Knee osteoarthritis Clinical Trials
Recruiting knee osteoarthritis studies with sites across the US, sourced from ClinicalTrials.gov and refreshed daily. Free to join — find one near you below.
Clinical trials study new ways to prevent, detect, or treat knee osteoarthritis. Joining one can give you access to investigational treatments and close monitoring by a specialist research team — at no cost — while helping advance care for others. Below are recruiting knee osteoarthritis studies with sites across the US; use the location tools to find ones near you.
What to expect
- Screening first. The study team reviews your eligibility before anything else — there's no obligation to continue.
- Informed consent. You'll get a full explanation of the study, its potential risks and benefits, and can withdraw at any time.
- No cost to you. Study visits, tests, and the investigational treatment are covered; many studies reimburse travel.
Recruiting knee osteoarthritis trials
Duloxetine and aeRobic Exercise to Improve Function in VEterans With Knee Osteoarthritis (DRIVE)
Zynrelef Versus Adductor Canal Block
Mechanical Alignment Versus Kinematic Alignment Total Knee Arthroplasty
Heart Rate Variability Guided Physical Activity and Exercise Prescription in Individuals With Knee Osteoarthritis
Efficacy of Autologous Adipose Derived Stromal Vascular Fraction for Musculoskeletal Conditions
IMAGES: Identifying Metabolic Imaging Association With Genicular Artery Embolization Success
Effects of Music During Walking on Pain and Muscle Activation in People With Chronic Pain Due to Knee Osteoarthritis
A Study Evaluating the Safety, Tolerability, and Activity of ICM-203 in Subjects With Knee Osteoarthritis.
The ACT-ON: A Geriatric 5-Ms-Guided Physical Therapy Intervention for Knee Osteo-Arthritis in Older Adults.
Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis
NANOVAE to Treat Knee Osteoarthritis (KOA)
Effect of Nonsteroidal Anti-Inflammatory Drug Restriction on the Efficacy of Platelet-Rich Plasma in Knee Osteoarthritis
Effects of Different Collagen Formulations on Knee Osteoarthritis
Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis
Intra Articular Injection of Peripheral Blood Mononuclear Cells for Knee Osteoarthritis
Boosting Exercise Adherence in Knee Osteoarthritis
Use of Corticosteroid in Intraopertive Injections in Total Knee Replacement Surgery.
Effect of Inspiratory Muscle Training on Knee Osteoarthritis Pain
Effects of IMT on Cardiopulmonary Endurance and Functional Mobility in KOA
Unipolar Versus Bipolar Radiofrequency Ablation in Knee Osteoarthritis Pain
Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis
Phonophoresis With Bee Venom: Evaluating Its Efficacy in Managing Pain and Enhancing Mobility in Knee Osteoarthritis Patients
Effect of AI-Assisted Anatomical Visualization on Anxiety and Kinesiophobia in Knee Arthroplasty Patients
Suprainguinal Fascia Iliaca Block vs. Adductor Canal Block for Analgesia After Total Knee Arthroplasty
Pre-emptive Insulin to Prevent High Glucose After a Knee Steroid Injection in Adults With Type 2 Diabetes
A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)
Effect of Tergase Injection on Reducing Edema After Bilateral Total Knee Arthroplasty
Exploration of Appropriate BIS Range and Propofol Effect-site Concentration During Total Intravenous Anesthesia With Concomitant Adjuvants.
Formative Evaluation of a Mobile Application Facilitated Self-directed Rehabilitation Programme for Knee Osteoarthritis
Role of Suzetrigine as a Part of a Multimodal Regimen to Reduce Pain and Opioid Use After Total Knee Arthroplasty
Robotic-Assisted Versus Conventional Total Knee Arthroplasty With Virtual Home-Based Rehabilitation
Shock Wave Treatment in Patients With Knee Osteoarthritis
Paraspinal NMES and Spinopelvic Alignment After Knee Arthroplasty
Standard Versus Novel RFA for Chronic Knee Pain in Osteoarthritis
A Multicenter, Open-Label, Single-Arm Extension Study to Evaluate the Safety and Efficacy of FURESTEM-OA-Kit Inj. in Knee Osteoarthritis Patients Who Received Placebo in the K0701 Phase 2a Trial
Efficacy of Platelet-Rich Plasma Combined With Hyaluronic Acid in Knee Osteoarthritis
Efficacy of Platelet-Rich Plasma Added to Hyaluronic Acid in Knee Osteoarthritis
Genicular Artery Embolization for Knee Osteoarthritis
The Effect of Lipedema on Knee Osteoarthritis
Self-managed vs Supervised Exercise for Knee OA
MECHANICAL TRACTION APPLIED BEFORE VERSUS AFTER THERAPEUTIC EXERCISES IN PRIMARY KNEE OSTEOARTHRITIS
Effects of Sahrmann's Approach Versus Conventional Treatment Oin Patients With Knee Osteoarthritis
Health Aid for Knee Osteoarthritis
ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty
Artificial Intelligence-Assisted Advanced Analysis of Knee Imaging and Outcome Prediction
Clinical Trial to Evaluate the Efficacy and Safety of Conjuran® After First and Second Cycle (Repeat) Administration in Patients With Knee Osteoarthritis
A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain
Effect of Alexithymia on Response to Physical Therapy in Patients With Knee Osteoarthritis
Intraarticular Injection of Botox and Hyaluronic Acid in Knee Osteoarthritis
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
Circulatory Exercise After Total Knee Replacement
Effect of TECAR Therapy on Pain, Balance, and Quality of Life in Elderly Men With Knee Osteoarthritis
Cryoneurolysis Versus Radiofrequency in Knee Osteoarthritis
A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
Comparative Study on the Medium- and Long-term Benefits of Prosthesis Selection in Total Knee Arthroplasty
Effects of Two Bar Knee Off-Load Brace With Non Weight Bearing Strength Training Among Knee Osteoarthritis Patients
Effects of the Egoscue Exercises With and Without Mwm Among Patients With Knee Osteoarthritis
Effects of a Machine Learning-based Lower Limb Exercise Training System for Knee Pain
Nerve to Vastus Medialis Branches in Chronic Knee Pain
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Knee osteoarthritis clinical trials — common questions
Are knee osteoarthritis clinical trials free to join?
Yes. Participating in a knee osteoarthritis clinical trial is free — study-related visits, tests, and the investigational treatment are provided at no cost to you. Many studies also reimburse travel and time. You never pay to take part.
Who can join a knee osteoarthritis clinical trial?
Each knee osteoarthritis study sets its own eligibility criteria — typically based on age, medical history, current treatments, and overall health. Every trial listed here shows its criteria, and the study team confirms your eligibility before enrollment. You can review and apply to any that look like a fit.
How do I find a knee osteoarthritis trial near me?
Use the location controls above. We'll show recruiting knee osteoarthritis trials with sites near you, sorted by distance. You can widen the radius or share your exact location for the closest matches.
How many knee osteoarthritis trials are recruiting right now?
We're currently tracking roughly 92 recruiting knee osteoarthritis trials with US sites, sourced from ClinicalTrials.gov and refreshed daily.
Looking for a specific location? Browse trials by city and state.