Non-alcoholic fatty liver disease (NAFLD) Clinical Trials

Recruiting non-alcoholic fatty liver disease (nafld) studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.

Clinical trials study new ways to prevent, detect, or treat non-alcoholic fatty liver disease (nafld). Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting non-alcoholic fatty liver disease (nafld) studies with sites across the US; use the location tools to find ones near you.

What to expect

Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.

Recruiting non-alcoholic fatty liver disease (nafld) trials

Within

Liver Steatosis in Pediatric CD Patients

for Celiac Disease in Children

Sponsor: University of Palermo

Sex: All·Age: 1 - 14

Code: NCT06206616

Apply to this trial

SGLT2 Inhibitors as a Novel Treatment for Pediatric Non-Alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

1 site in Chicago

Sponsor: Justin Ryder

Sex: All·Age: 12 - 20

Code: NCT03867487·Phase 2

Human Models of Selective Insulin Resistance: Pancreatic Clamp

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06558422·Phase 1

Effect of Insulin Lowering on Lipogenesis

for Hyperinsulinemia

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT07403604·Phase 1

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Molecular Characterization of Autoimmune Hepatitis: A Lipidomic Approach

for Autoimmune Hepatitis

Sponsor: Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis

Sex: All·Age: 18+

Code: NCT07644936

Efficacy, Safety, and Tolerability of CS0159 Combined With Semaglutide in MAFLD Patients With Obesity and T2DM

for Type 2 Diabetes

Sponsor: Shanghai Jiao Tong University School of Medicine

Sex: All·Age: 18 - 65

Code: NCT07570810

A Randomized, Double-blind, Single-center Phase I/IIa Study of XTYW007 Tablets in Subjects.

for Non-Alcoholic Fatty Liver Disease

Sponsor: Xi'an Xintong Pharmaceutical Research Co.,Ltd.

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT07407634·EARLY_Phase 1

Additive Efficacy of Physical Activity Program in Hypthyroidism Elder Females With Glaucoma and Fatty Liver Issues

for Subclinical hypothyroïdism

Sponsor: Cairo University

Sex: Female·Age: 65 - 75

Code: NCT07599241

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A Study of Efimosfermin Alfa in Adults With Hepatic Impairment

for Non-alcoholic Fatty Liver Disease

3 sites incl. Rialto

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 70

Code: NCT07358546·Phase 1

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A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Efimosfermin Alfa Administered as a Single Dose to Healthy Participants of Chinese, Japanese, and White/European Ancestry

for Non-alcoholic Fatty Liver Disease

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 55·Accepts healthy volunteers

Code: NCT07335198·Phase 1

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A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH

for Non-alcoholic Fatty Liver Disease

43 sites incl. Arcadia

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 75

Code: NCT07221188·Phase 3

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Improving Diagnostic Safety Through STeatosis Identification, Risk Stratification, and Referral in the ED

for Non-Alcoholic Fatty Liver Disease

1 site in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT06944353

A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH

for Non-alcoholic Fatty Liver Disease

49 sites incl. Arcadia

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 75

Code: NCT07221227·Phase 3

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Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

Sponsor: Khyber Medical University Peshawar

Sex: All·Age: 18 - 42

Code: NCT07294963

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Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial

for Obesity

2 sites incl. Boston

Sponsor: Pichamol Jirapinyo, MD, MPH

Sex: All·Age: 18+

Code: NCT06138821

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Mediterranean Diet in Familial Mediterranean Fever: Is Fatty Liver Affected by Addition of Aerobic Exercise

for Familial Mediterranean Fever

Sponsor: Cairo University

Sex: Female·Age: 30 - 55

Code: NCT07130318

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Mechanisms of SGLT2 Inhibition in Pediatric Steatotic Liver Disease

for Non-Alcoholic Fatty Liver Disease

1 site in Chicago

Sponsor: Justin Ryder

Sex: All·Age: 16 - 20

Code: NCT06355310·Phase 2

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A Study of Efimosfermin Alfa in Participants With Biopsy-confirmed Cirrhosis (Compensated) Due to MASH

for Metabolic Dysfunction-Associated Steatohepatitis

30 sites incl. Chandler

Sponsor: GlaxoSmithKline

Sex: All·Age: 18 - 75

Code: NCT06920043·Phase 2

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Validity of Laboratory Biomarkers in Diagnosis of Nonalcoholic Fatty Liver Disease (NAFLD) and It's Consequences

for Non-alcoholic Fatty Liver Disease

Sponsor: Assiut University

Sex: All·Age: 19 - 60

Code: NCT06908122

Evaluating the Safety and Efficacy of Carbocisteine in the Treatment of Nonalcoholic Fatty Liver Disease Patients

for Non-Alcoholic Fatty Liver Disease

Sponsor: Tanta University

Sex: All·Age: 18 - 65

Code: NCT06863376·Phase 2

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Identification of Liver Fibrosis Biomarkers

for Non-alcoholic Fatty Liver

Sponsor: Roche Diagnostics GmbH

Sex: All·Age: 18 - 75

Code: NCT06819917

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Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise

for Adolescent Obesity

Sponsor: University of Lisbon

Sex: All·Age: 13 - 18

Code: NCT06520800

The Effects of Tai Chi on Metabolic Dysfunction-associated Fatty Liver Disease in Middle-Aged and Older Adults

for Non-Alcoholic Fatty Liver Disease

Sponsor: Fujian Provincial Hospital

Sex: All·Age: 40 - 75

Code: NCT06717828

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MASLD in Primary Hypothyroidism and Efficacy of Dapaglifozin

for Hepatic Steato-Fibrosis

Sponsor: Post Graduate Institute of Medical Education and Research, Chandigarh

Sex: All·Age: 18 - 75

Code: NCT06373523·EARLY_Phase 1

Harnessing Macrophage Lysosomal Lipid Metabolism in Obesity (ATM)

for Obesity

1 site in Columbia

Sponsor: Bettina Mittendorfer

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06571474

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Establishment of Precise Histological Evaluation Criteria for NASH Fibrosis Reversal

for Non-alcoholic Fatty Liver Disease

Sponsor: Beijing Municipal Administration of Hospitals

Sex: All·Age: 18 - 70

Code: NCT06707129

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Pyramidal Versus Continuous Training Effects on Fatty Liver

for Non-Alcoholic Fatty Liver Disease

Sponsor: Cairo University

Sex: Female·Age: 37 - 51

Code: NCT06803108

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Fibrosis Lessens After Metabolic Surgery

for Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD)

4 sites incl. Phoenix

Sponsor: Ali Aminian

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06374875·Phase 4

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Liver-gut Axis Study Through Identification of Liver Disease-specific Microbiome

for Autoimmune Hepatitis

Sponsor: Chungnam National University Hospital

Sex: All·Age: 19+·Accepts healthy volunteers

Code: NCT06519162

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Study on the Correlation Between Fat Soluble Vitamins and Non-alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

Sponsor: First Affiliated Hospital of Zhejiang University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06512701

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Human Models of Selective Insulin Resistance: Alpelisib, Part I

for Insulin Resistance

1 site in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06354088·Phase 1

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Redirecting Immune, Lipid and Metabolic Drivers of Early Cardiovascular Disease: The RESET Cohort Study

for Cardiovascular Diseases

Sponsor: National University Hospital, Singapore

Sex: All·Age: 40 - 70

Code: NCT06211868

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Effects of TOTUM-448 on Liver Fat Content, Cardiometabolic Risk Factors and Gut Microbiota Among Participants with MASLD

for Non-Alcoholic Fatty Liver Disease

Sponsor: Valbiotis

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06704321

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Impact of Soymilk on Liver Disease Severity of Children With Non-alcoholic Fatty Liver Disease (NAFLD)

for Non-Alcoholic Fatty Liver Disease

1 site in Cincinnati

Sponsor: Marialena Mouzaki

Sex: All·Age: 5 - 12

Code: NCT06133101·Phase 2

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Feasibility Study of Deep Learning-based MDixon Quant for Quantitative Assessment of Chemotherapy-induced Fatty Liver

for Non-Alcoholic Fatty Liver Disease

Sponsor: Yunnan Cancer Hospital

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT06735118

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Increased Risk of Non-alcoholic Fatty Liver Disease in Low Birth Weight Individuals

for Non-Alcoholic Fatty Liver Disease

Sponsor: Steno Diabetes Center Copenhagen

Sex: All·Age: 34 - 49

Code: NCT05890365

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Role of Regulatory B Cells in the Pathogenesis of Metabolic Associated Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

Sponsor: Assiut University

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT04720560

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Effect of Timed-Restricted Eating on Metabolic Health

for Obesity

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Sex: All·Age: 50 - 75·Accepts healthy volunteers

Code: NCT06061042

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Clinical Trial Assessing Godex Carnitine Orotate Complex in Nonalcoholic Fatty Liver Disease Patients for Efficacy

for Non-Alcoholic Fatty Liver Disease

Sponsor: Yoon Jun Kim

Sex: All·Age: 19 - 74

Code: NCT06152991·Phase 3

Comorbidities Resolution After MGB Surgery and Change in Body Composition

for Morbid Obesity

Sponsor: All India Institute of Medical Sciences, Bhubaneswar

Sex: All·Age: 18 - 65

Code: NCT06015620

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Chronic Hepatitis B Patients With Concurrent MAFLD: Cohort Study and Exercise Intervention.

for Chronic Hepatitis B

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18 - 70

Code: NCT05956379

InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer

for Cancer Risk

1 site in Boston

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05463796

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Synbiotics and Fecal Microbiota Transplantation to Treat Non-Alcoholic Steatohepatitis

for Non Alcoholic Steatohepatitis

Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Sex: All·Age: 18 - 75

Code: NCT05821010·Phase 2

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Digitalized Surveillance Management for Liver Cancer Risk Population in Improving Eearly Diagnosis Efficancy in Chinese Population (dSEARCH)

for Carcinoma, Hepatocellular

Sponsor: Ruijin Hospital

Sex: All·Age: 18 - 75

Code: NCT05870969

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CHronic Hepatopathies Associated With ALcohol Consumption aNd metAbolic Syndrome

for Non-Alcoholic Fatty Liver Disease

Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Sex: All·Age: 18+

Code: NCT05623150

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Effects of VLCKD in Metabolic Syndrome

for Diabetes Mellitus, Type 2

Sponsor: Azienda Ospedaliero Universitaria Maggiore della Carita

Sex: All·Age: 25 - 65

Code: NCT05275608

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Quantifying Hepatic Mitochondrial Fluxes in Humans

for Non-Alcoholic Fatty Liver Disease

2 sites in San Antonio

Sponsor: The University of Texas Health Science Center at San Antonio

Sex: All·Age: 18 - 80

Code: NCT05305287·Phase 4

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The Effect of Bariatric Surgery on Hepatic Metabolism in Non-Alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

Sponsor: Helsinki University Central Hospital

Sex: All·Age: 18 - 75

Code: NCT05551559

Soluble Fibre Supplementation in NAFLD

for Non-Alcoholic Fatty Liver Disease

Sponsor: McMaster University

Sex: All·Age: 8 - 17

Code: NCT05480696·Phase 2

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Risk Factors for Hepatic Inflammation, Fibrosis and Prognosis in Patients With CHB and NAFLD

for Chronic Hepatitis b

Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Sex: All·Age: 18+

Code: NCT05766449

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Diet and Meal Timing in Patients With Metabolic Dysfunction Associated Steatoic Liver Disease

for Non-Alcoholic Fatty Liver Disease

1 site in New York

Sponsor: Weill Medical College of Cornell University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT05332613

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BeijngFH Health Cohort Study

for Non-Alcoholic Fatty Liver Disease

Sponsor: Beijing Friendship Hospital

Sex: All·Age: 18+

Code: NCT05546086

Apply to this trial

Intermittent Fasting for NAFLD in Adults

for Fatty Liver

1 site in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04899102

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Prevention of NAFLD and CVD Through Lifestyle Intervention

for Non-Alcoholic Fatty Liver Disease

Sponsor: Pontificia Universidad Catolica de Chile

Sex: All·Age: 45 - 60·Accepts healthy volunteers

Code: NCT05618626

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Endoscopic Ultrasound Shear Wave Elastography in Patients With Non-alcoholic Fatty Liver Disease

for Non-Alcoholic Fatty Liver Disease

2 sites in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05728697

Apply to this trial

AdventHealth Research Institute Non-Alcoholic Fatty Liver Disease Biobank and Registry (AVAIL)

for Non-Alcoholic Fatty Liver Disease

1 site in Orlando

Sponsor: AdventHealth Translational Research Institute

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04807868

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"Constitution of a Biological Collection to Establish Preclinical Translational Models for the Study of Tumors and Chronic Liver Diseases".

for Chronic Liver Disease and Cirrhosis

Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Sex: All·Age: 18+

Code: NCT04690972

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Integrated Diagnostics for Early Diagnosis of Liver Disease

for Non-Alcoholic Fatty Liver Disease

Sponsor: Manchester University NHS Foundation Trust

Sex: All·Age: 18+

Code: NCT04666402

Apply to this trial

The Olmsted NAFLD Epidemiology Study (TONES)

for Non-Alcoholic Fatty Liver Disease

1 site in Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 18+

Code: NCT04365855

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Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)

for Non-Alcoholic Steatohepatitis

1 site in Bethesda

Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sex: All·Age: 18 - 100·Accepts healthy volunteers

Code: NCT03884075·Phase 2

Apply to this trial

Non-alcoholic fatty liver disease (NAFLD) clinical trials — common questions

Are non-alcoholic fatty liver disease (nafld) clinical trials free to join?

Yes. Participating in a non-alcoholic fatty liver disease (nafld) clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.

Who can join a non-alcoholic fatty liver disease (nafld) clinical trial?

Each non-alcoholic fatty liver disease (nafld) study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.

How do I find a non-alcoholic fatty liver disease (nafld) trial near me?

Use the location controls above. We'll show recruiting non-alcoholic fatty liver disease (nafld) trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.

How many non-alcoholic fatty liver disease (nafld) trials are recruiting right now?

We're currently tracking roughly 25 recruiting non-alcoholic fatty liver disease (nafld) trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.

Looking for a specific location? Browse trials by city and state.

Non-alcoholic fatty liver disease (NAFLD) trials by city

Boston, MA Chicago, IL Cincinnati, OH Orlando, FL

Related specialties

Gastroenterology Hepatology Metabolic health