induced Peripheral Neuropathy

for Colon Cancer

Sponsor: AC Camargo Cancer Center

Sex: All·Age: 18+

Code: NCT07285356

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Surgical Outcomes in Splenic Flexure Cancers: A Multicenter Comparison of Segmental vs. Extended Hemicolectomy (SPARROW Study)

for Colon Cancer

Sponsor: Acibadem University

Sex: All·Age: 18 - 80

Code: NCT07289568

A Randomized, Double-blind, Placebo-controlled, Parallel-group, Comparative, Phase III Study to Evaluate the Efficacy and Safety of Nuvastatic® 300mg Capsule in Reducing Cancer-Tumor in Patients With Metastatic Colorectal Cancer Receiving Standard Chemotherapy.

for Fatigue Related to Cancer Treatment

Sponsor: Natureceuticals Sdn Bhd

Sex: All·Age: 18 - 65

Code: NCT07669454·Phase 3

Apply to this trial

Neoadjuvant Pembrolizumab With a Watch-and-wait Strategy for dMMR/MSI-H Localized Colon Cancer: PREMICES Study.

for Colon Cancer

Sponsor: GERCOR - Multidisciplinary Oncology Cooperative Group

Sex: All·Age: 18+

Code: NCT06646445·Phase 2

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)

for Colon Cancer

14 sites incl. Denver

Sponsor: SCRI Development Innovations, LLC

Sex: All·Age: 18+

Code: NCT07011576·Phase 2

Apply to this trial

QL1706 Plus XELOX as Neoadjuvant Therapy for MSS/pMMR Clinical Stage III Colon Cancer

for Colon Cancer

Sponsor: Qilu Hospital of Shandong University

Sex: All·Age: 18 - 75

Code: NCT07156682·Phase 2

A Study of PHN-012 in Patients With Advanced Solid Tumors

for Colon Cancer

11 sites incl. Los Angeles

Sponsor: Pheon Therapeutics

Sex: All·Age: 18+

Code: NCT07127874·Phase 1

Apply to this trial

MIMICC Study in Patients With Colorectal Cancer

for Colorectal Cancer

Sponsor: Fondazione del Piemonte per l'Oncologia

Sex: All·Age: 18 - 75

Code: NCT07494201

Apply to this trial

CEA-Targeted CAR-T Therapy in CEA-Positive Advanced Solid Tumors

for Lung Cancer

Sponsor: Chongqing Precision Biotech Co., Ltd

Sex: All·Age: 18+

Code: NCT07179692·Phase 1

Apply to this trial

Metastatic Lymph Node Distribution in the Ileum Mesentery of Cecal and Proximal Ascending Colon Cancer

for Colon Cancer

Sponsor: Peking Union Medical College Hospital

Sex: All·Age: 18 - 80

Code: NCT07149623

Effect of Perioperative Lidocaine or High-Dose Dexamethasone on Immune Response in Colon Cancer Surgery (PILDI Study)

for Colon Cancer

Sponsor: Institute of Oncology Ljubljana

Sex: All·Age: 18+

Code: NCT07432399·Phase 2

Apply to this trial

Mechanical Bowel Preparation in Laparoscopic Right Hemicolectomy With Intracorporeal Anastomosis

for Colon Cancer

Sponsor: University Medical Center Ho Chi Minh City (UMC)

Sex: All·Age: 18+

Code: NCT07546565

Apply to this trial

Endoscopic Therapy Or Surgery for Early Colon Cancer

for Colon Cancer

Sponsor: Norwegian Department of Health and Social Affairs

Sex: All·Age: All ages

Code: NCT06940947·Phase 3

Apply to this trial

Evaluation of NuvastaticTM in Reducing Cancer-Related Fatigue in Stage IV Colon Cancer Patients Undergoing First-Line Chemotherapy

for Fatigue

Sponsor: Natureceuticals Sdn Bhd

Sex: All·Age: 18 - 65

Code: NCT07669519·Phase 3

Apply to this trial

Postbiotics for Mitigation of Postoperative Dysbiosis in Gastrointestinal Cancer Surgery

for Colon Cancer

2 sites in Tampa

Sponsor: University of South Florida

Sex: All·Age: 18+

Code: NCT07050485

Rimegepant Combined With PD-1 in Liver Metastasis Colorectal Cancer Patients

for Colon Cancer

Sponsor: Fudan University

Sex: All·Age: 18+

Code: NCT06999252·Phase 2

NIMA-Colon Cancer Study

for Colon Cancer

Sponsor: Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud

Sex: All·Age: 18 - 75

Code: NCT07534852

Apply to this trial

Proteomic Analysis of Patients Undergoing Bariatric Surgery

for Obesity

Sponsor: Universidade Federal de Pernambuco

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06787807

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

for Solid Tumor, Adult

10 sites incl. Gilbert

Sponsor: A2 Biotherapeutics Inc.

Sex: All·Age: 18+

Code: NCT06682793·Phase 1, Phase 2

Apply to this trial

Radiotherapy + Systemic Therapy as Conversion Therapy for pMMR/MSS T4M0 Colon Cancer（Neo-Color）

for Colon Cancer

Sponsor: Hebei Medical University Fourth Hospital

Sex: All·Age: 18+

Code: NCT06949111·Phase 2

Apply to this trial

EXoPERT EMERALD Clinical Study

for Breast Cancer

9 sites incl. Long Beach

Sponsor: EXoPERT

Sex: All·Age: 45+·Accepts healthy volunteers

Code: NCT07186296

Apply to this trial

A Manualized Post-Traumatic Growth Intervention for People With Cancer in Greece - IC-Growth

for Breast Cancer

Sponsor: Centre for Research and Technology Hellas

Sex: All·Age: 18 - 80

Code: NCT07108517

Apply to this trial

Pre-Operative Treatment in REseCTable COlon CanceR

for Colo-rectal Cancer

Sponsor: Dominik Paul Modest

Sex: All·Age: 18 - 120

Code: NCT06899477·Phase 3

Neoadjuvant CAPOX Plus Ivonescimab Versus CAPOX for Locally Advanced Colon Cancer

for Colon Cancer

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT06790212·Phase 2

Study of Treatment With Intensified Omeprazole Treatment to Prevent High Output Stoma 1

for Stoma - Ileostomy

Sponsor: Medical University of Gdansk

Sex: All·Age: 18+

Code: NCT06917963

Apply to this trial

Optimised Post-discharge Care in Older Patients After Surgery for Colon Cancer (ERAS 3.0)

for Colon Cancer

Sponsor: Copenhagen University Hospital at Herlev

Sex: All·Age: 65+

Code: NCT06802991

Apply to this trial

Brodalumab in the Treatment of Immune-Related Adverse Events

for Breast Cancer

1 site in New York

Sponsor: Brian Henick, MD

Sex: All·Age: 18+

Code: NCT06673329·Phase 1

Apply to this trial

Sustainable Implementation of the EXCEL Exercise Oncology Program Across Canada

for Cancer

Sponsor: University of Calgary

Sex: All·Age: 18+

Code: NCT06960291

Apply to this trial

Effects of Cognitive Training on Chemotherapy-Induced Cognitive Impairment in Colon Cancer Patients Undergoing Treatment(Chemobrain) in Oncology Patients With Colon Cancer Undergoing Active Treatment

for Oncology

Sponsor: University of Salamanca

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06710639

Impact of Behavioral Activation on Depression and Quality of Life in Patients with Colon Cancer

for Depression - Major Depressive Disorder

Sponsor: Region Västmanland

Sex: All·Age: All ages

Code: NCT06745700

An Exosomal microRNA Signature for Preoperative Staging in Colon Cancer

for Colon Cancer

1 site in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07255729

Apply to this trial

Sentinel Node and Organ-sparing Surgery in Stage I Colon Carcinoma

for Colon Cancer

Sponsor: Meander Medical Center

Sex: All·Age: 18+

Code: NCT06652672

Apply to this trial

A Study of Neoadjuvant QL1706 in Participants With Untreated dMMR/MSI-H Resectable Colon Cancer

for Colon Cancer

Sponsor: Qilu Pharmaceutical Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT06686576·Phase 3

Apply to this trial

Vocorder Device Validation in Clinical Settings - Continuous Monitoring of Individuals (Vocorder Clinical Validation-VCV)

for Cancer of the Breast

Sponsor: Mitera Hospital

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06711939

Colon cancer clinical trials — common questions

Are colon cancer clinical trials free to join?

Yes. Participating in a colon cancer clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a colon cancer clinical trial?

Each colon cancer study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a colon cancer trial near me?

Use the location controls above. We'll show recruiting colon cancer trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many colon cancer trials are recruiting right now?

We're currently tracking roughly 42 recruiting colon cancer trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Colon cancer trials by city

Los Angeles, CA Denver, CO Duarte, CA Aurora, CO Birmingham, AL Boston, MA Cleveland, OH Dublin, CA Indianapolis, IN Long Beach, CA

Related specialties

Oncology GI oncology