Cystic fibrosis Clinical Trials

Recruiting cystic fibrosis studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat cystic fibrosis. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting cystic fibrosis studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting cystic fibrosis trials

Within

Pharmacokinetics of CFTR Modulators in Pregnant Individuals and in Postpartum Breastfeeding Mothers

for Cystic Fibrosis

1 site in Minneapolis

Sponsor: University of Minnesota

Sex: Female·Age: 18+

Code: NCT04940533

Novel Point-of-care Sweat Chloride Testing Device for Monitoring CFTR Function

for Cystic Fibrosis

2 sites in Atlanta

Sponsor: Emory University

Sex: All·Age: 2 Weeks - 90

Code: NCT07414810

Effects of High-Frequency Chest Wall Oscillation Combined With Concurrent Training on Cough,in Cystic Fibrosis Patients

for Cystic Fibrosis

Sponsor: Riphah International University

Sex: All·Age: 16 - 35

Code: NCT07519460

Tele-Rehabilitation in Adults With Cystic Fibrosis

for Cystic Fibrosis

Sponsor: King Saud University

Sex: All·Age: 18+

Code: NCT07500493

Safety and Efficacy of Inhaled BMD003 (CFTR mRNA) in Chinese Cystic Fibrosis Patients Aged ≥12 Years

for Cystic Fibrosis

Sponsor: Peking Union Medical College Hospital

Sex: All·Age: 12+

Code: NCT07485543·EARLY_Phase 1

Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-272 in Healthy Participants

for Cystic Fibrosis

1 site in Tempe

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07437105·Phase 1

Apply to this trial

Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants

for Cystic Fibrosis

1 site in Overland Park

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07283770·Phase 1

Apply to this trial

Study of the Prevalence of Active/Passive Smoking and Vaping Among Patients With Cystic Fibrosis

for Cystic Fibrosis

Sponsor: University Hospital, Strasbourg, France

Sex: All·Age: 18+

Code: NCT07342920

Apply to this trial

A Cohort for Inflammatory Respiratory Diseases: From Phenotyping to Personalised Medicine

for Chronic Obstructive Pulmonary Disease

Sponsor: CHU de Reims

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07274631

Apply to this trial

Comparative Effects of Mechanical and Manual Airway Clearance Techniques in Cystic Fibrosis

for Cystic Fibrosis

Sponsor: Riphah International University

Sex: All·Age: 16 - 40

Code: NCT07062939

Assessing Tenapanor as a Treatment of CF-related Constipation.

for Cystic Fibrosis

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18 - 75

Code: NCT06810167·Phase 3

Apply to this trial

Restarting Triple Therapy With Robust Monitoring for Adverse Events (RETRIAL)

for Cystic Fibrosis

18 sites incl. Birmingham

Sponsor: Boston Children's Hospital

Sex: All·Age: 6+

Code: NCT06683092

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Oral Health Status of Cystic Fibrosis Patients. An Online Survey in Collaboration With the Vaincre la Mucoviscidose Patient Association.

for Cystic Fibrosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT06356246

Apply to this trial

Maralixibat in Patients With Cystic Fibrosis and Constipation

for Constipation Chronic Idiopathic

1 site in Los Angeles

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 1 - 18

Code: NCT06413368·Phase 2, Phase 3

Apply to this trial

Remote Sputum Collection in Cystic Fibrosis

for Cystic Fibrosis

3 sites incl. Denver

Sponsor: University of Pennsylvania

Sex: All·Age: 18+

Code: NCT06950892

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Continuous Glucose Monitoring and OGTT Screen for Cystic Fibrosis Related Diabetes in Cystic Fibrosis

for Cystic Fibrosis-related Diabetes

1 site in Milwaukee

Sponsor: Medical College of Wisconsin

Sex: All·Age: 18+

Code: NCT06560463

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Evaluation of New Device for Beta-adrenergic Sweat Test in the Context of Stratification of Patient With Cystic Fibrosis

for Cystic Fibrosis

Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT06836453

Apply to this trial

Safety, Tolerability and Efficacy Study of ARCT-032 in People With Cystic Fibrosis

for Cystic Fibrosis

12 sites incl. Tucson

Sponsor: Arcturus Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT06747858·Phase 2

Apply to this trial

Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

for Cystic Fibrosis

31 sites incl. Birmingham

Sponsor: University of Washington, the Collaborative Health Studies Coordinating Center

Sex: All·Age: 3 - 18

Code: NCT06654752

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Impact of a Coordinated Dietetic-adapted Physical Activity Program on the Percentage of Lean Body Mass in Adults With Cystic Fibrosis Treated With Elexacaftor-Tezacaftor-Ivacaftor: Multicentre Randomised Controlled Trial

for Cystic Fibrosis

Sponsor: University Hospital, Tours

Sex: All·Age: 18+

Code: NCT06457451

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Development of Non-Invasive Prenatal Diagnosis for Single Gene Disorders

for Invasive PreNatal Diagnosis in a Context of Family History of Single-gene Disorders, Including

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: Female·Age: 18+

Code: NCT06147414

Apply to this trial

e-Health Program to Prevent Exacerbations in the Cystic Fibrosis Population

for Cystic Fibrosis

Sponsor: University of Valencia

Sex: All·Age: 6+

Code: NCT06313827

Apply to this trial

A Research Study to Advance the CF Therapeutics Pipeline for People Without Modulators

for Cystic Fibrosis

68 sites incl. Birmingham

Sponsor: Nicole Hamblett

Sex: All·Age: 12+

Code: NCT06504589

Apply to this trial

Physical Activity Profile and Sedentary Behaviour in Adults With Cystic Fibrosis

for Cystic Fibrosis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18 - 65

Code: NCT06507956

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A Phase 1/2 Trial of SP-101 for the Treatment of Cystic Fibrosis (CF)

for Cystic Fibrosis

4 sites incl. Kansas City

Sponsor: Spirovant Sciences, Inc.

Sex: All·Age: 18 - 65

Code: NCT06526923·Phase 1, Phase 2

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Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation

for Cystic Fibrosis

Sponsor: University Hospital, Brest

Sex: Male·Age: 18+·Accepts healthy volunteers

Code: NCT06045702

Apply to this trial

Acoustic Waveform Respiratory Evaluation

for Asthma

2 sites incl. Indianapolis

Sponsor: Indiana University

Sex: All·Age: 8 - 70·Accepts healthy volunteers

Code: NCT06512064

Apply to this trial

Skin-interfaced Colorimetric Bifluidic Sweat Sensor Device for the Diagnosis of Cystic Fibrosis (CF)

for Cystic Fibrosis

1 site in Hershey

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT05998629

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A Usability Validation of the MuCopilot Mobile Application, a Digital Tool for the Unsupervised Objective Assessment of Cystic Fibrosis

for Cystic Fibrosis

Sponsor: Ad scientiam

Sex: All·Age: 18+

Code: NCT06132048

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Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of SPL84 in Patients With Cystic Fibrosis

for Cystic Fibrosis

3 sites incl. Los Angeles

Sponsor: SpliSense Ltd.

Sex: All·Age: 18+

Code: NCT06429176·Phase 2

Apply to this trial

FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases

for Alpha-Thalassemia

1 site in Los Altos

Sponsor: xCures

Sex: All·Age: All ages

Code: NCT06539169

Apply to this trial

Targeting Inflammation With Losartan to Improve Response to Modulator Therapy in Cystic Fibrosis.

for Cystic Fibrosis

1 site in Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 12+

Code: NCT06364176·Phase 2

Apply to this trial

Health Outcomes of Parents With Cystic Fibrosis-Aim 2

for Cystic Fibrosis

18 sites incl. Birmingham

Sponsor: University of Pittsburgh

Sex: All·Age: 18+

Code: NCT06296394

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Circadian Rhythm Disorders in Children With Cystic Fibrosis Under CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Modulators

for Cystic Fibrosis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 2 - 17

Code: NCT06370962

Apply to this trial

Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis

for Cystic Fibrosis

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 13 - 20·Accepts healthy volunteers

Code: NCT06216704

Apply to this trial

CFTR Modulators in Pregnancy and Postpartum

for Cystic Fibrosis

Sponsor: Region Stockholm

Sex: All·Age: Up to 50

Code: NCT06302270

Apply to this trial

Mycobacteriophage Treatment of Non-tuberculosis Mycobacteria

for Cystic Fibrosis

18 sites incl. Birmingham

Sponsor: National Jewish Health

Sex: All·Age: 6+

Code: NCT06262282

A Phase 2 Study Evaluating Safety and Tolerability of RCT2100 (CFTR mRNA) in Healthy Participants and in Participants With CF

for Cystic Fibrosis

13 sites incl. Birmingham

Sponsor: ReCode Therapeutics

Sex: All·Age: 18 - 60·Accepts healthy volunteers

Code: NCT06237335·Phase 2

Apply to this trial

Regional Monitoring of CF Lung Disease

for Cystic Fibrosis

1 site in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 12 - 21

Code: NCT06339593·EARLY_Phase 1

Apply to this trial

Impact of Highly Effective Modulator Therapy on the Cystic Fibrosis Microbiome

for Cystic Fibrosis

1 site in Lebanon

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18 - 99

Code: NCT05982795

Apply to this trial

ENHANCE- Establishing Natural History in an Advanced New CF Care Era

for Cystic Fibrosis

Sponsor: Royal College of Surgeons, Ireland

Sex: All·Age: 1 Month - 5·Accepts healthy volunteers

Code: NCT05986045

Lung Transplant READY CF 2: CARING CF Ancillary RCT

for Cystic Fibrosis

1 site in Seattle

Sponsor: University of Washington

Sex: All·Age: 18+

Code: NCT06032273

Apply to this trial

The Effects of a Low Glycemic Load Diet on Dysglycemia and Body Composition in Adults With Cystic Fibrosis-Related Diabetes

for Cystic Fibrosis

2 sites incl. Boston

Sponsor: Rhode Island Hospital

Sex: All·Age: 18 - 70

Code: NCT05723445

Apply to this trial

Peer-supporting for Teenagers With Cystic Fibrosis in the Transition of Care From Paediatric to Adult Services

for Cystic Fibrosis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 15 - 24

Code: NCT05795673

CF Organization of Care in the Era of Highly Effective Modulator.

for Cystic Fibrosis

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 6+

Code: NCT06599892

Apply to this trial

Evaluation of Long-Term Safety and Efficacy of Vanzacaftor/Tezacaftor/Deutivacaftor in Cystic Fibrosis Participants 1 Year of Age and Older

for Cystic Fibrosis

18 sites incl. Orange

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 1+

Code: NCT05844449·Phase 3

A Study Assessing KB407 for the Treatment of Cystic Fibrosis

for Cystic Fibrosis

6 sites incl. Gainesville

Sponsor: Krystal Biotech, Inc.

Sex: All·Age: 18+

Code: NCT05504837·Phase 1

Apply to this trial

FEED-Cystic Fibrosis (FEED-CF)

for Cystic Fibrosis

1 site in Atlanta

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT05766774

Apply to this trial

Estrogen Supplementation and Bone Health in Women With CF

for Cystic Fibrosis

1 site in Baltimore

Sponsor: Johns Hopkins University

Sex: Female·Age: 0 - 100

Code: NCT05704036·Phase 4

Apply to this trial

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

59 sites incl. Birmingham

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4

Apply to this trial

Sinus Disease in Young Children With Cystic Fibrosis

for Cystic Fibrosis in Children

6 sites incl. Aurora

Sponsor: University of California, Los Angeles

Sex: All·Age: 2 - 8

Code: NCT06191640

Apply to this trial

Hormonal Responses to a Mixed Meal in People With Cystic Fibrosis

for Cystic Fibrosis

1 site in Cincinnati

Sponsor: University of Cincinnati

Sex: All·Age: 18 - 45·Accepts healthy volunteers

Code: NCT06163482·EARLY_Phase 1

Apply to this trial

Study to Assess Amphotericin B Cystetic for Inhalation (ABCI) Doses in Healthy Volunteers & People with Cystic Fibrosis

for Cystic Fibrosis

Sponsor: Cystetic Medicines, Inc.

Sex: All·Age: 16+·Accepts healthy volunteers

Code: NCT05802264·Phase 1

Apply to this trial

Breath Analysis and Arterial Stiffness in Patients With Respiratory Diseases

for Chronic Respiratory Diseases

Sponsor: I.M. Sechenov First Moscow State Medical University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05727852

Prospective Healthcare-Associated Links in Transmission of Nontuberculous Mycobacteria

for Cystic Fibrosis

7 sites incl. Denver

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 1 Month - 99

Code: NCT05686837

COVID-19 Antibody Responses In Cystic Fibrosis

for COVID-19

Sponsor: Pilar Azevedo

Sex: All·Age: All ages

Code: NCT06274840

Apply to this trial

BEGIN Novel ImagiNG Biomarkers

for Cystic Fibrosis

1 site in Charlottesville

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 6 - 8

Code: NCT05517655·Phase 4

Apply to this trial

Patienthèque of Finisterian (South of Brittany) Children With Cystic Fibrosis in the Time of Precision Medicine

for Cystic Fibrosis

Sponsor: University Hospital, Brest

Sex: All·Age: Up to 18

Code: NCT04137133

Apply to this trial

Metformin for People With CFRD on CFTR Modulator Therapy to Improve Ion Channel Function

for Cystic Fibrosis-related Diabetes

1 site in Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18+

Code: NCT04530383·Phase 2

Apply to this trial

Identification of Dysglycemia With Continuous Glucose Monitoring to Assess Clinical Evolution in Cystic Fibrosis

for Cystic Fibrosis

Sponsor: Institut de Recherches Cliniques de Montreal

Sex: All·Age: 18+

Code: NCT05099939

Apply to this trial

Cystic fibrosis clinical trials — common questions

Are cystic fibrosis clinical trials free to join?

Yes. Participating in a cystic fibrosis clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a cystic fibrosis clinical trial?

Each cystic fibrosis study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a cystic fibrosis trial near me?

Use the location controls above. We'll show recruiting cystic fibrosis trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many cystic fibrosis trials are recruiting right now?

We're currently tracking roughly 61 recruiting cystic fibrosis trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Cystic fibrosis trials by city

Birmingham, AL Cincinnati, OH Boston, MA Denver, CO Los Angeles, CA Aurora, CO Gainesville, FL Indianapolis, IN Irvine, CA Milwaukee, WI Orange, CA Seattle, WA

Related specialties

Pulmonology Lung disease