Ewing sarcoma Clinical Trials

Recruiting ewing sarcoma studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat ewing sarcoma. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting ewing sarcoma studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting ewing sarcoma trials

Within

EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT

for Ewing Sarcoma

1 site in Cleveland

Sponsor: Rabi Hanna

Sex: All·Age: 2+

Code: NCT07695311·Phase 1

Integration of Adaptive Proton Therapy in Pediatric Solid Tumors and Hodgkin's Lymphoma

for Pediatric Solid Tumors

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: All ages

Code: NCT07514819

my.naviGATE: A Guide to After-Treatment Effects for Adolescents and Young Adults

for Sarcoma

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 15 - 24

Code: NCT07516353

Combination Immunotherapy Targeting Sarcomas

for Sarcoma

Sponsor: Shenzhen Geno-Immune Medical Institute

Sex: All·Age: 1 - 75

Code: NCT04433221·Phase 1, Phase 2

Apply to this trial

Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

for Osteosarcoma

2 sites incl. Tampa

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: 0 - 50

Code: NCT07321912·Phase 2

Apply to this trial

Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas

for Sarcoma

Sponsor: Shenzhen Geno-Immune Medical Institute

Sex: All·Age: 1 - 75

Code: NCT03356782·Phase 1, Phase 2

Apply to this trial

Neoadjuvant Radiotherapy and Surgery for High-Risk Localized Ewing Sarcoma

for Ewing Sarcoma

Sponsor: Peking University People's Hospital

Sex: All·Age: 12 Months+

Code: NCT07620431

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

for Atypical Teratoid/Rhabdoid Tumor

12 sites incl. Birmingham

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: Up to 26

Code: NCT06465199·Phase 1, Phase 2

Apply to this trial

Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors

for Adenocarcinoma

1 site in Orange

Sponsor: University of California, Irvine

Sex: All·Age: 18+

Code: NCT07628634·EARLY_Phase 1

Apply to this trial

Evaluation of Xaluritamig in Adults, Adolescents and Children With Relapsed or Refractory Ewing Sarcoma (EWS)

for Ewing Sarcoma

5 sites incl. Los Angeles

Sponsor: Amgen

Sex: All·Age: 2+

Code: NCT07297979·Phase 1

Apply to this trial

Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors

for Neuroblastoma

1 site in Gainesville

Sponsor: University of Florida

Sex: All·Age: 6 Months - 25

Code: NCT06625190·Phase 1, Phase 2

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Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE)

for Rhabdomyosarcoma

2 sites in Washington D.C.

Sponsor: Children's National Research Institute

Sex: All·Age: 1 - 23

Code: NCT07172958·Phase 1

Apply to this trial

Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas

for Sarcoma

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT07222735·Phase 1

Apply to this trial

A Phase 1/1B Study of ST-01156, a Small Molecule RBM39 Degrader, in Patients With Advanced Solid Malignancies

for Advanced Solid Tumors

6 sites incl. Duarte

Sponsor: SEED Therapeutics, Inc.

Sex: All·Age: 16+

Code: NCT07197554·Phase 1

Apply to this trial

Biologically-Adapted, Dose-Escalated Radiotherapy for the Treatment of Ewing Sarcoma, BEAR Trial

for Ewing Sarcoma

2 sites incl. Phoenix

Sponsor: Mayo Clinic

Sex: All·Age: 2+

Code: NCT07188532

Apply to this trial

A Study of DXC008 in Patients With Prostate Cancer and Other Solid Tumors

for Prostate Cancer

Sponsor: Hangzhou DAC Biotechnology Co., Ltd.

Sex: All·Age: 18 - 75

Code: NCT06926283·Phase 1

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Phase II Study of Irinotecan Liposome (II) Combined With Temozolomide and Fluzoparib in Recurrent or Metastatic Ewing Sarcoma

for Ewing Sarcoma

Sponsor: Sun Yat-sen University

Sex: All·Age: 18 - 75

Code: NCT06827717·Phase 2

Apply to this trial

Targeted Oligometastatic Radiation in Pediatric and Young Adult Patients With Soft Tissue and Bone Sarcoma

for Metastatic Sarcoma

3 sites incl. Washington D.C.

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Sex: All·Age: Up to 39

Code: NCT06796543

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Fertility Preservation in Children With Solid Tumors: Detection of Residual Disease by a Sensitive Method

for Neuroblastoma

Sponsor: University Hospital, Clermont-Ferrand

Sex: All·Age: 2 - 45

Code: NCT07141862

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A Prospective, Randomized, Controlled Clinical Study on the Prevention of Chemotherapy Related Myelosuppression in Patients with Ewing's Sarcoma Using Trilaciclib

for Ewing Sarcoma

Sponsor: Fudan University

Sex: All·Age: 14 - 40

Code: NCT06699472·Phase 2

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Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

for Neuroblastoma

21 sites incl. Birmingham

Sponsor: Milton S. Hershey Medical Center

Sex: All·Age: Up to 30

Code: NCT06541262·Phase 1, Phase 2

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A Study of KC1036 in Adolescents With Advanced Ewing Sarcoma

for Ewing Sarcoma

Sponsor: Beijing Konruns Pharmaceutical Co., Ltd.

Sex: All·Age: 12 - 18

Code: NCT06564272·Phase 2

Apply to this trial

XL092 (Zanzalintinib) for the Treatment of Patients With Metastatic or Unresectable Leiomyosarcoma, Bone Sarcoma or Translocation-associated Soft Tissue Sarcoma

for Metastatic Leiomyosarcoma

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06571734·Phase 2

Apply to this trial

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

for B-cell Acute Lymphoblastic Leukemia

17 sites incl. Los Angeles

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 6 Months - 25

Code: NCT06395103·Phase 1, Phase 2

Apply to this trial

Weekly Irinotecan Liposomes in Recurrent or Refractory Ewing Sarcoma

for Ewing Sarcoma

Sponsor: Peking University People's Hospital

Sex: All·Age: 8 - 40

Code: NCT06340204·Phase 1

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Identification of Prognostic Factors and Role of Radiotherapy in Patients With Ewing Sarcoma

for Ewing Sarcoma

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 2+

Code: NCT06243588

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To Evaluate the Efficacy and Safety of Naxitamab in Patients With Refractory Ewing's Sarcoma (Butterfly)

for Ewing Sarcoma

Sponsor: Anna Raciborska

Sex: All·Age: 2 - 21

Code: NCT05968768·Phase 2

Apply to this trial

Cabozantinib With Ifosfamide in Relapsed/Refractory Sarcomas

for Ewing Sarcoma

4 sites incl. San Francisco

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 5 - 40

Code: NCT06156410·Phase 1

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Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision)

for Ewing Sarcoma

Sponsor: University Hospital Tuebingen

Sex: All·Age: 2 - 40

Code: NCT06094101·Phase 1, Phase 2

Apply to this trial

Analysis of the Toxicity and Efficacy of Daily 1 vs 2 Beam Proton Therapy

for Chordoma

Sponsor: Centre Antoine Lacassagne

Sex: All·Age: 18+

Code: NCT06029218

Apply to this trial

Lurbinectedin in FET-Fused Tumors

for Ewing Sarcoma

6 sites incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10+

Code: NCT05918640·Phase 1, Phase 2

Apply to this trial

Study of Lurbinectedin Monotherapy in Pediatric and Young Adult Participants With Relapsed/Refractory Ewing Sarcoma

for Refractory Ewing Sarcoma

14 sites incl. Los Angeles

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: 2 - 30

Code: NCT05734066·Phase 1, Phase 2

Apply to this trial

Use of GnRHa During Chemotherapy for Fertility Protection

for Breast Cancer Female

Sponsor: Kenny Rodriguez-Wallberg

Sex: Female·Age: 14 - 42

Code: NCT05328258·Phase 3

Apply to this trial

Adherence to a Personalized Home Exercise Program in Patients With Bone Tumor Undergoing Lower Extremity Salvage Surgery

for Osteosarcoma

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 12 - 90

Code: NCT05779670

Apply to this trial

B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR)

for Pediatric Solid Tumor

1 site in Memphis

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 21

Code: NCT04897321·Phase 1

Apply to this trial

Combination of Pembrolizumab and Cabozantinib in Patients With Advanced Sarcomas

for Soft Tissue Sarcoma Adult

Sponsor: Institut Bergonié

Sex: All·Age: 18+

Code: NCT05182164·Phase 2

Apply to this trial

Early Ageing During Therapy in AYA Cancer Patients

for Cancer

Sponsor: University Medical Center Groningen

Sex: All·Age: 18 - 39

Code: NCT05062707

Apply to this trial

HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma

for Sarcoma

1 site in Houston

Sponsor: Baylor College of Medicine

Sex: All·Age: 1 - 25

Code: NCT04995003·Phase 1

Apply to this trial

Metformin as Maintenance Therapy in Patients With Bone Sarcoma and High Risk of Relapse

for Osteosarcoma

Sponsor: Istituto Ortopedico Rizzoli

Sex: All·Age: 14+

Code: NCT04758000·Phase 2

Apply to this trial

Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas

for Bone Sarcoma

Sponsor: Centre Leon Berard

Sex: All·Age: 12+

Code: NCT04055220

Apply to this trial

Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

for Ewing Sarcoma

18 sites incl. Beverly Hills

Sponsor: Inhibrx Biosciences, Inc

Sex: All·Age: 12 - 85

Code: NCT03715933·Phase 1

Apply to this trial

Vorinostat in Combination With Chemotherapy in Relapsed/Refractory Solid Tumors and CNS Malignancies

for Ewing Sarcoma

1 site in Valhalla

Sponsor: New York Medical College

Sex: All·Age: 1 - 30

Code: NCT04308330·Phase 1

Apply to this trial

Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

for Acute Myeloid Leukemia

1 site in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 7 Months - 21

Code: NCT02508038·Phase 1

Apply to this trial

Ewing sarcoma clinical trials — common questions

Are ewing sarcoma clinical trials free to join?

Yes. Participating in a ewing sarcoma clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a ewing sarcoma clinical trial?

Each ewing sarcoma study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a ewing sarcoma trial near me?

Use the location controls above. We'll show recruiting ewing sarcoma trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many ewing sarcoma trials are recruiting right now?

We're currently tracking roughly 20 recruiting ewing sarcoma trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Ewing sarcoma trials by city

Los Angeles, CA Birmingham, AL Beverly Hills, CA Boston, MA Chicago, IL Cleveland, OH Duarte, CA Gainesville, FL Madison, WI Orange, CA San Francisco, CA Tampa, FL

Related specialties

Oncology Pediatric oncology